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  • Anja Wilmes
2019

A protocol for one-step differentiation of human induced pluripotent stem cells into mature podocytes

Murphy, C., Feifel, E., Jennings, P., Gstraunthaler, G. & Wilmes, A., 2019, Cell-Based Assays Using iPSCs for Drug Development and Testing. Mandenius, C. F. & Ross, J. (eds.). Humana Press Inc., p. 93-99 7 p. (Methods in Molecular Biology; vol. 1994).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Corrigendum: Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases

Zgheib, E., Limonciel, A., Jiang, X., Wilmes, A., Wink, S., Van De Water, B., Kopp-Schneider, A., Bois, F. Y. & Jennings, P., 4 Jun 2019, In : Frontiers in Genetics. 10, JUN, 517.

Research output: Contribution to JournalErratumAcademic

Open Access
2017

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion

Wilmes, A., Rauch, C., Carta, G., Kern, G., Meier, F., Posch, W., Wilflingseder, D., Armstrong, L., Lako, M., Beilmann, M., Gstraunthaler, G. & Jennings, P., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 445-454 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2016

Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing

Stacey, G. N., Coecke, S., Price, A-B., Healy, L., Jennings, P., Wilmes, A., Pinset, C., Ingelman-Sundberg, M., Louisse, J., Haupt, S., Kidd, D., Robitski, A., Jahnke, H-G., Lemaitre, G. & Myatt, G., 28 Sep 2016, In : Advances in Experimental Medicine and Biology. 856, p. 259-297 39 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

2015

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

Aschauer, L., Limonciel, A., Wilmes, A., Stanzel, S., Kopp-Schneider, A., Hewitt, P., Lukas, A., Leonard, M. O., Pfaller, W. & Jennings, P., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 106-116 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier

Bellwon, P., Culot, M., Wilmes, A., Schmidt, T., Zurich, M. G., Schultz, L., Schmal, O., Gramowski-Voss, A., Weiss, D. G., Jennings, P., Bal-Price, A., Testai, E. & Dekant, W., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 166-175 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing

Crean, D., Bellwon, P., Aschauer, L., Limonciel, A., Moenks, K., Hewitt, P., Schmidt, T., Herrgen, K., Dekant, W., Lukas, A., Bois, F. Y., Wilmes, A., Jennings, P. & Leonard, M. O., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 128-137 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Interleukin-19 as a translational indicator of renal injury

Jennings, P., Crean, D., Aschauer, L., Limonciel, A., Moenks, K., Kern, G., Hewitt, P., Lhotta, K., Lukas, A., Wilmes, A. & Leonard, M. O., Jan 2015, In : Archives of Toxicology. 89, 1, p. 101-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems

Bellwon, P., Truisi, G. L., Bois, F. Y., Wilmes, A., Schmidt, T., Savary, C. C., Parmentier, C. C., Hewitt, P. G., Schmal, O., Josse, R., Richert, L., Guillouzo, A., Mueller, S. O., Jennings, P., Testai, E. & Dekant, W., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 62-78 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics

Wilmes, A., Bielow, C., Ranninger, C., Bellwon, P., Aschauer, L., Limonciel, A., Chassaigne, H., Kristl, T., Aiche, S., Huber, C. G., Guillou, C., Hewitt, P., Leonard, M. O., Dekant, W., Bois, F. Y. & Jennings, P., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 117-27 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline

Ranninger, C., Rurik, M., Limonciel, A., Ruzek, S., Reischl, R., Wilmes, A., Jennings, P., Hewitt, P., Dekant, W., Kohlbacher, O. & Huber, C. G., 31 Jul 2015, In : Journal of Biological Chemistry. 290, 31, p. 19121-32 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The Use of Renal Cell Culture for Nephrotoxicity Investigations

Wilmes, A. & Jennings, P., 20 Jan 2015, Predictive Toxicology: From Vision to Reality. Wiley-Blackwell, Vol. 64. p. 195-216 22 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing

Limonciel, A., Moenks, K., Stanzel, S., Truisi, G. L., Parmentier, C., Aschauer, L., Wilmes, A., Richert, L., Hewitt, P., Mueller, S. O., Lukas, A., Kopp-Schneider, A., Leonard, M. O. & Jennings, P., 25 Dec 2015, In : Toxicology in Vitro. 30, 1 Pt A, p. 7-18 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2013

