Personal profile

Personal information

Professor of Organic Chemistry

Vrije Universiteit Amsterdam

The Netherlands



Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centra and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany


Additional Information

Since Jun 2016 - Editorial board member of Scientific Reports (Category: Chemical Biology)

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)


Major Recent Funding Schemes

  • Chemical Genomics Centre of the Max Planck Society
  • Emmy Noether Programme by the German research foundation
  • ERC Starting Grant by the European Research Council



Research Highlights

  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides (collaboration with Fürster and Waldmann lab)
  • Angew. Chem. Int. Ed. 2015, 54, 8896-8927: Structure-based design of inhibitors of protein-protein interactions: Mimicking peptide binding epitopes (review)
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes
  • Angew. Chem. Int. Ed. 2014, 53, 4337-4340: Protein-templated peptide ligation
  • Angew. Chem. Int. Ed. 2014, 53, 2489-2503: Constrained peptides with target-adapted crosslinks as inhibitors of a pathogenic protein-protein interacton


Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 205 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany


Ancillary activities

  • Max Planck Society | Dortmund | consultant | 2018-01-03
  • Merck | Darmstadt | consultant | 2018-01-03

Last update Ancillary Activities: Amsterdam (2018-02-25)

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Research Output 2006 2018

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D. & Grossmann, T. N. 17 Aug 2017 In : Cell Chemical Biology. 24, p. 958–968

Research output: Scientific - peer-reviewArticle

New Modalities for Challenging Targets in Drug Discovery

Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., Grossmann, T. N. & Plowright, A. T. 21 Aug 2017 In : Angewandte Chemie International Edition in English. 56, p. 10294–10323

Research output: Scientific - peer-reviewReview article

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

White, M. D., Klecker, M., Hopkinson, R. J., Weits, D. A., Mueller, C., Naumann, C., O'Neill, R., Wickens, J., Yang, J., Brooks-Bartlett, J. C., Garman, E. F., Grossmann, T. N., Dissmeyer, N. & Flashman, E. 23 Mar 2017 In : Nature Communications. 8, p. 14690

Research output: Scientific - peer-reviewArticle

Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions

Krüger, D. M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O., Hennig, S. & Grossmann, T. N. 13 Oct 2017 In : Journal of Medicinal Chemistry.

Research output: Scientific - peer-reviewArticle