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2019
Open Access
Suicidal Ideation
Mental Disorders
Longitudinal Studies
Anxiety
Psychiatry

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Anisotropy
Genome
Radiation
Diffusion Tensor Imaging

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Bipolar Disorder
Psychiatry
Schizophrenia
Depression
Major Depressive Disorder

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, P. H., Anttila, V., Won, H., Feng, Y., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M., Grotzinger, A. D., Posthuma, D., Derks, E. M., op Landt Slof, M. C. T., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., W J H Penninx, B., Cath, D. C. & 11 othersDenys, D., Santangelo, S., Scharf, J. M., Stein, M. B., Thornton, L. M., Walters, J. T. R., Wray, N. R., Geschwind, D. H., Neale, B. M., Kendler, K. S. & Smoller, J. W., 12 Dec 2019, In : Cell. 179, 7, p. 1469-1482.e11

Research output: Contribution to JournalArticleAcademicpeer-review

Psychiatry
Genes
Tourette Syndrome
Obsessive-Compulsive Disorder
Anorexia Nervosa

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Phenotype
Sample Size
Meta-Analysis
Autism Spectrum Disorder

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

EArly Genetics Lifecourse Epidemiology (EAGLE) consortium & Early Growth Genetics (EGG) Consortium, Mar 2019, In : European Journal of Epidemiology. 34, 3, p. 279-300

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Molecular Epidemiology
Sample Size
Genetic Research
Low Birth Weight Infant
Atopic Dermatitis

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Posthuma, D., 1 Nov 2019, In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Inborn Genetic Diseases
Genome-Wide Association Study
Mood Disorders
Bipolar Disorder
Major Depressive Disorder

Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 15 Mar 2019, In : Translational Psychiatry. 9, 1, p. 1-9 9 p., 117.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Pharmaceutical Preparations
Genome-Wide Association Study
Psychiatry
Drug Repositioning
2018

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, 22 Jun 2018, In : Science. 360, 6395, p. 1-15 15 p., 8757.

Research output: Contribution to JournalArticleAcademicpeer-review

Brain Diseases
Psychiatry
Phenotype
Genetic Heterogeneity
Genome-Wide Association Study

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project

Bartels, M., Hendriks, A., Mauri, M., Krapohl, E., Whipp, A., Bolhuis, K., Conde, L. C., Luningham, J., Fung Ip, H., Hagenbeek, F., Roetman, P., Gatej, R., Lamers, A., Nivard, M., van Dongen, J., Lu, Y., Middeldorp, C., van Beijsterveldt, T., Vermeiren, R., Hankemeijer, T. & 16 othersKluft, C., Medland, S., Lundström, S., Rose, R., Pulkkinen, L., Vuoksimaa, E., Korhonen, T., Martin, N. G., Lubke, G., Finkenauer, C., Fanos, V., Tiemeier, H., Lichtenstein, P., Plomin, R., Kaprio, J. & Boomsma, D. I., Sep 2018, In : European Child and Adolescent Psychiatry. 27, 9, p. 1105-1121 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aggression
Psychopathology
Problem Behavior
Social Problems
Child Behavior

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olié, E., Villafuerte, S., Air, T. M. & 73 othersAraya, R., Bowes, L., Burns, M. R., Byrne, E. M., Coffey, J. C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A., Hottenga, J-J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J. R., Lajnef, M., Little, K., Meyer zu Schwabedissen, H., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W. J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., Van der Auwera, S., Wainwright, N. W., Wang, J-C., Willemsen, G., Anderson, I. M., Arolt, V., Åslund, C., Bagdy, G., Baune, B. T., Bellivier, F., Boomsma, D. I., Courtet, P., Dannlowski, U., de Geus, E. J. C., Deakin, J. F. W., Easteal, S., Eley, T. C., Fergusson, D. M., Goate, A. M., Gonda, X., Grabe, H. J., Holzman, C., Johnson, E. O., Kennedy, D. M., Laucht, M., Martin, N. G., Munafò, M. R., Nilsson, K. W., Oldehinkel, A. J., Olsson, C. A., Ormel, J., Otte, C., Patton, G. C., Penninx, B. W. J. H., Ritchie, K., Sarchiapone, M., Scheid, J. M., Serretti, A., Smit, J. H., Stefanis, N. C., Surtees, P. G., Völzke, H., Weinstein, M., Whooley, M. A., Nurnberger, J. I., Breslau, N. & Bierut, L. J., 2 Jan 2018, In : Molecular Psychiatry. 23, 1, p. 133-142

