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  • Timo Hamers
2020

Development of a high-throughput bioassay for screening of antibiotics in aquatic environmental samples

Jonkers, T. J. H., Steenhuis, M., Schalkwijk, L., Luirink, J., Bald, D., Houtman, C. J., Kool, J., Lamoree, M. H. & Hamers, T., 28 Apr 2020, In : Science of the Total Environment. 729, p. 1-9 9 p., 139028.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Identification of mutagenic and endocrine disrupting compounds in surface water and wastewater treatment plant effluents using high-resolution effect-directed analysis

Zwart, N., Jonker, W., Broek, R. T., de Boer, J., Somsen, G., Kool, J., Hamers, T., Houtman, C. J. & Lamoree, M. H., 1 Jan 2020, In : Water Research. 168, p. 1-9 9 p., 115204.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals—the ATHENA project

Kortenkamp, A., Axelstad, M., Baig, A. H., Bergman, Å., Bornehag, C. G., Cenijn, P., Christiansen, S., Demeneix, B., Derakhshan, A., Fini, J. B., Frädrich, C., Hamers, T., Hellwig, L., Köhrle, J., Korevaar, T. I. M., Lindberg, J., Martin, O., Meima, M. E., Mergenthaler, P., Nikolov, N. & 12 others, Pasquier, D. D., Peeters, R. P., Platzack, B., Ramhøj, L., Remaud, S., Renko, K., Scholze, M., Stachelscheid, H., Svingen, T., Wagenaars, F., Wedebye, E. B. & Zoeller, R. T., 1 May 2020, In : International Journal of Molecular Sciences. 21, 9, p. 1-13 13 p., 3123.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Transthyretin-binding activity of complex mixtures representing the composition of thyroid-hormone disrupting contaminants in house dust and human serum

Hamers, T., Kortenkamp, A., Scholze, M., Molenaar, D., Cenijn, P. H. & Weiss, J. M., 31 Jan 2020, In : Environmental Health Perspectives. 128, 1, p. 1-15 15 p., 017015.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2019

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve

Jonker, W., de Vries, K., Althuisius, N., van Iperen, D., Janssen, E., ten Broek, R., Houtman, C., Zwart, N., Hamers, T., Lamoree, M. H., Ooms, B., Hidding, J., Somsen, G. W. & Kool, J., 1 Dec 2019, In : SLAS Technology. 24, 6, p. 543-555 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Environmental toxicology, an open online textbook

van Gestel, K., Van Belleghem, F., van den Brink, N. W., Droge, S. T. J., Hamers, T., Hermens, J. L. M., Kraak, M. H. S., Lohr, A. J., Parsons, J. R., Ragas, A., van Straalen, N. & Vijver, M. G., Sep 2019, online ed.

Research output: Book / ReportBook editing

Open Access
2018

Analysis of Lipid Metabolism, Immune Function, and Neurobehavior in Adult C57BL/6JxFVB Mice After Developmental Exposure to di (2-ethylhexyl) Phthalate

Bastos Sales, L., van Esterik, C. J., Hodemaekers, H. M., Lamoree, M. H., Hamers, T. H. M., van der Ven, L. T. M. & Legler, J., 21 Nov 2018, In : Frontiers in endocrinology. 9, p. 684

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

Comparison of in vitro and in vivo bioassays to measure thyroid hormone disrupting activity in water extracts

Leusch, F. D. L., Aneck-Hahn, N. H., Cavanagh, J. A. E., Du Pasquier, D., Hamers, T., Hebert, A., Neale, P. A., Scheurer, M., Simmons, S. O. & Schriks, M., Jan 2018, In : Chemosphere. 191, p. 868-875 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Development of a luminescent mutagenicity test for high-throughput screening of aquatic samples

Zwart, N., Lamoree, M. H., Houtman, C. J., de Boer, J., Kool, J. & Hamers, T., Feb 2018, In : Toxicology in Vitro. 46, p. 350-360 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

Escher, B. I., Aїt-Aїssa, S., Behnisch, P. A., Brack, W., Brion, F., Brouwer, A., Buchinger, S., Crawford, S. E., Du Pasquier, D., Hamers, T., Hettwer, K., Hilscherová, K., Hollert, H., Kase, R., Kienle, C., Tindall, A. J., Tuerk, J., van der Oost, R., Vermeirssen, E. & Neale, P. A., Jul 2018, In : Science of the Total Environment. 628-629, July, p. 748-765 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Effects of environmental pollutants on calcium release and uptake by rat cortical microsomes

