Personal profile

Personal information

Professor of Organic Chemistry

Vrije Universiteit Amsterdam

The Netherlands

website: www.grossmannlab.com

 

Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centra and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany

 

Additional Information

Since Jun 2016 - Editorial board member of Scientific Reports (Category: Chemical Biology)

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)

 

Major Recent Funding Schemes

  • Chemical Genomics Centre of the Max Planck Society
  • Emmy Noether Programme by the German research foundation
  • ERC Starting Grant by the European Research Council

 

Research

Research Highlights

  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides (collaboration with Fürster and Waldmann lab)
  • Angew. Chem. Int. Ed. 2015, 54, 8896-8927: Structure-based design of inhibitors of protein-protein interactions: Mimicking peptide binding epitopes (review)
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes
  • Angew. Chem. Int. Ed. 2014, 53, 4337-4340: Protein-templated peptide ligation
  • Angew. Chem. Int. Ed. 2014, 53, 2489-2503: Constrained peptides with target-adapted crosslinks as inhibitors of a pathogenic protein-protein interacton

 

Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 205 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany

 

Ancillary activities

  • Max Planck Society | Dortmund | consultant | 2018-01-03
  • Merck | Darmstadt | consultant | 2018-01-03

Ancillary activities are updated daily

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Research Output 2006 2018

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N. 30 May 2018 In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

Schmidtgall, B., Kuepper, A., Meng, M., Grossmann, T. N. & Ducho, C. 1 Feb 2018 In : Chemistry: A European Journal. 24, 7, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

Held, A., Glas, A., Dietrich, L., Bollmann, M., Brandstädter, K., Grossmann, T. N., Lohmann, C. H., Pap, T. & Bertrand, J. Jun 2018 In : Osteoarthritis and Cartilage. 26, 6, p. 818-823 6 p.

Research output: Contribution to journalArticle

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D. & Grossmann, T. N. 17 Aug 2017 In : Cell Chemical Biology. 24, p. 958–968

Research output: Contribution to journalArticle