3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.

B.M. de Rooij; P.J. Boogaard; J.N.M. Commandeur; N.P.E. Vermeulen

doi:10.1016/S1382-6689(97)00011-2

3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.

B.M. de Rooij, P.J. Boogaard, J.N.M. Commandeur, N.P.E. Vermeulen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Until now no urinary biomarker of exposure was available to assess human exposure to epichlorohydrin (ECH). For this purpose the urinary excretion of mercapturic acids and α-chlorohydrin (α-CH), which are potential metabolites of ECH in humans was investigated. This study was undertaken in a chemical plant in which ECH is used in the production of glycidyl ethers. Urine samples were collected from 19 persons at the beginning and at the end of work-shifts and at the morning after the last work-shift. Respiratory air concentrations of ECH were determined by personal air monitoring (PAM) and were found to range from < 0.03 to 1.1 mg/m

Original language	English
Pages (from-to)	175-185
Journal	Environmental Toxicology and Pharmacology
Volume	3
DOIs	https://doi.org/10.1016/S1382-6689(97)00011-2
Publication status	Published - 1997

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title = "3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.",

abstract = "Until now no urinary biomarker of exposure was available to assess human exposure to epichlorohydrin (ECH). For this purpose the urinary excretion of mercapturic acids and α-chlorohydrin (α-CH), which are potential metabolites of ECH in humans was investigated. This study was undertaken in a chemical plant in which ECH is used in the production of glycidyl ethers. Urine samples were collected from 19 persons at the beginning and at the end of work-shifts and at the morning after the last work-shift. Respiratory air concentrations of ECH were determined by personal air monitoring (PAM) and were found to range from < 0.03 to 1.1 mg/m",

author = "{de Rooij}, B.M. and P.J. Boogaard and J.N.M. Commandeur and N.P.E. Vermeulen",

year = "1997",

doi = "10.1016/S1382-6689(97)00011-2",

language = "English",

volume = "3",

pages = "175--185",

journal = "Environmental Toxicology and Pharmacology",

issn = "1382-6689",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - 3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.

AU - de Rooij, B.M.

AU - Boogaard, P.J.

AU - Commandeur, J.N.M.

AU - Vermeulen, N.P.E.

PY - 1997

Y1 - 1997

N2 - Until now no urinary biomarker of exposure was available to assess human exposure to epichlorohydrin (ECH). For this purpose the urinary excretion of mercapturic acids and α-chlorohydrin (α-CH), which are potential metabolites of ECH in humans was investigated. This study was undertaken in a chemical plant in which ECH is used in the production of glycidyl ethers. Urine samples were collected from 19 persons at the beginning and at the end of work-shifts and at the morning after the last work-shift. Respiratory air concentrations of ECH were determined by personal air monitoring (PAM) and were found to range from < 0.03 to 1.1 mg/m

AB - Until now no urinary biomarker of exposure was available to assess human exposure to epichlorohydrin (ECH). For this purpose the urinary excretion of mercapturic acids and α-chlorohydrin (α-CH), which are potential metabolites of ECH in humans was investigated. This study was undertaken in a chemical plant in which ECH is used in the production of glycidyl ethers. Urine samples were collected from 19 persons at the beginning and at the end of work-shifts and at the morning after the last work-shift. Respiratory air concentrations of ECH were determined by personal air monitoring (PAM) and were found to range from < 0.03 to 1.1 mg/m

U2 - 10.1016/S1382-6689(97)00011-2

DO - 10.1016/S1382-6689(97)00011-2

M3 - Article

SN - 1382-6689

VL - 3

SP - 175

EP - 185

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

ER -

3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.

Abstract

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