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• 2019

  Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole

  Dekker, S. J., Dohmen, F., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Feb 2019, In : British Journal of Pharmacology. 176, 3, p. 466-477 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Sulfaphenazole
  • Floxacillin
  • Hydroxylation
  • Cytochrome P-450 CYP3A
  • Cytochromes

• Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis

  Ortega Ugalde, S., Ma, D., Cali, J. J. & Commandeur, J. N. M., 1 Aug 2019, In : SLAS Discovery. 24, 7, p. 745-754 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Substrates
  • Luminescence
  • Lanosterol

• Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

  Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Oxidation-Reduction
  • Pharmaceutical Preparations
  • Ferredoxins

• Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

  Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., 1 May 2019, In : PLoS ONE. 14, 5, e0217292.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Dithiothreitol
  • dithiothreitol
  • Structural analysis
  • Cytochrome P-450 Enzyme System
  • cytochrome P-450
• 2018

  A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

  Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Hydroxylation
  • Floxacillin
  • Cytochrome P-450 Enzyme System
  • Metabolites
  • Synthetic Chemistry Techniques

• Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

  Lazarska, K. E., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Mar 2018, In : Toxicology Letters. 284, 1 March, p. 70-78 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP2C8
  • Metabolism
  • Polymorphism
  • Diclofenac
  • 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid

• Glutathione S-transferase P1 protects against Amodiaquine Quinoneimines-induced cytotoxicity but does not prevent activation of endoplasmic reticulum stress in HepG2 cells

  Zhang, Y., den Braver-Sewradj, S. P., den Braver, M. W., Hiemstra, S., Vermeulen, N. P. E., van de Water, B., Commandeur, J. N. M. & Vos, J. C., 18 Apr 2018, In : Frontiers in Pharmacology. 9, APRIL, p. 1-13 13 p., 388.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • amodiaquine quinoneimine
  • desethylamodiaquine
  • Amodiaquine
  • Endoplasmic Reticulum Stress
  • Hep G2 Cells

• High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions

  Zhang, Y., Wijaya, L., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 15 Jul 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 156, p. 181-188 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • High performance liquid chromatography
  • Liver
  • Assays
  • Sulfates
  • Glutathione Transferase

• Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals

  den Braver-Sewradj, S. P., den Braver, M. W., van Dijk, M., Zhang, Y., Dekker, S. J., Wijaya, L., Vermeulen, N. P. E., Richert, L., Commandeur, J. N. M. & Vos, J. C., 2018, In : Current Drug Metabolism. 19, 4, p. 370-381 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • quinone
  • Liver
  • Oxidoreductases
  • Glucuronosyltransferase
  • Enzyme activity

• Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

  Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Ferredoxins
  • Mycobacterium tuberculosis
  • Cytochrome P-450 Enzyme System
  • Oxidation-Reduction
  • Electrons

• Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

  den Braver-Sewradj, S. P., den Braver, M. W., Toorneman, R. M., Van Leeuwen, S., Zhang, Y., Dekker, S. J., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 19 Feb 2018, In : Chemical Research in Toxicology. 31, 2, p. 116-126 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Metabolites
  • Scavenging
  • quinone
  • NAD
  • Oxidoreductases
• 2016

  Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.

  Reinen, J. R., Postma, G., Tump, C., Bloemberg, T., Engel, J., Vermeulen, N. P. E., Commandeur, J. N. M. & Honing, M., 2016, In : Analytical and Bioanalytical Chemistry. 408, 5, p. 1425-1443 19 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

  den Braver, M. W., Sewradj, S. P., Vermeulen, N. P. E. & Commandeur, J. N. M., 2016, In : Toxicology Letters. 253, p. 46-54

  Research output: Contribution to Journal › Article › Academic › peer-review

• Different reacive metabolites of nevirapine require distinct glutathione S-tranferase isoforms for bioinactivation.

  Dekker, S. J., Zhang, Y., Vos, J. C., Vermeulen, N. P. E. & Commandeur, J. N. M., 2016, In : Chemical Research in Toxicology. 29, 12, p. 2136-2144

  Research output: Contribution to Journal › Article › Academic › peer-review

• Different reactive metabolites of nevirapine require distinct glutathione S-transferase isoforms for bio-inactivation

  Dekker, S. J., Vos, J., Vermeulen, N. P. & Commandeur, J. N., 16 Sep 2016, In : Toxicology Letters. 29, 12, p. 2136-2144 9 p.

  Research output: Contribution to Journal › Article › Professional

• Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.

  Van der Weide, K., Loovers, H., Pondman, K., Bogers, J., van der Straaten, T., Langemeijer, E. V., Cohen, D., Commandeur, J. N. M. & van der Weide, J., 2016, In : Pharmacogenomics Journal.

