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  • Wouter Roos
2019

Atomic force microscopy-based mechanobiology

Krieg, M., Fläschner, G., Alsteens, D., Gaub, B. M., Roos, W. H., Wuite, G. J. L., Gaub, H. E., Gerber, C., Dufrêne, Y. F. & Müller, D. J., Jan 2019, In : Nature Reviews Physics. 1, 1, p. 41-57 17 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Maturation of adenovirus primes the protein nano-shell for successful endosomal escape

Denning, D., Bennett, S., Mullen, T., Moyer, C., Vorselen, D., Wuite, G. J. L., Nemerow, G. & Roos, W. H., 7 Mar 2019, In : Nanoscale. 11, 9, p. 3799-3803 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Real-Time Assembly of Viruslike Nucleocapsids Elucidated at the Single-Particle Level

Marchetti, M., Kamsma, D., Cazares Vargas, E., Hernandez García, A., Van Der Schoot, P., De Vries, R., Wuite, G. J. L. & Roos, W. H., 14 Aug 2019, In : Nano Letters. 19, 8, p. 5746-5753 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2018

Acetylation and phosphorylation of human TFAM regulate TFAM-DNA interactions via contrasting mechanisms

Shabestari, M. H., King, G. A., Taris, K-K. H., Pandey, A. K., Venkatesh, S., Thilagavathi, J., Singh, K., Koppisetti, R. K., Temiakov, D., Roos, W. H., Suzuki, C. K. & Wuite, G. J. L., 20 Apr 2018, In : Nucleic Acids Research. 46, 7, p. 3633-3642 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

A single point mutation in precursor protein VI doubles the mechanical strength of human adenovirus

van Rosmalen, M. G. M., Nemerow, G. R., Wuite, G. J. L. & Roos, W. H., Jun 2018, In : Journal of Biological Physics. 44, 2, p. 119-132 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Effect of dsDNA on the Assembly Pathway and Mechanical Strength of SV40 VP1 Virus-like Particles

van Rosmalen, M. G. M., Li, C., Zlotnick, A., Wuite, G. J. L. & Roos, W. H., 6 Nov 2018, In : Biophysical Journal. 115, 9, p. 1656-1665 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multilamellar nanovesicles show distinct mechanical properties depending on their degree of lamellarity

Vorselen, D., Marchetti, M., López-Iglesias, C., Peters, P. J., Roos, W. H. & Wuite, G. J. L., 21 Mar 2018, In : Nanoscale. 10, 11, p. 5318-5324 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways

Sorkin, R., Huisjes, R., Bošković, F., Vorselen, D., Pignatelli, S., Ofir-Birin, Y., Freitas Leal, J. K., Schiller, J., Mullick, D., Roos, W. H., Bosman, G., Regev-Rudzki, N., Schiffelers, R. M. & Wuite, G. J. L., 27 Sep 2018, In : Small. 14, 39, p. 1-8 8 p., 1801650.

Research output: Contribution to JournalArticleAcademicpeer-review

Probing cellular mechanics with acoustic force spectroscopy

Sorkin, R., Bergamaschi, G., Kamsma, D., Brand, G., Dekel, E., Ofir-Birin, Y., Rudik, A., Gironella, M., Ritort, F., Regev-Rudzki, N., Roos, W. H. & Wuite, G. J. L., 8 Aug 2018, In : Molecular Biology of the Cell. 29, 16, p. 2005-2011 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

Vorselen, D., van Dommelen, S. M., Sorkin, R., Piontek, M. C., Schiller, J., Döpp, S. T., Kooijmans, S. A. A., van Oirschot, B. A., Versluijs, B. A., Bierings, M. B., van Wijk, R., Schiffelers, R. M., Wuite, G. J. L. & Roos, W. H., 23 Nov 2018, In : Nature Communications. 9, p. 1-9 9 p., 4960.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The Soft Side of Extracellular Vesicles

Sorkin, R., Huisjes, R., Boskovic, F., Vorselen, D., Pignatelli, S., Ofir-Birin, Y., Leal, J. K. F., Schiller, J., Roos, W. H., Bosman, G., Regev-Rudzki, N., Schiffelers, R. M. & Wuite, G. J. L., 2 Feb 2018, In : Biophysical Journal. 114, 3, p. 562A-562A

Research output: Contribution to JournalMeeting AbstractAcademic

2017

Competition between Bending and Internal Pressure Governs the Mechanics of Fluid Nanovesicles

Vorselen, D., MacKintosh, F. C., Roos, W. H. & Wuite, G. J. L., Mar 2017, In : ACS Nano. 11, 3, p. 2628-2636 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Probing the mechanical stability of bridged DNA-H-NS protein complexes by single-molecule AFM pulling

Liang, Y., van der Valk, R. A., Dame, R. T., Roos, W. H. & Wuite, G. J. L., 10 Nov 2017, In : Scientific Reports. 7, 1, 15275.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Recent Advances in Biological Single-Molecule Applications of Optical Tweezers and Fluorescence Microscopy

Hashemi Shabestari, M., Meijering, A. E. C., Roos, W. H., Wuite, G. J. L. & Peterman, E., 2017, Single-Molecule Enzymology: Nanomechanical Manipulation and Hybrid Methods. Elsevier, Vol. 582. p. 85-119 35 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Understanding Adenovirus maturation: A nanomechanics approach

Denning, D., Bennett, S., Mullen, T., Moyer, C., Wuite, G. J., Nemerow, G. & Roos, W. H., Jul 2017, In : European Biophysics Journal. 46, p. S184-S184 1 p., Supplement 1.

