[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

H.J.C. Buiter, A.D. Windhorst, M.C. Huisman, M.M. Yaqub, D.L. Knol, A. Fisher, A.A. Lammertsma, J.E. Leysen

    Research output: Contribution to JournalArticleAcademicpeer-review


    Background: The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions. Muscarinic M1 agonists are potential therapeutic agents for cognitive disorders. The aim of this study was to evaluate [
    Original languageEnglish
    Pages (from-to)19
    JournalEJNMMI research
    Issue number1
    Publication statusPublished - 2013


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