[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

E.M.W. Eekhoff; E. Botman; J.C. Netelenbos; P. de Graaf; N. Bravenboer; D. Micha; G. Pals; T.J. de Vries; T. Schoenmaker; M. Hoebink; A.A. Lammertsma; P.G.H.M. Raijmakers

doi:10.1016/j.bone.2017.08.012

[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

E.M.W. Eekhoff, E. Botman, J.C. Netelenbos, P. de Graaf, N. Bravenboer, D. Micha, G. Pals, T.J. de Vries, T. Schoenmaker, M. Hoebink, A.A. Lammertsma, P.G.H.M. Raijmakers

Periodontology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

Original language	English
Pages (from-to)	143-146
Journal	Bone
Volume	109
DOIs	https://doi.org/10.1016/j.bone.2017.08.012
Publication status	Published - 2018

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Eekhoff, E. M. W., Botman, E., Netelenbos, J. C., de Graaf, P., Bravenboer, N., Micha, D., Pals, G., de Vries, T. J., Schoenmaker, T., Hoebink, M., Lammertsma, A. A., & Raijmakers, P. G. H. M. (2018). [18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva. Bone, 109, 143-146. https://doi.org/10.1016/j.bone.2017.08.012

@article{8d14154633464c36ba4097066e9e2ed8,

title = "[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva",

abstract = "Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.",

author = "E.M.W. Eekhoff and E. Botman and J.C. Netelenbos and {de Graaf}, P. and N. Bravenboer and D. Micha and G. Pals and {de Vries}, T.J. and T. Schoenmaker and M. Hoebink and A.A. Lammertsma and P.G.H.M. Raijmakers",

year = "2018",

doi = "10.1016/j.bone.2017.08.012",

language = "English",

volume = "109",

pages = "143--146",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier Inc.",

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T1 - [18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

AU - Eekhoff, E.M.W.

AU - Botman, E.

AU - Netelenbos, J.C.

AU - de Graaf, P.

AU - Bravenboer, N.

AU - Micha, D.

AU - Pals, G.

AU - de Vries, T.J.

AU - Schoenmaker, T.

AU - Hoebink, M.

AU - Lammertsma, A.A.

AU - Raijmakers, P.G.H.M.

PY - 2018

Y1 - 2018

N2 - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

AB - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

U2 - 10.1016/j.bone.2017.08.012

DO - 10.1016/j.bone.2017.08.012

M3 - Article

C2 - 28826841

SN - 8756-3282

VL - 109

SP - 143

EP - 146

JO - Bone

JF - Bone

ER -

[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

Abstract

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