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2019

Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques

Haselberg, R., Pirok, B. W. J., Gargano, A. F. G. & Kohler, I., Sep 2019, In : LC GC Europe. 32, 9, p. 465-480 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Computer-aided gradient optimization of hydrophilic interaction liquid chromatographic separations of intact proteins and protein glycoforms

van Schaick, G., Pirok, B. W. J., Haselberg, R., Somsen, G. W. & Gargano, A. F. G., 1 Jan 2019, In : Journal of Chromatography A. 1598, p. 67-76 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hydrophobic and Hydrophilic Interactions
Liquid chromatography
Liquid Chromatography
Glycoproteins
Liquids

Experimental design and measurement uncertainty in ligand binding studies by affinity capillary electrophoresis

Stein, M., Haselberg, R., Mozafari-Torshizi, M. & Wätzig, H., 14 Jan 2019, In : Electrophoresis. p. 1-14

Research output: Contribution to JournalArticleAcademicpeer-review

Capillary electrophoresis
Capillary Electrophoresis
Design of experiments
Uncertainty
Research Design

Rapid forensic chemical classification of confiscated flash banger fireworks using capillary electrophoresis

Bezemer, K. D. B., van Duin, L. V. A., Martin-Alberca, C., Somsen, G. W., Schoenmakers, P. J., Haselberg, R. & van Asten, A. C., Dec 2019, In : Forensic Chemistry. 16, p. 1-9 9 p., 100187.

Research output: Contribution to JournalArticleAcademicpeer-review

pyrotechnics
Capillary electrophoresis
Capillary Electrophoresis
imitation
electrophoresis
2018

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Lakayan, D., Haselberg, R., Gahoual, R., Somsen, G. W. & Kool, J., 1 Dec 2018, In : Analytical and Bioanalytical Chemistry. 410, 30, p. 7837-7848 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Drug Compounding
Surface Plasmon Resonance
Liquid chromatography
Surface plasmon resonance
Liquid Chromatography

Capillary Electrophoresis: Trends and Recent Advances

Voeten, R. L. C., Ventouri, I. K., Haselberg, R. & Somsen, G. W., 6 Feb 2018, In : Analytical Chemistry. 90, 3, p. 1464-1481 18 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Yao, H., Vandenbossche, J., Sänger-van de Griend, C. E., Janssens, Y., Fernández, C. S., Xu, X., Wynendaele, E., Somsen, G. W., Haselberg, R. & De Spiegeleer, B., 15 May 2018, In : Talanta. 182, p. 83-91 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Asparaginase
Electrophoresis
Escherichia coli
Electrolytes
Recovery

Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Domínguez-Vega, E., Haselberg, R., Iperen, D. V., Kool, J., Somsen, G. W. & de Jong, G. J., 1 Jan 2018, In : Sensors and Actuators B-Chemical. 254, p. 1040-1047 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Capillary electrophoresis
Surface plasmon resonance
electrophoresis
surface plasmon resonance
affinity

Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry

Haselberg, R., De Vijlder, T., Heukers, R., Smit, M. J., Romijn, E. P., Somsen, G. W. & Domínguez-Vega, E., 1 Jan 2018, (Accepted/In press) In : Analytica Chimica Acta. 1044, p. 181-190

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Capillary electrophoresis
Capillary Electrophoresis
low flow
antibody
Mass spectrometry

High-resolution glycoform profiling of intact therapeutic proteins by hydrophilic interaction chromatography-mass spectrometry

Domínguez-Vega, E., Tengattini, S., Peintner, C., van Angeren, J., Temporini, C., Haselberg, R., Massolini, G. & Somsen, G. W., Jul 2018, In : Talanta. 184, July, p. 375-381 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chromatography
Mass spectrometry
Liquid chromatography
Erythropoietin
Glycosylation
2017

A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using Zr-89-Desferal and Auristatin F-Conjugated Trastuzumab

Sijbrandi, N. J., Merkul, E., Muns, J. A., Waalboer, D. C. J., Adamzek, K., Bolijn, M., Montserrat, V., Somsen, G. W., Haselberg, R., Steverink, P. J. G. M., Houthoff, H-J. & van Dongen, G. A. M. S., 15 Jan 2017, In : Cancer Research. 77, 2, p. 257-267

Research output: Contribution to JournalArticleAcademicpeer-review

Fully compatible and ultra-sensitive micellar electrokinetic chromatography-tandem mass spectrometry using sheathless porous-tip interfacing

Moreno-González, D., Haselberg, R., Gámiz-Gracia, L., García-Campaña, A. M., de Jong, G. J. & Somsen, G. W., 2017, (Accepted/In press) In : Journal of Chromatography A.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tandem Mass Spectrometry
Chromatography
Mass spectrometry
Electrospray ionization
Mass Spectrometry
2016

