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Personal profile

Personal information

Professor of Chemistry
Chair of Biomimetic Chemistry
Vrije Universiteit Amsterdam
The Netherlands

website: www.grossmannlab.com
twitter: @TomNGrossmann

Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centre and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany

 

Additional Information

Since Jun 2016 - Editorial board member of Scientific Reports (Category: Chemical Biology)

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)

 

 

Research

Major Recent Funding Schemes

  • ERC Proof of Concept Grant by the European Research Council
  • ERC Starting Grant by the European Research Council
  • Emmy Noether Programme by the German research foundation

 

Research Highlights

  • Angew. Chem. Int. Ed. 2018, 57, 17079-17083: Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
  • Angew. Chem. Int. Ed. 2018, 57, 11164-11170: In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes
  • Angew. Chem. Int. Ed. 2014, 53, 4337-4340: Protein-templated peptide ligation

 

Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 205 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany

 

Ancillary activities

  • Max Planck Society | Dortmund | consultant | 2018-01-03 - present
  • Merck | Darmstadt | consultant | 2018-01-03 - present

Ancillary activities are updated daily

Fingerprint Dive into the research topics where Tom Grossmann is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Peptides Medicine & Life Sciences
Proteins Chemical Compounds
Cysteine Dioxygenase Medicine & Life Sciences
Catenins Medicine & Life Sciences
Sulfinic Acids Medicine & Life Sciences
Dioxygenases Chemical Compounds
Ferredoxins Medicine & Life Sciences
Stabilization Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2019

  • 44 Article
  • 4 Review article
  • 1 PhD Thesis - Research VU, graduation VU

Controlling the conformational constraint of peptides to modulate their target affinity

Müller, C., 2019, 146 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft

Neubacher, S., Hennig, S. & Grossmann, T. N., 1 May 2019, In : BioSpektrum. 25, 3, p. 338-339 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Mueller, C. & Grossmann, T. N., 21 Dec 2018, In : Angewandte Chemie - International Edition. 57, 52, p. 17079-17083 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Switches
Proteins
Epitopes
Protein folding

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N., 27 Aug 2018, In : Angewandte Chemie - International Edition. 57, 35, p. 11164-11170 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Enzymes
Proteins
Denaturation
Labeling

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ferredoxins
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Genome