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Stephanie Thee started studying Bio-Pharmaceutical Sciences in 2009 at Leiden University. During her Bachelor internship she synthesized ligands for the adenosine A1 receptor at the LACDR department of Medicinal Chemistry in Leiden. After obtaining her Bachelor’s degree in 2012, Thee obtained her Master’s degree (specialization Medicinal Chemistry) in 2014. For her Master’s program, she did two internships at the LACDR department of Medicinal Chemistry (Leiden University) on the design and synthesis of ligands for the HCA2 receptor and at the GRIP department of Pharmaceutical Gene Modulation (University of Groningen) on the synthesis and analysis of 15-LOX inhibitors. The results of both projects are published in Bioorg Med Chem2015 and Eur J Med Chem 2015 respectively.
In January 2015, Thee started her PhD program at VU University Amsterdam in the Medicinal Chemistry group, under the supervision of Prof. dr. Rob Leurs and Prof. dr. Iwan de Esch. In this project the focus will lie on the 14-3-3 protein family. Using a fragment-based approach, she works on the design and synthesis of inhibitors and stabilizers of 14-3-3 mediated protein-protein interactions.