Research output per year
Research output per year
Personal profile
Research
I use the nematode Caenorhabditis elegans to explore how we can live longer and healthier lives. The 1mm long worm is a highly effective model to explore the molecular basis of human diseases, including neurodegenerative disease, obesity, diabetes and cancer. My research portfolio explores the mechanisms underpinning disease, but also how to use C. elegans in a multidisciplinary platform to probe the effects of drugs, food and exercise and translate these to human health. In the department of Environment and Health (BETA) at the VU, my focus is on the effect of environmentally relevant chemicals e.g., pesticides and PFAS on (neuro)development.
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Acute, Sublethal, and Developmental Toxicity of Kratom (Mitragyna speciosa Korth.) Leaf Preparations on Caenorhabditis elegans as an Invertebrate Model for Human Exposure
Hughes, S., van de Klashorst, D., Veltri, C. A. & Grundmann, O., 2 May 2022, In: International Journal of Environmental Research and Public Health. 19, 10, p. 1-19 19 p., 6294.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated Caenorhabditis elegans screening platform
Haerkens, F., Kikken, C., Kirkels, L., van Amstel, M., Wouters, W., van Doornmalen, E., Francke, C. & Hughes, S., Aug 2022, In: Heliyon. 8, 8, p. 1-8 8 p., e10108.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans
Hughes, S., Kolsters, N., van de Klashorst, D., Kreuter, E. & Berger Büter, K., 13 Jan 2022, In: BMC Nutrition. 8, p. 1-12 12 p., 5.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Toxicological effects of polystyrene nanoparticles on the nematode Caenorhabditis elegans: A predictive model for human toxicity of microplastics
van Boxel, J., Darraz, O., van Duursen, M., Lamoree, M. & Hughes, S., 1 Sept 2022, In: Toxicology Letters. 368, Supplement, p. S115-S115 1 p.Research output: Contribution to Journal › Meeting Abstract › Academic
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Using a Caenorhabditis elegans Parkinson’s Disease Model to Assess Disease Progression and Therapy Efficiency
Hughes, S., van Dop, M., Kolsters, N., van de Klashorst, D., Pogosova, A. & Rijs, A. M., May 2022, In: Pharmaceuticals. 15, 5, p. 1-19 19 p., 512.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access