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2020

An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior

van der Zee, M. D., Helmer, Q., Boomsma, D. I., Dolan, C. V. & de Geus, E. J. C., 23 Jan 2020, In : Behavior Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Twin Studies
Pedigree
pedigree
exercise
Exercise

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D. & Willemsen, G., Mar 2020, In : Biological Psychiatry. 87, 5, p. 419-430 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
HLA Antigens
Haplotypes
Alleles
Depression
Major Histocompatibility Complex

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., Beekman, A. T. F., Jansen, R., Milaneschi, Y., Smit, J. H., W J H Penninx, B. & Posthuma, D., 23 Jan 2020, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Genome
Wounds and Injuries
Genes
Depression

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

BBMRI Metabolomics Consortium, 7 Jan 2020, In : Nature Communications. 11, 1, p. 39

Research output: Contribution to JournalArticleAcademicpeer-review

genome
metabolites
Genome-Wide Association Study
Metabolites
Phosphatidylcholines

The short Sing-a-Song Stress Test: A practical and valid test of autonomic responses induced by social-evaluative stress

van der Mee, D. J., Duivestein, Q., Gevonden, M. J., Westerink, J. H. D. M. & de Geus, E. J. C., 1 Mar 2020, In : Autonomic Neuroscience: Basic and Clinical. 224, 102612.

Research output: Contribution to JournalArticleAcademicpeer-review

Music
Exercise Test
Parasympathetic Nervous System
Sympathetic Nervous System
Skin
2019

A Genetic Investigation of the Well-Being Spectrum

Baselmans, B. M. L., van de Weijer, M. P., Abdellaoui, A., Vink, J. M., Hottenga, J. J., Willemsen, G., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Bartels, M., 15 May 2019, In : Behavior Genetics. 49, 3, p. 286-297 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Phenotype
phenotype
Loneliness
Health
genetic correlation

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In : Nature Communications. 10, p. 1-11 11 p., 2581.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
homeostasis
insulin
methylation
Methylation
DNA Methylation
Open Access
Suicidal Ideation
Mental Disorders
Longitudinal Studies
Anxiety
Psychiatry

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

Writing Committee for the ENIGMA-CNV Working Group , 30 Oct 2019, In : JAMA Psychiatry. p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cognition
Aptitude
Brain
Iceland
Parietal Lobe

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Anisotropy
Genome
Radiation
Diffusion Tensor Imaging

Associations between Loneliness and Personality are Mostly Driven by a Genetic Association with Neuroticism

Abdellaoui, A., Chen, H-Y., Willemsen, G., Ehli, E. A., Davies, G. E., Verweij, K. J. H., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Cacioppo, J. T., Apr 2019, In : Journal of Personality. 87, 2, p. 386-397 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Loneliness
Personality
Monozygotic Twins
Neuroticism
Molecular Biology

A twin study on the correlates of voluntary exercise behavior in adolescence

Schutte, N. M., Nederend, I., Bartels, M. & de Geus, E. J. C., 1 Jan 2019, In : Psychology of Sport and Exercise. 40, p. 99-109 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Twin Studies
Exercise
Aptitude
Individuality
Personality

Biological insights into multiple birth: genetic findings from UK Biobank

Mbarek, H., van de Weijer, M. P., van der Zee, M. D., Ip, H. F., Beck, J. J., Abdellaoui, A., Ehli, E. A., Davies, G. E., Baselmans, B. M. L., Nivard, M. G., Bartels, M., de Geus, E. J. & Boomsma, D. I., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 970-979 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multiple Birth Offspring
Fertility
Dizygotic Twins
Genome-Wide Association Study
Mothers

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Bipolar Disorder
Psychiatry
Schizophrenia
Depression
Major Depressive Disorder

Cardiac autonomic activity in depression and anxiety: Heartfelt afflictions of the mind

Hu, M. X., 2019, 264 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk

Finnicum, C. T., Beck, J. J., Dolan, C. V., Davis, C., Willemsen, G., Ehli, E. A., Boomsma, D. I., Davies, G. E. & de Geus, E. J. C., 22 Oct 2019, In : BMC Microbiology. 19, 1, p. 1-10 10 p., 230.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Spouses
Public Opinion
Microbiota
Gastrointestinal Microbiome

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 othersLi, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C-Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B-C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J-J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M-J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J-L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van 't Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 2019, In : Nature Genetics. 51, 11, p. 1624-1636 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Axonal Transport
Globus Pallidus
Caudate Nucleus
Genome-Wide Association Study
Putamen

Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms

Smit, D. J. A., Cath, D., Zilhão, N. R., Ip, H. F., Denys, D., den Braber, A., de Geus, E. J. C., Verweij, K. J. H., Hottenga, J-J. & Boomsma, D. I., 31 Dec 2019, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Obsessive-Compulsive Disorder
Self Report
Meta-Analysis
Genome-Wide Association Study
Genes

Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array

Beck, J. J., Hottenga, J. J., Mbarek, H., Finnicum, C. T., Ehli, E. A., Hur, Y-M., Martin, N. G., de Geus, E. J. C., Boomsma, D. I. & Davies, G. E., Aug 2019, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. 22, 4, p. 210-219 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Population
Netherlands
Genome-Wide Association Study
Nigeria
Genotype

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikäinen, L. P., Mei, H., Müller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I. & 41 othersCaulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J. J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Silva Aldana, C. T., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kääb, S., Kanters, J. K., Lehtimäki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Quantitative Trait Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
Genome

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., McMahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P. & 55 othersHerms, S., Heilmann-Heimbach, S., Kockum, I., Olsson, T., Alfredsson, L., Weber, H., Alpers, G. W., Arolt, V., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A., Kircher, T., Pané-Farré, C. A., Pauli, P., Rief, W., Ströhle, A., Plag, J., Lang, T., Wittchen, H-U., Mattheisen, M., Meier, S., Metspalu, A., Domschke, K., Reif, A., Hovatta, I., Lindefors, N., Andersson, E., Schalling, M., Mbarek, H., Milaneschi, Y., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Thorgeirsson, T. E., Steinberg, S., Stefansson, K., Stefansson, H., Müller-Myhsok, B., Hansen, T. F., Børglum, A. D., Werge, T., Mortensen, P. B., Nordentoft, M., Hougaard, D. M., Hultman, C. M., Sullivan, P. F., Nöthen, M. M., Woldbye, D. P. D., Mors, O., Binder, E. B., Rück, C., Ripke, S., Deckert, J. & Schumacher, J., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Panic Disorder
Depression
Single Nucleotide Polymorphism
Genome

Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts

Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L., McGuffin, P. & 13 othersMors, O., Owen, M. J., Preisig, M., Rietschel, M., Rice, J. P., Rivera, M., Uher, R., Gejman, P. V., Sanders, A. R., Boomsma, D., Penninx, B. W. J. H., Breen, G. & Levinson, D. F., 15 Jun 2019, In : Biological Psychiatry. 85, 12, p. 1065-1073 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Genome
Intergenic DNA
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, P. H., Anttila, V., Won, H., Feng, Y., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M., Grotzinger, A. D., Posthuma, D., Derks, E. M., op Landt Slof, M. C. T., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., W J H Penninx, B., Cath, D. C. & 11 othersDenys, D., Santangelo, S., Scharf, J. M., Stein, M. B., Thornton, L. M., Walters, J. T. R., Wray, N. R., Geschwind, D. H., Neale, B. M., Kendler, K. S. & Smoller, J. W., 12 Dec 2019, In : Cell. 179, 7, p. 1469-1482.e11

Research output: Contribution to JournalArticleAcademicpeer-review

Psychiatry
Genes
Tourette Syndrome
Obsessive-Compulsive Disorder
Anorexia Nervosa

Homogenizing estimates of heritability among SOLAR-eclipse, OpenMX, APACE, and FPHI software packages in neuroimaging data

Kochunov, P., Patel, B., Ganjgahi, H., Donohue, B., Ryan, M., Hong, E. L., Chen, X., Adhikari, B., Jahanshad, N., Thompson, P. M., Van’t Ent, D., den Braber, A., de Geus, E. J. C., Brouwer, R. M., Boomsma, D. I., Hulshoff Pol, H. E., de Zubicaray, G. I., McMahon, K. L., Martin, N. G., Wright, M. J. & 1 othersNichols, T. E., Mar 2019, In : Frontiers in Neuroinformatics. 13, March, p. 1-11 11 p., 16.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Diffusion tensor imaging
Neuroimaging
Maximum likelihood estimation
Software packages
Software

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Phenotype
Sample Size
Meta-Analysis
Autism Spectrum Disorder

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, p. 1-18 18 p., 2548.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
DNA Methylation
Fetal Blood
blood
Blood

