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  • R. Haselberg
2020

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, M. L. A., Duewer, D. L., Fung, A., Liu, L., Yau, H. K., Potter, O., Staples, G. O., Furuki, K., Frenkel, R., Hu, Y., Sosic, Z., Zhang, P., Altmann, F., Gru Nwald-Grube, C., Shao, C., Zaia, J., Evers, W., Pengelley, S., Suckau, D., Wiechmann, A. & 142 others, Resemann, A., Jabs, W., Beck, A., Froehlich, J. W., Huang, C., Li, Y., Liu, Y., Sun, S., Wang, Y., Seo, Y., An, H. J., Reichardt, N. C., Ruiz, J. E., Archer-Hartmann, S., Azadi, P., Bell, L., Lakos, Z., An, Y., Cipollo, J. F., Pucic-Bakovic, M., Štambuk, J., Lauc, G., Li, X., Wang, P. G., Bock, A., Hennig, R., Rapp, E., Creskey, M., Cyr, T. D., Nakano, M., Sugiyama, T., Leung, P. K. A., Link-Lenczowski, P., Jaworek, J., Yang, S., Zhang, H., Kelly, T., Klapoetke, S., Cao, R., Kim, J. Y., Lee, H. K., Lee, J. Y., Yoo, J. S., Kim, S. R., Suh, S. K., de Haan, N., Falck, D., Lageveen-Kammeijer, G. S. M., Wuhrer, M., Emery, R. J., Kozak, R. P., Liew, L. P., Royle, L., Urbanowicz, P. A., Packer, N. H., Song, X., Everest-Dass, A., Lattová, E., Cajic, S., Alagesan, K., Kolarich, D., Kasali, T., Lindo, V., Chen, Y., Goswami, K., Gau, B., Amunugama, R., Jones, R., Stroop, C. J. M., Kato, K., Yagi, H., Kondo, S., Yuen, C. T., Harazono, A., Shi, X., Magnelli, P. E., Kasper, B. T., Mahal, L., Harvey, D. J., O'Flaherty, R., Rudd, P. M., Saldova, R., Hecht, E. S., Muddiman, D. C., Kang, J., Bhoskar, P., Menard, D., Saati, A., Merle, C., Mast, S., Tep, S., Truong, J., Nishikaze, T., Sekiya, S., Shafer, A., Funaoka, S., Toyoda, M., de Vreugd, P., Caron, C., Pradhan, P., Tan, N. C., Mechref, Y., Patil, S., Rohrer, J. S., Chakrabarti, R., Dadke, D., Lahori, M., Zou, C., Cairo, C., Reiz, B., Whittal, R. M., Lebrilla, C. B., Wu, L., Guttman, A., Szigeti, M., Kremkow, B. G., Lee, K. H., Sihlbom, C., Adamczyk, B., Jin, C., Karlsson, N. G., Örnros, J., Larson, G., Nilsson, J., Meyer, B., Wiegandt, A., Komatsu, E., Perreault, H., Bodnar, E. D., Said, N., Francois, Y. N., Leize-Wagner, E., Maier, S., Zeck, A., Heck, A. J. R., Yang, Y., Haselberg, R., Yu, Y. Q., Alley, W., Leone, J. W., Yuan, H. & Stein, S. E., 1 Jan 2020, In : Molecular & cellular proteomics : MCP. 19, 1, p. 11-30 20 p.

Research output: Contribution to JournalArticle

Open Access

Profiling of a high mannose-type N-glycosylated lipase using hydrophilic interaction chromatography-mass spectrometry

Gargano, A. F. G., Schouten, O., van Schaick, G., Roca, L. S., van den Berg-Verleg, J. H., Haselberg, R., Akeroyd, M., Abello, N. & Somsen, G. W., 28 Feb 2020, In : Analytica Chimica Acta. 1109, p. 69-77 9 p.

Research output: Contribution to JournalArticle

2019

Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques

Haselberg, R., Pirok, B. W. J., Gargano, A. F. G. & Kohler, I., 1 Sep 2019, In : LC GC Europe. 32, 9, p. 465-480 16 p.

Research output: Contribution to JournalArticle

Experimental design and measurement uncertainty in ligand binding studies by affinity capillary electrophoresis

Stein, M., Haselberg, R., Mozafari-Torshizi, M. & Wätzig, H., 14 Jan 2019, In : Electrophoresis. 40, 7, p. 1-14 14 p.

Research output: Contribution to JournalArticle

Rapid forensic chemical classification of confiscated flash banger fireworks using capillary electrophoresis

Bezemer, K. D. B., van Duin, L. V. A., Martin-Alberca, C., Somsen, G. W., Schoenmakers, P. J., Haselberg, R. & van Asten, A. C., Dec 2019, In : Forensic Chemistry. 16, p. 1-9 9 p., 100187.

Research output: Contribution to JournalArticle

2018
Open Access

Capillary Electrophoresis: Trends and Recent Advances

Voeten, R. L. C., Ventouri, I. K., Haselberg, R. & Somsen, G. W., 6 Feb 2018, In : Analytical Chemistry. 90, 3, p. 1464-1481 18 p.

