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  • W.M.A. Niessen

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

Kool, J., Giera, M. A., Irth, H. & Niessen, W. M. A., 2011, In : Analytical and Bioanalytical Chemistry. 399, 8, p. 2655-2668

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
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A high-throughput sample preparation method for cellular proteomics using 96-well filter plates.

Switzar, L., van Angeren, J. A., Pinkse, M., Kool, J. & Niessen, W. M. A., 2013, In : Journal of Proteomics. 13, p. 2980-2983

Research output: Contribution to JournalArticleAcademicpeer-review

Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In : Biomedical Chromatography. 25, 1-2, p. 278-299

Research output: Contribution to JournalArticleAcademicpeer-review

Analytical workflow for rapid screening and purification of bioactives from venom proteomes

Otvos, R. A., Heus, F. A. M., Vonk, F. J., Halff, J., Bruynzeel, B., Paliukhovich, I., Smit, A. B., Niessen, W. M. A. & Kool, J., 2013, In : Toxicon. 76, p. 270-281

Research output: Contribution to JournalArticleAcademicpeer-review

An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity.

Heus, F. A. H., Vonk, F., Otvos, R. A., Bruyneel, B., Smit, A. B., Lingeman, H., Richardson, M., Niessen, W. M. A. & Kool, J., 2013, In : Toxicon. 61, p. 112-124

Research output: Contribution to JournalArticleAcademicpeer-review

At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Journal of Biomolecular Screening. 21, p. 459-467

Research output: Contribution to JournalArticleAcademicpeer-review

At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In : Toxicon. 110, p. 79-89

Research output: Contribution to JournalArticleAcademicpeer-review

Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

van den Broek, I., van Dongen, W. D. & Niessen, W. M. A., 2013, In : Journal of Chromatography B. 929, p. 161-179

Research output: Contribution to JournalArticleAcademicpeer-review

Bioanalytical LC-MS of therapeutic oligonucleotides

van Dongen, W. D. & Niessen, W. M. A., 2011, In : Bioanalysis. 3, p. 541-564

Research output: Contribution to JournalArticleAcademicpeer-review

Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : TrAC. Trends in Analytical Chemistry. 61, p. 17-28

Research output: Contribution to JournalArticleAcademicpeer-review

Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

Research output: Contribution to JournalArticleAcademicpeer-review

Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

Research output: Contribution to JournalArticleAcademicpeer-review

Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography B. 879, 17-18, p. 1393-1401

Research output: Contribution to JournalArticleAcademicpeer-review

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization

Kloos, D., Derks, R. J. E., Wijtmans, M., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2012, In : Journal of Chromatography A. 1232, p. 19-26

Research output: Contribution to JournalArticleAcademicpeer-review

Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Analytical Chemistry. 88, p. 4825-4832

Research output: Contribution to JournalArticleAcademicpeer-review

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In : Journal of Biomolecular Screening. 17, p. 1329-1338

Research output: Contribution to JournalArticleAcademicpeer-review

Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures.

Falck, D., Schebb, N. H., Prinatiningtyas, S., Zhang, J., Heus, F. A. H., Morisseau, C., Kool, J., Hammock, B. D. & Niessen, W. M. A., 2013, In : Chromatographia. 76, p. 13-21

Research output: Contribution to JournalArticleAcademicpeer-review

EC–SPE–stripline-NMR analysis of reactive products: A feasibility study.

Falck, D., Oosthoek-de Vries, A. J., Kolkman, A. J., Lingeman, H., Honing, M., Wijmenga, S. S., Kentgens, A. P. M. & Niessen, W. M. A., 2013, In : Analytical and Bioanalytical Chemistry. 405, p. 6711-6720

Research output: Contribution to JournalArticleAcademicpeer-review

Evaluation of different column chemistries for fast urinary metabolic profiling.

