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  • A.H.M. Willemsen
2015

Genetic studies of body mass index yield new insights for obesity biology

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Maegi, R., Randall, J. C., Winkler, T. W. & 461 others, Wood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Zhao, J. H., Zhao, W., Chen, J., Fehrmann, R., Hedman, A. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, L., Buyske, S., Demirkan, A., Deng, G., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Goel, A., Gong, J., Jackson, A. U., Kanoni, S., Kleber, M. E., Kristiansson, K., Lim, U., Lotay, V., Mangino, M., Leach, I. M., Medina-Gomez, C., Medland, S. E., Nalls, M. A., Palmer, C. D., Pasko, D., Pechlivanis, S., Peters, MJ., Prokopenko, I., Shungin, D., Stancakova, A., Strawbridge, R. J., Sung, Y. J., Teumer, A., Trompet, S., van der Laan, S. W., van Settee, J., Van Vliet-Ostaptchouk, J. V., Wang, Z., Yengo, L., Zhang, W., Isaacs, A., Albrecht, E., Arnlov, J., Arscott, G. M., Attwood, A. P., Bandinelli, S., Barrett, A., Bas, I. N., Bellis, C., Bennett, A. J., Berne, C., Blagieva, R., Blueher, M., Bohringer, S., Bonnycastle, L. L., Boettcher, Y., Boyd, H. A., Bruinenberg, M., Caspersen, I. H., Chen, Y. I., Clarke, R., Daw, E. W., de Craen, A. J. M., Delgado, G., Dimitriou, M., Doney, A. S. F., Eklund, N., Estrada, K., Eury, E., Folkersen, L., Fraser, R. M., Garcia, M. E., Geller, F., Giedraitis, V., Gigante, B., Go, A. S., Golay, A., Goodall, A. H., Gordon, S. D., Gorski, M., Grabe, H., Grallert, H., Grammer, T. B., Graessler, J., Gronberg, H., Groves, C. J., Gusto, G., Haessler, J., Hall, P., Haller, T., Hallmans, G., Hartman, C. A., Hassinen, M., Hayward, C., Heard-Costa, N. L., Helmer, Q., Hengstenberg, C., Holmen, O., Hottenga, J. J., James, A. L., Jeff, J. M., Johansson, A., Jolley, J., Juliusdottir, T., Kinnunen, L., Koenig, W., Koskenvuo, M., Kratzer, W., Laitinen, J., Lamina, C., Leander, K., Lee, N. R., Lichtner, P., Lind, L., Lindstrom, J., Lo, K. S., Lobbens, S., Lorbeer, R., Lu, Y., Mach, F., Magnusson, P. K. E., Mahajan, A., McArdle, W. L., McLachlan, S., Menni, C., Merger, S., Mihailov, E., Milani, L., Moayyeri, A., Monda, K. L., Morken, M. A., Mulas, A., Mueller, G., Mueller-Nurasyid, M., Musk, A. W., Nagaraja, R., Noethen, M. M., Nolte, I. M., Pilz, S., Rayner, N. W., Renstrom, F., Rettig, R., Ried, J. S., Ripke, S., Robertson, N. R., Rose, L. M., Sanna, S., Scharnagl, H., Scholtens, S., Schumacher, F. R., Scott, W. R., Seufferlein, T., Shi, J., Smith, A. V., Smolonska, J., Stanton, A. V., Steinthorsdottir, V., Stirrups, K., Stringham, H. M., Sundstrom, J., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Tayo, B. O., Thorand, B., Thorleifsson, G., Tyrer, J. P., Uh, H., Vandenput, L., Verhulst, F. C., Vermeulen, S. H., Verweij, N., Vonk, J. M., Waite, L. L., Warren, H. R., Waterworth, D., Weedon, M. N., Wilkens, L. R., Willenborg, C., Wilsgaard, T., Wojczynski, M. K., Wong, A., Wrightl, A. F., Zhang, Q., Brennan, E. P., Choi, M., Dastani, Z., Drong, A. W., Eriksson, P., Franco-Cereceda, A., Gadin, J. R., Gharavi, A. G., Goddard, M. E., Handsaker, R. E., Huang, J., Karpe, F., Kathiresan, S., Keildson, S., Kiryluk, K., Kubo, M., Lee, J., Liang, L., Lifton, R. P., Ma, B., McCarroll, S. A., McKnight, A. J., Min, J. L., Moffatt, M. F., Montgomery, G. W., Murabito, J. M., Nicholson, G., Nyholt, DR., Okada, Y., Perry, J. R. B., Dorajoo, R., Reinmaa, E., Salem, R. M., Sandholm, N., Scott, R. A., Stolk, L., Takahashi, A., Tanaka, T., van 't Hooft, F. M., Vinkhuyzen, A. A. E., Westra, H., Zheng, W., Zondervan, K. T., Heath, A. C., Arveiler, D., Bakker, S. J. L., Beilby, J., Bergman, R. N., Blangero, J., Bovet, P., Campbell, H., Caulfield, M. J., Cesana, G., Chakravarti, A., Chasman, D. I., Chines, P. S., Collins, F. S., Crawford, D. C., Cupples, L. A., Cusi, D., Danesh, J., de Faire, U., den Ruijter, H. M., Dominiczak, A. F., Erbel, R., Erdmann, J., Eriksson, J. G., Farrall, M., Felix, S. B., Ferrannini, E., Ferrieres, J., Ford, I., Forouhi, N. G., Forrester, T., Franco, O. H., Gansevoort, R. T., Gejman, P. V., Gieger, C., Gottesman, O., Gudnason, V., Gyllensten, U., Hall, A. S., Harris, T. B., Hattersley, A. T., Hicks, A. A., Hindorff, L. A., Hingorani, A. D., Hofman, A., Homuth, G., Hovingh, G. K., Humphries, S. E., Hunt, S. C., Hypponen, E., Illig, T., Jacobs, K. B., Jarvelin, M., Joeckel, K., Johansen, B., Jousilahti, P., Jukema, J. W., Jula, A. M., Kaprio, J., Kastelein, J. J. P., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Knekt, P., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraja, A. T., Kumari, M., Kuusisto, J., Lakka, T. A., Langenberg, C., Le Marchand, L., Lehtimaki, T., Lyssenko, V., Mannisto, S., Marette, A., Matise, T. C., McKenzie, C. A., McKnight, B., Moll, F. L., Morris, A. D., Morris, A. P., Murray, J. C., Nelis, M., Ohlsson, C., Oldehinkel, A. J., Ong, K. K., Madden, P. A. F., Pasterkamp, G., Peden, J. F., Peters, A., Postma, D. S., Pramstaller, P. P., Price, J. F., Qi, L., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Ridker, P. M., Rioux, J. D., Ritchie, M. D., Rudan, I., Salomaa, V., Samani, N. J., Saramines, J., Sarzynski, M. A., Schunkert, H., Schwarz, P. E. H., Sever, P., Shuldiner, A. R., Sinisalo, J., Stolk, R. P., Strauch, K., Toenjes, A., Tregouet, D., Tremblay, A., Tremoli, E., Virtamo, J., Vohl, M., Voelker, U., Waeber, G., Willemsen, G., Witteman, J. C., Zillikens, M. C., Adair, L. S., Amouyel, P., Asselbergs, F. W., Assimes, T. L., Bochud, M., Boehm, B. O., Boerwinkle, E., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Cauchi, S., Chambers, J. C., Chanock, S. J., Cooper, R. S., de Bakker, P. I. W., Dedoussis, G., Ferrucci, L., Franks, P. W., Froguel, P., Groop, L. C., Haiman, C. A., Hamsten, A., Hui, J., Hunter, D. J., Hveem, K., Kaplan, R. C., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Martin, N. G., Maerz, W., Melbve, M., Metspalu, A., Moebus, S., Munroe, P. B., Njolstad, I., Oostra, B. A., Palmer, C. N. A., Pedersen, N. L., Perola, M., Perusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T. E., Saleheen, D., Sattar, N., Schadt, E. E., Schlessinger, D., Slagboom, P. E., Snieder, H., Spector, T. D., Thorsteinsdottir, U. R., Stumvoll, M., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Weir, D. R., Wichmann, H., Wilson, J. F., Zanen, P., Borecki, I. B., Deloukas, P., Fox, C. S., Heid, I. M., O'Connell, J. R., Strachan, D. P., Stefansson, K., van Duijri, C. M., Abecasis, G. R., Franke, L., Frayling, T. M., McCarthy, M. I., Visscher, P. M., Scherag, A., Willer, C. J., Boehnke, M., Mohlke, K. L., Lindgren, C. M., Beckmann, J. S., Barroso, I., North, K. E., Ingelsson, E., Hirschhorn, J. N., Loos, R. J. F. & Speliotes, E. K., 2015, In : Nature. 518, 7538, p. 197-206

