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  • A.H.M. Willemsen
2017

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Ferreira, M. A., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Y., Rüschendorf, F., Esparza-Gordillo, J., Medway, C. W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B. M., Witte, J. S. & 31 others, Hottenga, J-J., Willemsen, G., Zheng, J., Rodríguez, E., Hotze, M., Franke, A., Revez, J. A., Beesley, J., Matheson, M. C., Dharmage, S. C., Bain, L. M., Fritsche, L. G., Gabrielsen, M. E., Balliu, B., Nielsen, J. B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O. L., Løset, M., Abecasis, G. R., Willer, C. J., Arnold, A., Homuth, G., Schmidt, C. O., Thompson, P. J., Martin, N. G., Duffy, D. L., Novak, N., Boomsma, D. I. & 23andMe Research Team, Dec 2017, In : Nature Genetics. 49, 12, p. 1752-1757 6 p.

Research output: Contribution to JournalArticle

Short communication: Genetic association between schizophrenia and cannabis use

Verweij, C. J. H., Abdellaoui, A., Nivard, M. G., Sainz Cort, A., Ligthart, L., Draisma, H. H. M., Minica, C. C., International Cannabis Consortium, Willemsen, G., Hottenga, J. J., Boomsma, D. I. & Vink, J. M., 1 Feb 2017, In : Drug and Alcohol Dependence. 171, p. 117-121 5 p.

Research output: Contribution to JournalArticle

Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile

McArtor, D. B., Lin, B. D., Hottenga, J-J., Boomsma, D. I., Willemsen, G. & Lubke, G. H., 1 Jun 2017, In : Biomarkers in medicine. 11, 6, p. 427-438 12 p.

Research output: Contribution to JournalArticle

2016

A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration

de Vries, P. S., Chasman, D. I., Sabater-Lleal, M., Chen, M. H., Huffman, J. E., Steri, M., Tang, W., Teumer, A., Marioni, R. E., Grossmann, V., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Cucca, F., Tracy, R., Watkins, H., Reiner, A. P., Folsom, A. R., Ridker, P. M. & 4 others, O'Donnell, C. J., Smith, N. L., Strachan, D. P. & Dehghan, A., 2016, In : Human Molecular Genetics. 25, 2, p. 358-370

Research output: Contribution to JournalArticle

Open Access
Open Access

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., de Geus, E. J. C., Hottenga, J. J., Penninx, B. W. J. H., Willemsen, G., Boomsma, D. I., McCarthy, M. I., North, K. E., O'Connell, J. R., Schlessinger, D., Thorsteinsdottir, U. & 5 others, Strachan, D. P., Frayling, T. M., Hirschhorn, J. N., Müller-Nurasyid, M. & Loos, R. J. F., 2016, In : Nature Communications. 7, 13357.

Research output: Contribution to JournalArticle

Open Access

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Quteineh, L., Preisig, M., Rivera, M., Milaneschi, Y., Castelao, E., Gholam-Rezaee, M., Vandenberghe, F., Saigi-Morgui, N., Delacrétaz, A., Cardinaux, J. R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Ching-López, A., Conus, P. & Eap, C. B., 2016, In : Journal of Affective Disorders. 198, p. 43-49

Research output: Contribution to JournalArticle

Associations between smoking and caffeine consumption in two European cohorts

Treur, J. L., Taylor, A. E., Ware, J. J., McMahon, G., Hottenga, J. J., Baselmans, B. M. L., Willemsen, G., Boomsma, D. I., Munafò, M. & Vink, J. M., 2016, In : Addiction. 111, 6, p. 1059-1068

Research output: Contribution to JournalArticle

Open Access

Blood lipids influence DNA methylation in circulating cells

Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., Van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G. & 14 others, Zhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 2016, In : Genome Biology. 17, 138, p. 1-12

Research output: Contribution to JournalArticle

Open Access

Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study

Lin, B., Hottenga, J. J., Abdellaoui, A., Dolan, C. V., de Geus, E. J. C., Kluft, C., Boomsma, D. I. & Willemsen, G., 2016, In : Biomarkers in medicine. 10, 10, p. 1061-1072

Research output: Contribution to JournalArticle

Open Access

Gene expression in major depressive disorder.

Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F. & 2 others, Sun, W. & Sullivan, P. F., 2016, In : Molecular Psychiatry. 21, p. 339 347 p.

Research output: Contribution to JournalArticle

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Silventoinen, K., Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Honda, C., Hjelmborg, J., Möller, S., Ooki, S., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K. J., Jang, K. L., Cozen, W., Hwang, A. E. & 84 others, Mack, T. M., Gao, W., Yu, C., Li, L., Corley, R. P., Huibregtse, B. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Heikkilä, K., Wardle, J., Llewellyn, C. H., Fisher, A., McAdams, T. A., Eley, T. C., Gregory, A. M., He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Stazi, M. A., Fagnani, C., D'Ippolito, C., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Silberg, J. L., Eaves, L. J., Maes, H. H., Krueger, R. F., McGue, M., Pahlen, S., Gatz, M., Butler, D. A., Bartels, M., van Beijsterveldt, C. E. M., Craig, J. M., Saffery, R., Freitas, D. L., Maia, J. A., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N. G., Medland, S. E., Montgomery, G. W., Chong, Y., Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Tynelius, P., Lichtenstein, P., Haworth, C. M. A., Plomin, R., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Öncel, S. Y., Aliev, F., Spector, T. D., Mangino, M., Lachance, G., Baker, L. A., Tuvblad, C., Duncan, G. E., Buchwald, D., Willemsen, G., Rasmussen, F., Goldberg, J. H., Sørensen, T. I. A., Boomsma, D. I. & Kaprio, J., 2016, In : American Journal of Clinical Nutrition. 104, 2, p. 371-379

Research output: Contribution to JournalArticle

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J. J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., Pool, R., Suchiman, H. E. D., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E. & Boomsma, D. I., 2016, In : Nature Communications. 7, 11115, p. 1-13 11115.

Research output: Contribution to JournalArticle

Open Access

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Jelenkovic, A., Hur, Y. M., Sund, R., Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F. V., Tan, Q., Zhang, D., Pang, Z., Aaltonen, S., Heikkilä, K., Öncel, S. Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., Skytthe, A. & 79 others, Kyvik, K. O., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Cozen, W., Hwang, A. E., Mack, T. M., Sung, J., Song, Y. M., Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. U., Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T. D., Mangino, M., Lachance, G., Bartels, M., van Beijsterveldt, C. E. M., Willemsen, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Sevenius Nilsen, T., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Hjelmborg, J., Goldberg, J. H., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B. M., Boomsma, D. I., Sørensen, T. I. A., Kaprio, J. & Silventoinen, K., 2016, In : eLife. 5, e20320.

Research output: Contribution to JournalArticle

Open Access

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Hjelmborg, J., Möller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., Aaltonen, S., Stazi, M. A., Fagnani, C., D'Ippolito, C., Freitas, D. L., Antonio Maia, D., Ji, F., Ning, F., Pang, Z., Rebato, E. & 83 others, Busjahn, A., Kandler, C., Saudino, K. J., Jang, K. L., Cozen, W., Hwang, A. E., Mack, T. M., Gao, W., Yu, C., Li, L., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Heikkilä, K., Wardle, J., Llewellyn, C. H., Fisher, A., McAdams, T. A., Eley, T. C., Gregory, A. M., He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Silberg, J. L., Eaves, L. J., Maes, H. H., Krueger, R. F., McGue, M., Pahlen, S., Gatz, M., Butler, D. A., Bartels, M., van Beijsterveldt, C. E. M., Craig, J. M., Saffery, R., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N. G., Medland, S. E., Montgomery, G. W., Swan, G. E., Krasnow, R., Tynelius, P., Lichtenstein, P., Haworth, C. M. A., Plomin, R., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Spector, T. D., Mangino, M., Lachance, G., Baker, L. A., Tuvblad, C., Duncan, G. E., Buchwald, D., Willemsen, G., Skytthe, A., Kyvik, K. O., Christensen, K., Öncel, S. Y., Aliev, F., Rasmussen, F., Goldberg, J. H., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J. & Silventoinen, K., 2016, In : Scientific Reports. 6, p. 1-13 28496.

