20112020
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Research Output 2011 2020

  • 25 Article
  • 4 PhD Thesis - Research VU, graduation VU
  • 2 Review article
  • 1 Book
2020

Astrocytes lost in translation: From novel Vanishing White Matter models to the first therapeutic strategies

Dooves, S., 2020, 222 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2019

Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter

Dooves, S., Leferink, P. S., Krabbenborg, S., Breeuwsma, N., Bots, S., Hillen, A. E. J., Jacobs, G., van der Knaap, M. S. & Heine, V. M., 5 Mar 2019, In : Stem cell reports. 12, 3, p. 441-450 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Leukoencephalopathies
Cell- and Tissue-Based Therapy
Neuroglia
Stem Cells
Stem cells

Induced pluripotent stem cell research for Vanishing White Matter: From in vitro disease modeling to in vivo cell replacement therapy

Leferink, P. S., 2019, 285 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Hinz, L., Torrella Barrufet, J. & Heine, V. M., 3 Dec 2019, In : Acta Neuropathologica Communications. 7, 1, 196.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Rett Syndrome
Symporters
Brain
Sodium-Potassium-Chloride Symporters
Chlorine

Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

G. Nadadhur, A., Alsaqati, M., Gasparotto, L., Cornelissen-Steijger, P., van Hugte, E., Dooves, S., Harwood, A. J. & Heine, V. M., 8 Jan 2019, In : Stem cell reports. 12, 1, p. 42-56 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tuberous Sclerosis
Oligodendroglia
Neuroglia
Neurons
Phenotype

The involvement of astrocytes in early-life adversity induced programming of the brain

Abbink, M. R., van Deijk, A. L. F., Heine, V. M., Verheijen, M. H. & Korosi, A., Sep 2019, In : Glia. 67, 9, p. 1637-1653 17 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Astrocytes
Brain
Aptitude
Recycling
Psychopathology
2018

Adult mouse eIF2Bϵ Arg191His astrocytes display a normal integrated stress response in vitro

Wisse, L. E., Ter Braak, T. J., Van De Beek, M. C., Van Berkel, C. G. M., Wortel, J., Heine, V. M., Proud, C. G., Van Der Knaap, M. S. & Abbink, T. E. M., 28 Feb 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 3773.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Eukaryotic Initiation Factor-2B
Astrocytes
Mutation
White Matter
In Vitro Techniques

Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter

Leferink, P. S., Breeuwsma, N., Bugiani, M., van der Knaap, M. S. & Heine, V. M., Apr 2018, In : Glia. 66, 4, p. 862-873 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Leukoencephalopathies
Astrocytes
Spinal Cord
Pathology
Oligodendroglia

Axonal abnormalities in vanishing white matter

Klok, M. D., Bugiani, M., de Vries, S. I., Gerritsen, W., Breur, M., van der Sluis, S., Heine, V. M., Kole, M. H. P., Baron, W. & van der Knaap, M. S., 1 Apr 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 429-444 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Astrocytes
Axons
Myelin Sheath
Prosencephalon
Coculture Techniques

Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment

Dooves, S., Bugiani, M., Wisse, L. E., Abbink, T. E. M., van der Knaap, M. S. & Heine, V. M., Jun 2018, In : Neuropathology and Applied Neurobiology. 44, 4, p. 391-403 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Guanabenz
Therapeutic Uses
Neuroglia
Pathology
Therapeutics

From neural induction towards disease models for Tuberous sclerosis complex using human stem cells

Geeyarpuram Nadadhur, A., 2018, 175 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Open Access
Chromosome Disorders
Fibroblasts
Induced Pluripotent Stem Cells
X Chromosome Inactivation
Rett Syndrome

Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro

Nadadhur, A. G., Leferink, P. S., Holmes, D., Hinz, L., Cornelissen-Steijger, P., Gasparotto, L. & Heine, V. M., Oct 2018, In : Stem Cell Research. 32, p. 25-34 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neural Inhibition
Tretinoin
Astrocytes
Phenotype
Pluripotent Stem Cells

Report from the Edge of Neuroscience: Investigating an RNA Polymerase III related leukodystrophy using patient-derived iPSCs, neural cells, and mini-brains

Holmes, D. B., 2018, 158 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine

Leferink, P. S. & Heine, V. M., Jan 2018, In : American Journal of Pathology. 188, 1, p. 39-52 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Regenerative Medicine
Oligodendroglia
Myelin Sheath
Cellular Microenvironment
Neurologic Manifestations
2017

Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium

Bennis, A., Ten Brink, J. B., Moerland, P. D., Heine, V. M. & Bergen, A. A., 2017, In : PLoS ONE. 12, 8, p. e0182983

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
iris (eyes)
Retinal Pigments
Retinal Pigment Epithelium
Iris
Gene expression

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons

Emperador Melero, J., Nadadhur, A. G., Schut, D., Weering, J. V., Heine, V. M., Toonen, R. F. & Verhage, M., 14 Mar 2017, In : Stem cell reports. 8, 3, p. 659-672 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Secretory Pathway
Secretory Vesicles
Neurons
Synaptic Vesicles
SNARE Proteins
Open Access
Induced Pluripotent Stem Cells
Patient Selection
Sample Size
Schizophrenia
Technology