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-Analysis
Genotype
Depression
Alleles
Serotonin Plasma Membrane Transport Proteins

Do Parental Psychiatric Symptoms Predict Outcome in Children With Psychiatric Disorders? A Naturalistic Clinical Study

Wesseldijk, L. W., Dieleman, G. C., van Steensel, F. J. A., Bleijenberg, E. J., Bartels, M., Bögels, S. M. & Middeldorp, C. M., Sep 2018, In : Journal of the American Academy of Child and Adolescent Psychiatry. 57, 9, p. 669-677.e6 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Child Psychiatry
Psychiatry
Mothers
Psychopathology
Fathers
Open Access
Antisocial Personality Disorder
Crime
Sex Characteristics
Netherlands

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N. & 30 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I. & Penninx, B. W. J. H., May 2018, In : Nature Genetics. 50, 5, p. 668-681 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Depression
Schizophrenia
Major Depressive Disorder
Suicide

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 20 Dec 2018, In : PLoS ONE. 13, 12, p. 1-29 29 p., e0209160.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Proxy
Genes
Genome
genome

Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology

Wesseldijk, L. W., Dieleman, G. C., van Steensel, F. J. A., Bartels, M., Hudziak, J. J., Lindauer, R. J. L., Bögels, S. M. & Middeldorp, C. M., Dec 2018, In : European Child and Adolescent Psychiatry. 27, 12, p. 1575-1584 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Psychopathology
Mental Disorders
Fathers
Adolescent Psychiatry
Personality

Risk factors for the development and outcome of childhood psychopathology

Wesseldijk, L. W., 2018, 203 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

The value of polygenic analyses in psychiatry

Middeldorp, C. M. & Wray, N. R., Feb 2018, In : World Psychiatry. 17, 1, p. 26-28 3 p.

Research output: Contribution to JournalEditorialAcademicpeer-review

2017

Behavior Genetics: From Heritability to Gene Finding

Nivard, M. G., Dolan, C. V., Middeldorp, C. M. & Boomsma, D. I., 1 Feb 2017, Handbook of Psychophysiology. Cacioppo, J. T., Tassinary, L. G. & Berntson, G. G. (eds.). 4 ed. Cambridge University Press, p. 339-354 16 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L., Föcker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M. & 19 othersAdan, R., Brandys, M., van Elburg, A., Boraska Perica, V., Franklin, C. S., Tschöp, M. H., Zeggini, E., Bulik, C. M., Collier, D., Scherag, A., Müller, T. D., Hebebrand, J., GCAN, Hottenga, J. J., Willemsen, G., Boomsma, D. I., van Beijsterveldt, C. E. M., Middeldorp, C. M. & de Geus, E., Feb 2017, In : Molecular Psychiatry. 22, 2, p. 192-201 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Anorexia Nervosa
Body Mass Index
Genome-Wide Association Study
Meta-Analysis

Genetic effects influencing risk for major depressive disorder in China and Europe

