Find Research Outputs

Search results

• 2014

  Transgenerationele overdracht van psychische stoornissen. Een overzicht van de huidige kennis en een blik op de toekomst

  Middeldorp, C. M. & Batelaan, N. M., 2014, In : Tijdschrift Kinder- en Jeugdpsychotherapie. 2014, 2, p. 6-16 11 p.

  Research output: Contribution to Journal › Article › Professional
• 2011

  De invloed van genen en omgeving op de ontwikkeling van angststoornissen

  Middeldorp, C. M. & Cath, D. C., 2011, Handboek angststoornissen. van Balkom, A. J. L. M., Oosterbaan, D., Visser, S. & van Vliet, I. M. (eds.). Utrecht: De Tijdstroom, p. 287-302 15 p.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic
• 2015

  The genetic overlap between schizophrenia and childhood psychopathology

  Middeldorp, C. M., 2015.

  Research output: Contribution to Conference › Poster › Other research output

• Genetica en psychische stoornissen op de kinderleeftijd: erfelijkheid en de zoektocht naar genen

  Middeldorp, C. M., 2015, In : Tijdschrift voor Psychiatrie. 57, 12, p. 876-880 5 p.

  Research output: Contribution to Journal › Article › Professional
• 2018

  Corrigendum to “Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age” [Drug Alcohol Depend. 153 (2015) 221–228]

  Treur, J. L., Vink, J. M., Boomsma, D. I. & Middeldorp, C. M., 1 Jan 2018, In : Drug and Alcohol Dependence. 182, p. 123-123 1 p.

  Research output: Contribution to Journal › Erratum › Academic
• 2012

  Common variants at 6q22 and 17q21 are associated with intracranial volume

  Arfan Ikram, M., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, J. W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 43 others, Uitterlinden, A. G., Knopman, D. S., Hartikainen, A-L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M-R., McCarthy, M. I., Grant, S. F. A., St Pourcain, B., Timpson, N. J., Smith, G. D., Sovio, U., van Beijsterveldt, C. E. M., Groen-Blokhuis, M. M., Hottenga, J. J., Middeldorp, C. M., Nivard, M. G., Willemsen, G., Boomsma, D. I., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., van der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B. & DeCarli, C. S., 2012, In : Nature Genetics. 44, 5, p. 539-544

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Brain
  • Genome-Wide Association Study
  • Independent Living
  • Biological Phenomena
  • Genome

• Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

  Luciano, M., Huffman, J. E., Arias-Vasquez, A., Vinkhuyzen, A. A. E., Middeldorp, C. M., Giegling, I., Payton, A., Davies, G. E., Zgaga, L., Janzing, J. G., Ke, X. Y., Galesloot, T., Hartmann, A. M., Ollier, W., Tenesa, A., Hayward, C., Verhagen, M., Montgomery, G. W., Hottenga, J. J., Konte, B. & 24 others, Starr, J. M., Vitart, V., Vos, P. E., Madden, P. A. F., Willemsen, G., Konnerth, H., Horan, M. A., Porteous, D. J., Campbell, H., Vermeulen, S. H., Heath, A. C., Wright, A., Polasek, O., Kovacevic, S. B., Hastie, N., Franke, B., Boomsma, D. I., Martin, N. G., Rujescu, D., Wilson, J. F., Buitelaar, J., Pendleton, N., Rudan, I. & Deary, I. J., 2012, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 159B, 6, p. 684-695

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Personality
  • Single Nucleotide Polymorphism
  • Genome
  • Psychology
  • Extraversion (Psychology)

• Gene–environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins

  Ponsen-Lamb, D. J., Middeldorp, C. M., van Beijsterveldt, C. E. M. & Boomsma, D. I., 2012, In : Journal of Child Psychology and Psychiatry. 53, 8, p. 818-825

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Twins
  • Problem Behavior
  • Gene-Environment Interaction
  • Adolescent Health
  • Latent Class Analysis
• 2011

  Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: A genetic analysis of comorbidity

  Distel, M. A., Carlier, A., Middeldorp, C. M., Derom, C. A., Lubke, G. H. & Boomsma, D. I., 2011, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156, 7, p. 817-825

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Attention Deficit Disorder with Hyperactivity
  • Personality
  • Comorbidity
  • Borderline Personality Disorder
  • Personality Assessment
• 2014

  Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

  Cousminer, D. L., Stergiakouli, E., Berry, D. J., Ang, W., Blokhuis, M. M., Körner, A., Siitonen, N., Ntalla, I., Marinelli, M., Perry, J. R. B., Kettunen, J., Jansen, R., Surakka, I., Timpson, N. J., Ring, S., McMahon, G., Power, C., Wang, C., Kähönen, M., Viikari, J. & 24 others, Lehtimäki, T., Middeldorp, C. M., van Beijsterveldt, C. E. M., Hulshoff Pol, H. E., Neef, R. M., Weise, S., Pahkala, K., Niinikoski, H., Zeggini, E., Panoutsopoulou, K., Bustamante, M., Penninx, B. W. J. H., Murabito, J., Torrent, M., Dedoussis, G. V., Kiess, W., Boomsma, D. I., Pennell, C. E., Raitakari, O. T., Hyppönen, E., Davey Smith, G., Ripatti, S., McCarthy, M. I. & Widen, E., 2014, In : Human Molecular Genetics. 23, 16, p. 4452-4464 13 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Sexual Maturation
  • Menarche
  • Puberty
  • Genome-Wide Association Study
  • myocardin
• 2018

  Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

  Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 20 Dec 2018, In : PLoS ONE. 13, 12, p. 1-29 29 p., e0209160.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • mental depression
  • Neuroticism
  • Proxy
  • Major Depressive Disorder
  • Genes
• 2011

  Life events and borderline personality features: the influence of gene–environment interaction and gene–environment correlation

  Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G. & Boomsma, D. I., 2011, In : Psychological Medicine. 41, 4, p. 849-860

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Borderline Personality Disorder
  • Personality
  • Gene-Environment Interaction
  • Divorce
  • Genotype
• 2015

  Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

  Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bonnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 130 others, Kalb, B., Pino-Yanes, M., Xu, C., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Moller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rueschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodriguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Foelster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., de Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Soederhaell, C., Melen, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M., Noethen, M. M., Lau, S., Huebner, N., Lee, Y., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M. & Weidinger, S., 2015, In : Nature Genetics. 47, 12, p. 1449-1456

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Genome-Wide Association Study
  • Atopic Dermatitis
  • Genetic Association Studies
  • Skin Diseases
  • Hispanic Americans
• 2019

  Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

  Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bipolar Disorder
  • Psychiatry
  • Schizophrenia
  • Depression
  • Major Depressive Disorder

• Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

  Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Major Depressive Disorder
  • Anisotropy
  • White Matter
  • Genome
  • Radiation
• 2015

  Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

  Pappa, I., Fedko, I. O., Mileva-Seitz, V. R., Hottenga, J. J., Bakermans-Kranenburg, M. J., Bartels, M., van Beijsterveldt, C. E. M., Jaddoe, V. W. V., Middeldorp, C. M., Rippe, R. C. A., Rivadeneira, F., Tiemeier, H., Verhulst, F. C., van IJzendoorn, M. H. & Boomsma, D. I., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 54, 9, p. 737-744 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Multifactorial Inheritance
  • Problem Behavior
  • Single Nucleotide Polymorphism
  • Genome
  • Phenotype
• 2012

  Common variants at 12q15 and 12q24 are associated with infant head circumference

  Taal, H. R., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., van Beijsterveldt, C. E. M., Groen-Blokhuis, M. M., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Boomsma, D. I., Hakonarson, H., Smith, G. D., Heinrich, J., Jarvelin, M-R. & Jaddoe, V. W. V., 2012, In : Nature Genetics. 44, 5, p. 532-538

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Lead
  • Chromosomes
  • Meta-Analysis
  • Head

• Sex Differences in Genetic Architecture of Complex Phenotypes?

  Vink, J. M., Bartels, M., van Beijsterveldt, C. E. M., van Dongen, J., van Beek, J. H. D. A., Distel, M. A., de Moor, M. H. M., Smit, D. J. A., Minica, C. C., Ligthart, L., Geels, L. M., Abdellaoui, A., Middeldorp, C. M., Hottenga, J. J., Willemsen, G., de Geus, E. J. C. & Boomsma, D. I., 2012, In : PLoS ONE. 7, 12, e47371.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Sex Characteristics
  • Multifactorial Inheritance
  • Sample Size
  • Phenotype
  • Genome-Wide Association Study
  154 Downloads (Pure)
• 2015

  Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years

  Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K. J., Willemsen, G., van Beijsterveldt, C. E. M., Lindauer, R. J. L., van Beek, J. H. D. A., Geels, L. M., Bartels, M., Middeldorp, C. M. & Boomsma, D. I., 2015, In : Psychological Medicine. 45, 05, p. 1039-1049 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Twin Studies
  • Longitudinal Studies
  • Anxiety
  • Genotype
  • Depression
• 2012

