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  • A.H.M. Willemsen
2020

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., Beekman, A. F. T., Jansen, R., Milaneschi, Y., Peyrot, W. J., Smit, J. H., W J H Penninx, B. & Posthuma, D., 16 Mar 2020, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D. & Willemsen, G., Mar 2020, In : Biological Psychiatry. 87, 5, p. 419-430 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Li, C., Stoma, S., Lotta, L. A., Warner, S., Albrecht, E., Allione, A., Arp, P. P., Broer, L., Buxton, J. L., Da Silva Couto Alves, A., Deelen, J., Fedko, I. O., Gordon, S. D., Jiang, T., Karlsson, R., Kerrison, N., Loe, T. K., Mangino, M., Milaneschi, Y., Miraglio, B. & 76 others, Pervjakova, N., Russo, A., Surakka, I., van der Spek, A., Verhoeven, J. E., Amin, N., Beekman, M., Blakemore, A. I., Canzian, F., Hamby, S. E., Hottenga, J-J., Jones, P. D., Jousilahti, P., Mägi, R., Medland, S. E., Montgomery, G. W., Nyholt, D. R., Perola, M., Pietiläinen, K. H., Salomaa, V., Sillanpää, E., Suchiman, H. E., van Heemst, D., Willemsen, G., Agudo, A., Boeing, H., Boomsma, D. I., Chirlaque, M-D., Fagherazzi, G., Ferrari, P., Franks, P., Gieger, C., Eriksson, J. G., Gunter, M., Hägg, S., Hovatta, I., Imaz, L., Kaprio, J., Kaaks, R., Key, T., Krogh, V., Martin, N. G., Melander, O., Metspalu, A., Moreno, C., Onland-Moret, N. C., Nilsson, P., Ong, K. K., Overvad, K., Palli, D., Panico, S., Pedersen, N. L., Penninx, B. W. J. H., Quirós, J. R., Jarvelin, M. R., Rodríguez-Barranco, M., Scott, R. A., Severi, G., Slagboom, P. E., Spector, T. D., Tjonneland, A., Trichopoulou, A., Tumino, R., Uitterlinden, A. G., van der Schouw, Y. T., van Duijn, C. M., Weiderpass, E., Denchi, E. L., Matullo, G., Butterworth, A. S., Danesh, J., Samani, N. J., Wareham, N. J., Nelson, C. P., Langenberg, C. & Codd, V., 5 Mar 2020, In : American Journal of Human Genetics. 106, 3, p. 389-404 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., Beekman, A. T. F., Jansen, R., Milaneschi, Y., Smit, J. H., W J H Penninx, B. & Posthuma, D., 23 Jan 2020, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

BBMRI Metabolomics Consortium, 7 Jan 2020, In : Nature Communications. 11, 1, p. 39 39.

Research output: Contribution to JournalArticleAcademicpeer-review

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

Liu, J., Lahousse, L., Nivard, M. G., Bot, M., Chen, L., van Klinken, J. B., Thesing, C. S., Beekman, M., van den Akker, E. B., Slieker, R. C., Waterham, E., van der Kallen, C. J. H., de Boer, I., Li-Gao, R., Vojinovic, D., Amin, N., Radjabzadeh, D., Kraaij, R., Alferink, L. J. M., Murad, S. D. & 29 others, Uitterlinden, A. G., Willemsen, G., Pool, R., Milaneschi, Y., van Heemst, D., Suchiman, H. E. D., Rutters, F., Elders, P. J. M., Beulens, J. W. J., van der Heijden, A. A. W. A., van Greevenbroek, M. M. J., Arts, I. C. W., Onderwater, G. L. J., van den Maagdenberg, A. M. J. M., Mook-Kanamori, D. O., Hankemeier, T., Terwindt, G. M., Stehouwer, C. D. A., Geleijnse, J. M., 't Hart, L. M., Slagboom, P. E., van Dijk, K. W., Zhernakova, A., Fu, J., Penninx, B. W. J. H., Boomsma, D. I., Demirkan, A., Stricker, B. H. C. & van Duijn, C. M., Jan 2020, In : Nature Medicine. 26, 1, p. 110-117 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Substance use: Interplay between polygenic risk and neighborhood environment

Pasman, J. A., Verweij, K. J. H., Abdellaoui, A., Hottenga, J. J., Fedko, I. O., Willemsen, G., Boomsma, D. I. & Vink, J. M., 28 Feb 2020, In : Drug and Alcohol Dependence. 209, p. 107948 107948.

