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• The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by Cytochrome P450 BM3 mutants

  de Beer, S. B. A., van Bergen, L. A. H., Keijzer, K., Rea, V., Venkataraman, H., Fonseca Guerra, C., Bickelhaupt, F. M., Vermeulen, N. P. E., Commandeur, J. N. M. & Geerke, D. P., 2012, In : Current Drug Metabolism. 13, 2, p. 155-166

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Regioselectivity
  • Hydroxylation
  • Cytochrome P-450 Enzyme System
  • Plasticity
  • Testosterone

• Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

  Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., 1 May 2019, In : PLoS ONE. 14, 5, e0217292.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Dithiothreitol
  • dithiothreitol
  • Structural analysis
  • Cytochrome P-450 Enzyme System
  • cytochrome P-450

• Role of Human Glutathione S-Transferases on the Inactivation of Reactive Drug METABOLITES of Clozapine

  Dragovic, S., Boerma, J. S., van Bergen, L., Vermeulen, N. P. E. & Commandeur, J. N. M., Aug 2010, In : Drug Metabolism Reviews. 42, p. 67-67

  Research output: Contribution to Journal › Article › Professional

• Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.

  Dragovic, S., Boerma, J. S., van Bergen, L., Vermeulen, N. P. E. & Commandeur, J. N. M., 2010, In : Chemical Research in Toxicology. 23, 9, p. 1467-1476

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolites
  • Clozapine
  • Glutathione Transferase
  • Detoxification
  • Pharmaceutical Preparations

• Regio- and Stereoselective Hydroxylation of Optically Active α-Ionone Enantiomers by Engineered Cytochrome P450 BM3 Mutants

  Venkataraman, H., de Beer, S. B. A., Geerke, D. P., Vermeulen, N. P. E. & Commandeur, J. N. M., 2012, In : Advanced Synthesis and Catalysis. 354, 11-12, p. 2172-2184

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Norisoprenoids
  • Cytochrome P-450 Enzyme System
  • Hydroxylation
  • Enantiomers
  • Secondary Metabolism

• Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

  den Braver-Sewradj, S. P., den Braver, M. W., Toorneman, R. M., Van Leeuwen, S., Zhang, Y., Dekker, S. J., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 19 Feb 2018, In : Chemical Research in Toxicology. 31, 2, p. 116-126 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Metabolites
  • Scavenging
  • quinone
  • NAD
  • Oxidoreductases

• Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.

  Vredenburg, G., Vassell, K. P., Commandeur, J. N. M., Vermeulen, N. P. E. & Vos, J. C., 2013, In : Toxicology Letters. 222, 3, p. 247-256

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolism
  • Yeast
  • Clozapine
  • Glutathione Transferase
  • Cytochrome P-450 Enzyme System

• Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-S-transferase P1-1

  Boerma, J. S., Dragovic, S., Vermeulen, N. P. E. & Commandeur, J. N. M., 2012, In : Chemical Research in Toxicology. 25, 11, p. 2532-2541

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Glutathione S-Transferase pi
  • Diclofenac
  • Glutathione Transferase
  • hydroxide ion
  • Proteins

• Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

  Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Ferredoxins
  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Oxidation-Reduction
  • Electrons

• Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals

  den Braver-Sewradj, S. P., den Braver, M. W., van Dijk, M., Zhang, Y., Dekker, S. J., Wijaya, L., Vermeulen, N. P. E., Richert, L., Commandeur, J. N. M. & Vos, J. C., 2018, In : Current Drug Metabolism. 19, 4, p. 370-381 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • quinone
  • Liver
  • Oxidoreductases
  • Glucuronosyltransferase
  • Enzyme activity

• High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions

  Zhang, Y., Wijaya, L., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 15 Jul 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 156, p. 181-188 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • High performance liquid chromatography
  • Liver
  • Assays
  • Sulfates
  • Glutathione Transferase

• Glutathione S-transferase P1 protects against Amodiaquine Quinoneimines-induced cytotoxicity but does not prevent activation of endoplasmic reticulum stress in HepG2 cells

  Zhang, Y., den Braver-Sewradj, S. P., den Braver, M. W., Hiemstra, S., Vermeulen, N. P. E., van de Water, B., Commandeur, J. N. M. & Vos, J. C., 18 Apr 2018, In : Frontiers in Pharmacology. 9, APRIL, p. 1-13 13 p., 388.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • amodiaquine quinoneimine
  • desethylamodiaquine
  • Amodiaquine
  • Endoplasmic Reticulum Stress
  • Hep G2 Cells

• Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

  Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Oxidation-Reduction
  • Pharmaceutical Preparations
  • Ferredoxins

• Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis

  Ortega Ugalde, S., Ma, D., Cali, J. J. & Commandeur, J. N. M., 1 Aug 2019, In : SLAS Discovery. 24, 7, p. 745-754 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Substrates
  • Luminescence
  • Lanosterol

• Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

  Lazarska, K. E., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Mar 2018, In : Toxicology Letters. 284, 1 March, p. 70-78 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP2C8
  • Metabolism
  • Polymorphism
  • Diclofenac
  • 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid

• Effect of Organic Solvents on BM3-P450 Biotransformation

  Sun, L., Decker, C., Grootenhuis, P., Saunders, J., Commandeur, J. N. M., Reinen, J. & Vermeulen, N., Aug 2010, In : Drug Metabolism Reviews. 42, p. 83-84

  Research output: Contribution to Journal › Article › Professional

• Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.

  Dragovic, S., Boerma, J. S., Vermeulen, N. P. E. & Commandeur, J. N. M., 2013, In : Chemical Research in Toxicology. 26, 11, p. 1632-1641

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Diclofenac
  • Glutathione Transferase
  • Cytochrome P-450 Enzyme System
  • hydroxide ion
  • Glutathione

• Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

  de Vlieger, J. S. B., Kolkman, A. J., Ampt, K. A. M., Commandeur, J. N. M., Vermeulen, N. P. E., Kool, J., Wijmenga, S. S., Niessen, W. M. A., Irth, H. & Honing, M., 2010, In : Journal of Chromatography B. 878, 7-8, p. 667-674 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Liquid chromatography
  • Mass spectrometry
  • Nuclear magnetic resonance
  • Assays
  • Liquid Chromatography

• Cytochrome P450 BM3 Mutants as NOVEL Biocatalytic TOOLS for Regioselective Hydroxylation of Steroids

  Rea, V., Kolkman, J. A., Vottero, E., Honing, M., Wijmenga, S., Vermeulen, N. P. E. & Commandeur, J. N. M., Aug 2010, In : Drug Metabolism Reviews. 42, p. 285-286

  Research output: Contribution to Journal › Article › Professional

• Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitors.

  Rea, V., Falck, D., Kool, J., de Kanter, F. J. J., Commandeur, J. N. M., Vermeulen, N. P. E., Niessen, W. M. A. & Honing, M., 2013, In : MedChemComm. 4, p. 371-377

  Research output: Contribution to Journal › Article › Academic › peer-review

  • N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
  • Biotransformation
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole

  Dekker, S. J., Dohmen, F., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Feb 2019, In : British Journal of Pharmacology. 176, 3, p. 466-477 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Sulfaphenazole
  • Floxacillin
  • Hydroxylation
  • Cytochrome P-450 CYP3A
  • Cytochromes

• Characterisation of Human Cytochrome P450s Involved in the Bioactivation of Clozapine

  Dragovic, S., Gunness, P., Ingelman-Sundberg, M., Vermeulen, N. P. E. & Commandeur, J. N. M., 2013, In : Drug Metabolism and Disposition. 41, 3, p. 651-658

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Clozapine
  • Cytochromes
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP2D6
  • Liver

• A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.

  Venkataraman, H., de Beer, SB., Bergen, LA., van Essen, N., Geerke, D. P., Vermeulen, N. P. E. & Commandeur, J. N. M., 2012, In : ChemBioChem. 13, 4, p. 520-523

  Research output: Contribution to Journal › Article › Academic › peer-review

• AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

  Hadi, M., Dragovic, S., van Swelm, R., Herpers, B., van de Water, B., Russel, RG., Commandeur, J. N. M. & Groothuis, G. M., 2013, In : Archives of Toxicology. 87, 1, p. 155-165

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 3-aminophenol
  • Isomers
  • Liver
  • Rats
  • Acetaminophen

• Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

  Rea, V., Kolkman, A. J., Vottero, E. R., Stronks, E. J., Ampt, K. A., Honing, M., Vermeulen, N. P. E., Wijmenga, S. S. & Commandeur, J. N. M., 2012, In : Biochemistry. 51, 3, p. 750-760

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Regioselectivity
  • Hydroxylation
  • Nuclear magnetic resonance
  • Substitution reactions
  • Cytochrome P-450 Enzyme System

• A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

  Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Hydroxylation
  • Floxacillin
  • Cytochrome P-450 Enzyme System
  • Metabolites
  • Synthetic Chemistry Techniques