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• 2020

  Analytics for bioactivity profiling of complex mixtures with a focus on venoms

  Mladic, M., Niessen, W. M. A., Somsen, G. W. & Kool, J., 1 Jan 2020, Snake and spider toxins: methods and protocols. Humana Press Inc., p. 27-49 23 p. (Methods in Molecular Biology; vol. 2068).

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

  • Venoms
  • Complex Mixtures
  • Drug Discovery
  • Biological Assay
  • Biological Products
• 2012

  Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization

  Kloos, D., Derks, R. J. E., Wijtmans, M., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2012, In: Journal of Chromatography A. 1232, p. 19-26

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Electrospray ionization
  • Citric Acid Cycle
  • Spectrometry
  • Positive ions
  • Spectrum Analysis

• Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

  Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In: Journal of Biomolecular Screening. 17, p. 1329-1338

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Assays
  • human HRH4 protein
  • Reporter Genes

• Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography – tandem mass spectrometry

  Niessen, W. M. A., 2012, In: Mass Spectrometry Reviews. 31, p. 626-665

  Research output: Contribution to Journal › Article › Academic › peer-review

• High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

  Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In: Journal of Chromatography A. 1259, p. 213-220

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Histamine H4 Receptors
  • Bioassay
  • Biological Assay
  • G-Protein-Coupled Receptors
  • Screening

• LC–MS systems for quantitative bioanalysis

  van Dongen, W. D. & Niessen, W. M. A., 2012, In: Bioanalysis. 4, p. 2391-2399

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biological Products
  • Molecules
  • Molecular mass
  • Metabolites
  • Pharmaceutical Preparations

• On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

  Falck, D., de Vlieger, J. S. B., Giera, M., Honing, M., Irth, H., Niessen, W. M. A. & Kool, J., 2012, In: Analytical and Bioanalytical Chemistry. 403, p. 367-375

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
  • Electrochemistry
  • Assays
  • Fluorescence
  • Protein Kinase Inhibitors

• Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA) – a brief overview.

  Giera, M., Lingeman, H. & Niessen, W. M. A., 2012, In: Chromatographia. 75, p. 433-440

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Thromboxanes
  • Malondialdehyde
  • Lipid Peroxidation
  • Lipids
• 2011

  Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

  Kool, J., Giera, M. A., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2655-2668

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Screening
  • Mass Spectrometry
  • Complex Mixtures
  • Biological Assay
  170 Downloads (Pure)

• Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

  de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In: Biomedical Chromatography. 25, 1-2, p. 278-299

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolism
  • Cholinesterase Inhibitors
  • Degradation
  • Metabolites
  • Pharmaceutical Preparations

• Bioanalytical LC-MS of therapeutic oligonucleotides

  van Dongen, W. D. & Niessen, W. M. A., 2011, In: Bioanalysis. 3, p. 541-564

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Oligonucleotides
  • Metabolites
  • Fluids
  • Therapeutics
  • Biological Products

• Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

  Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography B. 879, 17-18, p. 1393-1401

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Carboxylic Acids
  • Positive ions
  • Prostaglandins
  • Ions
  • Anti-Inflammatory Agents

• Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry

  Niessen, W. M. A., 2011, In: Mass Spectrometry Reviews. 30, 4, p. 626-663

  Research output: Contribution to Journal › Article › Academic › peer-review

• Fragmentation pathway of drugs of abuse and their metabolites using accurate mass spectra of QTOF MS.

  Bijlsma, L., Sancho, J. V., Hernandéz, F. & Niessen, W. M. A., 2011, In: Journal of Mass Spectrometry. 46, p. 865-875

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• High-resolution bioactivity profiling of mixtures towards the acetylcholine binding protein aided by nanofractionation spotter technology.

  Kool, J., Heus, F., de Kloe, G. E., Lingeman, H., Smit, A. B., Leurs, R., de Esch, I. J. P., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Biomolecular Screening. 16, p. 917-924

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bioactivity
  • Fractionation
  • Acetylcholine
  • Carrier Proteins
  • Technology

• Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

  Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In: Analyst. 136, p. 2763-2769

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-aminoacridone
  • urine
  • labeling
  • Labeling
  • Malondialdehyde

• Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

  Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In: Analytical Chemistry. 83, 1, p. 125-132

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Chemical detection
  • Mass spectrometry
  • Assays
  • Fluorescence

• Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

  Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In: Journal of Chromatography B. 879, 20, p. 1781-1788

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Screening
  • Acetylcholine
  • Carrier Proteins
  • Ligands
  • Binders

• Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

  de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In: MedChemComm. 2, p. 590-595

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nicotinic Receptors
  • Screening
  • Proteins
  • Throughput
  • Injections

• On-line Protein Digestion in Combination with Chromatographic Separation and Mass Spectrometric Detection.

  Hoos, S. J. & Niessen, W. M. A., 2011, Protein and peptide analysis by LC-MS: Experimental strategies. Letzel, T. (ed.). RSC Publishing, p. 71-86

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

• Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

  Martha, C. T., Hoogendoorn, J. C., Irth, H. & Niessen, W. M. A., 2011, In: Talanta. 84, 3, p. 623-631

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Mass spectrometry
  • Catalysts
  • 2-imidazoline
  • Reaction products

• Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

  Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography A. 1218, 13, p. 1715-1723

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Characterization (materials science)
  • Human Serum Albumin
  • Pharmaceutical Preparations

• Recent developments in protein-ligand affinity mass spectrometry

  Jonker, N., Kool, J., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2669-2681

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Libraries
  • Ligands
  • Technology
  152 Downloads (Pure)

• Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

  de Azevedo Marques, L., Maada, I., De Kanter, F. J. J., Lingeman, H., Irth, H., Niessen, W. M. A. & Giera, M. A., 2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 1, p. 85-92

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Galantamine
  • Kinetics
  • Degradation
  • Acetylcholinesterase
  • Dehydration

• Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods.

  Kool, J., Jonker, N., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 401, p. 1109-1125

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Proteins
  • Immobilized Proteins
  • Ligands
  150 Downloads (Pure)

• Use of soft and hard MS ionization techniques for unknown compounds elucidation by GC-TOF-MS

  Portolés, T., Pitarch, E., Lopez, F. J., Hernandez, F. & Niessen, W. M. A., 2011, In: RCM. Rapid Communications in Mass Spectrometry. 25, p. 1589-1599

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access