Research output: Contribution to JournalReview article

Open Access

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Yao, H., Vandenbossche, J., Sänger-van de Griend, C. E., Janssens, Y., Fernández, C. S., Xu, X., Wynendaele, E., Somsen, G. W., Haselberg, R. & De Spiegeleer, B., 15 May 2018, In : Talanta. 182, p. 83-91 9 p.

Research output: Contribution to JournalArticle

Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Domínguez-Vega, E., Haselberg, R., Iperen, D. V., Kool, J., Somsen, G. W. & de Jong, G. J., 1 Jan 2018, In : Sensors and Actuators B-Chemical. 254, p. 1040-1047 8 p.

Research output: Contribution to JournalArticle

Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry

Haselberg, R., De Vijlder, T., Heukers, R., Smit, M. J., Romijn, E. P., Somsen, G. W. & Domínguez-Vega, E., 31 Dec 2018, In : Analytica Chimica Acta. 1044, p. 181-190 10 p.

Research output: Contribution to JournalArticle

Open Access

High-resolution glycoform profiling of intact therapeutic proteins by hydrophilic interaction chromatography-mass spectrometry

Domínguez-Vega, E., Tengattini, S., Peintner, C., van Angeren, J., Temporini, C., Haselberg, R., Massolini, G. & Somsen, G. W., Jul 2018, In : Talanta. 184, July, p. 375-381 7 p.

Research output: Contribution to JournalArticle

Open Access
2017

A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using Zr-89-Desferal and Auristatin F-Conjugated Trastuzumab

Sijbrandi, N. J., Merkul, E., Muns, J. A., Waalboer, D. C. J., Adamzek, K., Bolijn, M., Montserrat, V., Somsen, G. W., Haselberg, R., Steverink, P. J. G. M., Houthoff, H-J. & van Dongen, G. A. M. S., 15 Jan 2017, In : Cancer Research. 77, 2, p. 257-267 11 p.

Research output: Contribution to JournalArticle

Fully compatible and ultra-sensitive micellar electrokinetic chromatography-tandem mass spectrometry using sheathless porous-tip interfacing

Moreno-González, D., Haselberg, R., Gámiz-Gracia, L., García-Campaña, A. M., de Jong, G. J. & Somsen, G. W., 2017, (Accepted/In press) In : Journal of Chromatography A. 1524, p. 283-289 7 p.

Research output: Contribution to JournalArticle

Open Access
2016

Capillary zone electrophoresis-mass spectrometry of intact proteins

Domínguez-Vega, E., Haselberg, R. & Somsen, G. W., 2016, Capillary Electrophoresis of Proteins and Peptides: Methods and Protocols. Tran, N. T. & Taverna, M. (eds.). Humana Press Inc, p. 25-41 17 p. (Methods in Molecular Biology; vol. 1466).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Direct electrokinetic injection of inorganic cations from whole fruits and vegetables for electrophoresis analysis.

Kasloom, U., Guijt, R. M., Boyce, M. C., Townsend, A. T., Haselberg, R. & Breadmore, M. C., 2016, In : Journal of Chromatography A. 1428, p. 346-351

Research output: Contribution to JournalArticle

Evaluation of capillary electrophoresis-mass spectrometry for the analysis of the conformational heterogeneity of intact proteins using beta2-microglobulin as model compound.

Bertoletti, L., Schappler, J., Colombo, R., Rudaz, S., Haselberg, R., Dominguez Vega, E., Raimondi, S., Somsen, G. W. & De Lorenzi, E., 2016, In : Analytica Chimica Acta. 945, p. 102-109

Research output: Contribution to JournalArticle

Intact protein analysis by capillary electrophoresis - mass spectrometry.

Haselberg, R. & Somsen, G. W., 2016, Capillary electrophoresis - Mass Spectrometry: Principles and Applications.. De Jong, G. J. (ed.). Wiley, p. 159-192

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Quality and barch-to-batch consistency of original and biosimilar epoetin products.

Andhyk Halim, L., Brinks, V., Jiskoot, W., Romeijn, S., Haselberg, R., Burns, C., Wadhwa, M. & Schellekens, H., 2016, In : Journal of Pharmaceutical Sciences. 105, p. 542-550

Research output: Contribution to JournalArticle

2015

Developments in interfacing designs for CE–MS: towards enabling tools for proteomics and metabolomics

Lindenburg, P. W., Haselberg, R., Rozing, G. & Ramautar, R., 2015, In : Chromatographia. 78, p. 367-377

Research output: Contribution to JournalArticle

Open Access
File

Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping

Wenz, C., Barbas, C., Lõpez-Gonzálvez, Á., Garcia, A., Benavente, F., Sanz-Nebot, V., Blanc, T., Freckleton, G., Britz-McKibbin, P., Shanmuganathan, M., de l'Escaille, F., Far, J., Haselberg, R., Huang, S., Huhn, C., Pattky, M., Michels, D., Mou, S., Yang, F., Neusuess, C. & 4 others, Tromsdorf, N., Baidoo, E. E. K., Keasling, J. D. & Park, S. S., 1 Sep 2015, In : Journal of Separation Science. 38, 18, p. 3262-3270 9 p.

