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2019
Open Access
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Proteins
Infection

Isoniazid bactericidal activity involves electron transport chain perturbation

Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J. M., Mathys, V., Wattiez, R. & Fontaine, V., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. e01841-18.

Research output: Contribution to JournalArticleAcademicpeer-review

Isoniazid
Electron Transport
Adenosine Triphosphate
Electron Transport Complex IV
NADH Dehydrogenase
2018

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Energy Metabolism
Mycobacterium smegmatis
2017

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 10665.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Fluorescence
Mycobacterium marinum
Infection
Oxidative Phosphorylation

Targeting energy metabolism in Mycobacterium tuberculosis – a new paradigm in anti-mycobacterial drug discovery.

Bald, D., Villellas, C., Lu, P. & Koul, A., 2017, In : mBio. 8, 2, p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Oxidative Phosphorylation
Drug Discovery
Mycobacterium tuberculosis
Energy Metabolism
Drug Delivery Systems
2016

Cytochrome bd as survival factor in mycobacteria

Lu, P., Heineke, M., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. & Bald, D., Aug 2016, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857, p. e120

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Mycobacterium
Mycobacterium smegmatis
Electron Transport Complex III
bedaquiline

Cytochrome bd displays significant quinol peroxidase activity

Al-Attar, S., Yu, Y., Pinske, M., Hoeser, J., Friedrich, T., Bald, D. & de Vries, S., 2016, In : Scientific Reports. 6, 27631

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hydroquinones
Cytochromes
Heme
Peroxidase
Oxidoreductases

Direct Quantitative Detection of Doc2b-Induced Hemifusion in Optically Trapped Membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Groffen, A. J. A. & Wuite, G. J. L., 2016, In : Biophysical Journal. 110, 3, p. 520A-520A

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues.

Rombouts, J. A., Veenboer, R. M. P., Villellas, C., Lu, P., Ehlers, A. W., Andries, K., Koul, A., Lill, H., Ruijter, E., Orru, R. V. A., Lammertsma, K., Bald, D. & Slootweg, J. C., 2016, In : RSC Advances. 6, p. 108708-108716

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

A review on emerging diagnostic assay for viral detection: the case of avian influenza virus.

Roodbar Shojaei, T., Tabatabaei, M., Shawky, S., Salleh, M. A. M. & Bald, D., 2015, In : Molecular Biology Reports. 42, 1, p. 187-199

Research output: Contribution to JournalArticleAcademicpeer-review

Influenza in Birds
Orthomyxoviridae
Viruses
Biotechnology

Bactericidal mode of action of bedaquiline.

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K. & Cook, G. M., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 7, p. 2028-2037

Research output: Contribution to JournalArticleAcademicpeer-review

bedaquiline
Adenosine Triphosphate
Proton-Motive Force
Mycobacterium
Oxygen Consumption

Characterization of antibacterial drugs and drug combinations targeting oxidative phosphorylation in Mycobacteria

Lu, P., 2015, 177 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Wuite, G. J. L. & Groffen, A. J. A., 2015, In : Nature Communications. 6, p. 8387 8387.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
membranes
Membranes
SNARE Proteins
secretions
Phosphatidylserines

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. J. M. & Bald, D., 2015, In : Scientific Reports. 5, 10333.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium smegmatis
Peroxides
Cytochromes
Anti-Bacterial Agents
bedaquiline
2014

ATP synthase in mycobacteria: special features and implications for a function as drug target.

Lu, P., Lill, H. & Bald, D., 2014, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837, p. 1208-1218

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium
Adenosine Triphosphate
Pharmaceutical Preparations
Energy Metabolism
Macrophages

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Koul, A., Vranckx, L., Dhar, N., Göhlmann, H., Özdemir, E., Neefs, J-M., Schulz, M., Lu, P., Mortz, E., McKinney, J. D., Andries, K. & Bald, D., 2014, In : Nature Communications. 5, 3369.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
bedaquiline
tuberculosis
adenosine triphosphate
metabolism
Mycobacterium tuberculosis

The ATPsynthase inhibitor bedaquiline interferes with small-molecule efflux in Mycobacterium smegmatis.

Lu, P., Villelas, C., Koul, A., Andries, K., Lill, H. & Bald, D., 2014, In : The Journal of Antibiotics.

Research output: Contribution to JournalArticleAcademicpeer-review

2013

Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria

Bald, D. & Koul, A., 2013, In : Drug Discovery Today. 18, p. 250-255

Research output: Contribution to JournalArticleAcademicpeer-review

Anti-Bacterial Agents
Bacteria
Bacterial Infections
Pharmaceutical Preparations

Novel antibiotics targeting respiratory ATP in Gram-positive pathogenic bacteria

Balemans, W., Vranckx, L., Lounis, N., Pop, O., Guillemont, J., Vergauwen, K., Mol, S., Gilissen, R., Motte, M., Lanois, D., de Bolle, M., Bonroy, K., Lill, H., Andries, K., Bald, D. & Koul, A., 2013, In : Antimicrobial Agents and Chemotherapy. 56, p. 4131-4139

Research output: Contribution to JournalArticleAcademicpeer-review

Diarylquinolines
Gram-Positive Bacteria
bedaquiline
Adenosine Triphosphate
Anti-Bacterial Agents
2012

Respiratory ATP synthesis as drug target for combating tuberculosis

Haagsma, A. C., 2012, Houten: DPP. 107 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2011

Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase.

Haagsma, A. C., Podasca, I., Koul, A., Andries, K., Guillemont, J., Lill, H. & Bald, D., 2011, In : PLoS ONE. 6, p. e23575

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
bedaquiline
Diarylquinolines
H-transporting ATP synthase
Adenosine Triphosphate
drugs

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

Lu, P., Haagsma, A. C., Pham, H., Maaskant, J. J., Mol, S., Lill, H. & Bald, D., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5354-5357

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Proton-Motive Force
Adenosine Triphosphate
Mycobacterium bovis
Pyrazinamide
Microbiology
2010

ATP synthase from slow and fast growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.

Haagsma, A. C., Driessen, N. N., Hahn, M. M., Lill, H. & Bald, D., 2010, In : FEMS Microbiology Letters. 313, p. 68-74

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium
Hydrolysis
Adenosine Triphosphate
Proton-Motive Force
Mycobacterium bovis

Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles

Shawky, S. M., Bald, D. & Azzazy, H. M., 2010, In : Clinical Biochemistry. 43, p. 1163-1168

Research output: Contribution to JournalArticleAcademicpeer-review

Viruses
Gold
Hepacivirus
Nanoparticles
Assays

Resolution and Contrast Enhancement in Evanescent Wave Imaging

van 't Hoff, M., 2010, 111 p.

Research output: PhD ThesisPhD Thesis - Research external, graduation VUAcademic

Open Access
File

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

Bald, D. & Koul, A., 2010, In : FEMS Microbiology Letters. 308, p. 1-7

Research output: Contribution to JournalArticleAcademicpeer-review

Adenosine Triphosphate
Tuberculosis
Pharmaceutical Preparations
NADH Dehydrogenase
Mycobacterium tuberculosis