Capillary zone electrophoresis-mass spectrometry of intact proteins

Domínguez-Vega, E., Haselberg, R. & Somsen, G. W., 2016, Capillary Electrophoresis of Proteins and Peptides: Methods and Protocols. Tran, N. T. & Taverna, M. (eds.). Humana Press Inc, p. 25-41 17 p. (Methods in Molecular Biology; vol. 1466).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Capillary Electrophoresis
Mass Spectrometry
Proteins
Human Growth Hormone
Muramidase

Direct electrokinetic injection of inorganic cations from whole fruits and vegetables for electrophoresis analysis.

Kasloom, U., Guijt, R. M., Boyce, M. C., Townsend, A. T., Haselberg, R. & Breadmore, M. C., 2016, In : Journal of Chromatography A. 1428, p. 346-351

Research output: Contribution to JournalArticleAcademicpeer-review

Evaluation of capillary electrophoresis-mass spectrometry for the analysis of the conformational heterogeneity of intact proteins using beta2-microglobulin as model compound.

Bertoletti, L., Schappler, J., Colombo, R., Rudaz, S., Haselberg, R., Dominguez Vega, E., Raimondi, S., Somsen, G. W. & De Lorenzi, E., 2016, In : Analytica Chimica Acta. 945, p. 102-109

Research output: Contribution to JournalArticleAcademicpeer-review

Intact protein analysis by capillary electrophoresis - mass spectrometry.

Haselberg, R. & Somsen, G. W., 2016, Capillary electrophoresis - Mass Spectrometry: Principles and Applications.. De Jong, G. J. (ed.). Wiley, p. 159-192

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Quality and barch-to-batch consistency of original and biosimilar epoetin products.

Andhyk Halim, L., Brinks, V., Jiskoot, W., Romeijn, S., Haselberg, R., Burns, C., Wadhwa, M. & Schellekens, H., 2016, In : Journal of Pharmaceutical Sciences. 105, p. 542-550

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Developments in interfacing designs for CE–MS: towards enabling tools for proteomics and metabolomics

Lindenburg, P. W., Haselberg, R., Rozing, G. & Ramautar, R., 2015, In : Chromatographia. 78, p. 367-377

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Metabolomics
Proteomics
Spectrometry
Spectrum Analysis
Glycomics

Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping

Wenz, C., Barbas, C., Lõpez-Gonzálvez, Á., Garcia, A., Benavente, F., Sanz-Nebot, V., Blanc, T., Freckleton, G., Britz-McKibbin, P., Shanmuganathan, M., de l'Escaille, F., Far, J., Haselberg, R., Huang, S., Huhn, C., Pattky, M., Michels, D., Mou, S., Yang, F., Neusuess, C. & 4 othersTromsdorf, N., Baidoo, E. E. K., Keasling, J. D. & Park, S. S., 1 Sep 2015, In : Journal of Separation Science. 38, 18, p. 3262-3270 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mass spectrometry for glycosylation analysis of biopharmaceuticals

Dotz, V., Haselberg, R., Shubhakar, A., Kozak, R. P., Falck, D., Rombouts, Y., Reusch, D., Somsen, G. W., Fernandes, D. L. & Wuhrer, M., 2015, In : TrAC. Trends in Analytical Chemistry. 73, p. 1-9

Research output: Contribution to JournalArticleAcademicpeer-review

Glycosylation
Mass spectrometry
Biosimilar Pharmaceuticals
Pharmaceutical Preparations
Capillary electrophoresis

Platinum(II) as Bifunctional Linker in Antibody-Drug Conjugate Formation: Coupling of a 4-Nitrobenzo-2-oxa-1,3-diazole Fluorophore to Trastuzumab as a Model

Waalboer, D. C. J., Muns, J. A., Sijbrandi, N. J., Schasfoort, R. B. M., Haselberg, R., Somsen, G. W., Houthoff, H. J. & van Dongen, G. A. M. S., 2015, In : ChemMedChem. 10, 5, p. 797-803

Research output: Contribution to JournalArticleAcademicpeer-review

Fluorophores
Platinum
Antibodies
Cytotoxins
Pharmaceutical Preparations

Simultaneous Assessment of Protein Heterogeneity and Affinity by Capillary Electrophoresis-Mass Spectrometry

Domínguez-Vega, E., Haselberg, R., Somsen, G. W. & De Jong, G. J., 1 Sep 2015, In : Analytical Chemistry. 87, 17, p. 8781-8788 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Capillary electrophoresis
Capillary Electrophoresis
Mass spectrometry
Mass Spectrometry
Aprotinin
2014