Is physical activity regulated by genetics? Evidence from studies in humans

Van Der Zee, M. D. & De Geus, E., 2019, Routledge Handbook of Sport and Exercise Systems Genetics. Lightfoot, J. T., Hubal, M. J. & Roth, S. M. (eds.). Taylor and Francis AS, p. 67-79 13 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Exercise
Agglomeration
Health
Twin Studies
Registries

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, 1 May 2019, In : Nature Genetics. 51, 5, p. 804-814 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Birth Weight
Mothers
Blood Pressure
Alleles
Genome-Wide Association Study

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A. & 19 othersMedland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Eline Slagboom, P., Spector, T. D., Boomsma, D. I., van Duijn, C. M. & Gieger, C., 12 Aug 2019, In : Scientific Reports. 9, 1, p. 11623

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolomics
Telomere
Homocysteine
Lipid Metabolism
Leukocytes

Multivariate genome-wide analyses of the well-being spectrum

BIOS Consortium, Mar 2019, In : Nature Genetics. 51, 3, p. 445-451 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genome
Meta-Analysis
Interneurons
Computational Biology

Probability learning and feedback processing in dyslexia: A performance and heart rate analysis

Fraga González, G., Smit, D. J. A., van der Molen, M. J. W., Tijms, J., de Geus, E. J. C. & van der Molen, M. W., Dec 2019, In : Psychophysiology. 56, 12, p. 1-17 17 p., e13460.

Research output: Contribution to JournalArticleAcademicpeer-review

Probability Learning
Dyslexia
Heart Rate
Learning
Phonetics

Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations

de Geus, E. J. C., Gianaros, P. J., Brindle, R. C., Jennings, J. R. & Berntson, G. G., Feb 2019, In : Psychophysiology. 56, 2, p. 1-26 26 p., e13287.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Heart Rate
Behavioral Sciences

The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants

Hu, M. X., Milaneschi, Y., Lamers, F., Nolte, I. M., Snieder, H., Dolan, C. V., Penninx, B. W. J. H. & de Geus, E. J. C., 17 Oct 2019, In : Depression and Anxiety.

Research output: Contribution to JournalArticleAcademicpeer-review

Antidepressive Agents
Anxiety
Heart Rate
Depression
Genetic Pleiotropy

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Posthuma, D., 1 Nov 2019, In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Inborn Genetic Diseases
Genome-Wide Association Study
Mood Disorders
Bipolar Disorder
Major Depressive Disorder
Netherlands
Research
Genetic Association Studies
Biocompatible Materials
Pedigree

The Nigerian Twin and Sibling Registry: An Update

Hur, Y-M., Jeong, H-U., Kang, M. C., Ajose, F., Kim, J. W., Beck, J. J., Hottenga, J-J., Mbarek, H., Finnicum, C. T., Ehli, E. A., Martin, N. G., de Geus, E. J., Boomsma, D. I., Davies, G. E. & Bates, T., 3 Dec 2019, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. p. 1-4 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Registries
Siblings
Birth Rate
Nigeria
Population

Tracking of voluntary exercise behaviour over the lifespan

Van Der Zee, M. D., Van Der Mee, D., Bartels, M. & De Geus, E. J. C., 4 Feb 2019, In : International Journal of Behavioral Nutrition and Physical Activity. 16, p. 1-11 11 p., 17.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Leisure Activities
Habits
Sex Characteristics
Netherlands
Sports

Validated inference of smoking habits from blood with a finite DNA methylation marker set

BIOS Consortium, Nov 2019, In : European Journal of Epidemiology. 34, 11, p. 1055-1074 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Genetic Markers
Habits
Smoking
Area Under Curve
2018

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, 22 Jun 2018, In : Science. 360, 6395, p. 1-15 15 p., 8757.

Research output: Contribution to JournalArticleAcademicpeer-review

Brain Diseases
Psychiatry
Phenotype
Genetic Heterogeneity
Genome-Wide Association Study

An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Boomsma, D. I., Helmer, Q., Nieuwboer, H. A., Hottenga, J. J., de Moor, M. H., van den Berg, S. M., Davies, G. E., Vink, J. M., Schouten, M. J., Dolan, C. V., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ligthart, L. & de Geus, E. J., 1 Jan 2018, In : Behavior Genetics. 48, 1, p. 1-11

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Twin Studies
Pedigree
pedigree
Netherlands
households