Research output: Contribution to JournalArticleAcademicpeer-review

2019

A Genetic Investigation of the Well-Being Spectrum

Baselmans, B. M. L., van de Weijer, M. P., Abdellaoui, A., Vink, J. M., Hottenga, J. J., Willemsen, G., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Bartels, M., 15 May 2019, In : Behavior Genetics. 49, 3, p. 286-297 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies

Doering, S., Lichtenstein, P., Gillberg, C., Boomsma, D. I., Van Beijsterveldt, T. C. E. M., Ligthart, L., Willemsen, G., De Geus, E., Middeldorp, C. M., Bartels, M., Kuja-Halkola, R. & Lundström, S., 14 Nov 2019, In : BMC Psychiatry. 19, 1, p. 1-11 11 p., 363.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Association between rs1051730 and smoking during pregnancy in Dutch women

Mbarek, H., van Beijsterveldt, C. E. M., Hottenga, J. J., Dolan, C. V., Boomsma, D. I., Willemsen, G. & Vink, J. M., Jun 2019, In : Nicotine and Tobacco Research. 21, 6, p. 835-840 6 p., ntx267.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Associations between Loneliness and Personality are Mostly Driven by a Genetic Association with Neuroticism

Abdellaoui, A., Chen, H-Y., Willemsen, G., Ehli, E. A., Davies, G. E., Verweij, K. J. H., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Cacioppo, J. T., Apr 2019, In : Journal of Personality. 87, 2, p. 386-397 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23Andme Research Team & HUNT All-In Psychiatry, Feb 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.

Research output: Contribution to JournalLetterAcademicpeer-review

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk

Finnicum, C. T., Beck, J. J., Dolan, C. V., Davis, C., Willemsen, G., Ehli, E. A., Boomsma, D. I., Davies, G. E. & de Geus, E. J. C., 22 Oct 2019, In : BMC Microbiology. 19, 1, p. 1-10 10 p., 230.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use

International Cannabis Consortium, 21 May 2019, In : Nicotine and Tobacco Research. 21, 6, p. 723-730 8 p., nty150.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Social Science Genetic Association Consortium, 23and Me Research Team, eQTLGen Consortium & International Cannabis Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 245-257 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes

Chen, J., Loukola, A., Gillespie, N. A., Peterson, R., Jia, P., Riley, B., Maes, H., Dick, D. M., Kendler, K. S., Damaj, M. I., Miles, M. F., Zhao, Z., Li, M. D., Vink, J. M., Minica, C. C., Willemsen, G., Boomsma, D. I., Qaiser, B., Madden, P. A. F., Korhonen, T. & 26 others, Jousilahti, P., Hällfors, J., Gelernter, J., Kranzler, H. R., Sherva, R., Farrer, L., Maher, B., Vanyukov, M., Taylor, M., Ware, J. J., Munafò, M. R., Lutz, S. M., Hokanson, J. E., Gu, F., Landi, M. T., Caporaso, N. E., Hancock, D. B., Gaddis, N. C., Baker, T. B., Bierut, L. J., Johnson, E. O., Chenoweth, M., Lerman, C., Tyndale, R., Kaprio, J. & Chen, X., 11 Jul 2019, In : Nicotine and Tobacco Research.

