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  • Hamdi Mbarek
2018

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, S., Diniz, M. J. A., Saloma, A., Gadelha, A., Santoro, M. L., Ota, V. K., Noto, C., Curtis, C., Newhouse, S. J., Patel, H., Hall, L. S., O`Reilly, P. F., Belangero, S. I., Bressan, R. A., Breen, G. & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 8 Oct 2018, In : Communications biology. 1, p. 1-10 10 p., 163.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N. & 30 others, Castelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I. & Penninx, B. W. J. H., May 2018, In : Nature Genetics. 50, 5, p. 668-681 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Genome-wide association meta-analysis of age at first cannabis use

Minică, C. C., Verweij, K. J. H., van der Most, P. J., Mbarek, H., Bernard, M., van Eijk, K. R., Lind, P. A., Liu, M. Z., Maciejewski, D. F., Palviainen, T., Sánchez-Mora, C., Sherva, R., Taylor, M., Walters, R. K., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Casas, M., Corley, R. P. & 50 others, Davey-Smith, G., Davies, G. E., Ehli, E. A., Farrer, L., Fedko, I. O., Garcia-Martínez, I., Gordon, S. D., Hartman, C. A., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Kahn, R. S., Kaprio, J., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Madden, P. A. F., Medland, S. E., Neale, M. C., Meeus, W. H. J., Montgomery, G. W., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Wall, T. L., Ware, J. J., Wright, M. J., Zhao, H., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Loukola, A., Boks, M. P., Snieder, H., Munafò, M. R., Gelernter, J., Boomsma, D. I., Martin, N. G., Gillespie, N. A., Vink, J. M. & Derks, E. M., Nov 2018, In : Addiction. 113, 11, p. 2073-2086 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 20 Dec 2018, In : PLoS ONE. 13, 12, p. 1-29 29 p., e0209160.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

Boomsma, D. I., Davies, G. E., de Geus, E., Ehli, E. A., Finnicum, C. T. F., Mbarek, H., Willemsen, G. & MiBioGen Consortium Initiative, 8 Jun 2018, In : Microbiome. 6, 1, p. 101 101.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O. C., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., Bisgaard, H., Bjornsdottir, U. S., Bleecker, E., Bønnelykke, K., Boomsma, D. I., Bouzigon, E., Brightling, C. E., Brossard, M., Brusselle, G. G., Burchard, E. & 31 others, Burkart, K. M., Bush, A., Chan-Yeung, M., Chung, K. F., Couto Alves, A., Curtin, J. A., Custovic, A., Daley, D., de Jongste, J. C., Del-Rio-Navarro, B. E., Donohue, K. M., Duijts, L., Eng, C., Eriksson, J. G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M. A., Freidin, M. B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S. A., Gilliland, F., Heckbert, S. R., Hottenga, J., Mbarek, H., Willemsen, G. & Australian Asthma Genetics Consortium (AAGC) collaborators, Jan 2018, In : Nature Genetics. 50, 1, p. 42-53 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

23Andme Research Team, 26 Nov 2018, In : Nature Neuroscience. 21, 12, p. 1656-1669 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2017

Design and implementation of a customized genotyping array for imputation-based genome-wide association studies: the Avera-NTR Global Screening Array

Beck, J. J., Ehli, E. A., مبارك, ., Kallsen, N., Peyton, S., Abdellaoui, A., Fedko, I. O., Willemsen, G., de Geus, E., Boomsma, D. I., Davies, G. E. & Hottenga, J. J., 6 Mar 2017.

