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2019

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Anisotropy
Genome
Radiation
Diffusion Tensor Imaging

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (Nature Neuroscience, (2018), 21, 9, (1161-1170), 10.1038/s41593-018-0206-1)

The 23andMe Research Team, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium & International Cannabis Consortium, 1 Jul 2019, In : Nature Neuroscience. 22, 7, p. 1196 1 p.

Research output: Contribution to JournalComment / Letter to the editorAcademic

Open Access
File
Genetic Loci
Genome-Wide Association Study
Cannabis
Neurosciences
Psychiatry

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Bipolar Disorder
Psychiatry
Schizophrenia
Depression
Major Depressive Disorder

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D. & Willemsen, G., 5 Aug 2019, In : Biological Psychiatry. p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
HLA Antigens
Haplotypes
Alleles
Depression
Major Histocompatibility Complex

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population

Alemany, S., Jansen, P. R., Muetzel, R. L., Marques, N., El Marroun, H., Jaddoe, V. W. V., Polderman, T. J. C., Tiemeier, H., Posthuma, D. & White, T., 9 Jan 2019, (Accepted/In press) In : Journal of the American Academy of Child and Adolescent Psychiatry. p. 1-8 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cognition Disorders
Attention Deficit Disorder with Hyperactivity
Psychiatry
Pediatrics
Intelligence

Decoding Genetic Associations of Human Complex Traits

Watanabe, K., 2019, 212 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Discovering the genetic architecture of the mind: (Epi-)genome-wide association studies on human psychology and behavior

Karlsson Linnér, R., 2019, 170 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium, 25 Mar 2019, In : Nature Genetics. 51, 4, p. 659–674 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Prefrontal Cortex
Schizophrenia
Tay-Sachs Disease
Gene Expression

Gene-set analysis: unraveling genetic mysteries using the power of molten rock

de Leeuw, C. A., 2019, 256 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls-Corrigendum

Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Agrawal, A., Borglum, A. D., Bulik, C. M., Daly, M. J., Davis, L. K., Demontis, D., Edenberg, H. J., Grove, J., Gelernter, J., Neale, B. M., Pardinãs, A. F., Stahl, E., Walters, J. T. R., Walters, R., Sullivan, P. F., Posthuma, D. & 1 othersPolderman, T. J. C., Jan 2019, In : Psychological Medicine. 49, 2, p. 351-351 1 p.

Research output: Contribution to JournalLetterAcademicpeer-review

Open Access
File

Genetic mapping and evolutionary analysis of human-expanded cognitive networks

Wei, Y., de Lange, S. C., Scholtens, L. H., Watanabe, K., Ardesch, D. J., Jansen, P. R., Savage, J. E., Li, L., Preuss, T. M., Rilling, J. K., Posthuma, D. & van den Heuvel, M. P., 24 Oct 2019, In : Nature Communications. 10, 1, p. 4839

Research output: Contribution to JournalArticleAcademicpeer-review

Brain
Genes
genes
brain
Genetic Loci

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

The 23andMe Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 394-403 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Sleep Initiation and Maintenance Disorders
Genome
Sleep
Genes
Neurons

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

Smeland, O. B., Bahrami, S., Frei, O., Shadrin, A., O’Connell, K., Savage, J., Watanabe, K., Krull, F., Bettella, F., Steen, N. E., Ueland, T., Posthuma, D., Djurovic, S., Dale, A. M. & Andreassen, O. A., 4 Jan 2019, In : Molecular Psychiatry. p. 1-10 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Intelligence
Bipolar Disorder
Schizophrenia
Genome
Alleles

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Social Science Genetic Association Consortium, 23and Me Research Team, eQTLGen Consortium & International Cannabis Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 245-257 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Computational Biology
Synaptic Transmission

Genome-wide association study identifies 30 loci associated with bipolar disorder

eQTLGen Consortium, BIOS Consortium & the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, 1 May 2019, In : Nature Genetics. 51, 5, p. 793-803 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Bipolar Disorder
Genome
Neurotransmitter Transport Proteins
Endocannabinoids