  Maternal prenatal smoking and offspring emotional problems: No moderating effect of maternal or child 5-HTTLPR genotype

  Geels, L. M., Groen-Blokhuis, M. M., van Beijsterveldt, C. E. M., Vink, J. M., Middeldorp, C. M., Bartels, M., Nelson, K. A., Huizenga, P. E., Davies, G. E. & Boomsma, D. I., 2012, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 159B, 8, p. 1009-1012

  Research output: Contribution to Journal › Article › Academic › peer-review
• 2018

  Genetic and environmental influences on conduct and antisocial personality problems in childhood, adolescence, and adulthood

  Wesseldijk, L. W., Bartels, M., Vink, J. M., van Beijsterveldt, C. E. M., Ligthart, L., Boomsma, D. I. & Middeldorp, C. M., Sep 2018, In : European Child and Adolescent Psychiatry. 27, 9, p. 1123-1132 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Antisocial Personality Disorder
  • Twins
  • Crime
  • Netherlands
  • Sex Characteristics
• 2011

  The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

  Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, DR., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S. & 41 others, Spinhoven, P., Hartman, C. A., Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davies, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, GW., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Räikkönen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. & Boomsma, D. I., 2011, In : Translational Psychiatry. 1, e50.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Genome-Wide Association Study
  • Bipolar Disorder
  • Major Depressive Disorder
  • Personality
  • Depression
  125 Downloads (Pure)

• Birth weight in a large series of triplets

  Ponsen-Lamb, D. J., Middeldorp, C. M., van Beijsterveldt, C. E. M., Vink, J. M., Haak, M. C. & Boomsma, D. I., 2011, In : BMC Pediatrics. 11, 24.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Birth Weight
  • Gestational Age
  • Mothers
  • Twins
  • Netherlands
  177 Downloads (Pure)
• 2019

  Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 15 Mar 2019, In : Translational Psychiatry. 9, 1, p. 1-9 9 p., 117.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Major Depressive Disorder
  • Pharmaceutical Preparations
  • Genome-Wide Association Study
  • Psychiatry
  • Drug Repositioning
• 2015

  The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

  Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 others, Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Major Depressive Disorder
  • Depression
  • Genetic Profile
  • Single Nucleotide Polymorphism
  • Genomics
• 2012

  Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

  Wray, N. R., Pergadia, M. L., Blackwood, D. H., Penninx, B. W. J. H., Gordon, S. D., Nyholt, DR., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., de Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., van den Oord, E. J. C. G., Liu, J. Z. & 12 others, Macgregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Madden, P. A. F. & Sullivan, P. F., 2012, In : Molecular Psychiatry. 17, 1, p. 36-48

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Genome-Wide Association Study
  • Major Depressive Disorder
  • Meta-Analysis
  • Single Nucleotide Polymorphism
  • adenylate cyclase 3
• 2018

  Analysis of shared heritability in common disorders of the brain

  The Brainstorm Consortium, 22 Jun 2018, In : Science. 360, 6395, p. 1-15 15 p., eaap8757.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Brain Diseases
  • Psychiatry
  • Phenotype
  • Genetic Heterogeneity
  • Genome-Wide Association Study
  32 Downloads (Pure)
• 2019

  Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Apr 2019, In : JAMA Psychiatry. 76, 4, p. 399-408 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Major Depressive Disorder
  • Random Allocation
  • Depression
  • Exercise
  • Genome-Wide Association Study
  4 Downloads (Pure)

• A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

  The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. 49, 3, p. 1-16 16 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Impulsive Behavior
  • Single Nucleotide Polymorphism
  • signs and symptoms (animals and humans)
  • gene
  • Meta-Analysis
  263 Downloads (Pure)
• 2015

  Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

  O’Dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Krabbendam, A. C., Middeldorp, C. M., Penninx, B. W. J. H., Sergeant, J. A., Smit, J. H., Grootheest, G., Willemsen, G. & 2 others, Holmes, P. & Breen, G., 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Histones
  • Psychiatry
  • Post-Synaptic Density
  • Genomics
• 2014

  Further confirmation of the association between anxiety and CTNND2: replication in humans

  Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Penninx, B. W. J. H., Middeldorp, C. M. & Boomsma, D. I., 2014, In : Genes, Brain and Behavior. 13, 2, p. 195-201 7 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Anxiety
  • Agoraphobia
  • Catenins
  • Social Phobia
  • Chromosome Mapping