Research output: Contribution to ConferencePosterOther research output

Open Access

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Zeng, Y., Navarro, P., Shirali, M., Howard, D. M., Adams, M. J., Hall, L. S., Clarke, T-K., Thomson, P. A., Smith, B. H., Murray, A., Padmanabhan, S., Hayward, C., Boutin, T., MacIntyre, D. J., Lewis, C. M., Wray, N. R., Mehta, D., Penninx, B. W. J. H., Milaneschi, Y., Baune, B. T. & 20 others, Air, T., Hottenga, J-J., Mbarek, H., Castelao, E., Pistis, G., Schulze, T. G., Streit, F., Forstner, A. J., Byrne, E. M., Martin, N. G., Breen, G., Müller-Myhsok, B., Lucae, S., Kloiber, S., Domenici, E., Deary, I. J., Porteous, D. J., Haley, C. S., McIntosh, A. M. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Sep 2017, In : Biological Psychiatry. 82, 5, p. 312-321 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Mbarek, H., Milaneschi, Y., Hottenga, J-J., Ligthart, L., de Geus, E. J. C., Ehli, E. A., Willemsen, G., Davies, G. E., Smit, J. H., Boomsma, D. I. & Penninx, B. W. J. H., 1 Aug 2017, In : Twin Research and Human Genetics. 20, 4, p. 267-270 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Day, F. R., Thompson, D. J., Helgason, H., Chasman, D. I., Finucane, H., Sulem, P., Ruth, K. S., Whalen, S., Sarkar, A. K., Albrecht, E., Altmaier, E., Amini, M., Barbieri, C. M., Boutin, T., Campbell, A., Demerath, E., Giri, A., He, C., Hottenga, J. J., Karlsson, R. & 31 others, Kolcic, I., Loh, P-R., Lunetta, K. L., Mangino, M., Marco, B., McMahon, G., Medland, S. E., Nolte, I. M., Noordam, R., Nutile, T., Paternoster, L., Perjakova, N., Porcu, E., Rose, L. M., Schraut, K. E., Segrè, A. V., Smith, A. V., Stolk, L., Teumer, A., Andrulis, I. L., Bandinelli, S., Beckmann, M. W., Benitez, J., Bergmann, S., Bochud, M., de Geus, E. J. C. N., Mbarek, H., Willemsen, G., Boomsma, D. I., Visser, J. A. & LifeLines Cohort Study, 1 Jun 2017, In : Nature Genetics. 49, 6, p. 834-841 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A. & 12 others, Colodro-Conde, L., Medland, S. E., Martin, N. G., Rietschel, M., CORtisolNETwork (CORNET) Consortium, Abdellaoui, A., de Geus, E., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Willemsen, G. & Boomsma, D. I., 10 Nov 2017, In : Scientific Reports. 7, 1, p. 15351 15351.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis

Minicã, C. C., Mbarek, H., Pool, R., Dolan, C. V., Boomsma, D. I. & Vink, J. M., Jan 2017, In : Molecular Psychiatry. 22, 1, p. 82-88 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

SNP based genetic linkage of large pedigree ascertained for multiple mothers of DZ twins

مبارك, ., 6 Mar 2017.

Research output: Contribution to ConferencePosterOther research output

Open Access

The International Cannabis Consortium: What Did We Learn About The Genetics Of Cannabis Use

Verweij, K., Minica, C., Stringer, S., van der Most, P., Mbarek, H., Nivard, M. G., Abdellaoui, A., Hottenga, J-J., Martin, N., Boomsma, D., Gillespie, N., Derks, E. & Vink, J., 15 Aug 2017, In : European Neuropsychopharmacology. 27, p. S494-S495

Research output: Contribution to JournalArticleAcademicpeer-review

2016

Connecting the dots, genome-wide association studies in substance use

International Cannabis Consortium, 2016, In : Molecular Psychiatry. 21, 6, p. 733-735

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic variants in RBFOX3 are associated with sleep latency

Amin, N., Allebrandt, K. V., Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, M. F., Byrne, E. M., Oole, E., Kolcic, I., Chen, T., Evans, D. S., Coresh, J., Vogelzangs, N. & 55 others, Karjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C. G. N., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H. E., Müller-Nurasyid, M., Fehrmann, R. S. N., Montgomery, G. W., Hofman, A., Hong, W., Kao, L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van Ijcken, W. F. J., Penninx, B. W. J. H., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., 2016, In : European Journal of Human Genetics. 24, 10, p. 1488-1495