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F., Bjornsson, S. & 33 othersBrækhus, A., Bråthen, G., de Leeuw, C., Desikan, R. S., Djurovic, S., Dumitrescu, L., Fladby, T., Hohman, T. J., Jonsson, P. V., Kiddle, S. J., Rongve, A., Saltvedt, I., Sando, S. B., Selbæk, G., Shoai, M., Skene, N. G., Snaedal, J., Stordal, E., Ulstein, I. D., Wang, Y., White, L. R., Hardy, J., Hjerling-Leffler, J., Sullivan, P. F., van der Flier, W. M., Dobson, R., Davis, L. K., Stefansson, H., Stefansson, K., Pedersen, N. L., Ripke, S., Andreassen, O. A. & Posthuma, D., 1 Mar 2019, In : Nature Genetics. 51, 3, p. 404-413 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Meta-Analysis
Alzheimer Disease
Genome
Proxy
Genes

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Phenotype
Sample Size
Meta-Analysis
Autism Spectrum Disorder

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, p. 1-18 18 p., 2548.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
DNA Methylation
Fetal Blood
blood
Blood

Interrogating the genetic determinants of Tourette's syndrome and other tiC disorders through genome-wide association studies

Tourette Association of America International Consortium for Genetics, Gilles de la Tourette GWAS Replication Initiative, Tourette International Collaborative Genetics Study & Psychiatric Genomics Consortium Tourette Syndrome Working Group, 1 Mar 2019, In : American Journal of Psychiatry. 176, 3, p. 217-227 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
Tic Disorders
Tourette Syndrome
Genome-Wide Association Study
Tics
Meta-Analysis

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, 7 Jan 2019, In : Molecular Psychiatry. p. 1-18 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome

Polygenic Scores for Neuropsychiatric Traits and White Matter Microstructure in the Pediatric Population

Jansen, P. R., Muetzel, R. L., Polderman, T. J. C., Jaddoe, V. W., Verhulst, F. C., van der Lugt, A., Tiemeier, H., Posthuma, D. & White, T., Mar 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 3, p. 243-250 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Anisotropy
Intelligence
Pediatrics
Psychiatry
Diffusion Tensor Imaging

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 othersMi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., 17 Jul 2019, In : Neuron. 103, 2, p. 217-234.e4 22 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Knowledge Bases
Synapses
Genes
Gene Ontology
Molecular Sequence Annotation
Open Access
File
2018

[Erratum to] Author Correction: Majority of human traits do not show evidence for sex-specific genetic and environmental effects

Stringer, S., Polderman, T. J. C. & Posthuma, D., 21 Dec 2018, In : Scientific Reports. 8, p. 1-1 1 p., 18060.

Research output: Contribution to JournalComment / Letter to the editorAcademic

Open Access

Age at first birth in women is genetically associated with increased risk of schizophrenia

Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F. & 281 othersBacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., 5 Jul 2018, In : Scientific Reports. 8, p. 1-14 14 p., 10168.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Birth Order
Schizophrenia
Parents
Mental Health
Genetic Heterogeneity

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, S., Diniz, M. J. A., Saloma, A., Gadelha, A., Santoro, M. L., Ota, V. K., Noto, C., Curtis, C., Newhouse, S. J., Patel, H., Hall, L. S., O`Reilly, P. F., Belangero, S. I., Bressan, R. A., Breen, G. & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 8 Oct 2018, In : Communications biology. 1, p. 1-10 10 p., 163.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
behavior disorders
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Pedigree

Association of genetic risk for schizophrenia and bipolar disorder with infant neuromotor development

Serdarevic, F., Jansen, P. R., Ghassabian, A., White, T., Jaddoe, V. W. V., Posthuma, D. & Tiemeier, H., Jan 2018, In : JAMA Psychiatry. 75, 1, p. 96-98 3 p.

