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  • Lannie Ligthart
2017

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

Reus, L. M., Shen, X., Gibson, J., Wigmore, E., Ligthart, L., Adams, M. J., Davies, G., Cox, S. R., Hagenaars, S. P., Bastin, M. E., Deary, I. J., Whalley, H. C. & McIntosh, A. M., 10 Feb 2017, In : Scientific Reports. 7, 42140.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark, D. W., Nutile, T., Barnes, C. L. K., Timmers, P. R. H. J., Shen, X., Gandin, I., McDaid, A. F., Hansen, T. F., Gordon, S. D., Giulianini, F., Boutin, T. S., Abdellaoui, A., Zhao, W., Medina-Gomez, C. & 93 others, Bartz, T. M., Trompet, S., Lange, L. A., Raffield, L., van der Spek, A., Galesloot, T. E., Proitsi, P., Yanek, L. R., Bielak, L. F., Payton, A., Murgia, F., Concas, M. P., Biino, G., Tajuddin, S. M., Seppälä, I., Amin, N., Boerwinkle, E., Børglum, A. D., Campbell, A., Demerath, E. W., Demuth, I., Faul, J. D., Ford, I., Gialluisi, A., Gögele, M., Graff, M., Hingorani, A., Hottenga, J-J., Hougaard, D. M., Hurme, M. A., Ikram, M. A., Jylhä, M., Kuh, D., Ligthart, L., Lill, C. M., Lindenberger, U., Lumley, T., Mägi, R., Marques-Vidal, P., Medland, S. E., Milani, L., Nagy, R., Ollier, W. E. R., Peyser, P. A., Pramstaller, P. P., Ridker, P. M., Rivadeneira, F., Ruggiero, D., Saba, Y., Schmidt, R., Schmidt, H., Slagboom, P. E., Smith, B. H., Smith, J. A., Sotoodehnia, N., Steinhagen-Thiessen, E., van Rooij, F. J. A., Verbeek, A. L., Vermeulen, S. H., Vollenweider, P., Wang, Y., Werge, T., Whitfield, J. B., Zonderman, A. B., Lehtimäki, T., Evans, M. K., Pirastu, M., Fuchsberger, C., Bertram, L., Pendleton, N., Kardia, S. L. R., Ciullo, M., Becker, D. M., Wong, A., Psaty, B. M., van Duijn, C. M., Wilson, J. G., Jukema, J. W., Kiemeney, L., Uitterlinden, A. G., Franceschini, N., North, K. E., Weir, D. R., Metspalu, A., Boomsma, D. I., Hayward, C., Chasman, D., Martin, N. G., Sattar, N., Campbell, H., Esko, T., Kutalik, Z. & Wilson, J. F., 13 Oct 2017, In : Nature Communications. 8, 1, p. 910 910.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Mbarek, H., Milaneschi, Y., Hottenga, J-J., Ligthart, L., de Geus, E. J. C., Ehli, E. A., Willemsen, G., Davies, G. E., Smit, J. H., Boomsma, D. I. & Penninx, B. W. J. H., 1 Aug 2017, In : Twin Research and Human Genetics. 20, 4, p. 267-270 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Heritability of tic disorders: a twin-family study

Rodrigues Zilhao Nogueira, N., Olthof, M. C., Smit, D. J. A., Cath, D. C., Ligthart, L., Mathews, C. A., Delucchi, K., Boomsma, D. I. & Dolan, C. V., Mar 2017, In : Psychological Medicine. 47, 6, p. 1085-1096 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Prevalence of dieting and fear of weight gain across ages: a community sample from adolescents to the elderly

Slof-Op 't Landt, M. C. T., van Furth, E. F., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., de Geus, E. J., Ligthart, L. & Boomsma, D. I., 1 Nov 2017, In : International Journal of Public Health. 62, 8, p. 911-919 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Short communication: Genetic association between schizophrenia and cannabis use