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S. A., Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschøn, H. N., Byrne, E. M., Cichon, S., Clarke, T. K., Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F. & 77 othersDunn, E. C., Edwards, C. A., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D. S., Grabe, H. J., Hamilton, S. P., Hardiman, O., Hayward, C., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Hottenga, J-J., Ising, M., Jansen, R., Kloiber, S., Knowles, J. A., Lang, M., Li, Q. S., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Martin, N. G., McGrath, P. J., McGuffin, P., McIntosh, A. M., Medland, S. E., Mehta, D., Middeldorp, C. M., Milaneschi, Y., Montgomery, G. W., Mors, O., Müller-Myhsok, B., Nauck, M., Nyholt, D. R., Nöthen, M. M., Owen, M. J., Penninx, B. W. J. H., Pergadia, M. L., Perlis, R. H., Peyrot, W. J., Porteous, D. J., Potash, J. B., Rice, J. P., Rietschel, M., Riley, B. P., Rivera, M., Schoevers, R., Schulze, T. G., Shi, J., Shyn, S. I., Smit, J. H., Smoller, J. W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., van der Auwera, S. V., Grootheest, G., van Hemert, A. M., Völzke, H., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Witt, S. H., Levinson, D. F., Lewis, C. M., Wray, N. R., Flint, J., Sullivan, P. F. & Kendler, K. S., 28 Mar 2017, In : Translational Psychiatry. 7, 3, p. e1074

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
China
Single Nucleotide Polymorphism
Meta-Analysis
Population
Psychopathology
Psychiatry
Schizophrenia
Attention Deficit and Disruptive Behavior Disorders
Conduct Disorder

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., Kutalik, Z., Lee, S. H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N. R., Arolt, V., Baune, B. T., Boomsma, D. I., Børglum, A. D., Byrne, E. M., Castelao, E., Craddock, N. & 31 othersCraig, I. W., Dannlowski, U., Deary, I. J., Degenhardt, F., Forstner, A. J., Gordon, S. D., Grabe, H. J., Grove, J., Hamilton, S. P., Hayward, C., Heath, A. C., Hocking, L. J., Homuth, G., Hottenga, J. J., Kloiber, S., Krogh, J., Landén, M., Lang, M., Levinson, D. F., Lichtenstein, P., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Middeldorp, C. M., Milaneschi, Y., Penninx, B. W. J. H., Smit, J. H. & CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium, 15 Feb 2017, In : Biological Psychiatry. 81, 4, p. 325-335 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Genomics
Age of Onset
Psychiatry
Genome

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D. J., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Lopezz de Alda, M., Alliey-Rodriguez, N. & 31 othersAndreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S. E., Bethell, A., Biernacka, J. M., Blackwood, D. H. R., Boks, M. P., Boomsma, D. I., Børglum, A. D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H. N., Byrne, E. M., Cervantes, P., Clarke, T. K., Craddock, N., Cruceanu, C., Curtis, D., de Geus, E. J. C., Fischer, S. B., Hottenga, J-J., Middeldorp, C. M., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G. & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, 20 Jun 2017, In : Translational Psychiatry. 7, 6, p. e1155

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Borderline Personality Disorder
Genome-Wide Association Study
Bipolar Disorder
Schizophrenia
Depression

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A. & 12 othersColodro-Conde, L., Medland, S. E., Martin, N. G., Rietschel, M., CORtisolNETwork (CORNET) Consortium, Abdellaoui, A., de Geus, E., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Willemsen, G. & Boomsma, D. I., 10 Nov 2017, In : Scientific Reports. 7, 1, p. 15351

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Psychological Stress
Hair
Hydrocortisone
Genes
Psychology
Open Access
behavior problems
heritability
Mothers
Genome-Wide Association Study
Child Behavior

Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence

Nivard, M. G., Lubke, G. H., Dolan, C. V., Evans, D. M., St Pourcain, B., Munafò, M. R. & Middeldorp, C. M., 1 Aug 2017, In : Development and Psychopathology. 29, 3, p. 919-928 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Joints
Comorbidity
Diagnostic and Statistical Manual of Mental Disorders
Growth
Therapeutics
Open Access
Molecular Epidemiology
Psychopathology
Mothers
Fathers
Netherlands

Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder

Bot, M., Middeldorp, C. M., de Geus, E. J. C., Lau, H. M., Sinke, S. M., van Nieuwenhuizen, B., Smit, J. H., Boomsma, D. I. & Penninx, B. W. J. H., Jan 2017, In : Psychological Medicine. 47, 2, p. 279-289 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Self Report
Depression
Netherlands
Sensitivity and Specificity
2016

A cross-cultural comparison of the longitudinal heritability of childhood aggression

Porsch, R., Middeldorp, C., Cherny, S., Krapohl, E., van Beijsterveldt, C., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., Rhee, S. H., Kaprio, J., Rose, R. J., Hewitt, J. K., Sham, P., Plomin, R., Boomsma, D. & Bartels, M., Nov 2016, In : Behavior Genetics. 46, 6, p. 802-802

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

A genome-wide approach to children's aggressive behavior: The EAGLE consortium

Pappa, I., St Pourcain, B., Benke, K. S., Cavadino, A., Hakulinen, C., Nivard, M. G., Nolte, I. M., Tiesler, C. M. T., Bakermans-Kranenburg, M. J., Davies, G. E., Evans, D. M., Geoffroy, M. C., Grallert, H., Blokhuis, M. M., Hudziak, J. J., Kemp, J. P., Keltikangas-Järvinen, L., McMahon, G., Mileva-Seitz, V. R., Motazedi, E. & 23 othersPower, C., Raitakari, O. T., Ring, S. M., Rivadeneira, F., Rodriguez, A., Scheet, P., Seppälä, I., Snieder, H., Standl, M., Thiering, E., Timpson, N. J., Veenstra, R., Velders, F. P., Whitehouse, A. J. O., Davey Smith, G., Heinrich, J., Hypponen, E., Lehtimäki, T., Middeldorp, C. M., Oldehinkel, A. J., Pennell, C. E., Boomsma, D. I. & Tiemeier, H., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 562-572

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Child Behavior
Genome
Single Nucleotide Polymorphism
Meta-Analysis
Chromosomes, Human, Pair 2

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M., Hottenga, J. J. & 31 othersHudziak, J. J., Jugessur, A., Kemp, J. P., Krapohl, E., Martin, N. G., Murcia, M., Myhre, R., Ormel, J., Ring, S. M., Standl, M., Stergiakouli, E., Stoltenberg, C., Thiering, E., Timpson, N. J., Trzaskowski, M., van der Most, P. J., Wang, C., Nyholt, DR., Medland, S. E., Neale, B. M., Jacobsson, B., Sunyer, J., Hartman, C. A., Whitehouse, A. J. O., Pennell, C. E., Heinrich, J., Plomin, R., Davey Smith, G., Tiemeier, H., Posthuma, D. & Boomsma, D. I., 2016, In : Journal of the American Academy of Child and Adolescent Psychiatry. 55, 10, p. 896-905 10.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Attention Deficit Disorder with Hyperactivity
Single Nucleotide Polymorphism
Meta-Analysis
Pediatrics
Open Access
Anxiety
Depression
Phenotype
Genes
Genetic Models

Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts

Lee, M., Aggen, S. H., Otowa, T., Castelao, E., Preisig, M., Grabe, H. J., Hartman, C. A., Oldehinkel, A. J., Middeldorp, C. M., Tiemeier, H. & Hettema, J. M., Dec 2016, In : International Journal of Methods in Psychiatric Research. 25, 4, p. 255-266 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Anxiety Disorders
Statistical Factor Analysis
Psychiatry
Phenotype

Detection of gene-environment interaction in pedigree data using genome-wide genotypes

Nivard, M. G., Middeldorp, C. M., Lubke, G. H., Hottenga, J. J., Abdellaoui, A., Boomsma, D. I. & Dolan, C. V., 2016, In : European Journal of Human Genetics. 24, 12, p. 1803-1809

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Pedigree
Single Nucleotide Polymorphism
Body Mass Index
Genotype

Discovery of Biochemical Biomarkers for Aggression: A Role for Metabolomics in Psychiatry