Research output: Contribution to JournalArticle

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., Dijk, F. & 52 others, Willemsen, G., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J., Uh, H. W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Polasek, O., Vitart, V., Rudan, I., Wright, A. F., Rich, S. S., Psaty, B. M., Borecki, I. B., Kearney, P. M., Stott, D. J., Cupples, L. A., Jukema, J. W., van der Harst, P., Sijbrands, E. J., Hottenga, J. J., Uitterlinden, A. G., Swertz, M. A., van Ommen, G. J. B., Bakker, P. I. W., Slagboom, P. E., Boomsma, D. I., Wijmenga, C. & van Duijn, C. M., 2015, In : Nature Communications. 6, p. 6065 6 p., 6065.

Research output: Contribution to JournalArticle

Open Access

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A. K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J., van Leeuwen, E. M., Amin, N. & 28 others, Dharuri, H., Westra, H. J., Franke, L., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, DR., Whitfield, J. B., Penninx, B. W. J. H., Spector, T. D., Metspalu, A., Slagboom, P. E., Willems van Dijk, K., 't Hoen, P. A. C., Strauch, K., Martin, N. G., van Ommen, G. J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., van Duijn, C. M. & Boomsma, D. I., 2015, In : Nature Communications. 6, p. 7208 9 p., 7208.

Research output: Contribution to JournalArticle

Open Access

Genome-wide patterns and properties of de novo mutations in humans

Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I., van Duijn, C. M., Swertz, M. A., Wijmenga, C., van Ommen, G. J., Slagboom, P. E., Boomsma, D. I., Ye, K., Guryev, V., Arndt, P. F., Kloosterman, W. P., Bakker, P. I. W., Sunyaev, S. R., Dijk, F., Neerincx, P. B. T. & 68 others, Pulit, S. L., Deelen, P., Elbers, C. C., Palamara, P. F., Pe'er, I., Abdellaoui, A., van Oven, M., Vermaat, M., Li, M., Laros, J. F. J., Stoneking, M., de Knijff, P., Kayser, M., Veldink, J. H., Van den Berg, L. H., Byelas, H., den Dunnen, J. T., Dijkstra, M., Amin, N., van der Velde, K. J., Hottenga, J. J., van Setten, J., van Leeuwen, E. M., Kanterakis, A., Kattenberg, V. M., Karssen, L. C., van Schaik, B. D. C., Bot, J., Nijman, I. J., van Enckevort, D., Mei, H., Koval, V., Estrada, K., Medina-Gomez, C., Lameijer, E. W., Moed, M. H., Hehir-Kwa, J. Y., Handsaker, R. E., McCarroll, S. A., Vuzman, D., Sohail, M., Hormozdiari, F., Marschall, T., Schönhuth, A., Beekman, M., de Craen, A. J., Suchiman, H. E. D., Hofman, A., Oostra, B., Isaacs, A., Rivadeneira, F., Uitterlinden, A. G., Willemsen, G., Platteel, M., Pitts, S. J., Potluri, S., Sundar, P., Cox, D. R., Li, Q., Li, Y., Du, Y., Chen, R., Cao, H., Li, N., Cao, S., Wang, J., Bovenberg, J. A. & Brandsma, M., 2015, In : Nature Genetics. 47, 7, p. 822-826 5 p.

