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• 2017

  Behavior Genetics: From Heritability to Gene Finding

  Nivard, M. G., Dolan, C. V., Middeldorp, C. M. & Boomsma, D. I., 1 Feb 2017, Handbook of Psychophysiology. Cacioppo, J. T., Tassinary, L. G. & Berntson, G. G. (eds.). 4 ed. Cambridge University Press, p. 339-354 16 p.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

• EAGLE consortium. CAPICE: Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe

  Middeldorp, C. M., 2017.

  Research output: Contribution to Conference › Poster › Academic

• Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

  Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L., Föcker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M. & 19 others, Adan, R., Brandys, M., van Elburg, A., Boraska Perica, V., Franklin, C. S., Tschöp, M. H., Zeggini, E., Bulik, C. M., Collier, D., Scherag, A., Müller, T. D., Hebebrand, J., GCAN, Hottenga, J. J., Willemsen, G., Boomsma, D. I., van Beijsterveldt, C. E. M., Middeldorp, C. M. & de Geus, E., Feb 2017, In : Molecular Psychiatry. 22, 2, p. 192-201 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genetic Loci
  • Anorexia Nervosa
  • Genome-Wide Association Study
  • Meta-Analysis
  • Single Nucleotide Polymorphism

• Genetic effects influencing risk for major depressive disorder in China and Europe

  Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S. A., Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschøn, H. N., Byrne, E. M., Cichon, S., Clarke, T. K., Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F. & 77 others, Dunn, E. C., Edwards, C. A., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D. S., Grabe, H. J., Hamilton, S. P., Hardiman, O., Hayward, C., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Hottenga, J-J., Ising, M., Jansen, R., Kloiber, S., Knowles, J. A., Lang, M., Li, Q. S., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Martin, N. G., McGrath, P. J., McGuffin, P., McIntosh, A. M., Medland, S. E., Mehta, D., Middeldorp, C. M., Milaneschi, Y., Montgomery, G. W., Mors, O., Müller-Myhsok, B., Nauck, M., Nyholt, D. R., Nöthen, M. M., Owen, M. J., Penninx, B. W. J. H., Pergadia, M. L., Perlis, R. H., Peyrot, W. J., Porteous, D. J., Potash, J. B., Rice, J. P., Rietschel, M., Riley, B. P., Rivera, M., Schoevers, R., Schulze, T. G., Shi, J., Shyn, S. I., Smit, J. H., Smoller, J. W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., van der Auwera, S. V., Grootheest, G., van Hemert, A. M., Völzke, H., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Witt, S. H., Levinson, D. F., Lewis, C. M., Wray, N. R., Flint, J., Sullivan, P. F. & Kendler, K. S., 28 Mar 2017, In : Translational Psychiatry. 7, 3, p. e1074 e1074.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Major Depressive Disorder
  • China
  • Single Nucleotide Polymorphism
  • Meta-Analysis
  • Twin Studies

• Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development

  Nivard, M. G., Gage, S. H., Hottenga, J. J., van Beijsterveldt, C. E. M., Abdellaoui, A., Bartels, M., Baselmans, B. M. L., Ligthart, L., Pourcain, B. S., Boomsma, D. I., Munafò, M. R. & Middeldorp, C. M., 1 Nov 2017, In : Schizophrenia Bulletin. 43, 6, p. 1197-1207 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Psychopathology
  • Schizophrenia
  • Psychiatry
  • Attention Deficit and Disruptive Behavior Disorders
  • Conduct Disorder

• Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

  Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., Kutalik, Z., Lee, S. H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N. R., Arolt, V., Baune, B. T., Boomsma, D. I., Børglum, A. D., Byrne, E. M., Castelao, E., Craddock, N. & 31 others, Craig, I. W., Dannlowski, U., Deary, I. J., Degenhardt, F., Forstner, A. J., Gordon, S. D., Grabe, H. J., Grove, J., Hamilton, S. P., Hayward, C., Heath, A. C., Hocking, L. J., Homuth, G., Hottenga, J. J., Kloiber, S., Krogh, J., Landén, M., Lang, M., Levinson, D. F., Lichtenstein, P., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Middeldorp, C. M., Milaneschi, Y., Penninx, B. W. J. H., Smit, J. H. & CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium, 15 Feb 2017, In : Biological Psychiatry. 81, 4, p. 325-335 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Major Depressive Disorder
  • Genomics
  • Age of Onset
  • Psychiatry
  • Genome

• Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

  Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D. J., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Lopezz de Alda, M., Alliey-Rodriguez, N. & 31 others, Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S. E., Bethell, A., Biernacka, J. M., Blackwood, D. H. R., Boks, M. P., Boomsma, D. I., Børglum, A. D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H. N., Byrne, E. M., Cervantes, P., Clarke, T. K., Craddock, N., Cruceanu, C., Curtis, D., de Geus, E. J. C., Fischer, S. B., Hottenga, J-J., Middeldorp, C. M., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G. & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, 20 Jun 2017, In : Translational Psychiatry. 7, 6, p. e1155

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Borderline Personality Disorder
  • Genome-Wide Association Study
  • Bipolar Disorder
  • Schizophrenia
  • Depression

• Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

  Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A. & 12 others, Colodro-Conde, L., Medland, S. E., Martin, N. G., Rietschel, M., CORtisolNETwork (CORNET) Consortium, Abdellaoui, A., de Geus, E., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Willemsen, G. & Boomsma, D. I., 10 Nov 2017, In : Scientific Reports. 7, 1, p. 15351 15351.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Twins
  • Hair
  • Psychological Stress
  • Hydrocortisone
  • Genes

• Heritability of Behavioral Problems in 7-Year Olds Based on Shared and Unique Aspects of Parental Views

  Fedko, I. O., Wesseldijk, L. W., Nivard, M. G., Hottenga, J. J., van Beijsterveldt, C. E. M., Middeldorp, C. M., Bartels, M. & Boomsma, D. I., 1 Mar 2017, In : Behavior Genetics. 47, 2, p. 152-163 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • behavior problems
  • heritability
  • Problem Behavior
  • Child Behavior
  • Mothers

• Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence

  Nivard, M. G., Lubke, G. H., Dolan, C. V., Evans, D. M., St Pourcain, B., Munafò, M. R. & Middeldorp, C. M., 1 Aug 2017, In : Development and Psychopathology. 29, 3, p. 919-928 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Joints
  • Comorbidity
  • Child
  • Diagnostic and Statistical Manual of Mental Disorders
  • Growth

• Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology

  Wesseldijk, L. W., Fedko, I. O., Bartels, M., Nivard, M. G., van Beijsterveldt, C. E. M., Boomsma, D. I. & Middeldorp, C. M., 1 Mar 2017, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174, 3, p. 251-260 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Molecular Epidemiology
  • Psychopathology
  • Mothers
  • Child
  • Twins

• Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder

  Bot, M., Middeldorp, C. M., de Geus, E. J. C., Lau, H. M., Sinke, S. M., van Nieuwenhuizen, B., Smit, J. H., Boomsma, D. I. & Penninx, B. W. J. H., Jan 2017, In : Psychological Medicine. 47, 2, p. 279-289 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Major Depressive Disorder
  • Self Report
  • Depression
  • Sensitivity and Specificity
  • Netherlands
• 2016

  A cross-cultural comparison of the longitudinal heritability of childhood aggression

  Porsch, R., Middeldorp, C., Cherny, S., Krapohl, E., van Beijsterveldt, C., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., Rhee, S. H., Kaprio, J., Rose, R. J., Hewitt, J. K., Sham, P., Plomin, R., Boomsma, D. & Bartels, M., Nov 2016, In : Behavior Genetics. 46, 6, p. 802-802

  Research output: Contribution to Journal › Meeting Abstract › Other research output

