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  • D. Bald
2018

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticle

File

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8, 1, 2625.

Research output: Contribution to JournalArticle

Open Access
File
2017

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 1, 10665.

Research output: Contribution to JournalArticle

Open Access

Targeting energy metabolism in Mycobacterium tuberculosis – a new paradigm in anti-mycobacterial drug discovery.

Bald, D., Villellas, C., Lu, P. & Koul, A., 2017, In : mBio. 8, 2, p. 1-11 11 p., e00272-17.

Research output: Contribution to JournalArticle

Open Access
2016

Cytochrome bd as survival factor in mycobacteria

Lu, P., Heineke, M., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. & Bald, D., Aug 2016, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857, p. e120

Research output: Contribution to JournalArticle

Open Access

Cytochrome bd displays significant quinol peroxidase activity

Al-Attar, S., Yu, Y., Pinske, M., Hoeser, J., Friedrich, T., Bald, D. & de Vries, S., 2016, In : Scientific Reports. 6, 27631

Research output: Contribution to JournalArticle

Open Access

Direct Quantitative Detection of Doc2b-Induced Hemifusion in Optically Trapped Membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Groffen, A. J. A. & Wuite, G. J. L., 2016, In : Biophysical Journal. 110, 3, p. 520A-520A

Research output: Contribution to JournalMeeting Abstract

Open Access

Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues.

Rombouts, J. A., Veenboer, R. M. P., Villellas, C., Lu, P., Ehlers, A. W., Andries, K., Koul, A., Lill, H., Ruijter, E., Orru, R. V. A., Lammertsma, K., Bald, D. & Slootweg, J. C., 2016, In : RSC Advances. 6, p. 108708-108716

Research output: Contribution to JournalArticle

Open Access
2015

A review on emerging diagnostic assay for viral detection: the case of avian influenza virus.

Roodbar Shojaei, T., Tabatabaei, M., Shawky, S., Salleh, M. A. M. & Bald, D., 2015, In : Molecular Biology Reports. 42, 1, p. 187-199

Research output: Contribution to JournalArticle

Bactericidal mode of action of bedaquiline.

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K. & Cook, G. M., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 7, p. 2028-2037

Research output: Contribution to JournalArticle

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Wuite, G. J. L. & Groffen, A. J. A., 2015, In : Nature Communications. 6, p. 8387 8387.

Research output: Contribution to JournalArticle

Open Access

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. J. M. & Bald, D., 2015, In : Scientific Reports. 5, 10333.

Research output: Contribution to JournalArticle

Open Access
2014
Open Access

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Koul, A., Vranckx, L., Dhar, N., Göhlmann, H., Özdemir, E., Neefs, J-M., Schulz, M., Lu, P., Mortz, E., McKinney, J. D., Andries, K. & Bald, D., 2014, In : Nature Communications. 5, 3369.

Research output: Contribution to JournalArticle

Open Access

The ATPsynthase inhibitor bedaquiline interferes with small-molecule efflux in Mycobacterium smegmatis.

Lu, P., Villelas, C., Koul, A., Andries, K., Lill, H. & Bald, D., 2014, In : The Journal of Antibiotics.

Research output: Contribution to JournalArticle

2013

Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria

Bald, D. & Koul, A., 2013, In : Drug Discovery Today. 18, p. 250-255

Research output: Contribution to JournalArticle

Novel antibiotics targeting respiratory ATP in Gram-positive pathogenic bacteria

Balemans, W., Vranckx, L., Lounis, N., Pop, O., Guillemont, J., Vergauwen, K., Mol, S., Gilissen, R., Motte, M., Lanois, D., de Bolle, M., Bonroy, K., Lill, H., Andries, K., Bald, D. & Koul, A., 2013, In : Antimicrobial Agents and Chemotherapy. 56, p. 4131-4139

Research output: Contribution to JournalArticle

2011

Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase.

Haagsma, A. C., Podasca, I., Koul, A., Andries, K., Guillemont, J., Lill, H. & Bald, D., 2011, In : PLoS ONE. 6, p. e23575

Research output: Contribution to JournalArticle

Open Access
File

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

Lu, P., Haagsma, A. C., Pham, H., Maaskant, J. J., Mol, S., Lill, H. & Bald, D., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5354-5357

Research output: Contribution to JournalArticle

Open Access
File
2010

ATP synthase from slow and fast growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.

Haagsma, A. C., Driessen, N. N., Hahn, M. M., Lill, H. & Bald, D., 2010, In : FEMS Microbiology Letters. 313, p. 68-74

Research output: Contribution to JournalArticle

Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles

Shawky, S. M., Bald, D. & Azzazy, H. M., 2010, In : Clinical Biochemistry. 43, p. 1163-1168

Research output: Contribution to JournalArticle

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

Bald, D. & Koul, A., 2010, In : FEMS Microbiology Letters. 308, p. 1-7

Research output: Contribution to JournalArticle