Research output per year
Research output per year
Personal profile
Research
I use the nematode Caenorhabditis elegans to explore how we can live longer and healthier lives. The 1mm long worm is a highly effective model to explore the molecular basis of human diseases, including neurodegenerative disease, obesity, diabetes and cancer. My research portfolio explores the mechanisms underpinning disease, but also how to use C. elegans in a multidisciplinary platform to probe the effects of drugs, food and exercise and translate these to human health. In the department of Environment and Health (BETA) at the VU, my focus is on the effect of environmentally relevant chemicals e.g., pesticides and PFAS on (neuro)development.
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Collaborations and top research areas from the last five years
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Combined matrix-assisted laser desorption/ionisation-mass spectrometry imaging with liquid chromatography-tandem mass spectrometry for observing spatial distribution of lipids in whole Caenorhabditis elegans
Vandenbosch, M., Amstalden-van Hove, E. R., Mohren, R., Vermeulen, I., Dijkman, H., Heeren, R. M. A., Leonards, P. E. G. & Hughes, S., Sept 2024, In: Rapid Communications in Mass Spectrometry. 38, 17, p. 1-10 10 p., e9850.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Zebrafish and nematodes as whole organism models to measure developmental neurotoxicity
Hughes, S. & Hessel, E. V. S., 4 Jun 2024, In: Critical Reviews in Toxicology. 54, 5, p. 330-343Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Collins, E. M. S., Hessel, E. V. S. & Hughes, S., May 2024, In: Neurotoxicology. 102, p. 48-57 10 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open AccessFile43 Downloads (Pure) -
The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix
Schön, J. L., Groß, V. E., Post, W. B., Daum, A., Matúš, D., Pilz, J., Schnorr, R., Horn, S., Bäumers, M., Weidtkamp-Peters, S., Hughes, S., Schöneberg, T. & Prömel, S., Apr 2024, In: Matrix Biology. 128, p. 1-10 10 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project
Svingen, T., Andersson, A. M., Angelova, J., Axelstad, M., Bakker, J., Baumann, L., Beronius, A., Bouftas, N., Chalmel, F., Christiansen, S., Cornil, C., Damdimopoulou, P., Deepika, D., Dollé, M. E. T., Draskau, M. K., Fischer, M. B., Hagen, C. P., Hessel, E., Holmer, M. L. & Hughes, S. & 20 others, , 2024, In: Open Research Europe. 4, p. 1-13 13 p., 68.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Courses
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The Dutch Protein Aggregation Network
Hughes, S. (Participant)
2025Activity: Participating in or organising an event › Conference › Academic
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Frontiers in Toxicology (Journal)
Hughes, S. (Reviewer)
2025Activity: Peer review and Editorial work › Editorial work › Academic
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Resolving the black box of PFOS and PFDA toxicity: Using a whole-body organism to explore and define toxic endpoints
Hughes, S. (Speaker)
10 Oct 2024Activity: Lecture / Presentation › Professional
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Amsterdam TPI (Transition Program for Innovation without the use of animals)
Hughes, S. (Participant)
2024 → …Activity: Other
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The added value of nematodes to fill the gaps in Adverse Outcome Pathways
Hughes, S. (Speaker)
2023Activity: Lecture / Presentation › Academic