Verweij, C. J. H., Abdellaoui, A., Nivard, M. G., Sainz Cort, A., Ligthart, L., Draisma, H. H. M., Minica, C. C., International Cannabis Consortium, Willemsen, G., Hottenga, J. J., Boomsma, D. I. & Vink, J. M., 1 Feb 2017, In : Drug and Alcohol Dependence. 171, p. 117-121 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The factor structure of dental fear

van Houtem, C. M. H. H., van Wijk, A. J., Boomsma, D. I., Ligthart, L., Visscher, C. M. & de Jongh, A., Jun 2017, In : European Journal of Oral Sciences. 125, 3, p. 195-201 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2016

Epigenome-wide association study meta-analysis of aggressive behavior

van Dongen, J., Ismail, K., Mulder, R., Baselmans, B. M. L., Nivard, M. G., Jansen, R., Ligthart, L., Ollikainen, M., Vuoksimaa, E., Tiemeier, H., Kaprio, J., Bartels, M. & Boomsma, D., Nov 2016, In : Behavior Genetics. 46, 6, p. 810-810

Research output: Contribution to JournalMeeting AbstractOther research output

Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression

Molenaar, D., Middeldorp, C. M., Willemsen, G., Ligthart, L., Nivard, M. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 1, p. 59-71

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

Zhao, H., Eising, E., de Vries, B., Vijfhuizen, L. S., Anttila, V., Winsvold, B. S., Kurth, T., Stefansson, H., Kallela, M., Malik, R., Stam, A. H., Arfan Ikram, M., Ligthart, L., Freilinger, T., Alexander, M., Müller-Myhsok, B., Schreiber, S., Meitinger, T., Aromas, A., Eriksson, J. G. & 16 others, Boomsma, D. I., van Duijn, C. M., Zwart, J. A., Quaye, L., Kubisch, C., Dichgans, M., Wessman, M., Stefansson, K., Chasman, D. I., Palotie, A., Martin, N. G., Montgomery, G. W., Ferrari, M. D., Terwindt, G. M., van den Maagdenberg, A. M. J. M. & Nyholt, DR., 2016, In : Cephalalgia. 36, 7, p. 648-657

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic epidemiology of migraine and depression

Yang, Y., Ligthart, L., Terwindt, G. M., Boomsma, D. I., Rodriguez-Acevedo, A. J. & Nyholt, DR., 2016, In : Cephalalgia. 36, 7, p. 679-691

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide pleiotropy of adult aggression and blood metabolites

Hagenbeek, F. A., Nivard, M. G., Pool, R., van Dongen, J., Hottenga, J. J., Abdellaoui, A., Willemsen, G., Vink, J. M., Ligthart, L., Harms, A., Hankemeier, T., Bartels, M. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 6, p. 772-816

Research output: Contribution to JournalMeeting AbstractOther research output

Heritability of high sugar consumption through drinks and the genetic correlation with substance use

Treur, J. L., Boomsma, D. I., Ligthart, L., Willemsen, G. & Vink, J. M., 2016, In : The American Journal of Clinical Nutrition. 104, 4, p. 1144-1150

