1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

B. Groenendaal, E. Ruijter, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review


1-Azadienes are versatile building blocks for the efficient construction of various N-heterocycles. Depending on the substitution pattern and reaction partner, they may participate in a range of different reactions. An overview of recent methods for the generation of 1-azadienes is presented, as well as their application in cycloaddition, electrocyclization, and multicomponent reactions. Considering the broad range of reactivities and resulting heterocyclic scaffold structures, 1-azadienes are very useful reactive intermediates for the development of modular reaction sequences in diversity-oriented synthesis. © The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)5474-89
JournalChemical Commununications
Issue number43
Publication statusPublished - 2008


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