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, 1 May 2019, In : Nature Genetics. 51, 5, p. 804-814 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Küpers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C. V., Allard, C., Just, A. C., Bakulski, K. M., Holloway, J. W. & 107 others, Everson, T. M., Xu, C. J., Huang, R. C., van der Plaat, D. A., Wielscher, M., Merid, S. K., Ullemar, V., Rezwan, F. I., Lahti, J., van Dongen, J., Langie, S. A. S., Richardson, T. G., Magnus, M. C., Nohr, E. A., Xu, Z., Duijts, L., Zhao, S., Zhang, W., Plusquin, M., DeMeo, D. L., Solomon, O., Heimovaara, J. H., Jima, D. D., Gao, L., Bustamante, M., Perron, P., Wright, R. O., Hertz-Picciotto, I., Zhang, H., Karagas, M. R., Gehring, U., Marsit, C. J., Beilin, L. J., Vonk, J. M., Jarvelin, M. R., Bergström, A., Örtqvist, A. K., Ewart, S., Villa, P. M., Moore, S. E., Willemsen, G., Standaert, A. R. L., Håberg, S. E., Sørensen, T. I. A., Taylor, J. A., Räikkönen, K., Yang, I. V., Kechris, K., Nawrot, T. S., Silver, M. J., Gong, Y. Y., Richiardi, L., Kogevinas, M., Litonjua, A. A., Eskenazi, B., Huen, K., Mbarek, H., Maguire, R. L., Dwyer, T., Vrijheid, M., Bouchard, L., Baccarelli, A. A., Croen, L. A., Karmaus, W., Anderson, D., de Vries, M., Sebert, S., Kere, J., Karlsson, R., Arshad, S. H., Hämäläinen, E., Routledge, M. N., Boomsma, D. I., Feinberg, A. P., Newschaffer, C. J., Govarts, E., Moisse, M., Fallin, M. D., Melén, E., Prentice, A. M., Kajantie, E., Almqvist, C., Oken, E., Dabelea, D., Boezen, H. M., Melton, P. E., Wright, R. J., Koppelman, G. H., Trevisi, L., Hivert, M. F., Sunyer, J., Munthe-Kaas, M. C., Murphy, S. K., Corpeleijn, E., Wiemels, J., Holland, N., Herceg, Z., Binder, E. B., Davey Smith, G., Jaddoe, V. W. V., Lie, R. T., Nystad, W., London, S. J., Lawlor, D. A., Relton, C. L., Snieder, H. & Felix, J. F., 23 Apr 2019, In : Nature Communications. 10, p. 1-11 11 p., 1893.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A. & 19 others, Medland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Eline Slagboom, P., Spector, T. D., Boomsma, D. I., van Duijn, C. M. & Gieger, C., 12 Aug 2019, In : Scientific Reports. 9, 1, p. 11623 11623.

Research output: Contribution to JournalArticleAcademicpeer-review

Multivariate genome-wide analyses of the well-being spectrum

BIOS Consortium, Mar 2019, In : Nature Genetics. 51, 3, p. 445-451 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts

Silventoinen, K., Jelenkovic, A., Latvala, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Aaltonen, S., Piirtola, M., Freitas, D. L., Maia, J. A., Öncel, S. Y., Aliev, F., Ji, F., Ning, F., Pang, Z., Rebato, E., Saudino, K. J., Cutler, T. L. & 53 others, Hopper, J. L., Ullemar, V., Almqvist, C., Magnusson, P. K. E., Cozen, W., Hwang, A. E., Mack, T. M., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Nelson, T. L., Whitfield, K. E., Sung, J., Kim, J., Lee, J., Lee, S., Llewellyn, C. H., Fisher, A., Medda, E., Nisticò, L., Toccaceli, V., Baker, L. A., Tuvblad, C., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Silberg, J. L., Maes, H. H., Krueger, R. F., McGue, M., Pahlen, S., Gatz, M., Butler, D. A., Harris, J. R., Nilsen, T. S., Harden, K. P., Tucker-Drob, E. M., Franz, C. E., Kremen, W. S., Lyons, M. J., Lichtenstein, P., Jeong, H. U., Hur, Y. M., Boomsma, D. I., Sørensen, T. I. A. & Kaprio, J., 1 May 2019, In : Obesity. 27, 5, p. 855-865 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

23Andme Research Team, 15 Nov 2019, In : Human Molecular Genetics. 28, 22, p. 3853-3865 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Skewed X-inactivation is common in the general female population

Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Willemsen, G. & BIOS Consortium, Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. V. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., Pang, Z. & 118 others, Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Martin, N. G., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Öncel, S. Y., Aliev, F., Medda, E., Nisticò, L., Toccaceli, V., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Jeong, H-U., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Gao, W., Yu, C., Li, L., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Silberg, J. L., Maes, H. H., Cutler, T. L., Hopper, J. L., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Ullemar, V., Almqvist, C., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Rasmussen, F., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Harris, J. R., Sung, J., Park, H. A., Lee, J., Lee, S. J., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Llewellyn, C. H., Fisher, A., Rebato, E., Busjahn, A., Tomizawa, R., Inui, F., Watanabe, M., Honda, C., Sakai, N., Hur, Y-M., Sørensen, T. I. A., Boomsma, D. I. & Kaprio, J., Dec 2019, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. 22, 6, p. 800-808 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