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G. M., Kallela, M., Freilinger, T., Ran, C., Gordon, S. G., Stam, A. H. & 88 others, Steinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H. H. H., Lehtimäki, T., Sarin, A. P., Wedenoja, J., Hinds, D. A., Buring, J. E., Schürks, M., Ridker, P. M., Gudlaug Hrafnsdottir, M., Stefansson, H., Ring, S. M., Hottenga, J. J., Penninx, B. W. J. H., Färkkilä, M., Artto, V., Kaunisto, M. A., Vepsäläinen, S., Malik, R., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Kurki, M. I., Kals, M., Mägi, R., Pärn, K., Hämaläinen, E., Huang, H., Byrnes, A. E., Franke, L., Huang, J., Stergiakouli, E., Lee, P. H., Sandor, C., Webber, C., Cader, Z., Müller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J. G., Salomaa, V., Heikkilä, K., Loehrer, A. G., Uitterlinden, A. G., Hofman, A., van Duijn, C. M., Cherkas, L., Pedersen, L., Stubhaug, A., Nielsen, C. S., Männikkö, M., Mihailov, E., Milani, L., Göbel, H., Esserlind, A. L., Francke Christensen, A., Folkmann Hansen, T., Werge, T., Kaprio, J., Aromaa, A., Raitakari, O., Ikram, M. A., Spector, T. D., Järvelin, M. R., Metspalu, A., Kubisch, C., Strachan, D. P., Ferrari, M. D., Belin, A. C., Dichgans, M., Wessman, M., van den Maagdenberg, A. M. J. M., Zwart, J. A., Boomsma, D. I., Davey Smith, G., Stefansson, K., Eriksson, N., Daly, M. J., Neale, B. M., Olesen, J., Chasman, D. I., Nyholt, DR., Palotie, A. & Posthuma, D., 2016, In : Nature Genetics. 48, 8, p. 856-866

Research output: Contribution to JournalArticleAcademicpeer-review

2014

Comorbidity among multiple pain symptoms and anxious depression in a Dutch population sample

Ligthart, L., Visscher, C. M., van Houtem, C. M. H. H., Geels, L. M., Vink, J. M., de Jongh, A. & Boomsma, D. I., 2014, In : Journal of Pain. 15, 9, p. 945-955 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Ligthart, L., Hottenga, J. J., Lewis, C. M., Farmer, A. E., Craig, I. W., Breen, G., Willemsen, G., Vink, J. M., Middeldorp, C. M., Byrne, E. M., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Montgomery, G. W., Martin, N. G., Penninx, B. W. J. H., McGuffin, P., Boomsma, D. I. & Nyholt, DR., 2014, In : Human Genetics. 133, 2, p. 173-186 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetisch onderzoek met behulp van tweelingen

Ligthart, L., 2014, In : Quality Practice. Nascholingstijdschrift voor tandartsen. 9, 5, p. 8-11 4 p.

Research output: Contribution to JournalArticleProfessional

Is dental phobia a blood-injection-injury phobia?

van Houtem, C. M. H. H., Aartman, I. H. A., Boomsma, D. I., Ligthart, L., Visscher, C. & de Jongh, A., 2014, In : Depression and Anxiety. 31, 12, p. 1026-1034 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Prevalence and comorbidity of pain symptoms in the general population

Ligthart, L., 2014.

Research output: Contribution to ConferencePosterOther research output

2013

Anxiety and Depression Are Associated With Migraine and Pain in General: An Investigation of the Interrelationships

Ligthart, L., Gerrits, M. J. G., Boomsma, D. I. & Penninx, B. W. J. H., 2013, In : Journal of Pain. 14, 4, p. 363-370

Research output: Contribution to JournalArticleAcademicpeer-review

A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears

van Houtem, C. M. H. H., Laine, M. L., Boomsma, D. I., Ligthart, L., van Wijk, A. J. & de Jongh, A., 2013, In : Journal of Anxiety Disorders. 27, 4, p. 379-388