Kloos, D., Lingeman, H., Niessen, W. M. A., Deelder, A. M., Giera, M. & Mayboroda, O. A., 2013, In : Journal of Chromatography B. 927, p. 90-96

Research output: Contribution to JournalArticleAcademicpeer-review

Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography – tandem mass spectrometry

Niessen, W. M. A., 2012, In : Mass Spectrometry Reviews. 31, p. 626-665

Research output: Contribution to JournalArticleAcademicpeer-review

Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry

Niessen, W. M. A., 2011, In : Mass Spectrometry Reviews. 30, 4, p. 626-663

Research output: Contribution to JournalArticleAcademicpeer-review

Fragmentation pathway of drugs of abuse and their metabolites using accurate mass spectra of QTOF MS.

Bijlsma, L., Sancho, J. V., Hernandéz, F. & Niessen, W. M. A., 2011, In : Journal of Mass Spectrometry. 46, p. 865-875

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

High-resolution fractionation after gas chromatography for Effect Directed Analysis.

Pieke, E., Heus, F. A. H., Kamstra, J., Mladic, M., van Velzen, M., Kamminga, D., Lamoree, M. H., Hamers, T., Leonards, P. E. G., Niessen, W. M. A. & Kool, J., 2013, In : Analytical Chemistry. 85, 17, p. 8204-8211

Research output: Contribution to JournalArticleAcademicpeer-review

High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In : Journal of Chromatography A. 1259, p. 213-220

Research output: Contribution to JournalArticleAcademicpeer-review

Hyphenated Techniques, Applications of in Mass Spectrometry

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H. & Niessen, W. M. A., 2013, In : Journal of Chromatography B. 917-918, p. 53-61

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of new omeprazole metabolites in wastewaters and surface waters.

Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In : Science of the Total Environment. 468-469, p. 706-714

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry. (I) Degradation experiments.

Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2013, In : Journal of Mass Spectrometry. 48, p. 1091-1100

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment.

Bijlsma, L., Boix, C., Niessen, W. M. A., Ibañez, M., Sancho, J. V. & Hernandez, F., 2013, In : Science of the Total Environment. 443, p. 200-208

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In : Microchemical Journal. 141, p. 135-140 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

LC–MS systems for quantitative bioanalysis

van Dongen, W. D. & Niessen, W. M. A., 2012, In : Bioanalysis. 4, p. 2391-2399

Research output: Contribution to JournalArticleAcademicpeer-review

Liquid chromatography-mass spectrometry

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.). Elsevier

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Mass Spectrometry | Atmospheric-pressure ionization

Bruins, A. P. & Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In : Analyst. 136, p. 2763-2769

Research output: Contribution to JournalArticleAcademicpeer-review

Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In : Biology. 3, p. 139-156

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

MSMS and MSn

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In : SLAS Discovery. 23, 3, p. 283-293 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In : Analytical Chemistry. 83, 1, p. 125-132

Research output: Contribution to JournalArticleAcademicpeer-review

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

Falck, D., de Vlieger, J. S. B., Giera, M., Honing, M., Irth, H., Niessen, W. M. A. & Kool, J., 2012, In : Analytical and Bioanalytical Chemistry. 403, p. 367-375

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In : Journal of Chromatography B. 879, 20, p. 1781-1788

Research output: Contribution to JournalArticleAcademicpeer-review

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In : MedChemComm. 2, p. 590-595

Research output: Contribution to JournalArticleAcademicpeer-review

On-line Protein Digestion in Combination with Chromatographic Separation and Mass Spectrometric Detection.

Hoos, S. J. & Niessen, W. M. A., 2011, Protein and peptide analysis by LC-MS: Experimental strategies. Letzel, T. (ed.). RSC Publishing, p. 71-86

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

Martha, C. T., Hoogendoorn, J. C., Irth, H. & Niessen, W. M. A., 2011, In : Talanta. 84, 3, p. 623-631

Research output: Contribution to JournalArticleAcademicpeer-review

Protein digestion: An overview of the available techniques and recent developments

Switzar, L., Giera, M. & Niessen, W. M. A., 2013, In : Journal of Proteome Research. 12, p. 1067-1077

Research output: Contribution to JournalArticleAcademicpeer-review

Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography A. 1218, 13, p. 1715-1723

Research output: Contribution to JournalArticleAcademicpeer-review

Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA) – a brief overview.

Giera, M., Lingeman, H. & Niessen, W. M. A., 2012, In : Chromatographia. 75, p. 433-440

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access