EArly Genetics Lifecourse Epidemiology (EAGLE) consortium & Early Growth Genetics (EGG) Consortium, Mar 2019, In : European Journal of Epidemiology. 34, 3, p. 279-300

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Posthuma, D., 1 Nov 2019, In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Twin Family Registries Worldwide: An Important Resource for Scientific Research

Hur, Y. M., Bogl, L. H., Ordoñana, J. R., Taylor, J., Hart, S. A., Tuvblad, C., Ystrom, E., Dalgård, C., Skytthe, A. & Willemsen, G., Dec 2019, In : Twin Research and Human Genetics. 22, 6, p. 427-437 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

Validated inference of smoking habits from blood with a finite DNA methylation marker set

BIOS Consortium, Nov 2019, In : European Journal of Epidemiology. 34, 11, p. 1055-1074 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

The Genome of the Netherlands consortium, 10 Dec 2019, In : Scientific Reports. 9, 1, p. 1-9 9 p., 18758.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2017

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio

Lin, B. D., Carnero-Montoro, E., Bell, J. T., Boomsma, D. I., de Geus, E. J., Jansen, R., Kluft, C., Mangino, M., Penninx, B., Spector, T. D., Willemsen, G. & Hottenga, J-J., Nov 2017, In : Journal of human genetics. 62, 11, p. 979-988 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

A framework for the detection of de novo mutations in family-based sequencing data

Francioli, L. C., Cretu-Stancu, M., Garimella, K. V., Fromer, M., Kloosterman, W. P., Boomsma, D. I., Abdellaoui, A., Hottenga, J. J., Willemsen, G., Samocha, K. E., Neale, B. M., Daly, M. J., Banks, E., DePristo, M. A. & Bakker, P. I. W., Jan 2017, In : European Journal of Human Genetics. 25, 2, p. 227-233 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

A method to customize population-specific arrays for genome-wide association testing

Ehli, E. A., Abdellaoui, A., Fedko, I. O., Grieser, C., Nohzadeh-Malakshah, S., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Davies, G. E. & Hottenga, J. J., 1 Feb 2017, In : European Journal of Human Genetics. 25, 2, p. 267-270 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Direk, N., Williams, S., Smith, J. A., Ripke, S., Air, T., Amare, A. T., Amin, N., Baune, B. T., Bennett, D. A., Blackwood, D. H. R., Boomsma, D., Breen, G., Buttenschøn, H. N., Byrne, E. M., Børglum, A. D., Castelao, E., Cichon, S., Clarke, T-K., Cornelis, M. C., Dannlowski, U. & 82 others, De Jager, P. L., Demirkan, A., Domenici, E., van Duijn, C. M., Dunn, E. C., Eriksson, J. G., Esko, T., Faul, J. D., Ferrucci, L., Fornage, M., de Geus, E., Gill, M., Gordon, S. D., Grabe, H-J., van Grootheest, G., Hamilton, S. P., Hartman, C. A., Heath, A. C., Hek, K., Hofman, A., Homuth, G., Horn, C., Jan Hottenga, J., Kardia, S. L. R., Kloiber, S., Koenen, K., Kutalik, Z., Ladwig, K-H., Lahti, J., Levinson, D. F., Lewis, C. M., Lewis, G., Li, Q. S., Llewellyn, D. J., Lucae, S., Lunetta, K. L., MacIntyre, D. J., Madden, P. A. F., Martin, N. G., McIntosh, A. M., Metspalu, A., Milaneschi, Y., Montgomery, G. W., Mors, O., Mosley, T. H., Murabito, J. M., Müller-Myhsok, B., Nöthen, M. M., Nyholt, D. R., O'Donovan, M. C., Penninx, B. W., Pergadia, M. L., Perlis, R., Potash, J. B., Preisig, M., Purcell, S. M., Quiroz, J. A., Räikkönen, K., Rice, J. P., Rietschel, M., Rivera, M., Schulze, T. G., Shi, J., Shyn, S. I., Sinnamon, G. C., Smit, J. H., Smoller, J. W., Snieder, H., Tanaka, T., Tansey, K. E., Teumer, A., Uher, R., Umbricht, D., Van der Auwera, S., Ware, E. B., Weir, D. R., Weissman, M. M., Willemsen, G., Yang, J., Zhao, W., Tiemeier, H. & Sullivan, P. F., 1 Aug 2017, In : Biological Psychiatry. 82, 5, p. 322-329 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Jelenkovic, A., Yokoyama, Y., Sund, R., Pietiläinen, K. H., Hur, Y-M., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ooki, S., Saudino, K. J., Stazi, M. A., Fagnani, C., D'Ippolito, C., Nelson, T. L., Whitfield, K. E., Knafo-Noam, A., Mankuta, D., Abramson, L., Heikkilä, K., Cutler, T. L. & 46 others, Hopper, J. L., Wardle, J., Llewellyn, C. H., Fisher, A., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Burt, S. A., Klump, K. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Dubois, L., Boivin, M., Brendgen, M. R., Dionne, G., Vitaro, F., Harris, J. R., Brandt, I., Nilsen, T. S., Craig, J. M., Saffery, R., Rasmussen, F., Tynelius, P., Bayasgalan, G., Narandalai, D., Haworth, C. M., Plomin, R., Ji, F., Ning, F., Pang, Z., Rebato, E., Krueger, R. F., McGue, M., Pahlen, S., Boomsma, D. I., Sørensen, T. I., Kaprio, J. & Silventoinen, K., 1 Oct 2017, In : International Journal of Epidemiology. 46, 5, p. 1488-1498 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Design and implementation of a customized genotyping array for imputation-based genome-wide association studies: the Avera-NTR Global Screening Array