Dusza, H. M., Cenijn, P. H., Kamstra, J. H., Westerink, R. H. S., Leonards, P. E. G. & Hamers, T., Dec 2018, In : Neurotoxicology. 69, p. 266-277 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

High-Throughput Effect-Directed Analysis Using Downscaled in Vitro Reporter Gene Assays to Identify Endocrine Disruptors in Surface Water

Zwart, N., Nio, S. L., Houtman, C. J., De Boer, J., Kool, J., Hamers, T. & Lamoree, M. H., 3 Apr 2018, In : Environmental Science and Technology. 52, 7, p. 4367-4377 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro

Hill, K. L., Hamers, T., Kamstra, J. H., Willmore, W. G. & Letcher, R. J., 15 Mar 2018, In : Toxicology Letters. 285, p. 87-93 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

Hamers, T., Legradi, J., Zwart, N., Smedes, F., de Weert, J., van den Brandhof, E. J., van de Meent, D. & de Zwart, D., Dec 2018, In : Environmental Toxicology and Pharmacology. 64, p. 48-59 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2017

Continuous fraction collection of gas chromatographic separations with parallel mass spectrometric detection applied to cell-based bioactivity analysis

Jonker, W., Zwart, N., Stockl, J. B., de Koning, S., Schaap, J., Lamoree, M. H., Somsen, G. W., Hamers, T. & Kool, J., 2 Mar 2017, In : Talanta. 168, p. 162-167 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout

Zwart, N., Andringa, D., de Leeuw, W. J., Kojima, H., Iida, M., Houtman, C. J., de Boer, J., Kool, J., Lamoree, M. H. & Hamers, T., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Optimization of an in vitro assay methodology for competitive binding of thyroidogenic xenobiotics with thyroxine on human transthyretin and albumin

Hill, K. L., Hamers, T., Kamstra, J. H., Willmore, W. G. & Letcher, R. J., 20 Oct 2017, In : MethodsX. 4, p. 404-412 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Toxicity profiling of marine surface sediments: a case study using rapid screening bioassays of exhaustive total extracts, elutriates and passive sampler extracts

Vethaak, A. D., Hamers, T., Martinez-Gomez, C., Kamstra, J. H., de Weert, J., Leonards, P. E. G. & Smedes, F., 1 Jan 2017, In : Marine Environmental Research. 124, -, p. 81-91 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Challenges in effect-directed analysis with a focus on biological samples

Simon, E., Lamoree, M. H., Hamers, T. & de Boer, J., 2015, In : TrAC. Trends in Analytical Chemistry. 67, p. 179-191

Research output: Contribution to JournalArticleAcademicpeer-review

In silico approach to identify potential thyroid hormone disruptors among currently known dust contaminants and their metabolites

Zhang, J., Kamstra, J. H., Ghorbanzadeh, M., Weiss, J. M., Hamers, T. & Andersson, P. L., 2015, In : Environmental Science and Technology. 49, p. 10099-10107

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Rapid activity-directed screening of estrogens by parallel coupling of liquid chromatography with a functional gene reporter assay and mass spectrometry

Jonker, W., Lamoree, M. H., Houtman, C. J., Hamers, T., Somsen, G. W. & Kool, J., 2015, In : Journal of Chromatography A. 1406, p. 165-174

Research output: Contribution to JournalArticleAcademicpeer-review

The influence of extreme river discharge conditions on the quality of suspended particulate matter in Rivers Meuse and Rhine (The Netherlands)

Hamers, T., Kamstra, J. H., van Gils, J., Kotte, M. C. & van Hattum, A. G. M., 2015, In : Environmental Research. 143, p. 241-255

Research output: Contribution to JournalArticleAcademicpeer-review

Tracing thyroid hormone disrupting compounds: database compilation and structure activity evaluation for an effect-directed analysis of sediment

Weiss, J. M., Andersson, P. L., Zhang, J., Simon, E., Leonards, P. E. G., Hamers, T. & Lamoree, M. H., 2015, In : Analytical and Bioanalytical Chemistry. 407, 19, p. 5625-5634

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2014

Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides

Meijer, M., Hamers, T. & Westerink, R. H. S., 2014, In : Neurotoxicology. 43, p. 110-116