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., Zondervan, K. T., Stefansson, K., Krueger, R. F., Lee, J. J., Benjamin, D. J. & 5 others, Cesarini, D., Koellinger, P. D., den Hoed, M. A. H., Snieder, H. & Mills, M. C., 2016, In : Nature Genetics. 48, 12, p. 1462-1472

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Stringer, S., Minică, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T. & 60 others, Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D. S., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Mägi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, J., Boks, M. P. M., Snieder, H., Spector, T., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M. & Vink, J. M., 29 Mar 2016, In : Translational Psychiatry. 6, p. e769

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Mbarek, H., Steinberg, S., Nyholt, DR., Gordon, S. D., Miller, M. B., McRae, A. F., Hottenga, J. J., Day, F. R., Willemsen, G., de Geus, E. J. C., Davies, G. E., Martin, H. C., Penninx, B. W. J. H., Jansen, R., McAloney, K., Vink, J. M., Kaprio, J., Plomin, R., Spector, T. D., Magnusson, P. K. & 17 others, Reversade, B., Harris, R. A., Aagaard, K., Kristjansson, R. P., Olafsson, I., Eyjolfsson, G. I., Sigurdardottir, O., Iacono, W. G., Lambalk, C. B., Montgomery, G. W., McGue, M., Ong, K. K., Perry, J. R. B., Martin, N. G., Stefansson, H., Stefansson, K. & Boomsma, D. I., 2016, In : American Journal of Human Genetics. 98, 5, p. 898-908

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S. R., Hottenga, J. J., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivieres, S. & 5 others, Kliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E. & 78 others, Lyytikäinen, L. P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyi, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S. T., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J., den Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kähönen, M., Lehtimäki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M. A., Ripatti, S., Willems van Dijk, K., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A. & van Duijn, C. M., 2016, In : Journal of Medical Genetics. 53, 7, p. 441-449

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

van den Berg, S. M., de Moor, M. H. M., Verweij, C. J. H., Krueger, R. F., Luciano, M., Vasquez, A. A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Miller, M., Nutile, T., Tanaka, T. & 95 others, Teumer, A., Viktorin, A., Wedenoja, J., Abdellaoui, A., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Davey Smith, G., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Ferrucci, L., Franke, B., Giegling, I., Grucza, R., Hartmann, A. M., Heath, A. C., Heinonen, K., Henders, A. K., Homuth, G., Hottenga, J. J., Iacono, W. G., Janzing, J., Jokela, M., Karlsson, R., Kemp, J. P., Kirkpatrick, M. G., Latvala, A., Lehtimäki, T., Liewald, D. C., Madden, P. A. F., Magri, C., Magnusson, P. K. E., Marten, J., Maschio, A., Mbarek, H., Medland, S. E., Mihailov, E., Milaneschi, Y., Montgomery, G. W., Nauck, M., Nivard, M. G., Ouwens, K. G., Palotie, A., Pettersson, E., Polasek, O., Qian, Y., Pulkki-Raback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Schmidt, C. O., Slutske, W. S., Sorice, R., Starr, J. M., St Pourcain, B., Sutin, A. R., Timpson, N. J., Trochet, H., Zgaga, L., Porteous, D., Minelli, A., Palmer, A. A., Rujescu, D., Ciullo, M., Hayward, C., Rudan, I., Metspalu, A., Kaprio, J., Deary, I. J., Räikkönen, K., Wilson, J. F., Keltikangas-Järvinen, L., Bierut, L. J., Hettema, J. M., Grabe, H. J., Penninx, B. W. J. H., van Duijn, C. M., Evans, D. M., Schlessinger, D., Pedersen, N. L., Terracciano, A., McGue, M., Martin, N. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 2, p. 170-182

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Polygenic dissection of major depression clinical heterogeneity