Analytical characterization of NOTA-modified somatropins

Bracke, N., Wynendale, E., D'Hondt, M., Haselberg, R., Somsen, G. W., Pauwels, E., Van de Wiele, C. & De Speigeleer, B., 2014, In : Journal of Pharmaceutical and Biomedical Analysis. 96, p. 1-9

Research output: Contribution to JournalArticleAcademicpeer-review

Human Growth Hormone
Lysine
Chelating Agents
Somatotropin Receptors
Gallium

A simple capillary electrophoresis-mass spectrometry method for complex glycan analysis using a flow-through microvial interface

Jayo, R. G., Thaysen-Andersen, M., Lindenburg, P. W., Haselberg, R., Hankemeijer, T., Ramautar, R. & Chen, D. D. Y., 2014, In : Analytical Chemistry. 86, p. 6479-6486

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Capillary electrophoresis
Mass spectrometry
Polysaccharides
Erythropoietin
Glycosylation

Capillary electrophoresis-based assessment of nanobody affinity and purity

Haselberg, R., Oliveira, S., van der Meel, R., Somsen, G. W. & de Jong, G. J., 2014, In : Analytica Chimica Acta. 818, p. 1-6

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
Capillary electrophoresis
Electrophoretic mobility
Capillary Electrophoresis
Epidermal Growth Factor Receptor

Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

Heukers, R., Altintas, I., Raghoenath, S., De Zan, E., Pepermans, R., Roovers, R. C., Haselberg, R., Hennink, W. E., Schiffelers, R. M., Kok, R. J. & van Bergen en Henegouwen, P. M. P., 2014, In : Biomaterials. 35, p. 601-610

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Single-Domain Antibodies
Proto-Oncogene Proteins c-met
Nanoparticles
Tumors
Albumins
2013

CE-MS for the analysis of intact proteins 2010-2012

Haselberg, R., de Jong, G. J. & Somsen, G. W., 2013, In : Electrophoresis. 34, p. 99-112

Research output: Contribution to JournalArticleAcademicpeer-review

Proteins
Protein Array Analysis
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Adsorption
Electrophoresis

Low-flow sheathless capillary electrophoresis-mass spectrometry for sensitive glycoform profiling of intact pharmaceutical proteins

Haselberg, R., de Jong, G. J. & Somsen, G. W., 2013, In : Analytical Chemistry. 85, p. 2289-2296

Research output: Contribution to JournalArticleAcademicpeer-review

Capillary electrophoresis
Electrospray ionization
Mass spectrometry
Biosimilar Pharmaceuticals
Ionization

Online Affinity Assessment and Immunoaffinity Sample Pretreatment in Capillary Electrophoresis-Mass Spectrometry

Haselberg, R. & Somsen, G. W., 1 Jan 2013, Analyzing Biomolecular Interactions by Mass Spectrometry. Wiley & Blackwell, p. 271-298 28 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Capillary electrophoresis
Mass spectrometry
Peptides

Thickness and morphology of polyelectrolyte coatings on silica surfaces before and after protein exposure studied by atomic force microscopy

Haselberg, R., Flesch, F., Boerke, A. & Somsen, G. W., 2013, In : Analytica Chimica Acta. 779, p. 90-95

Research output: Contribution to JournalArticleAcademicpeer-review

Hexadimethrine Bromide
atomic force microscopy
Atomic Force Microscopy
Polyelectrolytes
Silicon Dioxide
2011

Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals

Haselberg, R., Brinks, V., de Jong, G. J., Somsen, G. W. & Hawe, A., Apr 2011, In : Analytical and Bioanalytical Chemistry. 400, 1, p. 295-303

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Characterization of drug-lysozyme conjugates by sheathless capillary electrophoresis-time-of-flight mass spectrometry

Haselberg, R., Harmsen, S., Dolman, M. E. M., de Jong, G. J., Kok, R. J. & Somsen, G. W., 18 Jul 2011, In : Analytica Chimica Acta. 698, 1-2, p. 77-83

Research output: Contribution to JournalArticleAcademicpeer-review

2010

Evanescent-wave cavity enhanced spectroscopy as a tool in label-free biosensing

van der Sneppen, L., Ritchie, G. R. S., Hancock, G., Ariese, F., Gooijer, C., Ubachs, W., Haselberg, R., Somsen, G. W. & De Jong, G. J., 2010, Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference: 2010 Laser Science to Photonic Applications, CLEO/QELS 2010. 5499550

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Biofouling
evanescent waves
Labels
Spectroscopy
coatings