Hagenbeek, F. A., Kluft, C., Hankemeier, T., Bartels, M., Draisma, H. H. M., Middeldorp, C. M., Berger, R., Noto, A., Lussu, M., Pool, R., Fanos, V. & Boomsma, D. I., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 719-732

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolomics
Aggression
Psychiatry
Biomarkers
Diagnostic and Statistical Manual of Mental Disorders

Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression

Molenaar, D., Middeldorp, C. M., Willemsen, G., Ligthart, R. S. L., Nivard, M. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 1, p. 59-71

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
gender
genotype
Genotype
Depression
phenotypic variation

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Møller, E., Blokhuis, M. M., Horikoshi, M., Hottenga, J. J., Middeldorp, C. M., Uitterlinden, A. G., Plomin, R., Boomsma, D. I., Heinrich, J., Melbye, M., Rivadeneira, F. & 7 othersHakonarson, H., Ring, S. M., Davey Smith, G., Sørensen, T. I. A., Timpson, N. J., Grant, S. F. A. & Jaddoe, V. W. V., 2016, In : Human Molecular Genetics. 25, 2, p. 389-403

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Heritability of different aggression phenotypes in an Australian and a Dutch cohort

Conde, L. C., Martin, N. G., Hatemi, P., Boomsma, D., Middeldorp, C., Van Beijsterveldt, T., Bartels, M. & Medland, S. E., Nov 2016, In : Behavior Genetics. 46, 6, p. 776-777

Research output: Contribution to JournalMeeting AbstractOther research output

Longitudinal heritability of childhood aggression

Porsch, R. M. P., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E. M., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R. P., Rhee, S., Kaprio, J., Rose, R., Hewitt, J. K., Sham, P., Plomin, R., Boomsma, D. I. & Bartels, M., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 697-707

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aggression
Netherlands
Conduct Disorder
Child Behavior
Checklist

Meta-analysis of genome-wide association studies of anxiety disorders

Otowa, T., Hek, K., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T. B., Aggen, S. H., Adkins, D. E., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., van der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. J., Direk, N. & 26 othersHofman, A., Uitterlinden, A. G., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F., Pergadia, M. L., van der Most, P. J., Nolte, I. M., van Oort, F. V. A., Hartman, C. A., Oldehinkel, A. J., Preisig, M., Grabe, H. J., Middeldorp, C. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, G. W., Maher, B. S., van den Oord, E. J., Wray, N. R., Tiemeier, H. & Hettema, J. M., 2016, In : Molecular Psychiatry. 21, 10, p. 1391-1399

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Anxiety Disorders
Meta-Analysis
Phenotype
Genome

Multivariate and repeated measure GWAS of aggression phenotypes

Nivard, M., Middeldorp, C., Hottenga, J-J., Fedko, I., Ehli, E. A., Davies, G., van Beijsterveldt, C., Bartels, M. & Boomsma, D., Nov 2016, In : Behavior Genetics. 46, 6, p. 798-799

Research output: Contribution to JournalMeeting AbstractOther research output

Psychiatrische stoornissen binnen gezinnen: een integrale benadering via de familiepoli

van Veen, S. C., Batelaan, N. M., Wesseldijk, L. W., Rozeboom, J. & Middeldorp, C. M., 2016, In : Tijdschrift voor Psychiatrie. 58, 2, p. 95-104 10 p.

Research output: Contribution to JournalArticleProfessional

Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology

Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. & Middeldorp, C. M., 2016, In : European Psychiatry. 2016 Apr, 34, p. 49-55 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Psychopathology
Spouses
Attention Deficit Disorder with Hyperactivity
Parents
Fathers
2015

Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype 9 Environment Interaction

Molenaar, D., Middeldorp, C. M., van Beijsterveldt, C. E. M. & Boomsma, D. I., 2015, In : Child Development. 86, 6, p. 1999-2016 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genotype
interaction
Anxiety
anxiety
Social Isolation

Developmental genetics of psychopathology

Nivard, M. G., 2015

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Psychopathology