Timo De Groof

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Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated cum laude in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.


In 2015, De Groof started working as a PhD student in the Medicinal Chemistry group at VU University under the supervision of prof. dr. Martine Smit. He is focusing on the identification and characterization of nanobodies targeting HCMV-encoded GPCRs to further investigate the role of HCMV in the progression of glioblastoma. 

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  • 4 Similar Profiles
Single-Domain Antibodies Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Pharmaceutical Chemistry Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences
Photochemotherapy Medicine & Life Sciences
Viral Proteins Medicine & Life Sciences
Photosensitizing Agents Medicine & Life Sciences

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Research Output 2018 2019

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

De Groof, T. W. M., Bobkov, V., Heukers, R. & Smit, M. J., 15 Mar 2019, In : Molecular and Cellular Endocrinology. 484, p. 15-24 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Single-Domain Antibodies
G-Protein-Coupled Receptors
Imaging techniques
Immunoglobulin Fragments

Nanobodies detecting and modulating GPCRs outside in and inside out

Heukers, R., De Groof, T. W. M. & Smit, M. J., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 115-122 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
G-Protein-Coupled Receptors
Immunoglobulin Fragments
Physiological Phenomena
Drug Discovery

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells

De Groof, T. W. M., Mashayekhi, V., Fan, T. S., Bergkamp, N. D., Toraño, J. S., Van Senten, J. R., Heukers, R., Smit, M. J. & Oliveira, S., 1 Jan 2019, In : Molecular Pharmaceutics.

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
Viral Proteins
G-Protein-Coupled Receptors

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

Heukers, R., Fan, T. S., de Wit, R. H., van Senten, J. R., de Groof, T. W. M., Bebelman, M. P., Lagerweij, T., Vieira, J., de Munnik, S. M., Smits-de Vries, L., van Offenbeek, J., Rahbar, A., van Hoorick, D., Söderberg-Naucler, C., Würdinger, T., Leurs, R., Siderius, M., Vischer, H. F. & Smit, M. J., 30 Apr 2018, In : Oncogene. 2018, p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Single-Domain Antibodies