  Research output: Contribution to Journal › Article › Academic › peer-review

• Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.

  Capoferri, L., Leth, R., ter Haar, E., Mohanty, A. K., Grootenhuis, P. D. J., Vottero, E. R., Commandeur, J. N. M., Vermeulen, N. P. E., Jorgensen, F. S., Olsen, L. & Geerke, D. P., 2016, In : Proteins. 84, 3, p. 383-396

  Research output: Contribution to Journal › Article › Academic › peer-review

• Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.

  Sewradj, S. P., den Braver, M. W., Vermeulen, N. P. E., Commandeur, J. N. M., Richert, L. & Vos, J. C., 2016, In : Toxicology in Vitro. 33, p. 71-79 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

• Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.

  den Braver, M. W., Zhang, Y., Venkataraman, H., Vermeulen, N. P. E. & Commandeur, J. N. M., 2016, In : Toxicology Letters. 255, p. 52-62

  Research output: Contribution to Journal › Article › Academic › peer-review
• 2014

  Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs

  Venkataraman, H., Verkade-Vreeker, M. C. A., Capoferri, L., Geerke, D. P., Vermeulen, N. P. E. & Commandeur, J. N. M., 15 Oct 2014, In : Bioorganic and Medicinal Chemistry. 22, 20, p. 5613-5620

  Research output: Contribution to Journal › Article › Academic › peer-review

• Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases

  Venkataraman, H., Den Braver, M. W., Vermeulen, N. P. E. & Commandeur, J. N. M., 15 Dec 2014, In : Chemical Research in Toxicology. 27, 12, p. 2071-2081 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Mefenamic Acid
  • Glutathione Transferase
  • Cytochrome P-450 Enzyme System
  • Hydroxy Acids
  • Metabolites

• Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen

  Dragovic, S., Venkataraman, H., Begheijn, S., Vermeulen, N. P. E. & Commandeur, J. N. M., 2014, In : Toxicology Letters. 224, 2, p. 272-281

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Detoxification
  • Metabolites
  • Polymorphism
  • Diclofenac
  • Clozapine

• Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid

  Vredenburg, G., Elias, N. S., Venkataraman, H., Hendriks, D. F. G., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 21 Apr 2014, In : Chemical Research in Toxicology. 27, 4, p. 576-86 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • human NQO1 protein
  • Mefenamic Acid
  • Metabolites
  • Diclofenac
  • Acetaminophen

• One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.

  Boerma, J. S., Vermeulen, N. P. E. & Commandeur, J. N. M., 2014, In : Chemico-Biological Interactions. 207, p. 32-40

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Diclofenac
  • Cytochromes
  • Glutathione
  • Oxidation
  • Electrons
• 2010

  Cytochrome P450 BM3 Mutants as NOVEL Biocatalytic TOOLS for Regioselective Hydroxylation of Steroids

  Rea, V., Kolkman, J. A., Vottero, E., Honing, M., Wijmenga, S., Vermeulen, N. P. E. & Commandeur, J. N. M., Aug 2010, In : Drug Metabolism Reviews. 42, p. 285-286

  Research output: Contribution to Journal › Article › Professional

• Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

  de Vlieger, J. S. B., Kolkman, A. J., Ampt, K. A. M., Commandeur, J. N. M., Vermeulen, N. P. E., Kool, J., Wijmenga, S. S., Niessen, W. M. A., Irth, H. & Honing, M., 2010, In : Journal of Chromatography B. 878, 7-8, p. 667-674 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Liquid chromatography
  • Mass spectrometry
  • Nuclear magnetic resonance
  • Assays
  • Liquid Chromatography

• Effect of Organic Solvents on BM3-P450 Biotransformation

  Sun, L., Decker, C., Grootenhuis, P., Saunders, J., Commandeur, J. N. M., Reinen, J. & Vermeulen, N., Aug 2010, In : Drug Metabolism Reviews. 42, p. 83-84

  Research output: Contribution to Journal › Article › Professional

• Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.

  Dragovic, S., Boerma, J. S., van Bergen, L., Vermeulen, N. P. E. & Commandeur, J. N. M., 2010, In : Chemical Research in Toxicology. 23, 9, p. 1467-1476

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolites
  • Clozapine
  • Glutathione Transferase
  • Detoxification
  • Pharmaceutical Preparations

• Role of Human Glutathione S-Transferases on the Inactivation of Reactive Drug METABOLITES of Clozapine

  Dragovic, S., Boerma, J. S., van Bergen, L., Vermeulen, N. P. E. & Commandeur, J. N. M., Aug 2010, In : Drug Metabolism Reviews. 42, p. 67-67

  Research output: Contribution to Journal › Article › Professional