Wouter Jong

20072019
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Research Output 2007 2019

  • 22 Article
  • 1 Review article
  • 1 PhD Thesis - Research VU, graduation VU
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Article
2019

Inhibition of autotransporter biogenesis by small molecules

Steenhuis, M., Abdallah, A. M., de Munnik, S. M., Kuhne, S., Sterk, G. J., van den Berg van Saparoea, B., Westerhausen, S., Wagner, S., van der Wel, N. N., Wijtmans, M., van Ulsen, P., Jong, W. S. P. & Luirink, J., 1 Jul 2019, In : Molecular Microbiology. 112, 1, p. 81-98 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Membrane Proteins
Virulence Factors
Libraries
Hemoglobins
Peptide Hydrolases

Inhibition of autotransporter biogenesis by small molecules

Steenhuis, M., Luirink, S., Jong, W. S. P., van Ulsen, J. P., Wijtmans, M., van den Berg van Saparoea, H. B., Sterk, G. J., Kuhne, S., de Munnik, S. M., Abdallah, A. M., van der Wel, N. N., Wagner, S. & Westerhausen, S., 28 Mar 2019, In : Molecular Microbiology. p. 1-18 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Virulence Factors
Libraries
Hemoglobins
Peptide Hydrolases

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 + T cells

Schetters, S. T. T., Jong, W. S. P., Horrevorts, S. K., Kruijssen, L. J. W., Engels, S., Stolk, D., Daleke-Schermerhorn, M. H., Garcia-Vallejo, J., Houben, D., Unger, W. W. J., den Haan, J. M. M., Luirink, J. & van Kooyk, Y., 1 Jun 2019, In : Acta Biomaterialia. 91, p. 248-257 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cross-Priming
T-cells
Antigens
Dendritic Cells
Membranes
2018

Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface

Jong, W. S. P., Schillemans, M., ten Hagen-Jongman, C. M., Luirink, J. & van Ulsen, P., 7 Feb 2018, In : PLoS ONE. 13, 2, e0191622.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
IgA-specific serine endopeptidase
recombinant proteins
Membrane Proteins
Recombinant Proteins
Membranes

Display of recombinant proteins on bacterial outer membrane vesicles by using protein ligation

van den Berg van Saparoea, H. B., Houben, D., de Jonge, M. I., Jong, W. S. P. & Luirink, J., Apr 2018, In : Applied and Environmental Microbiology. 84, 8, p. 1-17 17 p., e02567-17.

Research output: Contribution to JournalArticleAcademicpeer-review

hemoglobin
vesicle
Recombinant Proteins
recombinant proteins
Ligation
2017

Application of an E. coli signal sequence as a versatile inclusion body tag

Jong, W. S. P., Vikström, D., Houben, D., Berg van Saparoea, H. B., de Gier, J. W. & Luirink, J., 21 Mar 2017, In : Microbial Cell Factories. 16, 1, 50.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Inclusion Bodies
Protein Sorting Signals
Escherichia coli
Proteins
Fusion reactions

Th17-mediated cross protection against pneumococcal carriage by vaccination with a variable antigen

Kuipers, K., Jong, W. S. P., van der Gaast-de Jongh, C. E., Houben, D., van Opzeeland, F., Simonetti, E., van Selm, S., de Groot, R., Koenders, M. I., Azarian, T., Pupo, E., van der Ley, P., Langereis, J. D., Zomer, A., Luirink, J. & de Jonge, M. I., 1 Jan 2017, In : Infection and Immunity. 85, 10, e00281-17.

Research output: Contribution to JournalArticleAcademicpeer-review

Cross Protection
Vaccination
Vaccines
Antigens
Salmonella enterica
2015
lysis
antigen
vaccine
Escherichia coli
antigens

Autotransporter-based antigen display in bacterial ghosts.

Hjelm, A., Söderström, B., Vikström, D., Jong, W. S. P., Luirink, S. & de Gier, J. W., Jan 2015, In : Applied and Environmental Microbiology. 81, 2, p. 726-735 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

lysis
antigen
vaccine
Escherichia coli
antigens

Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.

Kuipers, K., Gallay, C., Martínek, V., Rohde, M., Martínková, M., van der Beek, S. L., Jong, W. S. P., Venselaar, H., Zomer, A., Bootsma, H., Veening, J. W. & de Jonge, M. I., 2015, In : Molecular Microbiology. 21 Dec

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Lipids
Streptococcus pneumoniae
Phosphoric Monoester Hydrolases
Homeostasis
Nucleotides

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization.