Research output: Contribution to JournalArticle

Open Access

Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium

Morris, R. W., Taylor, A. E., Fluharty, M. E., Bjorngaard, J. H., Asvold, B. O., Elvestad Gabrielsen, M., Campbell, A., Marioni, R., Kumari, M., Korhonen, T., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. S., Treur, J. L., Willemsen, G. & 42 others, Dale, C., Wannamethee, S. G., Lahti, J., Palotie, A., Räikkönen, K., McConnachie, A., Padmanabhan, S., Wong, A., Dalgard, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D. M., Kennedy, M. A., Nohr, E. A., Christiansen, L., Kyvik, K. O., Kuh, D., Watt, G., Eriksson, J. G., Whincup, P. H., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D., Linneberg, A., Ford, I., Jukema, J. W., Power, C., Hyppönen, E., Jarvelin, M. R., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Romundstad, P. R., Sørensen, T. I. A., Munafò, M. & Sattar, N., 2015, In : BMJ Open. 5, 8, p. e008808 10 p.

Research output: Contribution to JournalArticle

Open Access
Open Access

Heritability and Temporal Stability of Ambulatory Autonomic Stress Reactivity in Unstructured 24-Hour Recordings

Neijts, M., van Lien, R., Kupper, N., Boomsma, D. I., Willemsen, G. & de Geus, E. J. C., 2015, In : Psychosomatic Medicine. 77, 8, p. 870-881 12 p.

Research output: Contribution to JournalArticle

Heritability of liver enzyme levels estimated from genome-wide SNP data

van Beek, J. H. D. A., Lubke, G. H., de Moor, M. H. M., Willemsen, G., de Geus, E. J. C., Hottenga, J. J., Walters, R. K., Smit, J. H., Penninx, B. W. J. H. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 9, p. 1223-1228 6 p.

Research output: Contribution to JournalArticle

Open Access

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Maier, R., Moser, G., Chen, G. B., Ripke, S., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Coryell, W. H., Potash, J. B., Scheftner, W. A., Shi, J., Weissmann, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R. & 1 others, Lee, S. H., 2015, In : American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

Research output: Contribution to JournalArticle

Open Access

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., Stolk, L., Finucane, H. K., Sulem, P., Bulik-Sullivan, B. K., Esko, T., Johnson, A. D., Elks, C. E., Franceschini, N., He, C., Altmaier, E., Brody, J. A., Franke, L. L., Huffman, J. E., Keller, M. F. & 221 others, McArdle, P. F., Nutile, T., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Smith, J. A., Teumer, A., Traglia, M., Vuckovic, D., Yao, J., Zhao, W., Albrecht, E., Amin, N., Corre, T., Hottenga, J. J., Mangino, M., Smith, A. V., Tanaka, T., Abecasis, G. R., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Arndt, V., Arnold, A. M., Barbieri, C., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernstein, L., Bielinski, S. J., Blomqvist, C., Boerwinkle, E., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borresen-Dale, A. L., Boutin, T. S., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Campbell, A., Campbell, H., Chanock, S. J., Chapman, J. R., Ida Chen, Y. D., Chenevix-Trench, G., Couch, F. J., Coviello, A. D., Cox, A., Czene, K., Darabi, H., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dörk, T., dos-Santos-Silva, I., Dunning, A. M., Eicher, J. D., Fasching, P. A., Faul, J. D., Figueroa, J., Flesch-Janys, D., Gandin, I., Garcia, M. E., García-Closas, M., Giles, G. G., Girotto, G. G., Goldberg, M. S., González-Neira, A., Goodarzi, M. O., Grove, M. L., Gudbjartsson, D. F., Guénel, P., Guo, X., Haiman, C. A., Hall, P., Hamann, U., Henderson, B. E., Hocking, L. J., Hofman, A., Homuth, G., Hooning, M. J., Hopper, J. L., Hu, F. B., Huang, J., Humphreys, K., Hunter, D. J., Jakubowska, A., Jones, S. E., Kabisch, M., Karasik, D., Knight, J. A., Kolcic, I., Kooperberg, C., Kosma, V. M., Kriebel, J., Kristensen, V., Lambrechts, D., Langenberg, C., Li, J., Li, X., Lindström, S., Liu, Y., Luan, J., Lubinski, J., Mägi, R., Mannermaa, A., Manz, J., Margolin, S., Marten, J., Martin, N. G., Masciullo, C., Meindl, A., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Müller-Nurasyid, M., Nalls, M., Neale, B. M., Nevanlinna, H., Neven, P., Newman, A. B., Nordestgaard, B. G., Olson, J. E., Padmanabhan, S., Peterlongo, P., Peters, U., Petersmann, A., Peto, J., Pharoah, P. D. P., Pirastu, N. N., Pirie, A., Pistis, G., Polasek, O., Porteous, D., Psaty, B. M., Pylkäs, K., Radice, P., Raffel, L. J., Rivadeneira, F., Rudan, I., Rudolph, A., Ruggiero, D., Sala, C. F., Sanna, S., Sawyer, E. J., Schlessinger, D., Schmidt, M. K., Schmidt, F., Schmutzler, R. K., Schoemaker, M. J., Scott, R. A., Seynaeve, C. M., Simard, J., Sorice, R., Southey, M. C., Stöckl, D., Strauch, K., Swerdlow, A., Taylor, K. D., Thorsteinsdottir, U., Toland, A. E., Tomlinson, I., Truong, T., Tryggvadottir, L., Turner, S. T., Vozzi, D., Wang, Q., Wellons, M., Willemsen, G., Wilson, J. F., Winqvist, R., Wolffenbuttel, B. H. R., Wright, A. F., Yannoukakos, D., Zemunik, T., Zheng, W., Zygmunt, M., Bergmann, S., Boomsma, D. I., Buring, J. E., Ferrucci, L., Montgomery, G. W., Gudnason, V., Spector, T. D., van Duijn, C. M., Alizadeh, BZ., Ciullo, M., Crisponi, L., Easton, D. F., Gasparini, P. P., Gieger, C., Harris, T. B., Hayward, C., Kardia, S. L. R., Kraft, P., McKnight, B., Metspalu, A., Morrison, A. C., Reiner, A. P., Ridker, P. M., Rotter, J. I., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Weir, D. R., Yerges-Armstrong, L. M., Price, A. L., Stefansson, K., Visser, J. A., Ong, K. K., Chang-Claude, J., Murabito, J. M. M., Perry, J. R. B. & Murray, A., 2015, In : Nature Genetics. 47, 11, p. 1294-1303 12 p.