Milaneschi, Y., Winkelman, F., Peyrot, W., Abdellaoui, A., Willemsen, G., Hottenga, J. J., Jansen, R., Mbarek, H., Dehghan, A., Lu, C., Boomsma, D. I. & Penninx, B. W. J. H., 2016, In : Molecular Psychiatry. 21, 4, p. 516-522

Research output: Contribution to JournalArticleAcademicpeer-review

Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them

Mbarek, H., Dolan, C. V. & Boomsma, D. I., 2016, In : Twin Research and Human Genetics. 19, 5, p. 418-421

Research output: Contribution to JournalArticleAcademicpeer-review

2015

CNV Concordance in 1,097 MZ Twin Pairs

Abdellaoui, A., Ehli, E. A., Hottenga, J. J., Weber, Z., Mbarek, H., Willemsen, G., van Beijsterveldt, C. E. M., Brooks, A., Hudziak, J. J., Sullivan, P. F., de Geus, E. J. C., Davies, G. E. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 1, p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Effect of Smoking on Blood Pressure and Resting Heart Rate - A Mendelian Randomization Meta-Analysis in the CARTA Consortium

Linneberg, A., Jacobsen, R. K., Skaaby, T., Taylor, A. E., Fluharty, M. E., Jeppesen, J., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R. E., Kumari, M., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Ahluwalia, T. S., Wannamethee, S. G., Lahti, J., Räikkönen, K. & 40 others, Palotie, A., Wong, A., Dalgard, C., Ford, I., Ben-Shlomo, Y., Christiansen, L., Kyvik, K. O., Kuh, D., Eriksson, J. G., Whincup, P. H., Mbarek, H., de Geus, E. J. C., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D. A., Kisialiou, A., McConnachie, A., Padmanabhan, S., Jukema, J. W., Power, C., Hyppönen, E., Preisig, M., Waeber, G., Vollenweider, P., Korhonen, T., Laatikainen, T., Salomaa, V., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Sorensen, T. I. A., Thuesen, B. H., Sattar, N., Morris, R. W., Romundstad, P. R., Munafò, M., Jarvelin, M. R. & Husemoen, L. L. N., 2015, In : Circulation-cardiovascular genetics. 8, 6, p. 832-841 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., Dijk, F. & 52 others, Willemsen, G., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J., Uh, H. W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Polasek, O., Vitart, V., Rudan, I., Wright, A. F., Rich, S. S., Psaty, B. M., Borecki, I. B., Kearney, P. M., Stott, D. J., Cupples, L. A., Jukema, J. W., van der Harst, P., Sijbrands, E. J., Hottenga, J. J., Uitterlinden, A. G., Swertz, M. A., van Ommen, G. J. B., Bakker, P. I. W., Slagboom, P. E., Boomsma, D. I., Wijmenga, C. & van Duijn, C. M., 2015, In : Nature Communications. 6, p. 6065 6 p., 6065.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Heritability and Genome-Wide Association Studies for Hair Color in a Dutch Twin Family Based Sample

Lin, B., Mbarek, H., Willemsen, G., Dolan, C. V., Fedko, I. O., Abdellaoui, A., de Geus, E. J. C., Boomsma, D. I. & Hottenga, J. J., 2015, In : Genes. 6, 3, p. 559-576 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Multicohort analysis of the maternal age effect on recombination

Martin, H. C., Christ, R., Hussin, J. G., O'Connell, J., Gordon, S., Mbarek, H., Hottenga, J. J., McAloney, K., Willemsen, G., Gasparini, P., Pirastu, N., Montgomery, G. W., Navarro, P., Soranzo, N., Toniolo, D., Vitart, V., Wilson, J. F., Marchini, J., Boomsma, D. I., Martin, N. G. & 1 others, Donnelly, P., 2015, In : Nature Communications. 6, 10 p., 7846.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The genetics of alcohol dependence: Heritability and genome wide association analyses

Mbarek, H., 2015.