Beck, J. J., Ehli, E. A., مبارك, ., Kallsen, N., Peyton, S., Abdellaoui, A., Fedko, I. O., Willemsen, G., de Geus, E., Boomsma, D. I., Davies, G. E. & Hottenga, J. J., 6 Mar 2017.

Research output: Contribution to ConferencePosterOther research output

Open Access

Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Silventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y-M., Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietiläinen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q. & 82 others, Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Öncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. V. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Song, Y-M., Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H-U., Swan, G. E., Krasnow, R., Magnusson, P. K., Pedersen, N. L., Dahl Aslan, A. K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., LaChance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., van Beijsterveldt, C. E., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. & Kaprio, J., 1 Aug 2017, In : American Journal of Clinical Nutrition. 106, 2, p. 457-466 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Differential gene expression patterns between smokers and non-smokers: cause or consequence?

Vink, J. M., Jansen, R., Brooks, A., Willemsen, G., van Grootheest, G., de Geus, E., Smit, J. H., Penninx, B. W. & Boomsma, D. I., Mar 2017, In : Addiction Biology. 22, 2, p. 550-560 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Bogl, L. H., Jelenkovic, A., Vuoksimaa, E., Ahrenfeldt, L., Pietiläinen, K. H., Stazi, M. A., Fagnani, C., D'Ippolito, C., Hur, Y-M., Jeong, H-U., Silberg, J. L., Eaves, L. J., Maes, H. H., Bayasgalan, G., Narandalai, D., Cutler, T. L., Kandler, C., Jang, K. L., Christensen, K., Skytthe, A. & 56 others, Kyvik, K. O., Cozen, W., Hwang, A. E., Mack, T. M., Derom, C. A., Vlietinck, R. F., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., McAdams, T. A., Eley, T. C., Gregory, A. M., Krueger, R. F., McGue, M., Pahlen, S., Willemsen, G., Bartels, M., Pang, Z., Tan, Q., Zhang, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Hjelmborg, J. V. B., Rebato, E., Swan, G. E., Krasnow, R., Busjahn, A., Lichtenstein, P., Öncel, S. Y., Aliev, F., Baker, L. A., Tuvblad, C., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Duncan, G. E., Buchwald, D., Tarnoki, A. D., Tarnoki, D. L., Yokoyama, Y., Hopper, J. L., Loos, R. J. F., Boomsma, D. I., Sørensen, T. I. A., Silventoinen, K., Kaprio, J. & van Beijsterveldt, C. E. M., 2017, In : Biology of sex differences. 8, 1, p. 14 14.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