• A Genome-wide Association Meta-analysis of Preschool Internalizing Problems

  Benke, K. S., Nivard, M. G., Velders, F. P., Walters, R. K., Pappa, I., Scheet, P., Xiao, X., Ehli, E. A., Palmer, L. J., Whitehouse, A. J. O., Verhulst, F. C., Jaddoe, V. W., Rivadeneira, F., Blokhuis, M. M., van Beijsterveldt, C. E. M., Davies, G. E., Hudziak, J. J., Lubke, G. H., Boomsma, D. I., Pennell, C. E. & 2 others, Tiemeier, H. & Middeldorp, C. M., 2014, In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 6, p. 667-676 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Meta-Analysis
  • Genome
  • Psychiatry

• A recessive genetic model and runs of homozygosity in major depressive disorder

  Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Penninx, B. W. J. H., Willemsen, G. & Breen, G., 2014, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165, 2, p. 157-166 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Genetic Models
  • Genome-Wide Association Study
  • Major Depressive Disorder
  • Genome
  • Schizophrenia
• 2011

  The Impact of Environmental Experiences on Symptoms of Anxiety and Depression Across the Life Span

  Kendler, K. S., Eaves, L. J., Loken, E. K., Pedersen, N. L., Middeldorp, C. M., Reynolds, C., Boomsma, D. I., Lichtenstein, P., Silberg, J. & Gardner, C. O., 2011, In : Psychological Science. 22, 10, p. 1343-1352

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Longevity
  • Anxiety
  • Twins
  • Depression
  • Individuality
• 2015

  Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

  Byrne, E. M., Boomsma, D. I., Martin, N. G., Penninx, B. W. J. H., de Geus, E. J. C., Hoogendijk, W. J. G., Hottenga, J. J., Middeldorp, C. M., Nyholt, DR., Smit, J. H., van den Oord, E. J., Grootheest, G., Willemsen, G., Zitman, F. G., Neale, B. M., Sullivan, P. F., Raheja, U. K., Stephens, S. H., Heath, A. C., Madden, P. A. F. & 11 others, Vaswani, D., Nijjar, G. V., Ryan, K. A., Youssufi, H., Gehrman, P. R., Shuldiner, A. R., Montgomery, G. W., Wray, N. R., Nelson, E. C., Mitchell, B. D. & Postolache, T. T., 2015, In : Journal of Clinical Psychiatry. 76, 2, p. 128-134 7 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bipolar Disorder
  • Schizophrenia
  • Major Depressive Disorder
  • Genetic Profile
  • Genome-Wide Association Study
• 2014

  Research Review: Polygenic methods and their application to psychiatric traits

  Wray, N. R., Lee, S. H., Mehta, D., Vinkhuyzen, A. A. E., Dudbridge, F. & Middeldorp, C. M., 2014, In : Journal of Child Psychology and Psychiatry. 55, 10, p. 1068-1087 20 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Psychiatry
  • Sample Size
  • Advance Directives
  • Multifactorial Inheritance
  • Twin Studies
• 2019

  Genetisch onderzoek: Onderdeel van psychiatrische kliniek

  Middeldorp, C. M., 1 Jan 2019, In : Tijdschrift voor Psychiatrie. 61, 6, p. 373-374 2 p.

  Research output: Contribution to Journal › Comment / Letter to the editor › Academic
• 2012

  Effects of Chorionicity and Zygosity on Triplet Birth Weight

  Ponsen-Lamb, D. J., Vink, J. M., Middeldorp, C. M., van Beijsterveldt, C. E. M., Haak, M., Overbeek, L. I. H. & Boomsma, D. I., 2012, In : Twin Research and Human Genetics. 15, 2, p. 149-157

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Birth Weight
  • Chorion
  • Low Birth Weight Infant
  • Twins
  • Surrogate Mothers
• 2011

  Crying Without a Cause and Being Easily Upset in Two-Year-Olds: Heritability and Predictive Power of Behavioral Problems

  Groen-Blokhuis, M. M., Middeldorp, C. M., van Beijsterveldt, C. E. M. & Boomsma, D. I., 2011, In : Twin Research and Human Genetics. 14, 5, p. 393-400

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Crying
  • Problem Behavior
  • Twins
  • Mothers
  • Personality
• 2015

  Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

  Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., Altmann, A., Trümbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C. E., Drabant Conley, E., Boomsma, D. I. & 10 others, Penninx, B. W. J. H., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Smit, J. H., Ruepp, A., Müller-Myhsok, B., Hariri, A. & Binder, E. B., 2015, In : Neuron. 86, p. 1189-1202 15 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Transcriptome
  • Psychiatry
  • Glucocorticoid Receptors
  • Brain
  • Endophenotypes
• 2011

  Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study

  van Beijsterveldt, C. E. M., Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Bartels, M., Hottenga, J. J., Suchiman, H. E. D., Slagboom, P. E. & Boomsma, D. I., 2011, In : Behavior Genetics. 41, 1, p. 155-164

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • longitudinal studies
  • polymorphism
  • Longitudinal Studies
  • gene
  • single nucleotide polymorphism
  157 Downloads (Pure)
• 2018

  Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology

  Wesseldijk, L. W., Dieleman, G. C., van Steensel, F. J. A., Bartels, M., Hudziak, J. J., Lindauer, R. J. L., Bögels, S. M. & Middeldorp, C. M., Dec 2018, In : European Child and Adolescent Psychiatry. 27, 12, p. 1575-1584 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Psychopathology
  • Fathers
  • Mental Disorders
  • Personality
  • Adolescent Psychiatry
• 2014

  Heritability and genomics of gene expression in peripheral blood

  Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y. H., Abdellaoui, A., Batista, S., Butler, C., Chen, G., Chen, T. H., D’Ambrosio, D., Gallins, P., Ha, M. J., Hottenga, J. J., Huang, S. & 18 others, Kattenberg, V. M., Kochar, J., Middeldorp, C. M., Qu, A., Shabalin, A., Tischfield, J., Todd, L., Tzeng, J. Y., Grootheest, G., Vink, J. M., Wang, Q., Wang, W., Willemsen, G., Smit, J. H., de Geus, E. J. C., Yin, Z., Penninx, B. W. J. H. & Boomsma, D. I., 2014, In : Nature Genetics. 46, 5, p. 430-437 8 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Quantitative Trait Loci
  • Genomics
  • Gene Expression
  • Genetic Transcription
  • Genes
• 2018

  Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

  Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N. & 30 others, Castelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I. & Penninx, B. W. J. H., May 2018, In : Nature Genetics. 50, 5, p. 668-681 14 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Genome-Wide Association Study
  • Depression
  • Schizophrenia
  • Major Depressive Disorder
  • Suicide
  1490 Downloads (Pure)
• 2019

  Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

  Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, P. H., Anttila, V., Won, H., Feng, Y., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., Derks, E. M., op Landt Slof, M. C. T., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., W J H Penninx, B., Cath, D. C. & 11 others, Denys, D., Santangelo, S., Scharf, J. M., Stein, M. B., Thornton, L. M., Walters, J. T. R., Wray, N. R., Geschwind, D. H., Neale, B. M., Kendler, K. S. & Smoller, J. W., 12 Dec 2019, In : Cell. 179, 7, p. 1469-1482.e11 26 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Psychiatry
  • Genes
  • Tourette Syndrome
  • Anorexia Nervosa
  • Obsessive-Compulsive Disorder
  110 Downloads (Pure)
• 2014

  Waarom hebben we moeite met vernieuwing en verandering?

  Vink, J. M. & Middeldorp, C. M., 1 Apr 2014, In : UP - clientenblad Lister.

  Research output: Contribution to Journal › Article › Popular

• Interview

  Middeldorp, C. M., 1 May 2014, In : Nieuwsbrief Fonds Psychische Gezondheid.

  Research output: Contribution to Journal › Article › Popular

• Agenda for future research. Psychiatric perpective.

  van Dyck, R., van Balkom, A. J. L. M., van den Heuvel, O. & Middeldorp, C. M., 2014, The Wiley Handbook of Anxiety Disorders. Volume II: Clinical assessment and treatment.. Emmelkamp, P. M. G. & Ehring, T. (eds.). Chichester: Wiley, p. 1369-1381

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• De meerwaarde van een familiepoli

  Batelaan, N. M. & Middeldorp, C. M., 2014, In : PsychoPraktijk. 6, 3, p. 14-17 4 p.

  Research output: Contribution to Journal › Article › Professional
• 2011

  Genome-wide complex trait analysis (gcta) for complex traits including major depressive disorder and smoking

  Boomsma, D. I., Hottenga, J. J., Walters, R., Laurin, C., de Geus, E. J. C., Willemsen, G., Smit, J. H., Middeldorp, C. M., Penninx, B. W. J. H., Vink, J. M. & Lubke, G. H., 2011.

  Research output: Contribution to Conference › Poster › Other research output