  Open Access

• A genome-wide approach to children's aggressive behavior: The EAGLE consortium

  Pappa, I., St Pourcain, B., Benke, K. S., Cavadino, A., Hakulinen, C., Nivard, M. G., Nolte, I. M., Tiesler, C. M. T., Bakermans-Kranenburg, M. J., Davies, G. E., Evans, D. M., Geoffroy, M. C., Grallert, H., Blokhuis, M. M., Hudziak, J. J., Kemp, J. P., Keltikangas-Järvinen, L., McMahon, G., Mileva-Seitz, V. R., Motazedi, E. & 23 others, Power, C., Raitakari, O. T., Ring, S. M., Rivadeneira, F., Rodriguez, A., Scheet, P., Seppälä, I., Snieder, H., Standl, M., Thiering, E., Timpson, N. J., Veenstra, R., Velders, F. P., Whitehouse, A. J. O., Davey Smith, G., Heinrich, J., Hypponen, E., Lehtimäki, T., Middeldorp, C. M., Oldehinkel, A. J., Pennell, C. E., Boomsma, D. I. & Tiemeier, H., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 562-572

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Child Behavior
  • Genome
  • Single Nucleotide Polymorphism
  • Multifactorial Inheritance
  • Meta-Analysis

• A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

  Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M., Hottenga, J. J. & 31 others, Hudziak, J. J., Jugessur, A., Kemp, J. P., Krapohl, E., Martin, N. G., Murcia, M., Myhre, R., Ormel, J., Ring, S. M., Standl, M., Stergiakouli, E., Stoltenberg, C., Thiering, E., Timpson, N. J., Trzaskowski, M., van der Most, P. J., Wang, C., Nyholt, DR., Medland, S. E., Neale, B. M., Jacobsson, B., Sunyer, J., Hartman, C. A., Whitehouse, A. J. O., Pennell, C. E., Heinrich, J., Plomin, R., Davey Smith, G., Tiemeier, H., Posthuma, D. & Boomsma, D. I., 2016, In : Journal of the American Academy of Child and Adolescent Psychiatry. 55, 10, p. 896-905 10.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Attention Deficit Disorder with Hyperactivity
  • Single Nucleotide Polymorphism
  • Meta-Analysis
  • Pediatrics

• A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18

  Lubke, G. H., Miller, P. J., Verhulst, B., Bartels, M., van Beijsterveldt, C. E. M., Willemsen, G., Boomsma, D. I. & Middeldorp, C. M., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 7, p. 948-957

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Twins
  • Anxiety
  • Depression
  • Phenotype
  • Genes

• Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts

  Lee, M., Aggen, S. H., Otowa, T., Castelao, E., Preisig, M., Grabe, H. J., Hartman, C. A., Oldehinkel, A. J., Middeldorp, C. M., Tiemeier, H. & Hettema, J. M., Dec 2016, In : International Journal of Methods in Psychiatric Research. 25, 4, p. 255-266 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Anxiety Disorders
  • Statistical Factor Analysis
  • Psychiatry
  • Phenotype

• Detection of gene-environment interaction in pedigree data using genome-wide genotypes

  Nivard, M. G., Middeldorp, C. M., Lubke, G. H., Hottenga, J. J., Abdellaoui, A., Boomsma, D. I. & Dolan, C. V., 2016, In : European Journal of Human Genetics. 24, 12, p. 1803-1809

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Gene-Environment Interaction
  • Pedigree
  • Single Nucleotide Polymorphism
  • Genotype
  • Genome

• Differences in maternal and paternal ratings of psychopathology and the genetic epidemiology in 12,000 7-year old twin pairs

  Wesseldijk, L., Fedko, I., Bartels, M., Nivard, M. G., Hottenga, J-J., van Beijsterveldt, C., Boomsma, D. & Middeldorp, C., Nov 2016, In : Behavior Genetics. 46, 6, p. 813-814

  Research output: Contribution to Journal › Article › Academic › peer-review

• Discovery of Biochemical Biomarkers for Aggression: A Role for Metabolomics in Psychiatry

  Hagenbeek, F. A., Kluft, C., Hankemeier, T., Bartels, M., Draisma, H. H. M., Middeldorp, C. M., Berger, R., Noto, A., Lussu, M., Pool, R., Fanos, V. & Boomsma, D. I., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 719-732

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Metabolomics
  • Aggression
  • Psychiatry
  • Biomarkers
  • Lipoproteins

• Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression

  Molenaar, D., Middeldorp, C. M., Willemsen, G., Ligthart, L., Nivard, M. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 1, p. 59-71