Research output: Contribution to JournalArticle

Open Access

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins

van Dongen, J., Willemsen, G., Heijmans, B. T., Neuteboom, J., Kluft, C., Jansen, R., Penninx, B. W. J. H., Slagboom, P. E., de Geus, E. J. C. & Boomsma, D. I., 2015, In : International Journal of Obesity. 39, 6, p. 899-909 11 p.

Research output: Contribution to JournalArticle

Open Access

Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life

Strohmaier, J., van Dongen, J., Willemsen, G., Nyholt, DR., Zhu, G., Codd, V., Novakovic, B., Hansell, N. K., Wright, M. J., Rietschel, L., Streit, F., Henders, A. K., Montgomery, G. W., Samani, N. J., Gillespie, N. A., Hickie, I. B., Craig, J. M., Saffery, R., Boomsma, D. I., Rietschel, M. & 1 others, Martin, N. G., 2015, In : Twin Research and Human Genetics. 18, 2, p. 198-209 12 p.

Research output: Contribution to JournalArticle

Multicohort analysis of the maternal age effect on recombination

Martin, H. C., Christ, R., Hussin, J. G., O'Connell, J., Gordon, S., Mbarek, H., Hottenga, J. J., McAloney, K., Willemsen, G., Gasparini, P., Pirastu, N., Montgomery, G. W., Navarro, P., Soranzo, N., Toniolo, D., Vitart, V., Wilson, J. F., Marchini, J., Boomsma, D. I., Martin, N. G. & 1 others, Donnelly, P., 2015, In : Nature Communications. 6, 10 p., 7846.

Research output: Contribution to JournalArticle

Open Access

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimäki, T., Lumley, T., Marciante, K., Pérusse, L., Psaty, B. M., Robbins, J. & 66 others, Tranah, G., Vink, J. M., Wilk, J. B., Stafford, J. M., Bellis, M., Biffar, R., Bouchard, C., Cade, B., Curhan, G. C., Eriksson, J. G., Ewert, R., Ferrucci, L., Fülöp, T., Gehrman, P. R., Goodloe, R., Harris, T. B., Heath, A. C., Hernandez, D., Hofman, A., Hottenga, J. J., Hunter, D. J., Jensen, M. K., Johnson, A. D., Kähönen, M., Kao, L., Kraft, P., Larkin, E. K., Lauderdale, D. S., Luik, A. I., Medici, M., Montgomery, G. W., Palotie, A., Patel, S. R., Pistis, G., Porcu, E., Quaye, L., Raitakari, O., Redline, S., Rimm, E. B., Rotter, J. I., Smith, A. V., Spector, T. D., Teumer, A., Uitterlinden, A. G., Vohl, M-C., Widén, E., Willemsen, G., Young, T., Zhang, X., Liu, Y., Blanger, J., Boomsma, D. I., Gudnason, V., Hu, F., Mangino, M., Martin, N. G., O'Connor, G. T., Stone, K. L., Tanaka, T., Viikari, J., Gharib, S. A., Punjabi, N. M., Räikkönen, K., Völzke, H., Mignot, E. & Tiemeier, H., 2015, In : Molecular Psychiatry. 20, 10, p. 1232-1239 8 p.

Research output: Contribution to JournalArticle

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K., Ullén, F., Tiemeier, H., Hofman, A., van Rooij, F. J., Walters, G. B., Sigurdsson, E., Thorgeirsson, T. E. & 9 others, Ingason, A., Helgason, A., Kong, A., Kiemeney, L. A., Koellinger, P. D., Boomsma, D. I., Gudbjartsson, D., Stefansson, H. & Stefansson, K., 2015, In : Nature Neuroscience. 18, 7, p. 953-955

Research output: Contribution to JournalArticle

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O’Dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Krabbendam, A. C., Middeldorp, C. M., Penninx, B. W. J. H., Sergeant, J. A., Smit, J. H., Grootheest, G., Willemsen, G. & 2 others, Holmes, P. & Breen, G., 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

Research output: Contribution to JournalArticle

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, E. M., Boomsma, D. I., Martin, N. G., Penninx, B. W. J. H., de Geus, E. J. C., Hoogendijk, W. J. G., Hottenga, J. J., Middeldorp, C. M., Nyholt, DR., Smit, J. H., van den Oord, E. J., Grootheest, G., Willemsen, G., Zitman, F. G., Neale, B. M., Sullivan, P. F., Raheja, U. K., Stephens, S. H., Heath, A. C., Madden, P. A. F. & 11 others, Vaswani, D., Nijjar, G. V., Ryan, K. A., Youssufi, H., Gehrman, P. R., Shuldiner, A. R., Montgomery, G. W., Wray, N. R., Nelson, E. C., Mitchell, B. D. & Postolache, T. T., 2015, In : Journal of Clinical Psychiatry. 76, 2, p. 128-134 7 p.

