1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.

S.S. Sardjiman; M.S. Reksohadiprodjo; L. Hakim; H. van der Goot; H. Timmerman

doi:10.1016/S0223-5234(97)83288-6

1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.

S.S. Sardjiman, M.S. Reksohadiprodjo, L. Hakim, H. van der Goot, H. Timmerman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the para position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when all the meta positions were substituted by methoxy groups.

Original language	English
Pages (from-to)	625-630
Journal	European Journal of Medicinal Chemistry
Volume	32
DOIs	https://doi.org/10.1016/S0223-5234(97)83288-6
Publication status	Published - 1997

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title = "1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.",

abstract = "A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the para position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when all the meta positions were substituted by methoxy groups.",

author = "S.S. Sardjiman and M.S. Reksohadiprodjo and L. Hakim and {van der Goot}, H. and H. Timmerman",

year = "1997",

doi = "10.1016/S0223-5234(97)83288-6",

language = "English",

volume = "32",

pages = "625--630",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

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T1 - 1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.

AU - Sardjiman, S.S.

AU - Reksohadiprodjo, M.S.

AU - Hakim, L.

AU - van der Goot, H.

AU - Timmerman, H.

PY - 1997

Y1 - 1997

N2 - A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the para position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when all the meta positions were substituted by methoxy groups.

AB - A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the para position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when all the meta positions were substituted by methoxy groups.

U2 - 10.1016/S0223-5234(97)83288-6

DO - 10.1016/S0223-5234(97)83288-6

M3 - Article

SN - 0223-5234

VL - 32

SP - 625

EP - 630

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.

Abstract

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