Research output: Contribution to JournalArticle

Open Access

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, V., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., de Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Davey Smith, G., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., 2016, In : JAMA. 315, 11, p. 1129-1140

Research output: Contribution to JournalArticle

Open Access

Genetic variants in RBFOX3 are associated with sleep latency

Amin, N., Allebrandt, K. V., Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, M. F., Byrne, E. M., Oole, E., Kolcic, I., Chen, T., Evans, D. S., Coresh, J., Vogelzangs, N. & 55 others, Karjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C. G. N., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H. E., Müller-Nurasyid, M., Fehrmann, R. S. N., Montgomery, G. W., Hofman, A., Hong, W., Kao, L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van Ijcken, W. F. J., Penninx, B. W. J. H., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., 2016, In : European Journal of Human Genetics. 24, 10, p. 1488-1495

Research output: Contribution to JournalArticle

Genetic variants linked to education predict longevity.

Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Abdellaoui, A., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D. C., Campbell, A., Wilson, J. F. & 6 others, Hayward, C., Esko, T., Porteous, D. J., Gale, C. R., Deary, I. J. & de Vlaming, R., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, p. 13366-13371 47.

Research output: Contribution to JournalArticle

Open Access

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., Zondervan, K. T., Stefansson, K., Krueger, R. F., Lee, J. J., Benjamin, D. J. & 5 others, Cesarini, D., Koellinger, P. D., den Hoed, M. A. H., Snieder, H. & Mills, M. C., 2016, In : Nature Genetics. 48, 12, p. 1462-1472

Research output: Contribution to JournalArticle

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., Hottenga, J. J., Rahmioglu, N., Nyholt, DR., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Frayling, T. M., Davey Smith, G., Morris, A. P. & 7 others, Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., 2016, In : Nature. 538, 7624, p. 248-252

Research output: Contribution to JournalArticle

Genome-wide association study identifies 74 loci associated with educational attainment

Okbay, A., Beauchamp, J., Fontana, M. A., Lee, J. J., Pers, T. H., Rietveld, C. A., Turley, P., Chen, G. B., Emilsson, V., Meddens, S. F. W., de Vlaming, R., Abdellaoui, A., Peyrot, W., Vinkhuyzen, A. A. E., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Laibson, D., Medland, S. E. & 8 others, Meyer, M. N., Yang, J., Johannesson, M., Visscher, P. M., Esko, T., Koellinger, P. D., Cesarini, D. & Benjamin, D. J., 2016, In : Nature. 533, 7604, p. 539-542

Research output: Contribution to JournalArticle

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

Ware, J. J., Chen, X., Vink, J. M., Loukola, A., Minica, C. C., Pool, R., Milaneschi, Y., Mangino, M., Menni, C., Chen, J., Peterson, R. E., Auro, K., Lyytikäinen, L. P., Wedenoja, J., Stiby, A. I., Hemani, G., Willemsen, G., Hottenga, J. J., Korhonen, T., Heliövaara, M. & 18 others, Perola, M., Rose, R. J., Paternoster, L., Timpson, N., Wassenaar, C. A., Zhu, A. Z. X., Davey Smith, G., Raitakari, O. T., Lehtimäki, T., Kähönen, M., Koskinen, S., Spector, T. D., Penninx, B. W. J. H., Salomaa, V., Boomsma, D. I., Tyndale, R. F., Kaprio, J. & Munafò, M., 2016, In : Scientific Reports. 6, 20092, 20092.

Research output: Contribution to JournalArticle

Open Access

Genome-wide pleiotropy of adult aggression and blood metabolites

Hagenbeek, F. A., Nivard, M. G., Pool, R., van Dongen, J., Hottenga, J. J., Abdellaoui, A., Willemsen, G., Vink, J. M., Ligthart, L., Harms, A., Hankemeier, T., Bartels, M. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 6, p. 772-816

Research output: Contribution to JournalMeeting Abstract

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, J., Demirkan, A., Würtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A. A. M., Kangas, A. J., Lyytikäinen, L. P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 others, Deelen, J., Willems van Dijk, K., Esko, T., Hottenga, J. J., van Leeuwen, E. M., Lehtimäki, T., Mihailov, E., Rose, R. J., de Craen, A. J., Gieger, C., Kähönen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Järvelin, M. R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., 2016, In : Nature Communications. 7, 11122.