Research output: Contribution to JournalArticle

Smoking During Adolescence as a Risk Factor for Attention Problems

Treur, J. L., Willemsen, G., Bartels, M., Geels, L. M., van Beek, J. H. D. A., Huppertz, C., van Beijsterveldt, C. E. M., Boomsma, D. I. & Vink, J. M., 2015, In : Biological Psychiatry. 78, 9, p. 656-663 8 p.

Research output: Contribution to JournalArticle

Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years

Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K. J., Willemsen, G., van Beijsterveldt, C. E. M., Lindauer, R. J. L., van Beek, J. H. D. A., Geels, L. M., Bartels, M., Middeldorp, C. M. & Boomsma, D. I., 2015, In : Psychological Medicine. 45, 05, p. 1039-1049 11 p.

Research output: Contribution to JournalArticle

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 others, Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

Research output: Contribution to JournalArticle

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A. D., Tarnoki, D. L., Ning, F., Ji, F., Pang, Z., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A. & 106 others, Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Haworth, C. M. A., Plomin, R., Oncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D'Ippolito, C., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freitas, D. L., Maia, J. A., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Hong, C., Chong, Y., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Song, Y., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkila, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Inui, F., Watanabe, M., Bartels, M., van Beijsterveldt, T. C. E. M., Wardle, J., Llewellyn, C. H., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Rasmussen, F., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Boomsma, D. I., Hur, Y., Sorensen, T. I. A. & Kaprio, J., 2015, In : Twin Research and Human Genetics. 18, 4, p. 348-360

Research output: Contribution to JournalArticle

The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

Willemsen, G., Ward, K. J., Bell, C. G., Christensen, K., Bowden, J., Dalgard, C., Harris, J. R., Kaprio, J., Lyle, R., Magnusson, P. K. E., Mather, K. A., Ordoñana, J. R., Perez-Riquelme, F., Pedersen, N. L., Pietilainen, K. H., Sachdev, P. S., Boomsma, D. I. & Spector, T. D., 2015, In : Twin Research and Human Genetics. 18, 6, p. 762-771

Research output: Contribution to JournalArticle

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticle

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J. J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 66 others, Ried, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H., Blades, M., Craen, A. J. M., de Geus, E. J. C., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Muller-Nurasyid, M., Mpindi, J., Pedersen, N. L., Penninx, B. W. J. H., Perola, M., Pers, T. H., Peters, A., Rung, J., Smit, J. H., Steinthorsdottir, V., Tobin, M. D., Tsernikova, N., van Leeuwen, E. M., Viikari, J. S., Willems, S. M., Willemsen, G., Schunkert, H., Erdmann, J., Samani, N. J., Kaprio, J., Lind, L., Gieger, C., Metspalu, A., Slagboom, P. E., Groop, L., van Duijn, C. M., Eriksson, J. G., Jula, A., Salomaa, V., Boomsma, D. I., Power, C., Raitakari, O. T., Ingelsson, E., Jarvelin, M., Thorsteinsdottir, U., Franke, L., Ikonen, E., Kallioniemi, O., Pietiainen, V., Lindgren, C. M., Stefansson, K., Palotie, A., McCarthy, M. I., Morris, A. P., Prokopenko, I. & Ripatti, S., 2015, In : Nature Genetics. 47, 6, p. 589-597

Research output: Contribution to JournalArticle

Open Access

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 418 others, Lagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y., Chiang, C. W. K., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, A., Kaakinen, M., Kleber, M. E., Lahti, J., Leach, I. M., Lehne, B., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A. F., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Mueller, G., Mueller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renstrom, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stancakova, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J. L., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blueher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J. C., de Groot, L. C. P. G. M., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Graessler, J., Grallert, H., Grarup, N., Gu, Y., Broer, L., van der Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kahonen, N., Hysi, P. G., Illig, T., de Jager, P. L., Jalilzadeh, S., Jorgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krueger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindstrom, J., Linneberg, A., Liu, Y., Lobbens, S., Luben, R., Lyssenko, V., Mannisto, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Perusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparso, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Thorand, B., Toenjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Voelker, U., Vohl, M., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widen, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., Bakker, P. I. W., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Boeger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Gronberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliovaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kaehoenen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A. L. M., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimaki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M., Mantyselka, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W. J. H., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E. H., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L. M., Vermeulen, S. H., Viikari, J. S., Vitart, V., Voelzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z. & Loos, R. J. F., 2015, In : PLoS Genetics. 11, 10, e1005378.

Research output: Contribution to JournalArticle

Open Access

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Jelenkovic, A., Yokoyama, Y., Sund, R., Honda, C., Bogl, L. H., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M. & 110 others, Saudino, K. J., Dubois, L., Boivin, M., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Öncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D'Ippolito, C., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Spector, T. D., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freitas, D. L., Maia, J. A., Harden, K. P., Tucker-Drob, E. M., Kim, B., Chong, Y., Hong, C., Shin, H. J., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Song, Y. M., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkilä, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Sevenius Nilsen, T., Inui, F., Watanabe, N., Bartels, M., van Beijsterveldt, C. E. M., Wardle, J., Llewellyn, C. H., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Rasmussen, F., Hur, Y. M., Boomsma, D. I., Sorensen, T. I. A., Kaprio, J. & Silventoinen, K., 2015, In : Twin Research and Human Genetics. 18, 05, p. 557-570 14 p.

Research output: Contribution to JournalArticle

2014

A recessive genetic model and runs of homozygosity in major depressive disorder

Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Penninx, B. W. J. H., Willemsen, G. & Breen, G., 2014, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165, 2, p. 157-166 10 p.

Research output: Contribution to JournalArticle

A Twin-Sibling Study on the Relationship Between Exercise Attitudes and Exercise Behavior

Huppertz, C., Bartels, M., Jansen, I. E., Boomsma, D. I., Willemsen, G., de Moor, M. H. M. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 1, p. 45-55 11 p.

