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Personal profile

Personal information

Professor of Chemistry
Chair of Biomimetic Chemistry
Vrije Universiteit Amsterdam
The Netherlands

website: www.grossmannlab.com
twitter: @TomNGrossmann

Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centre and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany


Additional Information

Since Apr 2022 - Editorial advisory board member of the Journal of Peptide Science

Since Oct 2021 - Editorial advisory board member of ChemBioChem

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)




Major Recent Funding Schemes

  • ERC Proof of Concept Grant by the European Research Council
  • ERC Starting Grant by the European Research Council
  • Emmy Noether Programme by the German research foundation


Selected Publications

  • Nucleic Acids Res. 202149, 12622-12633: Contrained peptides mimic a viral suppressor of RNA silencing
  • Nature Chem. 202012, 331-337: Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns (perspective)
  • Angew. Chem. Int. Ed. 2019, 58, 17351-17358: Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
  • Angew. Chem. Int. Ed. 2018, 57, 17079-17083: Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
  • Angew. Chem. Int. Ed. 2018, 57, 11164-11170: In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes


Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 2005 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany


Ancillary activities

  • Max Planck Society | Dortmund | consulent | 2016-01-01 - 2018-03-31
  • Merck | Darmstadt | consulent | 2016-01-03 - 2020-12-30
  • Incircular B.V. | Amsterdam | | 2021-02-10 - present

Ancillary activities are updated daily


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