Research output: Contribution to JournalArticle

Open Access

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

Spjuth, O., Krestyaninova, M., Hastings, J., Shen, H. Y., Heikkinen, J., Waldenberger, M., Langhammer, A., Ladenvall, C., Esko, T., Persson, M. Å., Heggland, J., Dietrich, J., Ose, S., Gieger, C., Ried, J. S., Peters, A., Fortier, I., de Geus, E. J. C., Klovins, J., Zaharenko, L. & 16 others, Willemsen, G., Hottenga, J. J., Litton, J. E., Karvanen, J., Boomsma, D. I., Groop, L., Rung, J., Palmgren, J., Pedersen, N. L., McCarthy, M. I., van Duijn, C. M., Hveem, K., Metspalu, A., Ripatti, S., Prokopenko, I. & Harris, J. R., 2016, In : European Journal of Human Genetics. 24, 4, p. 521-528

Research output: Contribution to JournalArticle

Open Access

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs

Hodkinson, E. C., Neijts, M., Sadrieh, A., Imtiaz, M. S., Baumert, M., Subbiah, R. N., Hayward, C. S., Boomsma, D. I., Willemsen, G., Vandenberg, J. I., Hill, A. P. & de Geus, E. J. C., 2016, In : Frontiers in Physiology. 7, 154

Research output: Contribution to JournalArticle

Open Access

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Mbarek, H., Steinberg, S., Nyholt, DR., Gordon, S. D., Miller, M. B., McRae, A. F., Hottenga, J. J., Day, F. R., Willemsen, G., de Geus, E. J. C., Davies, G. E., Martin, H. C., Penninx, B. W. J. H., Jansen, R., McAloney, K., Vink, J. M., Kaprio, J., Plomin, R., Spector, T. D., Magnusson, P. K. & 17 others, Reversade, B., Harris, R. A., Aagaard, K., Kristjansson, R. P., Olafsson, I., Eyjolfsson, G. I., Sigurdardottir, O., Iacono, W. G., Lambalk, C. B., Montgomery, G. W., McGue, M., Ong, K. K., Perry, J. R. B., Martin, N. G., Stefansson, H., Stefansson, K. & Boomsma, D. I., 2016, In : American Journal of Human Genetics. 98, 5, p. 898-908

Research output: Contribution to JournalArticle

Open Access
Open Access

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E. & 78 others, Lyytikäinen, L. P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyi, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S. T., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J., den Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kähönen, M., Lehtimäki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M. A., Ripatti, S., Willems van Dijk, K., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A. & van Duijn, C. M., 2016, In : Journal of Medical Genetics. 53, 7, p. 441-449

Research output: Contribution to JournalArticle

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Polygenic dissection of major depression clinical heterogeneity

Milaneschi, Y., Winkelman, F., Peyrot, W., Abdellaoui, A., Willemsen, G., Hottenga, J. J., Jansen, R., Mbarek, H., Dehghan, A., Lu, C., Boomsma, D. I. & Penninx, B. W. J. H., 2016, In : Molecular Psychiatry. 21, 4, p. 516-522

Research output: Contribution to JournalArticle

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Zanoni, P., Khetarpal, S. A., Larach, D. B., Hancock-Cerutti, W. F., Millar, J. S., Cuchel, M., DerOhannessian, S., Kontush, A., Surendran, P., Saleheen, D., Trompet, S., Jukema, J. W., Craen, A. J. M., Deloukas, P., Sattar, N., Ford, I., Packard, C., Majumder, A., Alam, D. S., Di Angelantonio, E. & 31 others, Abecasis, G., Chowdhury, R., Erdmann, J., Nordestgaard, B. G., Nielsen, S. F., Tybjærg-Hansen, A., Schmidt, R. F., Kuulasmaa, K., Liu, D. J., Perola, M., Blankenberg, S., Salomaa, V., Männistö, S., Amouyel, P., Arveiler, D., Ferrières, J., Müller-Nurasyid, M., Ferrario, M. M., Kee, F., Willer, C. J., Samani, N., Schunkert, H., Butterworth, A. S., Howson, J. M., Peloso, G. M., Stitziel, N. O., Danesh, J., Kathiresan, S., Rader, D. J., Willemsen, G. & Boomsma, D. I., 2016, In : Science. 351, 6278, p. 1166-1171