Research output: Contribution to JournalArticle

Explaining Individual Differences in Alcohol Intake in Adults: Evidence for Genetic and Cultural Transmission?

van Beek, J. H. D. A., de Moor, M. H. M., Geels, L. M., Willemsen, G. & Boomsma, D. I., 2014, In : Journal of Studies on Alcohol and Drugs. 75, 2, p. 201-210 10 p.

Research output: Contribution to JournalArticle

Genetic and environmental influences on the relationship between adult ADHD symptoms and self-reported problem drinking in 6024 Dutch twins

Derks, E. M., Vink, J. M., Willemsen, G., van den Brink, W. & Boomsma, D. I., 2014, In : Psychological Medicine. 44, 12, p. 2673-2683 11 p.

Research output: Contribution to JournalArticle

Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Ligthart, R. S. L., Hottenga, J. J., Lewis, C. M., Farmer, A. E., Craig, I. W., Breen, G., Willemsen, G., Vink, J. M., Middeldorp, C. M., Byrne, E. M., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Montgomery, G. W., Martin, N. G., Penninx, B. W. J. H., McGuffin, P., Boomsma, D. I. & Nyholt, DR., 2014, In : Human Genetics. 133, 2, p. 173-186 14 p.

Research output: Contribution to JournalArticle

Genome-wide analyses of borderline personality features

Lubke, G. H., Laurin, C., Amin, N., Hottenga, J. J., Willemsen, G., Grootheest, G., Abdellaoui, A., Karssen, L. C., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H. & Boomsma, D. I., 2014, In : Molecular Psychiatry. 19, 8, p. 923-929 7 p.

Research output: Contribution to JournalArticle

Open Access

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H. W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Gudbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 others, Helmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Andersen-Ranberg, K., Breen, M. E., van der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., van Heemst, D., Heijmans, B. T., Heinsen, F. A., Hottenga, J. J., Hofman, A., Jeune, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., McNerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefansson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Jukema, J. W., Maeve Rea, I., Passarino, G., de Craen, A. J., Christensen, K., Nebel, A., Stefansson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 2014, In : Human Molecular Genetics. 23, 16, p. 4420-4432 13 p.

Research output: Contribution to JournalArticle

Open Access

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

van den Berg, S. M., de Moor, M. H. M., McGue, M., Pettersson, E., Terracciano, A., Verweij, C. J. H., Amin, N., Derringer, J., Esko, T., Grootheest, G., Hansell, N. K., Huffman, J., Konte, B., Lahti, J., Luciano, M., Matteson, L. K., Viktorin, A., Wouda, J., Agrawal, A., Allik, J. & 66 others, Bierut, L. J., Broms, U., Campbell, H., Smith, G. D., Eriksson, J. G., Ferrucci, L., Franke, B., Fox, J. P., de Geus, E. J. C., Giegling, I., Gow, A. J., Grucza, R. A., Hartmann, A. M., Heath, A. C., Heikkilä, K., Iacono, W. G., Janzing, J., Jokela, M., Kiemeney, L., Lehtimäki, T., Madden, P. A. F., Magnusson, P. K. E., Northstone, K., Nutile, T., Ouwens, K. G., Palotie, A., Pattie, A., Pesonen, A. K., Pulkki-Råback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Seppälä, I., Slutske, W. S., Smyth, D. C., Sorice, R., Starr, J. M., Sutin, A. R., Tanaka, T., Verhagen, J., Vermeulen, S., Vuoksimaa, E., Widen, E., Willemsen, G., Wright, M. J., Zgaga, L., Rujescu, D., Metspalu, A., Wilson, J. F., Ciullo, M., Hayward, C., Rudan, I., Deary, I. J., Räikkönen, K., Arias-Vasquez, A., Costa, P. T., Keltikangas-Järvinen, L., van Duijn, C. M., Penninx, B. W. J. H., Krueger, R. F., Evans, D. M., Kaprio, J., Pedersen, N. L., Martin, N. G. & Boomsma, D. I., 2014, In : Behavior Genetics. 44, 4, p. 295-313 19 p.

Research output: Contribution to JournalArticle

Open Access

Heritability and genomics of gene expression in peripheral blood

Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y. H., Abdellaoui, A., Batista, S., Butler, C., Chen, G., Chen, T. H., D’Ambrosio, D., Gallins, P., Ha, M. J., Hottenga, J. J., Huang, S. & 18 others, Kattenberg, V. M., Kochar, J., Middeldorp, C. M., Qu, A., Shabalin, A., Tischfield, J., Todd, L., Tzeng, J. Y., Grootheest, G., Vink, J. M., Wang, Q., Wang, W., Willemsen, G., Smit, J. H., de Geus, E. J. C., Yin, Z., Penninx, B. W. J. H. & Boomsma, D. I., 2014, In : Nature Genetics. 46, 5, p. 430-437 8 p.

Research output: Contribution to JournalArticle

Open Access

Heritability of cardiac vagal control in 24-h heart rate variability recordings: Influence of ceiling effects at low heart rates

Neijts, M., van Lien, R., Kupper, N., Boomsma, D. I., Willemsen, G. & de Geus, E. J. C., 2014, In : Psychophysiology. 51, 10, p. 1023-1036 14 p.

Research output: Contribution to JournalArticle

Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway

Riese, H., Munoz, L. M., Hartman, C. A., Ding, X., Su, S., Oldehinkel, A. J., van Room, A. M., van der Most, P. J., Lefrandt, J., Gansevoort, R. T., van der Harst, P., Verweij, N., Licht, C. M. M., Boomsma, D. I., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H., Nolte, I. M., de Geus, E. J. C., Wang, X. & 1 others, Snieder, H., 2014, In : PLoS ONE. 9, 11, 9 p., e112476.

Research output: Contribution to JournalArticle

Open Access

Individual feedback on personal research results via the Netherlands Twin Register Portal: Participants love it!