Research output: Contribution to ConferencePosterOther research output

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2014

Further confirmation of the association between anxiety and CTNND2: replication in humans

Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Penninx, B. W. J. H., Middeldorp, C. M. & Boomsma, D. I., 2014, In : Genes, Brain and Behavior. 13, 2, p. 195-201 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder

Korhonen, T., Loukola, A., Wedenoja, J., Nyman, E., Latvala, A., Broms, U., Häppölä, A., Paunio, T., Schrage, A. J., Vink, J. M., Mbarek, H., Boomsma, D. I., Penninx, B. W. J. H., Pergadia, M. L., Madden, P. A. F. & Kaprio, J., 2014, In : PLoS ONE. 9, 6, p. e98199 10 p., e98199.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Sex differences in the human peripheral blood transcriptome

Jansen, R., Batista, S., Brooks, A. I., Tischfield, J. A., Willemsen, G., Grootheest, G., Hottenga, J. J., Milaneschi, Y., Mbarek, H., Madar, V., Peyrot, W., Vink, J. M., Verweij, C. L., de Geus, E. J. C., Smit, J. H., Wright, F. A., Sullivan, P. F., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : BMC Genomics. 15, p. 33 12 p., 33.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J. J., Mbarek, H., Willemsen, G., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A., Boomsma, D. I. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 4, p. 368-382 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The effect of FTO rs9939609 on major depression differs across MDD subtypes

Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J. J., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : Molecular Psychiatry. 19, 9, p. 960-962 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The Genetic Landscape of Twinning : A Meta-Analysis of Genome-Wide Association Studies from The Twinning Gwas Consortium

Mbarek, H., 2014.

Research output: Contribution to ConferencePosterOther research output

2013

The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection

Willemsen, G., Vink, J. M., Abdellaoui, A., den Braber, A., van Beek, J. H. D. A., Draisma, H. H. M., van Dongen, J., van t Ent, D., Geels, L. M., van Lien, R., Ligthart, L., Kattenberg, V. M., Mbarek, H., de Moor, M. H. M., Neijts, M., Pool, R., Stroo, N., Kluft, C., Suchiman, H. E. D., Slagboom, P. E. & 2 others, de Geus, E. J. C. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 1, p. 271-281

Research output: Contribution to JournalArticleAcademicpeer-review

2012

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Sawai, H., Nishida, N., Mbarek, H., Matsuda, K., Mawatari, Y., Yamaoka, M., Hige, S., Kang, J-H., Abe, K., Mochida, S., Watanabe, M., Kurosaki, M., Asahina, Y., Izumi, N., Honda, M., Kaneko, S., Tanaka, E., Matsuura, K., Itoh, Y., Mita, E. & 15 others, Korenaga, M., Hino, K., Murawaki, Y., Hiasa, Y., Ide, T., Ito, K., Sugiyama, M., Ahn, S. H., Han, K-H., Park, J. Y., Yuen, M-F., Nakamura, Y., Tanaka, Y., Mizokami, M. & Tokunaga, K., 19 Jun 2012, In : BMC Medical Genetics. 13, p. 47

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2011

A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population

Mbarek, H., Ochi, H., Urabe, Y., Kumar, V., Kubo, M., Hosono, N., Takahashi, A., Kamatani, Y., Miki, D., Abe, H., Tsunoda, T., Kamatani, N., Chayama, K., Nakamura, Y. & Matsuda, K., 1 Oct 2011, In : Human Molecular Genetics. 20, 19, p. 3884-92 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2010

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

Plant, D., Flynn, E., Mbarek, H., Dieudé, P., Cornelis, F., Arlestig, L., Dahlqvist, S. R., Goulielmos, G., Boumpas, D. T., Sidiropoulos, P., Johansen, J. S., Ørnbjerg, L. M., Hetland, M. L., Klareskog, L., Filer, A., Buckley, C. D., Raza, K., Witte, T., Schmidt, R. E. & Worthington, J., Aug 2010, In : Annals of the Rheumatic Diseases. 69, 8, p. 1548-53 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access