Research output: Contribution to JournalArticle

Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology

Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. & Middeldorp, C. M., 2016, In : European Psychiatry. 2016 Apr, 34, p. 49-55 6 p.

Research output: Contribution to JournalArticle

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The genetic architecture of body mass index from infancy to adulthood modified by parental education

Silventoinen, K., Huppertz, C., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G. & Boomsma, D. I., 2016, In : Obesity. 24, 9, p. 2004-2011

Research output: Contribution to JournalArticle

The Genetic Overlap Between Hair and Eye Color

Lin, B., Willemsen, G., Abdellaoui, A., Bartels, M., Ehli, E. A., Davies, G. E., Boomsma, D. I. & Hottenga, J. J., 2016, In : Twin Research and Human Genetics. 19, 6, p. 595-599

Research output: Contribution to JournalArticle

Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Yokoyama, Y., Jelenkovic, A., Sund, R., Sung, J., Hopper, J. L., Ooki, S., Heikkilä, K., Aaltonen, S., Tarnoki, A. D., Tarnoki, D. L., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Saudino, K. J., Cutler, T. L., Nelson, T. L., Whitfield, K. E., Wardle, J., Llewellyn, C. H., Fisher, A. & 48 others, He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Song, Y. M., Yang, S., Lee, K., Jeong, H. U., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Harris, J. R., Brandt, I., Sevenius Nilsen, T., Craig, J. M., Saffery, R., Ji, F., Ning, F., Pang, Z., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N. G., Medland, S. E., Montgomery, G. W., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Tynelius, P., Haworth, C. M. A., Plomin, R., Rebato, E., Rose, R. J., Goldberg, J. H., Rasmussen, F., Hur, Y. M., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J. & Silventoinen, K., 2016, In : Twin Research and Human Genetics. 19, 2, p. 112-124

Research output: Contribution to JournalArticle

Open Access
2015

A fluid response: Alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate

Nagy, T., van Lien, R., Willemsen, G., Proctor, G., Efting, M., Fülöp, M., Bárdos, G., Veerman, E. C. & Bosch, JA., 2015, In : Biological Psychology. 109, p. 111-119 9 p.

Research output: Contribution to JournalArticle

Ambulatory measurement of the ECG T-wave amplitude

van Lien, R., Neijts, M., Willemsen, G. & de Geus, E. J. C., 2015, In : Psychophysiology. 52, 2, p. 225-237 13 p.

Research output: Contribution to JournalArticle

Open Access

CNV Concordance in 1,097 MZ Twin Pairs

Abdellaoui, A., Ehli, E. A., Hottenga, J. J., Weber, Z., Mbarek, H., Willemsen, G., van Beijsterveldt, C. E. M., Brooks, A., Hudziak, J. J., Sullivan, P. F., de Geus, E. J. C., Davies, G. E. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 1, p. 1-12 12 p.