Research output: Contribution to JournalArticle

Mass spectrometry for glycosylation analysis of biopharmaceuticals

Dotz, V., Haselberg, R., Shubhakar, A., Kozak, R. P., Falck, D., Rombouts, Y., Reusch, D., Somsen, G. W., Fernandes, D. L. & Wuhrer, M., 2015, In : TrAC. Trends in Analytical Chemistry. 73, p. 1-9

Research output: Contribution to JournalArticle

Platinum(II) as Bifunctional Linker in Antibody-Drug Conjugate Formation: Coupling of a 4-Nitrobenzo-2-oxa-1,3-diazole Fluorophore to Trastuzumab as a Model

Waalboer, D. C. J., Muns, J. A., Sijbrandi, N. J., Schasfoort, R. B. M., Haselberg, R., Somsen, G. W., Houthoff, H. J. & van Dongen, G. A. M. S., 2015, In : ChemMedChem. 10, 5, p. 797-803

Research output: Contribution to JournalArticle

Simultaneous Assessment of Protein Heterogeneity and Affinity by Capillary Electrophoresis-Mass Spectrometry

Domínguez-Vega, E., Haselberg, R., Somsen, G. W. & De Jong, G. J., 1 Sep 2015, In : Analytical Chemistry. 87, 17, p. 8781-8788 8 p.

Research output: Contribution to JournalArticle

2014

Analytical characterization of NOTA-modified somatropins

Bracke, N., Wynendale, E., D'Hondt, M., Haselberg, R., Somsen, G. W., Pauwels, E., Van de Wiele, C. & De Speigeleer, B., 2014, In : Journal of Pharmaceutical and Biomedical Analysis. 96, p. 1-9

Research output: Contribution to JournalArticle

A simple capillary electrophoresis-mass spectrometry method for complex glycan analysis using a flow-through microvial interface

Jayo, R. G., Thaysen-Andersen, M., Lindenburg, P. W., Haselberg, R., Hankemeijer, T., Ramautar, R. & Chen, D. D. Y., 2014, In : Analytical Chemistry. 86, p. 6479-6486

Research output: Contribution to JournalArticle

Open Access
File

Capillary electrophoresis-based assessment of nanobody affinity and purity

Haselberg, R., Oliveira, S., van der Meel, R., Somsen, G. W. & de Jong, G. J., 2014, In : Analytica Chimica Acta. 818, p. 1-6

Research output: Contribution to JournalArticle

Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

Heukers, R., Altintas, I., Raghoenath, S., De Zan, E., Pepermans, R., Roovers, R. C., Haselberg, R., Hennink, W. E., Schiffelers, R. M., Kok, R. J. & van Bergen en Henegouwen, P. M. P., 2014, In : Biomaterials. 35, p. 601-610

Research output: Contribution to JournalArticle

Open Access
File
2013

CE-MS for the analysis of intact proteins 2010-2012

Haselberg, R., de Jong, G. J. & Somsen, G. W., 2013, In : Electrophoresis. 34, p. 99-112

Research output: Contribution to JournalArticle

Online Affinity Assessment and Immunoaffinity Sample Pretreatment in Capillary Electrophoresis-Mass Spectrometry

Haselberg, R. & Somsen, G. W., 1 Jan 2013, Analyzing Biomolecular Interactions by Mass Spectrometry. Wiley & Blackwell, p. 271-298 28 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

2012

Capillary electrophoresis-mass spectrometry for the analysis of biopharmaceuticals

Haselberg, R., De Jong, G. J. & Somsen, G. W., Oct 2012, In : LC GC Europe. 25, 10, p. 551-562 12 p.

Research output: Contribution to JournalReview article

Capillary electrophoresis-mass spectrometry for the analysis of Biopharmaceuticals

Haselberg, R., de Jong, G. J. & Somsen, G. W., Jun 2012, In : LC GC North America. 30, 6, p. 504-518 15 p.

Research output: Contribution to JournalArticle

Tumor-targeted Nanobullets for Anti-cancer Combination Therapy

van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., Roovers, R. C., van Bergen En Henegouwen, P. M. P., Hennink, W. E., Storm, W. E., Schiffelers, R. M. & Kok, R. J., Nov 2012, In : European Journal of Cancer. 48, p. 38-38

Research output: Contribution to JournalArticle

2011

Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals

Haselberg, R., Brinks, V., de Jong, G. J., Somsen, G. W. & Hawe, A., Apr 2011, In : Analytical and Bioanalytical Chemistry. 400, 1, p. 295-303

Research output: Contribution to JournalArticle

Open Access

Characterization of drug-lysozyme conjugates by sheathless capillary electrophoresis-time-of-flight mass spectrometry

Haselberg, R., Harmsen, S., Dolman, M. E. M., de Jong, G. J., Kok, R. J. & Somsen, G. W., 18 Jul 2011, In : Analytica Chimica Acta. 698, 1-2, p. 77-83

Research output: Contribution to JournalArticle