3-Chloro-2-hydroxypropylmercapturic acid and alpha-chloridrin as biomarkers of occupational exposure to epichlorohydrin.

B.M. de Rooij, P.J. Boogaard, J.N.M. Commandeur, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Until now no urinary biomarker of exposure was available to assess human exposure to epichlorohydrin (ECH). For this purpose the urinary excretion of mercapturic acids and α-chlorohydrin (α-CH), which are potential metabolites of ECH in humans was investigated. This study was undertaken in a chemical plant in which ECH is used in the production of glycidyl ethers. Urine samples were collected from 19 persons at the beginning and at the end of work-shifts and at the morning after the last work-shift. Respiratory air concentrations of ECH were determined by personal air monitoring (PAM) and were found to range from < 0.03 to 1.1 mg/m
Original languageEnglish
Pages (from-to)175-185
JournalEnvironmental Toxicology and Pharmacology
Volume3
DOIs
Publication statusPublished - 1997

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