Research output: Contribution to JournalArticle

Directional dominance on stature and cognition in diverse human populations

Joshi, P. K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A. U., Schurmann, C., Smith, A. V., Zhang, W., Okada, Y., Stancáková, A., Faul, J. D., Zhao, W., Bartz, T. M., Pina Concas, M., Franceschini, N., Enroth, S., Vitart, V., Trompet, S. & 338 others, Guo, X., Chasman, D. I., O'Connel, J. R., Corre, T., Nongmaithem, S. S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A-E., Kacprowski, T., Bjonnes, A., Spek, A., Wu, Y., Giri, A. K., Yanek, L. R., Wang, L., Hofer, E., Rietveld, C. A., McLeod, O., Cornelis, M. C., Pattaro, C., Verweij, N., Baumbach, C., Abdellaoui, A., Warren, H. R., Vuckovic, D., Mei, H., Bouchard, C., Perry, J. R. B., Cappellani, S., Mirza, S. S., Benton, M. C., Broeckel, U., Medland, S. E., Lind, P. A., Malerba, G., Drong, A., Yengo, L., Bielak, L. F., Zhi, D., van der Most, P. J., Shriner, D., Mägi, R., Hemani, G., Karaderi, T., Wang, Z., Liu, T., Demuth, I., Zhao, J. H., Meng, W., Lataniotis, L., van der Laan, S. W., Brafdfield, J. P., Wood, A. R., Bonnefond, A., Ahluwalia, T. S., Hall, L. M., Salvi, E., Yazar, S., Carstensen, L., de Haan, H. G., Abney, M., Afzal, U., Allison, M. A., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Barr, R. G., Baumeister, S. E., Benjamin, D. J., Bergmann, S., Boerwinkle, E., Bottinger, E. P., Campbell, A., Chakravarti, A., Chan, Y., Chanock, S. J., Chen, C., Chen, Y. D. I., Colins, F. S., Connell, J., Correa, A., Cupples, L. A., Davey Smith, G., Davies, G., Dörr, M., Ehret, G., Ellis, S. B., Feenstra, B., Feitosa, M. F., Ford, I., Fox, C. S., Frayling, T. M., Friedrich, N., Geller, F., Gillham-Nasenya, I., Gottesman, O., Graff, M., Grodstein, F., Gu, C., Haley, C., Hammond, C. J., Harris, S. E., Harris, T. B., Hastie, N. D., Heard-Costa, N. L., Heikkilä, K., Hocking, L. J., Homuth, G., Hottenga, J. J., Huang, J., Huffman, J. E., Hysi, P. G., Arfan Ikram, M., Ingelsson, E., Joensuu, A., Johansson, A., Jousilahti, P., Jukema, J. W., Kähönen, M., Kamatani, Y., Kanoni, S., Kerr, S. M., Khan, N. M., Koellinger, P., Koistinen, H. A., Kooner, M. K., Kubo, M., Kuusisto, J., Lahti, J., Launer, L. J., Lea, R. A., Lehne, B., Lehtimäki, T., Liewald, D. C. M., Lind, L., Loh, M., Lokki, M. L., London, S. J., Loomis, S. J., Loukola, A., Lu, Y., Lumley, T., Lundqvist, A., Männistö, S., Marques-Vidal, P., Masciullo, C., Matchan, A., Mathias, R. A., Matsuda, K., Meigs, J. B., Meisinger, C., Meitinger, T., Menni, C., Mentch, F. D., Mihailov, E., Milani, L., Montasser, M. E., Montgomery, G. W., Morrison, A., Myers, R. H., Nadukuru, R., Navarro, P., Nelis, M., Nieminen, M. S., Nolte, I. M., O'Connor, G. T., Ogunniyi, A., Padmanabhan, S., Palmas, W. R., Pankow, J. S., Patarcic, I., Pavani, F., Peyser, P. A., Pietilainen, K. H., Poulter, N., Prokopenko, I., Ralhan, S., Redmond, P., Rich, S. S., Rissanen, H., Robino, A., Rose, L. M., Rose, R., Sala, C., Salako, B., Salomaa, V., Sarin, A-P., Saxena, R., Schmidt, H., Scott, L. J., Scott, W. R., Sennblad, B., Seshadri, S., Sever, P., Shrestha, S., Smith, B. H., Smith, J. A., Soranzo, N., Sotoodehnia, N., Southam, L., Stanton, A. V., Stathopoulou, M. G., Strauch, K., Strawbridge, R. J., Suderman, M. J., Tandon, N., Tang, S. T., Taylor, K. D., Tayo, B. O., Töglhofer, A. M., Tomaszewski, M., Tsernikova, N., Tuomilehto, J., Uitterlinden, A. G., Vaidya, D., Hylckama Vlieg, A., van Setten, J., Vasankari, T., Vedantam, S., Vlachopoulou, E., Vozzi, D., Vuoksimaa, E., Waldenberger, M., Ware, E. B., Wentworth-Shields, W., Whitfield, J. B., Wild, S., Willemsen, G., Yajnik, C. S., Yao, J., Zaza, G., Zhu, X., Salem, R. M., Melbye, M., Bisgaard, H., Samani, N. J., Cusi, D., Mackey, D. A., Cooper, R. S., Froguel, P., Pasterkamp, G., Grant, S. F. A., Hakonarson, H., Ferrucci, L., Scott, R. A., Morris, A. D., Palmer, C. N. A., Dedoussis, G., Deloukas, P., Bertram, L., Lindenberger, U., Berndt, S. I., Lindgren, C. M., Timpson, N. J., Tönjes, A., Munroe, P. B., Sorensen, T. I. A., Rotimi, C. N., Arnett, D. K., Oldehinkel, A. J., Kardia, S. L. R., Balkau, B., Gambaro, G., Morris, A. P., Eriksson, J. G., Wright, M. J., Martin, N. G., Hunt, S. C., Starr, J. M., Deary, I. J., Griffiths, L. R., Tiemeier, H., Pirastu, N., Kaprio, J., Wareham, N. J., Pérusse, L., Wilson, J. G., Girotto, G., Caulfield, M. J., Raitakari, O., Boomsma, D. I., Gieger, C., van der Harst, P., Hicks, A. A., Kraft, P., Sinisalo, J., Knekt, P., Johannesson, M., Magnusson, P. K. E., Hamsten, A., Schmidt, R., Borecki, I. B., Vartiainen, E., Becker, D. M., Bharadwaj, D., Mohlke, K. L., Boehnke, M., van Duijn, C. M., Sanghera, D. K., Teumer, A., Zeggini, E., Metspalu, A., Gasparini, P., Ulivi, S., Ober, C., Toniolo, D., Rudan, I., Porteous, D. J., Ciullo, M., Spector, T. D., Hayward, C., Dupuis, J., Loos, R. J. F., Wright, A. F., Chandak, G. R., Vollenweider, P., Shuldiner, A. R., Ridker, P. M., Rotter, J. I., Sattar, N., Gyllensten, U., North, K. E., Pirastu, M., Psaty, B. M., Weir, D. R., Laakso, M., Gudnason, V., Takahashi, A., Chambers, J. C., Kooner, J. S., Strachan, D. P., Campbell, H., Hirschhorn, J. N., Perola, M., Polasek, O. & Wilson, J. F., 2015, In : Nature. 523, 7561, p. 459-462 4 p.