Willemsen, G., 2014.

Research output: Contribution to ConferencePosterOther research output

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Elvestad Gabrielsen, M., Skorpen, F., Marioni, R. E., Campbell, A., Engmann, J., Saeed Mirza, S., Loukola, A., Laatikainen, T., Partonen, T., Kaakinen, M., Ducci, F., Cavadino, A., Husemoen, L. L. N., Singh Ahluwalia, T., Kart Jacobsen, R., Skaaby, T., Frost Ebstrup, J. & 42 others, Lykke Mortensen, E., Minica, C. C., Vink, J. M., Willemsen, G., Marques-Vidal, P., Dale, C. E., Amuzu, A., Lennon, L. T., Lahti, J., Palotie, A., Räikkönen, K., Wong, A., Paternoster, L., Pui-Yee Wong, A., Horwood, L. J., Murphy, M., Johnstone, E. C., Kennedy, M. A., Pausova, Z., Paus, T., Ben-Shlomo, Y., Nohr, E. A., Kuh, D., Kivimaki, M., Eriksson, J. G., Morris, R. W., Casas, J. P., Preisig, M., Boomsma, D. I., Linneberg, A., Power, C., Hyppönen, E., Veijola, J., Järvelin, M. R., Korhonen, T., Tiemeier, H., Kumari, M., Porteous, D. J., Hayward, C., Romundstad, P. R., Smith, G. D. & Munafo, M. R., 2014, In : BMJ Open. 4, 10, 13 p., e006141.

Research output: Contribution to JournalArticle

Open Access

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

van den Akker, E. B., Passtoors, W. M., Jansen, R., van Zwet, E. W., Goeman, J. J., Hulsman, M., Emilsson, V., Perola, M., Willemsen, G., Penninx, B. W. J. H., Heijmans, B. T., Maier, A. B., Boomsma, D. I., Kok, J. N., Slagboom, P. E., Reinders, M. J. T. & Beekman, M., Apr 2014, In : Aging Cell. 13, 2, p. 216-25 10 p.

Research output: Contribution to JournalArticle

Open Access

Multi-ethnic fine-mapping of 14 central adiposity loci

Liu, C. T., Buchkovich, M. L., Winkler, T. W., Heid, I. M., Hottenga, J. J., Boomsma, D. I., de Geus, E. J. C., Willemsen, G., Borecki, I. B., Fox, C. S., Mohlke, K. L., North, K. E. & Cupples, L. A., 2014, In : Human Molecular Genetics. 23, 17, p. 4738-4744 7 p.

Research output: Contribution to JournalArticle

Open Access

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80607 Subjects

Baumert, J., Huang, J., McKnight, B., Sabater-Lleal, M., Steri, M., Chu, A. Y., Trompet, S., Lopez, L. M., Fornage, M., Teumer, A., Tang, W., Rudnicka, A. R., Mälarstig, A., Hottenga, J. J., Kavousi, M., Lahti, J., Tanaka, T., Hayward, C., Huffman, J. E., Morange, P. E. & 83 others, Rose, L. M., Basu, S., Rumley, A., Stott, D. J., Buckley, B. M., de Craen, A. J., Sanna, S., Masala, M., Biffar, R., Homuth, G., Silveira, A., Sennblad, B., Goel, A., Watkins, H., Müller-Nurasyid, M., Rückerl, R., Taylor, K., Chen, M. H., de Geus, E. J. C., Hofman, A., Witteman, J. C. M., de Maat, M. P. M., Palotie, A., Davies, G. E., Siscovick, D. S., Kolcic, I., Wild, S. H., Song, J., McArdle, W. L., Ford, I., Sattar, N., Schlessinger, D., Grotevendt, A., Franzosi, M. G., Illig, T., Waldenberger, M., Lumley, T., Tofler, G. H., Willemsen, G., Uitterlinden, A. G., Rivadeneira, F., Räikkönen, K., Chasman, D. I., Folsom, A. R., Lowe, G. D., Westendorp, R. G. J., Slagboom, P. E., Cucca, F., Wallaschofski, H., Strawbridge, R. J., Seedorf, U., Koenig, W., Bis, J. C., Mukamal, K. J., van Dongen, J., Widen, E., Franco, O. H., Starr, J. M., Liu, K., Ferrucci, L., Polasek, O., Wilson, J. F., Oudot-Mellakh, T., Campbell, H., Navarro, P., Bandinelli, S., Eriksson, J., Boomsma, D. I., Dehghan, A., Clarke, R., Hamsten, A., Boerwinkle, E., Jukema, J. W., Naitza, S., Ridker, P. M., Völzke, H., Deary, I. J., Reiner, A. P., Trégouët, D. A., O'Donnell, C. J., Strachan, D. P., Peters, A. & Smith, N. L., 2014, In : PLoS ONE. 9, 12, 18 p., e111156.

Research output: Contribution to JournalArticle

Open Access

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Hoggart, C. J., Venturini, G., Mangino, M., Gomez, F., Ascari, G., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Rousson, V., Hirschhorn, J. N., Rivolta, C., Loos, R. J. F. & Kutali, Z., 2014, In : PLoS Genetics. 10, 7, 12 p., e1004508.