Research output: Contribution to JournalMeeting AbstractAcademic

Vertex-Specific Proteins pUL17 and pUL25 Mechanically Reinforce Herpes Simplex Virus Capsids

Snijder, J., Radtke, K., Anderson, F., Scholtes, L., Corradini, E., Baines, J., Heck, A. J. R., Wuite, G. J. L., Sodeik, B. & Roos, W. H., Jun 2017, In : Journal of Virology. 91, 12, UNSP e00123-17.

Research output: Contribution to JournalArticleAcademicpeer-review

2016

A Combined Imaging and Force Spectroscopy Approach Reveals the Material Properties of Viral Nanoparticles

Denning, D., Wuite, G. J. L. & Roos, W. H., 2016, In : Biophysical Journal. 110, 3, p. 500A-500A

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

Assembly and Mechanical Properties of the Cargo-Free and Cargo Loaded Bacterial Nanocompartment Encapsulin

Snijder, J., Kononova, O., Barbu, I. M., Uetrecht, C., Rurup, W. F., Koay, M. S. T., Cornelissen, J. J. L. M., Roos, W. H., Barsegov, V., Wuite, G. J. L. & Heck, A. J. R., 2016, In : Biomacromolecules. 17, 8, p. 2522-2529

Research output: Contribution to JournalArticleAcademicpeer-review

Atomic force microscopy observation and characterization of single virions and virus-like particles by nano-indentation

Marchetti, M., Wuite, G. J. L. & Roos, W. H., 2016, In : Current Opinion in Virology. 18, p. 82-88

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Controlled tip wear on high roughness surfaces yields gradual broadening and rounding of cantilever tips

Vorselen, D., Kooreman, E. S., Wuite, G. J. L. & Roos, W. H., 11 Nov 2016, In : Scientific Reports. 6, 36972.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Detection and Mechanical Characterization of Small Multilamellar Vesicles using Atomic Force Microscopy

Marchetti, M., Vorselen, D., Roos, W. H. & Wuite, G. J. L., 2016, In : Biophysical Journal. 110, 3, p. 73A-73A-73A

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles

Kononova, O., Snijder, J., Kholodov, Y., Marx, K. A., Wuite, G. J. L., Roos, W. H. & Barsegov, V., 2016, In : PLoS Computational Biology. 12, 1, e1004729.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Mechanical Unfolding of an Autotransporter Passenger Protein Reveals the Secretion Starting Point and Processive Transport Intermediates

Baclayon, M., van Ulsen, P., Mouhib, H., Hashemi Shabestari, M., Verzijden, T., Abeln, S., Roos, W. H. & Wuite, G. J. L., 2016, In : ACS Nano. 10, 6, p. 5710-5719

Research output: Contribution to JournalArticleAcademicpeer-review

Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM

Heinze, K., Sasaki, E., King, N. P., Baker, D., Hilvert, D., Wuite, G. J. L. & Roos, W. H., 2016, In : Journal of Physical Chemistry B. 120, 26, p. 5945-5952

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2014

In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and Transcription

Farge, G. A., Mehmedovic, M., Baclayon, M., Wildenberg, S. M. J. L., Roos, W. H., Gustafsson, C. M., Wuite, G. J. L. & Falkenberg, M., 2014, In : Cell Reports. 2014, 8, p. 66-74

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Probing the Unbinding Kinetics of DNA-H-NS-DNA Protein Complexes by a High-Speed and High-Throughput Single-Molecule Pulling Assay using Atomic Force Microscopy

Liang, Y., Baclayon, M., van der Valk, R., Dame, R. T., Roos, W. H. & Wuite, G. J. L., 2014, In : Biophysical Journal. 106, 2, p. 386A-386A

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

Self-assembly and characterization of small and monodisperse dye nanospheres in a protein cage

Luque, D., Snijder, J., Brasch, M., Burnley, R. J., Koay, M. S. T., Carrascosa, J. L., Wuite, G. J. L., Roos, W. H., Heck, A. J. R., Cornelissen, J. L. M., Torres, C. & Caston, J. R., 2014, In : Chemical Science. 5, p. 575-581

Research output: Contribution to JournalArticleAcademicpeer-review

The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells

Vorselen, D., Roos, W. H., MacKintosh, F. C., Wuite, G. J. L. & van Loon, J. J. W. A., 2014, In : FASEB Journal. 28, 2, p. 536-547