Research output: Contribution to JournalArticle

Open Access

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High- Density Imputation

Horikoshi, M., Mägi, R., van de Bunt, M., Surakka, I., Sarin, A-P., Mahajan, A., Marullo, L., Thorleifsson, G., Hägg, S., Hottenga, J. J., Ladenvall, C., Ried, J. S., Winkler, T. W., Willems, S. M., Pervjakova, N., Esko, T., Beekman, M., Nelson, C. P., Willenborg, C., Wiltshire, S. & 62 others, Ferreira, T., Fernandez, J., Gaulton, K. J., Steinthorsdottir, V., Hamsten, A., Magnusson, P. K. E., Willemsen, G., Milaneschi, Y., Robertson, N. R., Groves, C. J., Bennett, A. J., Lehtimäki, T., Viikari, J. S., Rung, J., Lyssenko, V., Perola, M., Heid, I. M., Herder, C., Grallert, H., Müller-Nurasyid, M., Roden, M., Hypponen, E., Isaacs, A., van Leeuwen, E. M., Karssen, L. C., Mihailov, E., Houwing-Duistermaat, J. J., de Craen, A. J., Deelen, J., Havulinna, A. S., Blades, M., Hengstenberg, C., Erdmann, J., Schunkert, H., Kaprio, J., Tobin, M. D., Samani, N. J., Lind, L., Salomaa, V., Lindgren, C. M., Slagboom, P. E., Metspalu, A., van Duijn, C. M., Eriksson, J. G., Peters, A., Gieger, C., Jula, A., Groop, L., Raitakari, O. T., Power, C., Penninx, B. W. J. H., de Geus, E. J. C., Smit, J. H., Boomsma, D. I., Pedersen, N. L., Ingelsson, E., Thorsteinsdottir, U., Stefansson, K., Ripatti, S., Prokopenko, I., McCarthy, M. I. & Morris, A. P., 2015, In : PLoS Genetics. 11, 7, 24 p., e1005230.