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., Wedenoja, J. & 75 others, Dunham, I., Neale, B. M., Palta, P., Hamalainen, E., Schürks, M., Rose, L. M., Buring, J. E., Ridker, P. M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D. A., Evans, D. M., Ring, S. M., Färkkilä, M., Artto, V., Kaunisto, M. A., Freilinger, T., Schoenen, J., Frants, R. R., Pelzer, N., Weller, C. M., Zielman, R., Heath, A. C., Madden, P. A. F., Montgomery, G. W., Martin, N. G., Borck, G., Göbel, H., Heinze, A., Heinze-Kuhn, K., Williams, F. M., Hartikainen, A-L., Pouta, A., van den Ende, J., Uitterlinden, A. G., Hofman, A., Amin, N., Hottenga, J. J., Vink, J. M., Heikkilä, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H. E., Aromaa, A., Eriksson, J. G., Traynor, B. J., Trabzuni, D., Rossin, E., Lage, K., Jacobs, S. B., Gibbs, J. R., Birney, E., Kaprio, J., Penninx, B. W. J. H., Boomsma, D. I., van Duijn, C. M., Raitakari, O., Jarvelin, M-R., Zwart, J. A., Cherkas, L., Strachan, D. P., Kubisch, C., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Dichgans, M., Wessman, M., Smith, G. D., Stefansson, K., Daly, M. J., Nyholt, DR., Chasman, D. I. & Palotie, A., 2013, In : Nature Genetics. 45, 8, p. 912-917

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Is tmd-pijn erfelijk?

Visscher, C. M., Ligthart, L. & Lobbezoo, F., 2013, In : Quality Practice. Nascholingstijdschrift voor tandartsen. 8, 4, p. 12-14

Research output: Contribution to JournalArticleProfessional

The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection

Willemsen, G., Vink, J. M., Abdellaoui, A., den Braber, A., van Beek, J. H. D. A., Draisma, H. H. M., van Dongen, J., van t Ent, D., Geels, L. M., van Lien, R., Ligthart, L., Kattenberg, V. M., Mbarek, H., de Moor, M. H. M., Neijts, M., Pool, R., Stroo, N., Kluft, C., Suchiman, H. E. D., Slagboom, P. E. & 2 others, de Geus, E. J. C. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 1, p. 271-281

Research output: Contribution to JournalArticleAcademicpeer-review

2012

Sex Differences in Genetic Architecture of Complex Phenotypes?

Vink, J. M., Bartels, M., van Beijsterveldt, C. E. M., van Dongen, J., van Beek, J. H. D. A., Distel, M. A., de Moor, M. H. M., Smit, D. J. A., Minica, C. C., Ligthart, L., Geels, L. M., Abdellaoui, A., Middeldorp, C. M., Hottenga, J. J., Willemsen, G., de Geus, E. J. C. & Boomsma, D. I., 2012, In : PLoS ONE. 7, 12, e47371.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
2011

Adolescent personality profiles, neighborhood income, and young adult alcohol use: A longitudinal study

Ayer, L., Rettew, D., Althoff, R. R., Willemsen, G., Ligthart, L., Hudziak, J. J. & Boomsma, D. I., 2011, In : Addictive Behaviors. 36, 12, p. 1301-1304

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Ligthart, L., de Vries, B., Smith, A. V., Arfan Ikram, M., Amin, N., Hottenga, J. J., Koelewijn, S. C., Kattenberg, V. M., de Moor, M. H. M., Janssens, A. J. W., Aulchenko, Y. S., Oostra, B. A., de Geus, E. J. C., Smit, J. H., Zitman, F. G., Uitterlinden, A. G., Hofman, A., Willemsen, G., Nyholt, DR., Montgomery, G. W. & 9 others, Terwindt, G. M., Gudnason, V., Penninx, B. W. J. H., Breteler, M., Ferrari, M. D., Launer, L. J., van Duijn, C. M., van den Maagdenberg, A. M. J. M. & Boomsma, D. I., 2011, In : European Journal of Human Genetics. 19, 8, p. 901-907

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Migraine, depression and other types of pain: a common etiology?

Ligthart, L., 2011.

Research output: Contribution to ConferencePosterOther research output

Qualitative and quantitative sex differences in genetic architecture for human phenotypes

Boomsma, D. I., Bartels, M., van Beijsterveldt, C. E. M., Distel, M. A., Smit, D. J. A., de Moor, M. H. M., Middeldorp, M., Ligthart, R. S. L., Willemsen, G., Hottenga, J. J., de Geus, E. J. C. & Vink, J. M., 2011, In : Behavior Genetics. 41, 6, p. 894-895

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
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