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Nadadhur, A. G., Melero, J. E., Meijer, M., Schut, D., Jacobs, G., Wan Li, K., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F., Van Kesteren, R. E., Smit, A. B., Verhage, M. & Heine, V. M., 1 Jun 2017, In : PLoS ONE. 12, 6, 0178533.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Confocal microscopy
Stem cells
Cell culture

Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium

Bennis, A., Jacobs, J. G., Catsburg, L. A. E., Ten Brink, J. B., Koster, C., Schlingemann, R. O., van Meurs, J., Gorgels, T. G. M. F., Moerland, P. D., Heine, V. M. & Bergen, A. A., Oct 2017, In : Stem cell reviews and reports. 13, 5, p. 659-669 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Retinal Pigment Epithelium
Pigmentation
Transcriptome
Stem Cells
Pluripotent Stem Cells

Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification

Holmes, D. B. & Heine, V. M., 9 Dec 2017, In : Journal of Visualized Experiments. 130

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Brain
Neurons
Organoids
Pluripotent Stem Cells
Lip
2016

Astrocytes are central in the pathomechanisms of vanishing white matter

Dooves, S., Bugiani, M., Postma, N. L., Polder, E., Land, N., Horan, S. T., van Deijk, A. L. F., van de Kreeke, A., Jacobs, J. G., Vuong, C., Klooster, J., Kamermans, M., Wortel, J., Loos, M., Wisse, L. E., Scheper, G. C., Abbink, G. E. M., Heine, V. M. & Knaap, M., 2016, In : Journal of Clinical Investigation. 126, p. 1512-1524 4.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Detection of silent cells, synchronization and modulatory activity in developing cellular networks.

Hjorth, J. J. J., Dawitz, J., Kroon, T., da Silva Dias Pires, J. H., Dassen, V. J., Berkhout, J. A., Emperador Melero, J., Nadadhur, A. G., Alevra, M., Toonen, R. F. G., Heine, V. M., Mansvelder, H. D. & Meredith, R. M., 2016, In : Developmental Neurobiology. 76, p. 357-374 4.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synapses
Ion Channels
Nervous System
Cell Movement
Coloring Agents

Leukodystrophies: Five new things.

Knaap, M., Wolf, N. & Heine, V. M., 2016, In : Neurology: Clinical Practice. 6, 6, p. 506-514 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Falk, A., Heine, V. M., Harwood, A., Sullivan, P. F., Peitz, M., Brüstle, O., Shen, S., Sun, Y. M. S., Glover, J. C., Posthuma, D. & Djurovic, S., 2016, In : Molecular Psychiatry. 21

Research output: Contribution to JournalArticleAcademicpeer-review

Psychiatry
Publications
Phenotype

Stem cell therapy for white matter disorders: don't forget the microenvironment!

Dooves, S., Knaap, M. & Heine, V. M., 2016, In : Journal of Inherited Metabolic Disease. 39, p. 513-518 4.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

Comparison of Mouse and Human Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related Macular Degeneration

Bennis, A., Gorgels, T. G. M. F., ten Brink, J. B., van der Spek, P. J., Bossers, K., Heine, V. M. & Bergen, A. A., 2015, In : PLoS ONE. 10, 10, e0141597.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Transcriptome
Gene expression

Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle

Dubey, M., Bugiani, M., Ridder, M. C., Postma, N. L., Brouwers, E., Polder, E., Jacobs, J. G., Baaijen, J. C., Klooster, J., Kamermans, M., Aardse, R., de Kock, C. P. J., Dekker, M. P., van Weering, J. R. T., Heine, V. M., Abbink, T. E. M., Scheper, G. C., Boor, P. K. I., Lodder, J. C., Mansvelder, H. D. & 1 othersKnaap, M., 2015, In : Annals of Neurology. 77, 11, p. 114-131

Research output: Contribution to JournalArticleAcademicpeer-review

Leukoencephalopathies
Cysts
Astrocytes
Edema
Brain
2014

Human ciliary epithelia do express genes with retinal progenitor cell characteristics in vivo

Janssen, S. F., Bennis, A., Heine, V. M. & Bergen, A. A. B., 2014, In : Experimental Eye Research. 121, p. 41-41

Research output: Contribution to JournalArticleAcademicpeer-review

Olig1 Function Is Required to Repress Dlx1/2 and Interneuron Production in Mammalian Brain

Silbereis, J. C., Nobuta, H., Tsai, H. H., Heine, V. M., McKinsey, G. L., Meijer, D. H., Howard, M. A., Petryniak, M. A., Potter, G. B., Alberta, J. A., Baraban, S. C., Stiles, C. D., Rubenstein, J. L. R. & Rowitch, D. H., 2014, In : Neuron. 81, 3, p. 574-587

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Interneurons
Brain
Telencephalon
Median Eminence
Psychiatry
2012

Induced Pluripotent Stem Cells in Brain Diseases

Heine, V. M., Dooves, S., Holmes, D. & Wagner, J. E., 2012, New York: Spring.

Research output: Book / ReportBookAcademic

2011

Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain

Biran, V., Heine, V. M., Verney, C., Sheldon, R. A., Spadafora, R., Vexler, Z. S., Rowitch, D. H. & Ferriero, D. M., 2011, In : Neurobiology of Disease. 41, 1, p. 138-146

Research output: Contribution to JournalArticleAcademicpeer-review

Prosencephalon
Wounds and Injuries
Brain
Cerebellum
Ischemia