Research output: Contribution to JournalArticle

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DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

Tsai, P. C., van Dongen, J., Tan, Q., Willemsen, G., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M. & Bell, J. T., 2015, In : Twin Research and Human Genetics. 18, 6, p. 635-646 12 p.

Research output: Contribution to JournalArticle

DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

Oh, G., Wang, S. C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., Mill, J., Gunasinghe, C., Tackett, J. L., Gottesman, I. I., Willemsen, G., de Geus, E. J. C., Vink, J. M., Slagboom, P. E., Wray, N. R., Heath, A. C. & 7 others, Montgomery, G. W., Turecki, G., Martin, N. G., Boomsma, D. I., McGuffin, P., Kustra, R. & Petronis, A., 2015, In : Biological Psychiatry. 77, 3, p. 246-255 10 p.

Research output: Contribution to JournalArticle

Open Access

Educational Attainment Influences Levels of Homozygosity through Migration and Assortative Mating

Abdellaoui, A., Hottenga, J. J., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Brooks, A., Sullivan, P. F., Penninx, B. W. J. H., de Geus, E. J. C. & Boomsma, D. I., 2015, In : PLoS ONE. 10, 3, 14 p., e0118935.

Research output: Contribution to JournalArticle

Open Access

Effect of Genome and Environment on Metabolic and Inflammatory Profiles

Sirota, M., Willemsen, G., Sundar, P., Pitts, S. J., Potluri, S., Prifti, E., Kennedy, S. H., Ehrlich, S. D., Neuteboom, J., Kluft, C., Malone, K. E., Cox, D. R., de Geus, E. J. C. & Boomsma, D. I., 2015, In : PLoS ONE. 10, 4, p. e0120898 19 p., e0120898.

Research output: Contribution to JournalArticle

Open Access

Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes

Xu, T., Brandmaier, S., Messias, A. C., Herder, C., Draisma, H. H. M., Demirkan, A., Yu, Z., Ried, J. S., Haller, T., Heier, M., Campillos, M., Fobo, G., Stark, R., Holzapfel, C., Adam, J., Chi, S., Rotter, M., Panni, T., Quante, A. S., He, Y. & 28 others, Prehn, C., Roemisch-Margl, W., Kastenmüller, G., Willemsen, G., Pool, R., Kasa, K., Willems van Dijk, K., Hankemeier, T., Meisinger, C., Thorand, B., Ruepp, A., Hrabé de Angelis, M., Li, Y., Wichmann, H-E., Stratmann, B., Strauch, K., Metspalu, A., Gieger, C., Suhre, K., Adamski, J., Illig, T., Rathmann, W., Roden, M., Peters, A., van Duijn, C. M., Boomsma, D. I., Meitinger, T. & Wang-Sattler, R., 2015, In : Diabetes Care. 38, 10, p. 1858-1867 10 p.

Research output: Contribution to JournalArticle

Genetic and Environmental Contributions to Stability in Adult Obsessive Compulsive Behavior

Rodrigues Zilhao Nogueira, N., Smit, D. J. A., den Braber, A., Dolan, C. V., Willemsen, G., Boomsma, D. I. & Cath, D. C., 2015, In : Twin Research and Human Genetics. 18, 1, p. 52-60 9 p.

Research output: Contribution to JournalArticle

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., Altmann, A., Trümbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C. E., Drabant Conley, E., Boomsma, D. I. & 10 others, Penninx, B. W. J. H., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Smit, J. H., Ruepp, A., Müller-Myhsok, B., Hariri, A. & Binder, E. B., 2015, In : Neuron. 86, p. 1189-1202 15 p.

Research output: Contribution to JournalArticle

Open Access