Research output: Contribution to JournalArticle

Open Access

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, J. R. B., Day, F. R., Elks, C. E., Sulem, P., Thompson, D. J., Ferreira, T., He, C., Chasman, D. I., Esko, T., Thorleifsson, G., Albrecht, E., Ang, W. Q., Corre, T., Cousminer, D. L., Feenstra, B., Franceschini, N., Ganna, A., Johnson, A. D., Kjellqvist, S., Lunetta, K. L. & 178 others, McMahon, G., Nolte, I. M., Paternoster, L., Porcu, E., Smith, A. V., Stolk, L., Teumer, A., Tsernikova, N., Tikkanen, E., Ulivi, S., Wagner, E. K., Amin, N., Bierut, L. J., Byrne, E. M., Hottenga, J. J., Koller, D. L., Mangino, M., Pers, T. H., Yerges-Armstrong, L. M., Zhao, J. H., Andrulis, I. L., Anton-Culver, H., Atsma, F., Bandinelli, S., Beckmann, M. W., Benitez, J., Blomqvist, C., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Brenner, H., Buring, J. E., Chang-Claude, J., Chanock, S., Chen, J., Chenevix-Trench, G., Collee, J. M., Couch, F. J., Couper, D., Coviello, A. D., Cox, A., Czene, K., Pio d'Adamo, A., Smith, G. D., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dieffenbach, A. K., Dunning, A. M., Eiriksdottir, G., Eriksson, J. G., Fasching, P. A., Ferrucci, L., Flesch-Janys, D., Flyger, H., Foroud, T., Franke, L., Garcia, M. E., Garcia-Closas, M., Geller, F., de Geus, E. J. C., Giles, G. G., Gudbjartsson, D. F., Gudnason, V., Guenel, P., Guo, S., Hall, P., Hamann, U., Haring, R., Hartman, C. A., Heath, A. C., Hofman, A., Hooning, M. J., Hopper, J. L., Hu, F. B., Hunter, D. J., Karasik, D., Kiel, D. P., Knight, J. A., Kosma, V. M., Kutalik, Z., Lai, S., Lambrechts, D., Lindblom, A., Mägi, R., Magnusson, P. K., Mannermaa, A., Martin, N. G., Masson, G., McArdle, P. F., McArdle, W. L., Melbye, M., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Nevanlinna, H., Neven, P., Nohr, E. A., Oldehinkel, A. J., Oostra, B. A., Palotie, A., Peacock, M., Pedersen, N. L., Peterlongo, P., Peto, J., Pharoah, P. D. P., Postma, D. S., Pouta, A., Pylkäs, K., Radice, P., Ring, S., Rivadeneira, F., Robino, A., Rose, L. M., Rudolph, A., Salomaa, V., Sanna, S., Schlessinger, D., Schmidt, M. K., Southey, M. C., Sovio, U., Stampfer, M. J., Stöckl, D., Storniolo, A. M., Timpson, N. J., Tyrer, J., Visser, J. A., Vollenweider, P., Völzke, H., Waeber, G., Waldenberger, M., Wallaschofski, H., Wang, Q., Willemsen, G., Winqvist, R., Wolffenbuttel, B. H. R., Wright, M. J., Boomsma, D. I., Econs, M. J., Khaw, K. T., Loos, R. J. F., McCarthy, M. I., Montgomery, G. W., Rice, J. P., Streeten, E. A., Thorsteinsdottir, U., van Duijn, C. M., Alizadeh, BZ., Bergmann, S., Boerwinkle, E., Boyd, H. A., Crisponi, L., Gasparini, P., Gieger, C., Harris, T. B., Ingelsson, E., Järvelin, M. R., Kraft, P., Lawlor, D., Metspalu, A., Pennell, C. E., Ridker, P. M., Snieder, H., Sorensen, T. I. A., Spector, T. D., Strachan, D. P., Uitterlinden, A. G., Wareham, N. J., Widen, E., Zygmunt, M., Murray, A., Easton, D. F., Stefansson, K., Murabito, J. M. & Ong, K. K., 2014, In : Nature. 514, 7520, p. 92-97 6 p.

Research output: Contribution to JournalArticle

Open Access

Partitioning the etiology of hoarding and obsessive–compulsive symptoms

Mathews, C. A., Delucchi, K., Cath, D. C., Willemsen, G. & Boomsma, D. I., 2014, In : Psychological Medicine. 44, 13, p. 2867-2876 10 p.

Research output: Contribution to JournalArticle

Polygenic risk scores for smoking: predictors for alcohol and cannabis use?

Vink, J. M., de Geus, E. J. C., Willemsen, G., Neale, M. C., Furberg, H. & Boomsma, D. I., 2014, In : Addiction. 109, 7, p. 1141-1151 11 p.

Research output: Contribution to JournalArticle

Quality control and conduct of genome-wide association meta-analyses

Winkler, T. W., Day, F. R., Croteau-Chonka, D. C., Wood, A. R., Locke, A. E., Mägi, R., Ferreira, T., Fall, T., Graff, M., Justice, A. E., Luan, J., Gustafsson, S., Randall, J. C., Vedantam, S., Workalemahu, T., Kilpeläinen, T. O., Scherag, A., Esko, T., Kutalik, Z., Heid, I. M. & 7 others, Loos, R. J. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H. & Smit, J. H., 2014, In : Nature Protocols. 9, 5, p. 1192-1212 21 p.

Research output: Contribution to JournalArticle

Sex differences in the human peripheral blood transcriptome

Jansen, R., Batista, S., Brooks, A. I., Tischfield, J. A., Willemsen, G., Grootheest, G., Hottenga, J. J., Milaneschi, Y., Mbarek, H., Madar, V., Peyrot, W., Vink, J. M., Verweij, C. L., de Geus, E. J. C., Smit, J. H., Wright, F. A., Sullivan, P. F., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : BMC Genomics. 15, p. 33 12 p., 33.

Research output: Contribution to JournalArticle

Open Access

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Guigas, B., de Leeuw van Weenen, J., van Leeuwen, N., Bik-Simonis, A. M. C., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 others, Lauritzen, T., Hansen, T., Pedersen, O., Hottenga, J. J., Romijn, J. A., Diamant, M., Kramer, M. H. H., Heine, R. J., Willemsen, G., Dekker, J. M., Eekhoff, E. M. W., Pijl, H., de Geus, E. J. C., Slagboom, P. E. & 't Hart, L. M., 2014, In : Diabetic Medicine. 31, 8, p. 1001-1008 8 p.

Research output: Contribution to JournalArticle