Silventoinen, K., Jelenkovic, A., Latvala, A., Sund, R., Yokoyama, Y., Ullemar, V., Almqvist, C., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Kandler, C., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Rebato, E., Stazi, M. A., Fagnani, C., Brescianini, S., Hur, Y-M. & 81 others, Jeong, H-U., Cutler, T. L., Hopper, J. L., Busjahn, A., Saudino, K. J., Ji, F., Ning, F., Pang, Z., Rose, R. J., Koskenvuo, M., Heikkilä, K., Cozen, W., Hwang, A. E., Mack, T. M., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Sung, J., Kim, J., Lee, J., Lee, S., Nelson, T. L., Whitfield, K. E., Tan, Q., Zhang, D., Llewellyn, C. H., Fisher, A., Burt, S. A., Klump, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Medland, S. E., Martin, N. G., Montgomery, G. W., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Corley, R. P., Huibregtse, B. M., Öncel, S. Y., Aliev, F., Krueger, R. F., McGue, M., Pahlen, S., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Silberg, J. L., Eaves, L. J., Maes, H. H., Harris, J. R., Brandt, I., Nilsen, T. S., Rasmussen, F., Tynelius, P., Baker, L. A., Tuvblad, C., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Gatz, M., Butler, D. A., Lichtenstein, P., Goldberg, J. H., Harden, K. P., Tucker-Drob, E. M., Duncan, G. E., Buchwald, D., Tarnoki, A. D., Tarnoki, D. L., Franz, C. E., Kremen, W. S., Lyons, M. J., Maia, J. A., Freitas, D. L., Turkheimer, E., Sørensen, T. I. A., Boomsma, D. I. & Kaprio, J., Oct 2017, In : Twin Research and Human Genetics. 20, 5, p. 395-405 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Establishment of the Avera Twin Register in the Midwest USA

Kittelsrud, J., Ehli, E. A., Petersen, V., Jung, T., Willemsen, G., Boomsma, D. & Davies, G. E., 1 Oct 2017, In : Twin Research and Human Genetics. 20, 5, p. 414-418 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L., Föcker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M. & 19 others, Adan, R., Brandys, M., van Elburg, A., Boraska Perica, V., Franklin, C. S., Tschöp, M. H., Zeggini, E., Bulik, C. M., Collier, D., Scherag, A., Müller, T. D., Hebebrand, J., GCAN, Hottenga, J. J., Willemsen, G., Boomsma, D. I., van Beijsterveldt, C. E. M., Middeldorp, C. M. & de Geus, E., Feb 2017, In : Molecular Psychiatry. 22, 2, p. 192-201 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W. J. H., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 2 others, Werder, R. B. & Phipps, S., Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., von der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S-J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 others, Kumar, J., van der Laan, S. W., Lyytikäinen, L-P., Maihofer, A. X., Minassian, A., van der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., de Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J-J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Zu Schwabedissen, H. M., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A-C., Tardif, J-C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z-M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., van der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M-R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., Van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., den Hoed, M., Snieder, H. & de Geus, E. J. C., 14 Jun 2017, In : Nature Communications. 8, p. 15805 15805.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genetic loci associated with heart rate variability and their effects on cardiac disease risk (vol 8, pg 15805, 2017)

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., von der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S-J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 others, Kumar, J., van der Laan, S. W., Lyytikainen, L-P., Maihofer, A. X., Minassian, A., van der Most, P. J., Mueller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., de Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J-J., Huikuri, H., Hutri-Kahonen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., zu Schwabedissen, H. M., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundstrom, J., Swenne, C. A., Syvanen, A-C., Tardif, J-C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z-M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., van der Harst, P., Hassan, M., Ingelsson, E., Jarvelin, M-R., Kaab, S., Kahonen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimaki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., den Hoed, M., Snieder, H. & de Geus, E. J. C., 2 Aug 2017, In : Nature Communications. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., Snieder, H. & 31 others, Kato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., International Consortium of Blood Pressure (ICBP) 1000G Analyses, Hottenga, J. J., de Geus, E., Willemsen, G. & Boomsma, D. I., Mar 2017, In : Nature Genetics. 49, 3, p. 403-415 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access