Research output: Contribution to JournalArticleAcademicpeer-review

Programming of metabolic effects in C57BL/6JxFVB mice by exposure to bisphenol A during gestation and lactation

van Esterik, C. J., Dollé, M. E. T., Lamoree, M. H., van Leeuwen, S. P. J., Hamers, T., Legler, J. & van der Ven, L. T. M., 2014, In : Toxicology. 321, p. 40-52

Research output: Contribution to JournalArticleAcademicpeer-review

Toxicological Profile of Ultrapure 2,2´,3,4,4´,5,5´-Heptachlorbiphenyl (PCB 180) in Adult Rats

Viluksela, M., Heikkinen, P., van der Ven, L. T. M., Rendel, F., Roos, R., Estaban, J., Korkalainen, M., Lensu, S., Miettinen, M. H., Savolainen, K., Sankari, S., Lilienthal, H., Adamsson, A., Toppari, J., Herlin, M., Finnilä, M., Tuukkanen, J., Leslie, H. A., Hamers, T., Hamscher, G. & 9 others, Al-Anati, L., Stenius, U., Dervola, K. S., Bogen, I. L., Fonnum, F., Andersson, P. L., Schrenk, D., Halldin, K. & Håkansson, H., 2014, In : PLoS ONE. 9, 9, p. e104639

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47

Kamstra, J. H., Hruba, E., Blumberg, B., Janesick, A., Mandrup, S., Hamers, T. & Legler, J., 2014, In : Environmental Science and Technology. 48, 7, p. 4110-4119

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2013

Developmental effects of aerosols and coal burning particles in zebrafish embryos

Olivares, A., van Drooge, B. L., Casado, M., Prats, E., Serra, M., van der Ven, L. T., Kamstra, J. H., Hamers, T., Hermsen, S., Grimalt, J. O. & Piña, B., 2013, In : Environmental Pollution. 178, p. 72-79

Research output: Contribution to JournalArticleAcademicpeer-review

Effect-Directed Analysis to Explore the Polar Bear Exposome: the Identification of Thyroid Hormone Disrupting Compounds in Plasma

Simon, E., van Velzen, M. J. M., Brandsma, S. H., Lie, E., Loken, K., de Boer, J., Bytingsvik, J., Jenssen, B. M., Aars, J., Hamers, T. & Lamoree, M. H., 2013, In : Environmental Science and Technology. 47, p. 8902-8912

Research output: Contribution to JournalArticleAcademicpeer-review

Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentation

Bastos Sales, L., Kamstra, J. H., Cenijn, P. H., van Rijt, L. S., Hamers, T. & Legler, J., 2013, In : Toxicology in Vitro. 27, 6, p. 1634-1643

Research output: Contribution to JournalArticleAcademicpeer-review

Expert Opinion on Toxicity Profiling - Report from a NORMAN Expert Group Meeting

Hamers, T., Legler, J., Blaha, L., Hylland, K., Marigomez, I., Schipper, C. A., Segner, H., Vethaak, A. D., Witters, H., de Zwart, D. & Leonards, P. E. G., 2013, In : Integrated Environmental Assessment and Management. 9, 2, p. 185-191

Research output: Contribution to JournalArticleAcademicpeer-review

High-resolution fractionation after gas chromatography for Effect Directed Analysis.

Pieke, E., Heus, F. A. H., Kamstra, J., Mladic, M., van Velzen, M., Kamminga, D., Lamoree, M. H., Hamers, T., Leonards, P. E. G., Niessen, W. M. A. & Kool, J., 2013, In : Analytical Chemistry. 85, 17, p. 8204-8211

Research output: Contribution to JournalArticleAcademicpeer-review

Integrated chemical and biological analysis to explain estrogenic potency in bile extracts of red mullet (Mullus barbatus)

Martínez-Gómez, C., Lamoree, M. H., Hamers, T., van Velzen, M. J. M., Kamstra, J. H., Fernández, B., Benedicto, J., León, V. M. & Vethaak, A. D., 2013, In : Aquatic Toxicology. 134-135, p. 1-10

Research output: Contribution to JournalArticleAcademicpeer-review

Transthyretin-Binding Activity of Contaminants in Blood from Polar Bear (Ursus maritimus) Cubs

Bytingsvik, J., Simon, E., Leonards, P. E. G., Lamoree, M. H., Lie, E., Aars, J., Derocher, A. E., Wiig, O., Jenssen, B. M. & Hamers, T., 2013, In : Environmental Science and Technology. 47, p. 4778-4786

Research output: Contribution to JournalArticleAcademicpeer-review

2012

Known unknowns: strategies for identification of toxicants in Effect Directed Analysis

Simon, E., Weiss, J. M., Hamers, T., Leonards, P. E. G. & Lamoree, M. H., 2012.

