25-hydroxyvitamin D status and change in physical performance and strength in older adults: the Health, Aging, and Body Composition Study

Denise K Houston, Janet A Tooze, Rebecca H Neiberg, Dorothy B Hausman, Mary Ann Johnson, Jane A Cauley, Doug C Bauer, Peggy M Cawthon, M Kyla Shea, Gary G Schwartz, Jeff D Williamson, Frances A Tylavsky, Marjolein Visser, Eleanor M Simonsick, Tamara B Harris, Stephen B Kritchevsky, Health ABC Study

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Low 25-hydroxyvitamin D (25(OH)D) concentrations are common among older adults and are associated with poorer physical performance and strength, but results from longitudinal studies have been inconsistent. The 25(OH)D threshold for physical performance and strength was determined, and both cross-sectional and longitudinal associations between 25(OH)D and physical performance and strength were examined, in men and women aged 71-80 years from the Health, Aging, and Body Composition Study (n 2,641). Baseline serum 25(OH)D was measured in 1998-1999, and physical performance and strength were measured at baseline and at 2-and 4-year follow-up. Piecewise regression models were used to determine 25(OH)D thresholds. Linear regression and mixed models were used to examine cross-sectional and longitudinal associations. The 25(OH)D thresholds were 70-80 nmol/L for physical performance and 55-70 nmol/L for strength. Participants with 25(OH)D <50 nmol/L had poorer physical performance at baseline and at 2-and 4-year follow-up than participants with 25(OH)D <75 nmol/L (P < 0.01). Although physical performance and strength declined over 4 years of follow-up (P < 0.0001), in general, the rate of decline was not associated with baseline 25(OH)D. Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength. © 2012 The Author.
Original languageEnglish
Pages (from-to)1025-1034
Number of pages10
JournalAmerican Journal of Epidemiology
Volume176
Issue number11
DOIs
Publication statusPublished - 1 Dec 2012

Keywords

  • Aged
  • Aged, 80 and over
  • Body Composition
  • Chi-Square Distribution
  • Confounding Factors (Epidemiology)
  • Cross-Sectional Studies
  • Female
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Male
  • Muscle Strength
  • Pain Measurement
  • Pennsylvania
  • Physical Fitness
  • Prospective Studies
  • Surveys and Questionnaires
  • Tennessee
  • Urban Population
  • Vitamin D Deficiency
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

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