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Education/Academic qualification

Molecular and Cellular Biology, PhD, Utrecht University

Keywords

  • Q Science
  • Molecular and Cellular Biology, Translational Neuroscience
  • R Medicine
  • Neurodegenerative disease, Translational Neuroscience, Alzheimer's disease

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Unfolded Protein Response Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
alpha-Synuclein Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Lysosomes Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences

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Research Output 2012 2017

  • 17 Article
  • 2 PhD Thesis - Research external, graduation external

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons

Heman-Ackah, S. M., Manzano, R., Hoozemans, J. J. M., Scheper, W., Flynn, R., Haerty, W., Cowley, S. A., Bassett, A. R. & Wood, M. J. A., 15 Nov 2017, In : Human Molecular Genetics. 26, 22, p. 4441-4450 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Unfolded Protein Response
Induced Pluripotent Stem Cells
alpha-Synuclein
Parkinson Disease
Neurons

Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers

Belegri, E., Rijnsburger, M., Eggels, L., Unmehopa, U., Scheper, W., Boelen, A. & la Fleur, S. E., 2017, In : Frontiers in Neuroscience. 11, p. 270

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endoplasmic Reticulum Stress
Fats
High Fat Diet
Brain
Unfolded Protein Response

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

van der Harg, J. M., Eggels, L., Bangel, F. N., Ruigrok, S. R., Zwart, R., Hoozemans, J. J. M., la Fleur, S. E. & Scheper, W., Jul 2017, In : Neurobiology of Disease. 103, p. 163-173 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyclic AMP-Dependent Protein Kinases
Phosphorylation
Insulin
Alzheimer Disease
Diabetes Mellitus

IRE1 signaling exacerbates Alzheimer's disease pathogenesis

Duran-Aniotz, C., Cornejo, V. H., Espinoza, S., Ardiles, Á. O., Medinas, D. B., Salazar, C., Foley, A., Gajardo, I., Thielen, P., Iwawaki, T., Scheper, W., Soto, C., Palacios, A. G., Hoozemans, J. J. M. & Hetz, C., Sep 2017, In : Acta Neuropathologica. 134, 3, p. 489-506 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alzheimer Disease
Endoplasmic Reticulum Stress
Unfolded Protein Response
Amyloid beta-Protein Precursor
Amyloid

Proteasome Activation by Small Molecules

Leestemaker, Y., de Jong, A., Witting, K. F., Penning, R., Schuurman, K., Rodenko, B., Zaal, E. A., van de Kooij, B., Laufer, S., Heck, A. J. R., Borst, J., Scheper, W., Berkers, C. R. & Ovaa, H., 22 Jun 2017, In : Cell Chemical Biology. 24, 6, p. 725-736.e7

Research output: Contribution to JournalArticleAcademicpeer-review

p38 Mitogen-Activated Protein Kinases
Proteasome Endopeptidase Complex
alpha-Synuclein
Chemical activation
Molecules