Research output: Contribution to ConferencePosterOther research output

Perfluoroalkyl substances in polar bear mother-cub pairs: A comparative study based on plasma levels from 1998 and 2008

Bytingsvik, J., Leeuwen, S., Hamers, T., Swart, C. P., Aars, J., Lie, E., Espseth Nilsen, E. M., Wiig, O., Derocher, A. E. & Jenssen, B. M., 2012, In : Environment International. 49, p. 92-99 11.

Research output: Contribution to JournalArticleAcademicpeer-review

Thyroid hormone disruption in Effect-Directed Analysis - An endpoint of growing concern

Weiss, J. M., Simon, E., Leonards, P. E. G., Hamers, T. & Lamoree, M. H., 2012.

Research output: Contribution to ConferencePosterOther research output

2011

Blood plasma sample preparation method to determine thyroid hormone-disrupting compounds in Effect-Directed Analysis

Simon, E., Bytingsvik, J., Jonker, W., Leonards, P. E. G., de Boer, J., Jenssen, B. M., Lie, E., Aars, J., Hamers, T. H. M. & Lamoree, M. H., 2011, In : Environmental Science and Technology. 45, 18, p. 7936-7944

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Effects of endocrine disrupting chemicals on global DNA methylation and differentiation using in vitro models

Bastos Sales, L., van Boxtel, A. L., Kamstra, J. H., Cenijn, P. H., van Rijt, L., Hamers, T. H. M. & Legler, J., 2011, In : Organohalogen Compounds. 73, p. 1509-1512 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Erratum to "A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats" [Toxicology 245 (2008) 109-122]

van der Ven, L. T. M., van de Kuil, T., Verhoef, A., Leonards, P. E. G., Slob, W., Cantón, R. F., Germer, S., Hamers, T., Visser, T. J., Litens, S., Håkansson, H., Fery, Y., Schrenk, D., van den Berg, M., Piersma, A. H. & Vos, J. G., 27 Feb 2011, In : Toxicology. 280, 3, p. 178 1 p.

Research output: Contribution to JournalErratumAcademic

Hepatic effects of a highly purified 2,2’,3,4,4’,5,5’-heptachlorobiphenyl (PCB-180) in male and female rats

Roos, R., Andersson, P. L., Halldin, K., Håkansson, H., Westerholm, E., Hamers, T. H. M., Hamscher, G., Heikkinen, P., Korkolainen, M., Leslie, H. A., Niitynen, N., Sankari, S., Schmitz, H. J., van der Ven, L., Viluksela, M. & Schrenk, D., 2011, In : Toxicology. 284, 1-3, p. 42-53

Research output: Contribution to JournalArticleAcademicpeer-review

In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl (NDL-PCB) congeners and their relative toxic contribution to PCB-mixtures in humans

Hamers, T. H. M., Kamstra, J. H., Cenijn, P. H., Palkova, L., Simeckova, P., Vondracek, J., Andersson, P. L., Stenberg, M. & Machala, M., 2011, In : Toxicological Sciences. 121, 1, p. 88-100

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Multivariate toxicity profiles and QSAR modelling of NDL-PCBs – an investigation of in vitro screening data from ultra-pure congeners

Stenberg, M., Hamers, T. H. M., Machala, M., Fonnum, F., Stenius, U., Al Anati, L., van Duursen, M., Westerink, R. H. S., Fernandes, E. C. A. & Andersson, P. L., 2011, In : Chemosphere. 85, 9, p. 1423-1429

Research output: Contribution to JournalArticleAcademicpeer-review

The OBELIX project: early life exposure to endocrine disruptors and obesity

Legler, J., Hamers, T. H. M., van de Bor, M., Schoeters, G., van der Ven, L., Eggesbo, M., Koppe, J. & Trnovec, T., 2011, In : American Journal of Clinical Nutrition. 94, 6 Suppl., p. 1933S-1938S

Research output: Contribution to JournalArticleAcademicpeer-review