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • genotype
  • gender
  • Genotype
  • Depression
  • Twins

• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

  Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Møller, E., Blokhuis, M. M., Horikoshi, M., Hottenga, J. J., Middeldorp, C. M., Uitterlinden, A. G., Plomin, R., Boomsma, D. I., Heinrich, J., Melbye, M., Rivadeneira, F. & 7 others, Hakonarson, H., Ring, S. M., Davey Smith, G., Sørensen, T. I. A., Timpson, N. J., Grant, S. F. A. & Jaddoe, V. W. V., 2016, In : Human Molecular Genetics. 25, 2, p. 389-403

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Heritability of different aggression phenotypes in an Australian and a Dutch cohort

  Conde, L. C., Martin, N. G., Hatemi, P., Boomsma, D., Middeldorp, C., Van Beijsterveldt, T., Bartels, M. & Medland, S. E., Nov 2016, In : Behavior Genetics. 46, 6, p. 776-777

  Research output: Contribution to Journal › Meeting Abstract › Other research output

• Longitudinal heritability of childhood aggression

  Porsch, R. M. P., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E. M., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R. P., Rhee, S., Kaprio, J., Rose, R., Hewitt, J. K., Sham, P., Plomin, R., Boomsma, D. I. & Bartels, M., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 697-707

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Twins
  • Aggression
  • Netherlands
  • Conduct Disorder
  • Child Behavior

• Meta-analysis of genome-wide association studies of anxiety disorders

  Otowa, T., Hek, K., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T. B., Aggen, S. H., Adkins, D. E., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., van der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. J., Direk, N. & 26 others, Hofman, A., Uitterlinden, A. G., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F., Pergadia, M. L., van der Most, P. J., Nolte, I. M., van Oort, F. V. A., Hartman, C. A., Oldehinkel, A. J., Preisig, M., Grabe, H. J., Middeldorp, C. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, G. W., Maher, B. S., van den Oord, E. J., Wray, N. R., Tiemeier, H. & Hettema, J. M., 2016, In : Molecular Psychiatry. 21, 10, p. 1391-1399

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Anxiety Disorders
  • Meta-Analysis
  • calmodulin-lysine methyltransferase
  • Phenotype

• Multivariate and repeated measure GWAS of aggression phenotypes

  Nivard, M. G., Middeldorp, C., Hottenga, J. J., Fedko, I., Ehli, E. A., Davies, G., van Beijsterveldt, C., Bartels, M. & Boomsma, D., Nov 2016, In : Behavior Genetics. 46, 6, p. 798-799

  Research output: Contribution to Journal › Meeting Abstract › Other research output

• Psychiatrische stoornissen binnen gezinnen: een integrale benadering via de familiepoli

  van Veen, S. C., Batelaan, N. M., Wesseldijk, L. W., Rozeboom, J. & Middeldorp, C. M., 2016, In : Tijdschrift voor Psychiatrie. 58, 2, p. 95-104 10 p.

  Research output: Contribution to Journal › Article › Professional

• Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology

  Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. & Middeldorp, C. M., 2016, In : European Psychiatry. 2016 Apr, 34, p. 49-55 6 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Spouses
  • Psychopathology
  • Attention Deficit Disorder with Hyperactivity
  • Parents
  • Fathers
  113 Downloads (Pure)
• 2015

  Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype 9 Environment Interaction

  Molenaar, D., Middeldorp, C. M., van Beijsterveldt, C. E. M. & Boomsma, D. I., 2015, In : Child Development. 86, 6, p. 1999-2016 18 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Problem Behavior
  • Genotype
  • interaction
  • Child
  • Anxiety

• Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height

  Fedko, I. O., Hottenga, J. J., Medina-Gomez, C., Pappa, I., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Rivadeneira, F., Tiemeier, H., Swertz, M. A., Middeldorp, C. M., Bartels, M. & Boomsma, D. I., 2015, In : Behavior Genetics. 45, 5, p. 514-528 15 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • childhood
  • polymorphism
  • genetic relationships
  • single nucleotide polymorphism
  • heritability

• Genetica en psychische stoornissen op de kinderleeftijd: erfelijkheid en de zoektocht naar genen

  Middeldorp, C. M., 2015, In : Tijdschrift voor Psychiatrie. 57, 12, p. 876-880 5 p.