Research output: Contribution to JournalArticleAcademicpeer-review

2013

Integrin and defensin modulate the mechanical properties of adenovirus

Snijder, J., Reddy, V. S., May, E. R., Roos, W. H., Nemerow, G. R. & Wuite, G. J. L., 2013, In : Journal of Virology. 87, 5, p. 2756-2766

Research output: Contribution to JournalArticleAcademicpeer-review

Probing the biophysical interplay between a viral genome and its capsid

Snijder, J., Uetrecht, C., Rose, R. J., Sanchez-Eugenia, R., Marti, G. A., Agirre, J., Guérin, D. M. A., Wuite, G. J. L., Heck, A. J. R. & Roos, W. H., 2013, In : Nature Chemistry. 5, 6, p. 502-509 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Role of Mechanical Properties of Cell Mediated Vesicles in Membrane Fusion

Vorselen, D., Roos, W. H., van Loon, J. J. W. A. & Wuite, G. J. L., 2013, In : Biophysical Journal. 104, 2, p. 620A-620A 1 p.

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access

Structural Transitions and Energy Landscape for Cowpea Chlorotic Mottle Virus Capsid Mechanics from Nanomanipulation in Vitro and in Silico

Kononova, O., Snijder, S., Brasch, M., Cornelissen, J., Dima, R. I., Marx, K. A., Wuite, G. J. L., Roos, W. H. & Barsegov, V., 2013, In : Biophysical Journal. 105, 8, p. 1893-1903

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2011

(89)Zr-Nanocolloidal Albumin-Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results

Heuveling, D. A., Visser, G. W. M., Salumbides - Baclayon, M., Roos, W. H., Wuite, G. J. L., Hoekstra, O. S., Leemans, C. R., de Bree, R. & van Dongen, G. A. M. S., 2011, In : Journal of Nuclear Medicine. 52, 10, p. 1580-1584 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Effects of Salts on Internal DNA Pressure and Mechanical Properties of Phage Capsids

Evilevitch, A., Roos, W. H., Ivanovska, I. L., Jeembaeva, M., Jonsson, B. & Wuite, G. J. L., 2011, In : Journal of Molecular Biology. 405, 1, p. 18-23 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

How to perform a nanoindentation experiment on a virus

Roos, W. H., 2011, Single Molecule Analysis, Series Methods in Molecular Biology. Peterman, EJG. & Wuite, GJL. (eds.). New York: Humama press, 2011 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Prestress strengthens the shell of norwalk virus nanoparticles

Baclayon, M., Shoemaker, G. K., Uetrecht, C., Crawford, S. E., Estes, M. K., Prasad, B. V. V., Heck, A. J. R., Wuite, G. J. L. & Roos, W. H., 2011, In : Nano Letters. 11, 11, p. 4865 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Voelen en Vervormen van Virussen

Snijder, J., Wuite, G. J. L. & Roos, W. H., 2011, In : Nederlands Tijdschrift voor Natuurkunde. 77, p. 70-74 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2010

Imaging and manipulation of single viruses by atomic force microscopy

Baclayon, M., Wuite, G. J. L. & Roos, W. H., 2010, In : Soft Matter. 6, 21, p. 5273-5285 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mechanical properties of viruses

Roos, W. H. & Wuite, G. J. L., 2010, Emerging Topics in Physical Virology. Stockley, P. & Twarock, R. (eds.). London: Imperial College Press

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Norwalk Virus Assembly and Stability Monitored by Mass Spectrometry

Shoemaker, G. K., van Duijn, E. J., Crawford, S. E., Uetrecht, C., Baclayon, M., Roos, W. H., Wuite, G. J. L., Estes, M. K., Prasad, B. V. V. & Heck, A. J. R., 2010, In : Molecular and Cellular Proteomics. 9, 8, p. 1742-1751 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Physical virology

Roos, W. H., Bruinsma, R. F. & Wuite, G. J. L., 2010, In : Nature Physics. 6, p. 733-743 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Sampling Protein Form and Function with the Atomic Force Microscope

Baclayon, M., Roos, W. H. & Wuite, G. J. L., 2010, In : Molecular and Cellular Proteomics. 9, 8, p. 1678-1688 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Squeezing Protein Shells: How Continuum Elastic Models, Molecular Dynamics Simulations, and Experiments Coalesce at the Nanoscale

Roos, W. H., Gibbons, M. M., Arkhipov, A., Uetrecht, C., Watts, N. R., Wingfield, P. T., Steven, A. C., Heck, A. J. R., Schulten, K., Klug, W. S. & Wuite, G. J. L., 2010, In : Biophysical Journal. 99, 4, p. 1175-1181 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The effect of ethylene oxide, glow discharge and electron beam on the surface characteristics of poly(L-lactide-co-caprolactone) and the corresponding cellular response of adipose stem cells

Kroeze, R. J., Helder, M. N., Roos, W. H., Wuite, G. J. L., Bank, R. A. & Smit, T. H., 2010, In : Acta Biomaterialia. 6, 6, p. 2060-2065

Research output: Contribution to JournalArticleAcademicpeer-review