Research output: Contribution to JournalLetterAcademicpeer-review

Open Access
File

Balancing the Scale of Lady Justice: Biosocial studies of antisocial behavior

Tielbeek, J. J., 2018

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

Coleman, J. R. I., Bryois, J., Gaspar, H. A., Jansen, P. R., Savage, J. E., Skene, N., Plomin, R., Muñoz-Manchado, A. B., Linnarsson, S., Crawford, G., Hjerling-Leffler, J., Sullivan, P. F., Posthuma, D. & Breen, G., 8 Mar 2018, In : Molecular Psychiatry. 2018, p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Intelligence
Meta-Analysis
Genome-Wide Association Study
Genes

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

Boomsma, D. I., Ligthart, R. S. L., Posthuma, D. & 23Andme Research Team, 16 May 2018, In : Neuron. 98, 4, p. 743-753.e4

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Migraine Disorders
Migraine without Aura
Migraine with Aura
Genome-Wide Association Study
Population

Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure

de Leeuw, C. A., Stringer, S., Dekkers, I. A., Heskes, T. & Posthuma, D., 14 Sep 2018, In : Nature Communications. 9, p. 1-13 13 p., 3768.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
blood pressure
Blood pressure
genes
Genes
Blood Pressure

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Posthuma, D. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 7 Jun 2018, In : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Linkage Disequilibrium
Schizophrenia
Likelihood Functions
Genetic Heterogeneity
Nucleic Acid Regulatory Sequences

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour, 6 Dec 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Exome
Meta-Analysis
Smoking
Alcohols
Phenotype

Exploring the genetic correlations of antisocial behaviour and life history traits

Tielbeek, J. J., Barnes, J. C., Popma, A., Polderman, T. J. C., Lee, J. J., Perry, J. R. B., Posthuma, D. & Boutwell, B. B., 2018, In : BJPsych Open. 4, 6, p. 467-470 4 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Alleles
Heritable Quantitative Trait
Behavioral Genetics
Birth Order
Genome-Wide Association Study

Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Marees, A. T., Hammerschlag, A. R., Bastarache, L., de Kluiver, H., Vorspan, F., van den Brink, W., Smit, D. J., Denys, D., Gamazon, E. R., Li-Gao, R., Breetvelt, E. J., de Groot, M. C. H., Galesloot, T. E., Vermeulen, S. H., Poppelaars, J. L., Souverein, P. C., Keeman, R., de Mutsert, R., Noordam, R., Rosendaal, F. R. & 13 othersStringa, N., Mook-Kanamori, D. O., Vaartjes, I., Kiemeney, L. A., den Heijer, M., van Schoor, N. M., Klungel, O. H., Maitland-Van der Zee, A. H., Schmidt, M. K., Polderman, T. J. C., van der Leij, A. R., Posthuma, D. & Derks, E. M., 1 Jul 2018, In : Drug and Alcohol Dependence. 188, p. 94-101 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tobacco
Tobacco Use
Alcohols
Alcohol Drinking
Exome

From genetic variants to biological pathways in neuropsychiatric traits

Hammerschlag, A. R., 2018, 191 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

23Andme Research Team, Abdellaoui, A., Peyrot, W. J., Hottenga, J. J., Vinkhuyzen, A. A. E., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Penninx, B., Posthuma, D. & Uitterlinden, A. G., Aug 2018, In : Nature Genetics. 50, 8, p. 1112-1121 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Genetic Association Studies
Single Nucleotide Polymorphism
Genome
Phenotype
Open Access
Chromosome Disorders
Fibroblasts
Induced Pluripotent Stem Cells
X Chromosome Inactivation
Rett Syndrome

Genetic correlation of antisocial behaviour with alcohol, nicotine, and cannabis use

