11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain

U. Funke, D.J. Vugts, B. Janssen, A. Spaans, P.S. Kruijer, A.A. Lammertsma, L.R. Perk, A.D. Windhorst

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor and cognitive functions, as well as in itch and nociception. This has raised interest in the role of the histaminergic system for the treatment and diagnosis of various pathologies such as allergy, sleeping and eating disorders, neurodegeneration, neuroinflammation, mood disorders, and pruritus. In the past 20 years, several ligands targeting the four different histamine receptor subtypes have been explored as potential radiotracers for positron emission tomography. This contribution provides an overview of the developments of subtype-selective carbon-11-labeled and fluorine-18-labeled compounds for imaging in the brain. Using specific radioligands, we could examine the H
    Original languageEnglish
    Pages (from-to)120-129
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume56
    Issue number3-4
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Histamine Receptors
    Nociception
    Pituitary Hormones
    Fluorine
    Wakefulness
    Pruritus
    Mood Disorders
    Neuroimaging
    Positron-Emission Tomography
    Cognition
    Histamine
    Neurotransmitter Agents
    Brain
    Stomach
    Hypersensitivity
    Carbon
    Central Nervous System
    Antigen-antibody reactions
    Pathology
    Ligands

    Cite this

    Funke, U., Vugts, D. J., Janssen, B., Spaans, A., Kruijer, P. S., Lammertsma, A. A., ... Windhorst, A. D. (2013). 11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain. Journal of Labelled Compounds and Radiopharmaceuticals, 56(3-4), 120-129. https://doi.org/10.1002/jlcr.3038
    Funke, U. ; Vugts, D.J. ; Janssen, B. ; Spaans, A. ; Kruijer, P.S. ; Lammertsma, A.A. ; Perk, L.R. ; Windhorst, A.D. / 11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2013 ; Vol. 56, No. 3-4. pp. 120-129.
    @article{bb0cd4bbd6dc48259d8f663042d4c6ea,
    title = "11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain",
    abstract = "The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor and cognitive functions, as well as in itch and nociception. This has raised interest in the role of the histaminergic system for the treatment and diagnosis of various pathologies such as allergy, sleeping and eating disorders, neurodegeneration, neuroinflammation, mood disorders, and pruritus. In the past 20 years, several ligands targeting the four different histamine receptor subtypes have been explored as potential radiotracers for positron emission tomography. This contribution provides an overview of the developments of subtype-selective carbon-11-labeled and fluorine-18-labeled compounds for imaging in the brain. Using specific radioligands, we could examine the H",
    author = "U. Funke and D.J. Vugts and B. Janssen and A. Spaans and P.S. Kruijer and A.A. Lammertsma and L.R. Perk and A.D. Windhorst",
    year = "2013",
    doi = "10.1002/jlcr.3038",
    language = "English",
    volume = "56",
    pages = "120--129",
    journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
    issn = "0362-4803",
    publisher = "John Wiley and Sons Ltd",
    number = "3-4",

    }

    Funke, U, Vugts, DJ, Janssen, B, Spaans, A, Kruijer, PS, Lammertsma, AA, Perk, LR & Windhorst, AD 2013, '11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain' Journal of Labelled Compounds and Radiopharmaceuticals, vol. 56, no. 3-4, pp. 120-129. https://doi.org/10.1002/jlcr.3038

    11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain. / Funke, U.; Vugts, D.J.; Janssen, B.; Spaans, A.; Kruijer, P.S.; Lammertsma, A.A.; Perk, L.R.; Windhorst, A.D.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56, No. 3-4, 2013, p. 120-129.

    Research output: Contribution to JournalArticleAcademicpeer-review

    TY - JOUR

    T1 - 11C-labeled and 18F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain

    AU - Funke, U.

    AU - Vugts, D.J.

    AU - Janssen, B.

    AU - Spaans, A.

    AU - Kruijer, P.S.

    AU - Lammertsma, A.A.

    AU - Perk, L.R.

    AU - Windhorst, A.D.

    PY - 2013

    Y1 - 2013

    N2 - The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor and cognitive functions, as well as in itch and nociception. This has raised interest in the role of the histaminergic system for the treatment and diagnosis of various pathologies such as allergy, sleeping and eating disorders, neurodegeneration, neuroinflammation, mood disorders, and pruritus. In the past 20 years, several ligands targeting the four different histamine receptor subtypes have been explored as potential radiotracers for positron emission tomography. This contribution provides an overview of the developments of subtype-selective carbon-11-labeled and fluorine-18-labeled compounds for imaging in the brain. Using specific radioligands, we could examine the H

    AB - The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor and cognitive functions, as well as in itch and nociception. This has raised interest in the role of the histaminergic system for the treatment and diagnosis of various pathologies such as allergy, sleeping and eating disorders, neurodegeneration, neuroinflammation, mood disorders, and pruritus. In the past 20 years, several ligands targeting the four different histamine receptor subtypes have been explored as potential radiotracers for positron emission tomography. This contribution provides an overview of the developments of subtype-selective carbon-11-labeled and fluorine-18-labeled compounds for imaging in the brain. Using specific radioligands, we could examine the H

    U2 - 10.1002/jlcr.3038

    DO - 10.1002/jlcr.3038

    M3 - Article

    VL - 56

    SP - 120

    EP - 129

    JO - Journal of Labelled Compounds and Radiopharmaceuticals

    JF - Journal of Labelled Compounds and Radiopharmaceuticals

    SN - 0362-4803

    IS - 3-4

    ER -