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Research Output 2005 2019

2019

Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft

Neubacher, S., Hennig, S. & Grossmann, T. N., 1 May 2019, In : BioSpektrum. 25, 3, p. 338-339 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers

Neubacher, S. & Hennig, S., 28 Jan 2019, In : Angewandte Chemie - International Edition. 58, 5, p. 1266-1279 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

RNA
Nucleotide Aptamers
Proteins
Long Noncoding RNA
Blueprints
2018

Identification of novel PANDAR protein interaction partners involved in splicing regulation

Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T. & Hennig, S., 12 Feb 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 2798.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Antisense DNA
DNA Damage
RNA
Long Noncoding RNA
Proteins

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N., 27 Aug 2018, In : Angewandte Chemie - International Edition. 57, 35, p. 11164-11170 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Enzymes
Proteins
Denaturation
Labeling
2017

Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions

Krüger, D. M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O., Hennig, S. & Grossmann, T. N., 13 Oct 2017, In : Journal of Medicinal Chemistry. 60, p. 8982-8988

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Proteins
Digital Libraries
Amino Acids
Workflow

Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach

Roszyk, L., Kollenda, S. & Hennig, S., 15 Dec 2017, In : Acs chemical biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Spinacia oleracea
RNA
Proteins
Energy Transfer
Energy transfer
2015

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G. J., Iyer, K. S., Ho, D., Newcombe, E. A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C. S. & Fox, A. H., 17 Aug 2015, In : Journal of Cell Biology. 210, 4, p. 529-39 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Prions
Phase Transition
RNA-Binding Protein FUS
Long Noncoding RNA
RNA Recognition Motif Proteins

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes

Lee, C-U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S. & Grossmann, T. N., 9 Nov 2015, In : Angewandte Chemie International Edition in English. 54, 46, p. 13796-13800 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2014

Modulators of protein-protein interactions

Milroy, L-G., Grossmann, T. N., Hennig, S., Brunsveld, L. & Ottmann, C., 14 May 2014, In : Chemical Reviews. 114, 9, p. 4695-4748 54 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., MacDonald, T. Y., Fontugne, J., Erho, N., Vergara, I. A., Ghadessi, M., Davicioni, E., Jenkins, R. B., Palanisamy, N., Chen, Z., Nakagawa, S. & 6 othersHirose, T., Bander, N. H., Beltran, H., Fox, A. H., Elemento, O. & Rubin, M. A., 21 Nov 2014, In : Nature Communications. 5, 5383.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Long Noncoding RNA
estrogens
Estrogen Receptor alpha
Androgen Receptors
Modulators
2013

Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions

Thiel, P., Röglin, L., Meissner, N., Hennig, S., Kohlbacher, O. & Ottmann, C., 4 Oct 2013, In : Chemical Commununications. 49, 76, p. 8468-70 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

14-3-3 Proteins
Assays
Screening
Proteins
CD13 Antigens
2012

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

Kucera, N., Schmalen, I., Hennig, S., Öllinger, R., Strauss, H. M., Grudziecki, A., Wieczorek, C., Kramer, A. & Wolf, E., 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3311-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cellular Structures
Tryptophan
Fluorescence Recovery After Photobleaching
Circadian Clocks
Ultracentrifugation
2011

Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1-NONO heterodimer

Lee, M., Passon, D. M., Hennig, S., Fox, A. H. & Bond, C. S., Nov 2011, In : Acta Crystallographica Section D. Biological Crystallography. 67, Pt 11, p. 981-7 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Crystallography
Crystallization
Computational Biology
Solubility
Carrier Proteins
2010

Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions

Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, M., Hennig, S., Waldmann, H. & Ottmann, C., 1 Jun 2010, In : Angewandte Chemie International Edition in English. 49, 24, p. 4129-32 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2009

Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2

Hennig, S., Strauss, H. M., Vanselow, K., Yildiz, O., Schulze, S., Arens, J., Kramer, A. & Wolf, E., 28 Apr 2009, In : PloS Biology. 7, 4, p. e94

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Drosophila
Crystal structure
mice
Mutagenesis
proteins
2007

A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome

Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. & Wolf, E., 27 Apr 2007, In : Journal of Biological Chemistry. 282, 17, p. 13011-21 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cryptochromes
Flavin-Adenine Dinucleotide
Drosophila
Light
Circadian Clocks

Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation

Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuya, M. & Staiger, D., Dec 2007, In : Plant Journal. 52, 6, p. 1119-30 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

autoregulation
RNA-Binding Proteins
alternative splicing
point mutation
Point Mutation
2005

Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD

Yildiz, O., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone-Corsi, P. & Wolf, E., 7 Jan 2005, In : Molecular Cell. 17, 1, p. 69-82 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Drosophila
Circadian Clocks
Phosphorylation
Drosophila Clk protein
Mutation