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

Wilmes, A., Limonciel, A., Aschauer, L., Moenks, K., Bielow, C., Leonard, M. O., Hamon, J., Carpi, D., Ruzek, S., Handler, A., Schmal, O., Herrgen, K., Bellwon, P., Burek, C., Truisi, G. L., Hewitt, P., Di Consiglio, E., Testai, E., Blaauboer, B. J., Guillou, C. & 7 others, Huber, C. G., Lukas, A., Pfaller, W., Mueller, S. O., Bois, F. Y., Dekant, W. & Jennings, P., 21 Feb 2013, In : Journal of Proteomics. 79, p. 180-94 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Delineation of the key aspects in the regulation of epithelial monolayer formation

Aschauer, L., Gruber, L. N., Pfaller, W., Limonciel, A., Athersuch, T. J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari-Voglauer, R., Hewitt, P., Leonard, M. O., Wilmes, A. & Jennings, P., Jul 2013, In : Molecular and Cellular Biology. 33, 13, p. 2535-2550 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nrf2 inducibility of aldo-keto reductases

Wilmes, A., Leonard, M. O. & Jennings, P., 31 Jul 2013, In : Toxicology Letters. 221, 1, p. 39

Research output: Contribution to JournalArticleAcademicpeer-review

2012

Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae

Wilmes, A., Hanna, R., Heathcott, RW., Northcote, PT., Atkinson, PH., Bellows, DS. & Miller, JH., 2012, In : Gene. 497, p. 140 146 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

Limonciel, A., Wilmes, A., Aschauer, L., Radford, R., Bloch, K. M., McMorrow, T., Pfaller, W., van Delft, J. H., Slattery, C., Ryan, M. P., Lock, E. A. & Jennings, P., Nov 2012, In : Archives of Toxicology. 86, 11, p. 1741-51 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A

Wilmes, A., Chan, A., Rawson, P., Jordan, TW. & Miller, JH., 2012, In : Investigational New Drugs. 30, p. 121 129 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

Jennings, P., Weiland, C., Limonciel, A., Bloch, K. M., Radford, R., Aschauer, L., McMorrow, T., Wilmes, A., Pfaller, W., Ahr, H. J., Slattery, C., Lock, E. A., Ryan, M. P. & Ellinger-Ziegelbauer, H., Apr 2012, In : Archives of Toxicology. 86, 4, p. 571-89 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Two-stage model-free tests of synergy in drug combinations

Kelly, C., Feng, P., Wilmes, A., Kawashima, T. & Miller, J., 2012, In : Journal of biopharmaceutical statistics. 22, p. 54 71 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2011

Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells

Wilmes, A., Rawson, P., McLauchlan, L., McLauchlan, D., Northcote, PT., Jordan, TW. & Miller, JH., 2011, In : Investigational New Drugs. 29, p. 544 553 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity

Wilmes, A., Crean, D., Aydin, S., Pfaller, W., Jennings, P. & Leonard, M. O., Apr 2011, In : Toxicology in Vitro. 25, 3, p. 613-22 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

Limonciel, A., Aschauer, L., Wilmes, A., Prajczer, S., Leonard, M. O., Pfaller, W. & Jennings, P., Dec 2011, In : Toxicology in Vitro. 25, 8, p. 1855-62 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes

Kanakkanthara, A., Wilmes, A., O'Brate, A., Escuin, D., Chan, A., Gjyrezi, A., Crawford, J., Rawson, P., Kivell, B., Northcote, PT., Hamel, E., Giannakakou, P. & Miller, JH., 2011, In : Molecular Cancer Therapeutics. 10, p. 1419 1429 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues

Singh, AJ., Razzak, M., Teesdale-Spittle, P., Gaitanos, TN., Wilmes, A., Paterson, I., Goodman, JM., Miller, JH. & Northcote, PT., 2011, In : Organic and Biomolecular Chemistry. 9, p. 4456 4466 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

Wilmes, A., O'Sullivan, D., Chan, A., Chandrahasen, C., Paterson, I., Northcote, PT., La Flamme, AC. & Miller, JH., 2011, In : Cancer Chemotherapy and Pharmacology. 68, p. 117 126 p.

Research output: Contribution to JournalArticleAcademicpeer-review