  Research output: Contribution to Journal › Article › Professional

• Genetic and Environmental Stability of Neuroticism From Adolescence to Adulthood

  Nivard, M. G., Middeldorp, C. M., Dolan, C. V. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 6, p. 746-754 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Neuroticism
  • Genetic Models
  • Twins
  • Individuality
  • Longitudinal Studies

• Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

  Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., Altmann, A., Trümbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C. E., Drabant Conley, E., Boomsma, D. I. & 10 others, Penninx, B. W. J. H., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Smit, J. H., Ruepp, A., Müller-Myhsok, B., Hariri, A. & Binder, E. B., 2015, In : Neuron. 86, p. 1189-1202 15 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Transcriptome
  • Psychiatry
  • Glucocorticoid Receptors
  • Brain
  • Endophenotypes

• Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

  Maier, R., Moser, G., Chen, G. B., Ripke, S., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Coryell, W. H., Potash, J. B., Scheftner, W. A., Shi, J., Weissmann, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R. & 1 others, Lee, S. H., 2015, In : American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Major Depressive Disorder
  • Bipolar Disorder
  • Schizophrenia
  • Joints
  • Psychiatry

• Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

  Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bonnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 130 others, Kalb, B., Pino-Yanes, M., Xu, C., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Moller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rueschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodriguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Foelster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., de Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Soederhaell, C., Melen, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M., Noethen, M. M., Lau, S., Huebner, N., Lee, Y., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M. & Weidinger, S., 2015, In : Nature Genetics. 47, 12, p. 1449-1456

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Genome-Wide Association Study
  • Atopic Dermatitis
  • Genetic Association Studies
  • Skin Diseases
  • Hispanic Americans

• Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

  O’Dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Krabbendam, A. C., Middeldorp, C. M., Penninx, B. W. J. H., Sergeant, J. A., Smit, J. H., Grootheest, G., Willemsen, G. & 2 others, Holmes, P. & Breen, G., 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Histones
  • Psychiatry
  • Post-Synaptic Density
  • Genomics

• Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

  Byrne, E. M., Boomsma, D. I., Martin, N. G., Penninx, B. W. J. H., de Geus, E. J. C., Hoogendijk, W. J. G., Hottenga, J. J., Middeldorp, C. M., Nyholt, DR., Smit, J. H., van den Oord, E. J., Grootheest, G., Willemsen, G., Zitman, F. G., Neale, B. M., Sullivan, P. F., Raheja, U. K., Stephens, S. H., Heath, A. C., Madden, P. A. F. & 11 others, Vaswani, D., Nijjar, G. V., Ryan, K. A., Youssufi, H., Gehrman, P. R., Shuldiner, A. R., Montgomery, G. W., Wray, N. R., Nelson, E. C., Mitchell, B. D. & Postolache, T. T., 2015, In : Journal of Clinical Psychiatry. 76, 2, p. 128-134 7 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bipolar Disorder
  • Schizophrenia
  • Major Depressive Disorder
  • Genetic Profile
  • Genome-Wide Association Study

• Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

  Pappa, I., Fedko, I. O., Mileva-Seitz, V. R., Hottenga, J. J., Bakermans-Kranenburg, M. J., Bartels, M., van Beijsterveldt, C. E. M., Jaddoe, V. W. V., Middeldorp, C. M., Rippe, R. C. A., Rivadeneira, F., Tiemeier, H., Verhulst, F. C., van IJzendoorn, M. H. & Boomsma, D. I., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 54, 9, p. 737-744 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Multifactorial Inheritance
  • Problem Behavior
  • Single Nucleotide Polymorphism
  • Genome
  • Phenotype

• Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age

  Treur, J. L., Vink, J. M., Boomsma, D. I. & Middeldorp, C. M., 2015, In : Drug and Alcohol Dependence. 153, p. 221-228 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Spouses
  • Twins
  • Smoking
  • Netherlands
  • Parents

• Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years

  Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K. J., Willemsen, G., van Beijsterveldt, C. E. M., Lindauer, R. J. L., van Beek, J. H. D. A., Geels, L. M., Bartels, M., Middeldorp, C. M. & Boomsma, D. I., 2015, In : Psychological Medicine. 45, 05, p. 1039-1049 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Twin Studies
  • Longitudinal Studies
  • Anxiety
  • Genotype
  • Depression

• The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

  Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 others, Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Major Depressive Disorder
  • Depression
  • Genetic Profile
  • Single Nucleotide Polymorphism
  • Genomics

• The genetic overlap between schizophrenia and childhood psychopathology

  Middeldorp, C. M., 2015.

