[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

H.J.C. Buiter, A.D. Windhorst, M.C. Huisman, M.M. Yaqub, D.L. Knol, A. Fisher, A.A. Lammertsma, J.E. Leysen

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Background: The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions. Muscarinic M1 agonists are potential therapeutic agents for cognitive disorders. The aim of this study was to evaluate [
    Original languageEnglish
    Pages (from-to)19
    JournalEJNMMI research
    Volume3
    Issue number1
    DOIs
    Publication statusPublished - 2013

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    Muscarinic Agonists
    Olfactory Bulb
    Muscarinic Receptors
    G-Protein-Coupled Receptors
    Basal Ganglia
    Cognition
    Hippocampus
    Ligands
    Therapeutics

    Cite this

    Buiter, H. J. C., Windhorst, A. D., Huisman, M. C., Yaqub, M. M., Knol, D. L., Fisher, A., ... Leysen, J. E. (2013). [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors. EJNMMI research, 3(1), 19. https://doi.org/10.1186/2191-219X-3-19
    Buiter, H.J.C. ; Windhorst, A.D. ; Huisman, M.C. ; Yaqub, M.M. ; Knol, D.L. ; Fisher, A. ; Lammertsma, A.A. ; Leysen, J.E. / [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors. In: EJNMMI research. 2013 ; Vol. 3, No. 1. pp. 19.
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    abstract = "Background: The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions. Muscarinic M1 agonists are potential therapeutic agents for cognitive disorders. The aim of this study was to evaluate [",
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    Buiter, HJC, Windhorst, AD, Huisman, MC, Yaqub, MM, Knol, DL, Fisher, A, Lammertsma, AA & Leysen, JE 2013, '[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors' EJNMMI research, vol. 3, no. 1, pp. 19. https://doi.org/10.1186/2191-219X-3-19

    [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors. / Buiter, H.J.C.; Windhorst, A.D.; Huisman, M.C.; Yaqub, M.M.; Knol, D.L.; Fisher, A.; Lammertsma, A.A.; Leysen, J.E.

    In: EJNMMI research, Vol. 3, No. 1, 2013, p. 19.

    Research output: Contribution to JournalArticleAcademicpeer-review

    TY - JOUR

    T1 - [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

    AU - Buiter, H.J.C.

    AU - Windhorst, A.D.

    AU - Huisman, M.C.

    AU - Yaqub, M.M.

    AU - Knol, D.L.

    AU - Fisher, A.

    AU - Lammertsma, A.A.

    AU - Leysen, J.E.

    PY - 2013

    Y1 - 2013

    N2 - Background: The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions. Muscarinic M1 agonists are potential therapeutic agents for cognitive disorders. The aim of this study was to evaluate [

    AB - Background: The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions. Muscarinic M1 agonists are potential therapeutic agents for cognitive disorders. The aim of this study was to evaluate [

    U2 - 10.1186/2191-219X-3-19

    DO - 10.1186/2191-219X-3-19

    M3 - Article

    VL - 3

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    JO - EJNMMI research

    JF - EJNMMI research

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    Buiter HJC, Windhorst AD, Huisman MC, Yaqub MM, Knol DL, Fisher A et al. [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors. EJNMMI research. 2013;3(1):19. https://doi.org/10.1186/2191-219X-3-19