Kuipers, K., Daleke, M. H., Jong, W. S. P., ten Hagen-Jongman ten, C. M., van Opzeeland, F., Simonneti, E., Luirink, S. & de Jonge, M. I., 2015, In : Vaccine. 33, 17, p. 2022-2029

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Antigens
Salmonella
antigens
Membranes
Antigens
2014

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.

Jong, W. S. P., Daleke, M. H., Vikstrom, D., ten Hagen-Jongman ten, C. M., de Punder, K., van der Wel, N. N., van de Sandt, C. E., Rimmelzwaan, G. F., Follman, F., Agger, E., Andersen, P., de Gier, J-W. & Luirink, J., 25 Nov 2014, In : Microbial Cell Factories. 13, p. 1-15 15 p., 162.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bacterial Vaccines
Synthetic Vaccines
Vaccines
Hemoglobin
Hemoglobins

Decoration of outer membrane vesicles with multiple antigens using an autotransporter approach.

Daleke, M. H., Felix, T., Soprova, Z., ten Hagen-Jongman ten, C. M., Vikström, D., Majlessi, L., Beskers, J., Follman, F., de Punder, K., van der Wel, N. N., Baumgarten, T., Pham, T. V., Piersma, S. R., Jimenez, C. R., van Ulsen, P., de Gier, J. W., Leclerc, C., Jong, W. S. & Luirink, S., 2014, In : Applied and Environmental Microbiology. 80, 18, p. 5854-5864

Research output: Contribution to JournalArticleAcademicpeer-review

vesicle
antigen
membrane
antigens
Antigens

Type V secretion: From biogenesis to biotechnology

van Ulsen, P., Rahman, S. U., Jong, W. S. P., Daleke, M. H. & Luirink, J., 2014, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1843, 8, p. 1592-1611

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Biotechnology
Membranes
Proteins
Membrane Proteins
Virulence Factors
2012

A structurally informed autotransporter platform for efficient heterologous protein secretion and display.

Jong, W. S. P., Soprova, Z., de Punder, K., ten Hagen-Jongman, C. M., Wagner, S., de Gier, J. W., Andersen, P., van der Wel, N. N. & Luirink, S., 2012, In : Microbial Cell Factories. 11, 85

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobin
Hemoglobins
Peptide Hydrolases
Display devices
Proteins
2011

Autotransporter beta-domains have a specific function in protein secretion beyond outer-membrane targeting

Sauri, A., Oreshkova, N., Soprova, Z., Jong, W. S. P., Sani, M., Peters, P. J., Luirink, J. & van Ulsen, P., 2011, In : Journal of Molecular Biology. 412, p. 553-67

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Proteins
Mutant Proteins
Gram-Negative Bacteria
Membrane Proteins
2010

A conserved aromatic residue in the autochaperone domain of the autotransporter Hbp is critical for initiation of outer membrane translocation

Soprova, Z., Sauri, A., van Ulsen, J. P., Tame, J. R. H., den Blaauwen, T., Jong, W. S. P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 49, p. 38224-38233 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Mutation

Extracellular production of recombinant proteins using bacterial autotransporters.

Jong, W. S. P., Sauri, A. & Luirink, S., 2010, In : Current Opinion in Biotechnology. 21, 5, p. 646-652 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Recombinant proteins
Recombinant Proteins
Escherichia coli
Display devices
Proteins

YidC is in involved in the biogenesis of the secreted autotransporter Hemoglobin Protease

Jong, W. S. P., ten Hagen-Jongman ten, C. M., Ruijter, E., Orru, R. V. A., Genevaux, P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 51, p. 39682-39690 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Periplasm
Signal Recognition Particle
2009

The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.

Sauri, A., Soprova, Z., Wickstrom, D., de Gier, J-W., van der Schors, R. C., Smit, A. B., Jong, W. S. P. & Luirink, S., 2009, In : Microbiology. 155, 12, p. 3982-3991

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Protein Transport
2008
Protein Sorting Signals
Hemoglobins
Peptide Hydrolases
Gram-Negative Bacteria
Bacteria
2007

Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

Jong, W. S. P., ten Hagen-Jongman ten, C. M., den Blaauwen, T., Slotboom, D. J., Tame, J. R. H., Wickstrom, D., de Gier, J-W., Otto, B. R. & Luirink, S., 2007, In : Molecular Microbiology. 63, 5, p. 1524-1536

Research output: Contribution to JournalArticleAcademic

Hemoglobins
Peptide Hydrolases
Disulfides
Membranes
Periplasm