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Personal profile

Personal information

Professor of Chemistry
Chair of Biomimetic Chemistry
Vrije Universiteit Amsterdam
The Netherlands

website: www.grossmannlab.com
twitter: @TomNGrossmann

Short CV

Since 2016 - Full Professor, Vrije Universiteit Amsterdam, The Netherlands

2011-2015 - Group leader, Chemical Genomics Centre and Technical University Dortmund, Germany

2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA

2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany

2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA

1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany

 

Additional Information

Since Jun 2016 - Editorial board member of Scientific Reports (Category: Chemical Biology)

Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum

Since Oct 1999 - Member of the German Chemical Society (GDCh)

 

 

Research

Major Recent Funding Schemes

  • ERC Proof of Concept Grant by the European Research Council
  • ERC Starting Grant by the European Research Council
  • Emmy Noether Programme by the German research foundation

 

Research Highlights

  • Angew. Chem. Int. Ed. 2018, 57, 17079-17083: Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
  • Angew. Chem. Int. Ed. 2018, 57, 11164-11170: In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
  • Cell Chem. Biol. 2017, 24, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 2016, 7, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
  • Angew. Chem. Int. Ed. 2015, 54, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes
  • Angew. Chem. Int. Ed. 2014, 53, 4337-4340: Protein-templated peptide ligation

 

Prizes and Awards

19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany

01 Jan 2014 - Thieme Chemistry Journal Award 2014

05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)

4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry

10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis

19 Oct 2005 - Fischer-Nernst study award 205 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany

 

Ancillary activities

  • Max Planck Society | Dortmund | consultant | 2018-01-03 - present
  • Merck | Darmstadt | consultant | 2018-01-03 - present

Ancillary activities are updated daily

Fingerprint Dive into the research topics where Tom Grossmann is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Peptides Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cysteine Dioxygenase Medicine & Life Sciences
Catenins Medicine & Life Sciences
Sulfinic Acids Medicine & Life Sciences
Dioxygenases Chemical Compounds
Ferredoxins Medicine & Life Sciences
Stabilization Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2019

  • 43 Article
  • 5 Review article
  • 1 PhD Thesis - Research VU, graduation VU

Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly

Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S. & Grossmann, T. N., 20 Sep 2019, In : Angewandte Chemie - International Edition.

Research output: Contribution to JournalReview articleAcademicpeer-review

Transcription Factors
Epitopes
Peptides
Peptidomimetics
Hydrocarbons

Controlling the conformational constraint of peptides to modulate their target affinity

Müller, C., 2019, 146 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft

Neubacher, S., Hennig, S. & Grossmann, T. N., 1 May 2019, In : BioSpektrum. 25, 3, p. 338-339 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Enzymes
Protein Engineering
Enzyme Stability
Cyclization
Proteins

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Mueller, C. & Grossmann, T. N., 21 Dec 2018, In : Angewandte Chemie - International Edition. 57, 52, p. 17079-17083 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Switches
Proteins
Epitopes
Protein folding

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N., 27 Aug 2018, In : Angewandte Chemie - International Edition. 57, 35, p. 11164-11170 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Enzymes
Proteins
Denaturation
Labeling