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, S., Diniz, M. J. A., Saloma, A., Gadelha, A., Santoro, M. L., Ota, V. K., Noto, C., Curtis, C., Newhouse, S. J., Patel, H., Hall, L. S., O`Reilly, P. F., Belangero, S. I., Bressan, R. A., Breen, G. & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 8 Oct 2018, In : Communications biology. 1, p. 1-10 10 p., 163.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
behavior disorders
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Pedigree

Are Migraine and Tension-Type Headache Genetically Related? An Investigation of Twin Family Data

Ligthart, L., Huijgen, A., Willemsen, G., De Geus, E. J. C. & Boomsma, D. I., Apr 2018, In : Twin Research and Human Genetics. 21, 2, p. 112-118 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tension-Type Headache
Migraine Disorders
Comorbidity
Dizygotic Twins
Monozygotic Twins

Association between depression, anxiety, and antidepressant use with T-Wave amplitude and QT-interval

Hu, M. X., Lamers, F., Penninx, B. W. J. H. & de Geus, E. J. C., 5 Jun 2018, In : Frontiers in Neuroscience. 12, JUN, 375.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tricyclic Antidepressive Agents
Antidepressive Agents
Anxiety
Anxiety Disorders
Depression

Associations of immunometabolic risk factors with symptoms of depression and anxiety: The role of cardiac vagal activity

Hu, M. X., Penninx, B. W. J. H., de Geus, E. J. C., Lamers, F., Kuan, D. C. H., Wright, A. G. C., Marsland, A. L., Muldoon, M. F., Manuck, S. B. & Gianaros, P. J., Oct 2018, In : Brain, Behavior, and Immunity. 73, p. 493-503 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Anxiety
Depression
Equipment and Supplies
Heart Rate
Epidemiologic Studies

Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study

Oldenhof, H., Prätzlich, M., Ackermann, K., Baker, R., Batchelor, M., Baumann, S., Bernhard, A., Clanton, R., Dikeos, D., Dochnal, R., Fehlbaum, L. V., Fernández-Rivas, A., de Geus, E., Gonzalez, K., de Artaza-Lavesa, M. G., Guijarro, S., Gundlach, M., Herpertz-Dahlmann, B., Hervas, A., Jansen, L. & 20 othersKersten, L., Kohls, G., Konsta, A., Lazaratou, H., Kerexeta-Lizeaga, I., Martinelli, A., van Nimwegen, T., Puzzo, I., Raschle, N. M., Rogers, J., Siklósi, R., Smaragdi, A., Steppan, M., De Brito, S., Fairchild, G., Kieser, M., Konrad, K., Freitag, C., Stadler, C. & Popma, A., 1 Jun 2018, In : Journal of Criminal Justice. p. 1-10 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Conduct Disorder
Autonomic Nervous System
adolescent
emotion
Emotions

Bidirectional prospective associations between cardiac autonomic activity and inflammatory markers

Hu, M. X., Lamers, F., Neijts, M., Willemsen, G., De Geus, E. J. C. & Penninx, B. W. J. H., 1 Jun 2018, In : Psychosomatic Medicine. 80, 5, p. 475-482 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

C-Reactive Protein
Heart Rate
Autonomic Nervous System
Interleukin-6
Netherlands

Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC

Lightfoot, J. T., De Geus, E. J. C., Booth, F. W., Bray, M. S., Den Hoed, M., Kaprio, J., Kelly, S. A., Pomp, D., Saul, M. C., Thomis, M. A., Garland, T. & Bouchard, C., 1 Apr 2018, In : Medicine and Science in Sports and Exercise. 50, 4, p. 863-873 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Public Sector
Biological Factors
Public Policy
Animal Models
Health

Brain reward responses to food stimuli among female monozygotic twins discordant for BMI

Doornweerd, S., De Geus, E. J., Barkhof, F., van Bloemendaal, L., Boomsma, D. I., van Dongen, J., Drent, M. L., Willemsen, G., Veltman, D. J. & IJzerman, R. G., 8 Jun 2018, In : Brain Imaging and Behavior. 12, 3, p. 718-727

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Reward
Food
Brain
Obesity

Cardiac Autonomic Nervous System Activity and Cardiac Function in Children After Coarctation Repair

Nederend, I., de Geus, E. J. C., Kroft, L. J. M., Westenberg, J. J. M., Blom, N. A. & ten Harkel, A. D. J., Jun 2018, In : The Annals of Thoracic Surgery. 105, 6, p. 1803-1808 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Autonomic Nervous System
Aortic Coarctation
Cardiac Output
Left Ventricular Function
Impedance Cardiography