  Research output: Contribution to Conference › Poster › Other research output
• 2014

  Agenda for future research. Psychiatric perpective.

  van Dyck, R., van Balkom, A. J. L. M., van den Heuvel, O. & Middeldorp, C. M., 2014, The Wiley Handbook of Anxiety Disorders. Volume II: Clinical assessment and treatment.. Emmelkamp, P. M. G. & Ehring, T. (eds.). Chichester: Wiley, p. 1369-1381

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• A Genome-wide Association Meta-analysis of Preschool Internalizing Problems

  Benke, K. S., Nivard, M. G., Velders, F. P., Walters, R. K., Pappa, I., Scheet, P., Xiao, X., Ehli, E. A., Palmer, L. J., Whitehouse, A. J. O., Verhulst, F. C., Jaddoe, V. W., Rivadeneira, F., Blokhuis, M. M., van Beijsterveldt, C. E. M., Davies, G. E., Hudziak, J. J., Lubke, G. H., Boomsma, D. I., Pennell, C. E. & 2 others, Tiemeier, H. & Middeldorp, C. M., 2014, In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 6, p. 667-676 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Meta-Analysis
  • Genome
  • Psychiatry

• A recessive genetic model and runs of homozygosity in major depressive disorder

  Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Penninx, B. W. J. H., Willemsen, G. & Breen, G., 2014, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165, 2, p. 157-166 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genetic Models
  • Genome-Wide Association Study
  • Major Depressive Disorder
  • Genome
  • Schizophrenia

• Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

  Blokhuis, M. M., Middeldorp, C. M., Kan, K. J., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Scheet, P., Xiao, X., Hudziak, J. J., Hottenga, J. J., Neale, B. M. & Boomsma, D. I., 2014, In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 10, p. 1123-1129 7 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Attention Deficit Disorder with Hyperactivity
  • Child
  • Population
  • Impulsive Behavior

• Child Care, Socio-economic Status and Problem Behavior: A Study of Gene–Environment Interaction in Young Dutch Twins

  Middeldorp, C. M., Lamb, D. J., Vink, J. M., Bartels, M., van Beijsterveldt, C. E. M. & Boomsma, D. I., 2014, In : Behavior Genetics. 44, 4, p. 314-325 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • child care
  • behavior problems
  • socioeconomic status
  • Economic Status
  • Child Care

• De meerwaarde van een familiepoli

  Batelaan, N. M. & Middeldorp, C. M., 2014, In : PsychoPraktijk. 6, 3, p. 14-17 4 p.

  Research output: Contribution to Journal › Article › Professional

• Further confirmation of the association between anxiety and CTNND2: replication in humans

  Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Penninx, B. W. J. H., Middeldorp, C. M. & Boomsma, D. I., 2014, In : Genes, Brain and Behavior. 13, 2, p. 195-201 7 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Anxiety
  • Agoraphobia
  • Catenins
  • Social Phobia
  • Chromosome Mapping

• Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

  Ligthart, L., Hottenga, J. J., Lewis, C. M., Farmer, A. E., Craig, I. W., Breen, G., Willemsen, G., Vink, J. M., Middeldorp, C. M., Byrne, E. M., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Montgomery, G. W., Martin, N. G., Penninx, B. W. J. H., McGuffin, P., Boomsma, D. I. & Nyholt, DR., 2014, In : Human Genetics. 133, 2, p. 173-186 14 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Migraine Disorders
  • Major Depressive Disorder
  • Depression
  • Genome-Wide Association Study
  • Major Depressive Disorder 1