Ton Blaazer

  • Research Associate, AIMMS
20152019
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Personal profile

Ancillary activities

  • Aeolus Investments N.V. | Wormerveer | Directeur/eigenaar | 2018-07-01 - present

Ancillary activities are updated daily

Fingerprint Dive into the research topics where Ton Blaazer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Phosphodiesterase Inhibitors Medicine & Life Sciences
Phosphoric Diester Hydrolases Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Imidazoles Medicine & Life Sciences
Antiparasitic Agents Medicine & Life Sciences
Surface Plasmon Resonance Medicine & Life Sciences
Surface plasmon resonance Chemical Compounds

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Research Output 2015 2019

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2)

de Heuvel, E., Singh, A. K., Boronat, P., Kooistra, A. J., van der Meer, T., Sadek, P., Blaazer, A. R., Shaner, N. C., Bindels, D. S., Caljon, G., Maes, L., Sterk, G. J., Siderius, M., Oberholzer, M., de Esch, I. J. P., Brown, D. G. & Leurs, R., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry. 27, 18, p. 4013-4029 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Phosphodiesterase Inhibitors
Parasites
African Trypanosomiasis
Trypanosoma brucei brucei
Trypanosomiasis

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

Botros, S. S., William, S., Sabra, A. N. A., El-Lakkany, N. M., Seif el-Din, S. H., García-Rubia, A., Sebastián-Pérez, V., Blaazer, A. R., de Heuvel, E., Sijm, M., Zheng, Y., Salado, I. G., Munday, J. C., Maes, L., de Esch, I. J. P., Sterk, G. J., Augustyns, K., Leurs, R., Gil, C. & De Koning, H. P., Apr 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 9, p. 35-43 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Imidazoles
Eggs
Libraries
Praziquantel
Schistosoma mansoni

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Blaazer, A. R., Singh, A. K., De Heuvel, E., Edink, E., Orrling, K. M., Veerman, J. J. N., Van Den Bergh, T., Jansen, C., Balasubramaniam, E., Mooij, W. J., Custers, H., Sijm, M., Tagoe, D. N. A., Kalejaiye, T. D., Munday, J. C., Tenor, H., Matheeussen, A., Wijtmans, M., Siderius, M., De Graaf, C. & 7 othersMaes, L., De Koning, H. P., Bailey, D. S., Sterk, G. J., De Esch, I. J. P., Brown, D. G. & Leurs, R., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3870-3888 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Parasites
African Trypanosomiasis
Trypanosoma brucei brucei

Surface plasmon resonance biosensor assay for the analysis of small-molecule inhibitor binding to human and parasitic phosphodiesterases.

Siderius, M. H., Shanmugham, A., England, P., van der Meer, T. K., Bebelman, J. P., Blaazer, A. R., de Esch, I. J. P. & Leurs, R., 2016, In : Analytical Biochemistry. 503, p. 41-49

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Plasmon Resonance
Phosphoric Diester Hydrolases
Surface plasmon resonance
Biosensing Techniques
Biosensors

Exploration of the Molecular Architecture of the Orthosteric Binding Site in the 42 Nicotinic Acetylcholine Receptor with Analogs of 3-(Dimethylamino)butyl Dimethylcarbamate (DMABC) and 1-(Pyridin-3-yl)-1,4-diazepane

Bach, T. T., Jensen, A. A., Petersen, J. G., Sørensen, T. E., Della Volpe, S., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, B., 2015, In : European Journal of Medicinal Chemistry. 102, p. 425-444

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access