Tielbeek, J. J., Vink, J. M., Polderman, T. J. C., Popma, A., Posthuma, D. & Verweij, K. J. H., 1 Jun 2018, In : Drug and Alcohol Dependence. 187, p. 296-299 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cannabis
Polymorphism
Nicotine
Nucleotides
Tobacco Products

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Agrawal, A., Børglum, A. D., Bulik, C. M., Daly, M. J., Davis, L. K., Demontis, D., Edenberg, H. J., Grove, J., Gelernter, J., Neale, B. M., Pardiñas, A. F., Stahl, E., Walters, J. T. R., Walters, R., Sullivan, P. F., Posthuma, D. & 1 othersPolderman, T. J. C., 17 Sep 2018, In : Psychological Medicine. p. 1-8 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Psychiatry
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Alcoholism
Genotype

Genetics of intellectual ability and disability: The importance of common variants and rare syndromes illustrated by studies of SNAP25 and AUTS2

Beunders, G., 2018, 160 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N. & 30 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I. & Penninx, B. W. J. H., May 2018, In : Nature Genetics. 50, 5, p. 668-681 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Depression
Schizophrenia
Major Depressive Disorder
Suicide

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 othersZabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., DeRosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., van der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., 1 Jul 2018, In : Nature Genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Intelligence
Meta-Analysis
Mendelian Randomization Analysis
Genes

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 20 Dec 2018, In : PLoS ONE. 13, 12, p. 1-29 29 p., e0209160.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Proxy
Genes
Genome
genome

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Posthuma, D. & Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: douglas.ruderfer@vanderbilt.edu, 14 Jun 2018, In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Dissection
Bipolar Disorder
Schizophrenia
Genes
Potassium

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

23Andme Research Team, Sep 2018, In : Nature Neuroscience. 21, 9, p. 1161-1170 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Cannabis
Psychiatry
Schizophrenia

Higher Polygenetic Predisposition for Asthma in Cow's Milk Allergic Children

Jansen, P. R., Petrus, N. C. M., Venema, A., Posthuma, D., Mannens, M. M. A. M., Sprikkelman, A. B. & Henneman, P., Nov 2018, In : Nutrients. 10, 11, p. 1-12 12 p., 1582.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
milk allergy
Milk Hypersensitivity
asthma
Milk
Asthma

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

Li, M., Santpere, G., Kawasawa, Y. I., Evgrafov, O. V., Gulden, F. O., Pochareddy, S., Sunkin, S. M., Li, Z., Shin, Y., Zhu, Y., Sousa, A. M. M., Werling, D. M., Kitchen, R. R., Kang, H. J., Pletikos, M., Choi, J., Muchnik, S., Xu, X., Wang, D., Lorente-Galdos, B. & 25 othersLiu, S., Giusti-Rodríguez, P., Won, H., De Leeuw, C. A., Pardiñas, A. F., Hu, M., Jin, F., Li, Y., Owen, M. J., O'Donovan, M. C., Walters, J. T. R., Posthuma, D., Levitt, P., Weinberger, D. R., Hyde, T. M., Kleinman, J. E., Geschwind, D. H., Hawrylycz, M. J., State, M. W., Sanders, S. J., Sullivan, P. F., Gerstein, M. B., Lein, E. S., Knowles, J. A. & Sestan, N., 14 Dec 2018, In : Science. 362, 6420, p. 1-15 15 p., 1264.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Human Development
Epigenomics
Brain
Gene Regulatory Networks
Genes

Item-level analyses reveal genetic heterogeneity in neuroticism

Nagel, M., Watanabe, K., Stringer, S., Posthuma, D. & Van Der Sluis, S., 2 Mar 2018, In : Nature Communications. 9, 1, p. 1-10 10 p., 905.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genetic Heterogeneity
Genome-Wide Association Study
Genes
genome
Cluster Analysis

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

23Andme Research Team, 1 Jul 2018, In : Nature Genetics. 50, 7, p. 920-927 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Meta-Analysis
Mendelian Randomization Analysis
Psychiatry