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Personal profile

Personal information

Professor of Chemistry
Chair of Biomimetic Chemistry
Vrije Universiteit Amsterdam
The Netherlands

website: www.grossmannlab.com
twitter: @TomNGrossmann

Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centre and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany


Additional Information

Since Apr 2022 - Editorial advisory board member of the Journal of Peptide Science

Since Oct 2021 - Editorial advisory board member of ChemBioChem

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)




Major Recent Funding Schemes

  • ERC Proof of Concept Grant by the European Research Council
  • ERC Starting Grant by the European Research Council
  • Emmy Noether Programme by the German research foundation


Selected Publications

  • Nucleic Acids Res. 202149, 12622-12633: Contrained peptides mimic a viral suppressor of RNA silencing
  • Nature Chem. 202012, 331-337: Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns (perspective)
  • Angew. Chem. Int. Ed. 2019, 58, 17351-17358: Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
  • Angew. Chem. Int. Ed. 2018, 57, 17079-17083: Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
  • Angew. Chem. Int. Ed. 2018, 57, 11164-11170: In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes


Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 2005 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany


Ancillary activities

  • Incircular B.V. | Amsterdam | Cofounder | 2021-02-10 - present
  • Apollum GmbH | Münster | cofounder | 2022-07-01 - present
  • AstraZeneca | Mölndal | Adviseur | 2022-10-17 - 2025-04-30

Ancillary activities are updated daily

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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