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• Article

  Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

  Kool, J., Giera, M. A., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2655-2668

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Screening
  • Mass Spectrometry
  • Complex Mixtures
  • Biological Assay
  166 Downloads (Pure)

• A high-throughput sample preparation method for cellular proteomics using 96-well filter plates.

  Switzar, L., van Angeren, J. A., Pinkse, M., Kool, J. & Niessen, W. M. A., 2013, In: Journal of Proteomics. 13, p. 2980-2983

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteomics
  • Molecular weight
  • Denaturation
  • Alkylation
  • Organic solvents

• Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

  de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In: Biomedical Chromatography. 25, 1-2, p. 278-299

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolism
  • Cholinesterase Inhibitors
  • Degradation
  • Metabolites
  • Pharmaceutical Preparations

• Analytical workflow for rapid screening and purification of bioactives from venom proteomes

  Otvos, R. A., Heus, F. A. M., Vonk, F. J., Halff, J., Bruynzeel, B., Paliukhovich, I., Smit, A. B., Niessen, W. M. A. & Kool, J., 2013, In: Toxicon. 76, p. 270-281

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Venoms
  • Workflow
  • Purification
  • Proteome
  • Screening

• An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity.

  Heus, F. A. H., Vonk, F., Otvos, R. A., Bruyneel, B., Smit, A. B., Lingeman, H., Richardson, M., Niessen, W. M. A. & Kool, J., 2013, In: Toxicon. 61, p. 112-124

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Snake Venoms
  • Microfluidics
  • Venoms
  • Nicotinic Receptors
  • Bungarotoxins

• Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

  van den Broek, I., van Dongen, W. D. & Niessen, W. M. A., 2013, In: Journal of Chromatography B. 929, p. 161-179

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biological Products
  • Mass spectrometry
  • Purification
  • Proteins
  • Toxicokinetics

• Bioanalytical LC-MS of therapeutic oligonucleotides

  van Dongen, W. D. & Niessen, W. M. A., 2011, In: Bioanalysis. 3, p. 541-564

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Oligonucleotides
  • Metabolites
  • Fluids
  • Therapeutics
  • Biological Products

• Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

  Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: TrAC. Trends in Analytical Chemistry. 61, p. 17-28

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Carboxylic Acids
  • Liquid chromatography
  • Chain length

• Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitors.

  Rea, V., Falck, D., Kool, J., de Kanter, F. J. J., Commandeur, J. N. M., Vermeulen, N. P. E., Niessen, W. M. A. & Honing, M., 2013, In: MedChemComm. 4, p. 371-377

  Research output: Contribution to Journal › Article › Academic › peer-review

  • N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
  • Biotransformation
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

  Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biotransformation
  • Metabolites
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

  Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Sterols
  • Gas Chromatography

• Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

  Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography B. 879, 17-18, p. 1393-1401

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Carboxylic Acids
  • Positive ions
  • Prostaglandins
  • Ions
  • Anti-Inflammatory Agents

• Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures.

  Falck, D., Schebb, N. H., Prinatiningtyas, S., Zhang, J., Heus, F. A. H., Morisseau, C., Kool, J., Hammock, B. D. & Niessen, W. M. A., 2013, In: Chromatographia. 76, p. 13-21

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Liquid chromatography
  • Epoxide Hydrolases
  • Liquid Chromatography
  • Metabolites
  • Assays

• EC–SPE–stripline-NMR analysis of reactive products: A feasibility study.

  Falck, D., Oosthoek-de Vries, A. J., Kolkman, A. J., Lingeman, H., Honing, M., Wijmenga, S. S., Kentgens, A. P. M. & Niessen, W. M. A., 2013, In: Analytical and Bioanalytical Chemistry. 405, p. 6711-6720

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nuclear magnetic resonance spectroscopy
  • Feasibility Studies
  • Solid Phase Extraction
  • Magnetic Resonance Spectroscopy
  • BIRB 796

• Evaluation of different column chemistries for fast urinary metabolic profiling.

  Kloos, D., Lingeman, H., Niessen, W. M. A., Deelder, A. M., Giera, M. & Mayboroda, O. A., 2013, In: Journal of Chromatography B. 927, p. 90-96

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Porous materials

• Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry

  Niessen, W. M. A., 2011, In: Mass Spectrometry Reviews. 30, 4, p. 626-663

  Research output: Contribution to Journal › Article › Academic › peer-review

• Fragmentation pathway of drugs of abuse and their metabolites using accurate mass spectra of QTOF MS.

  Bijlsma, L., Sancho, J. V., Hernandéz, F. & Niessen, W. M. A., 2011, In: Journal of Mass Spectrometry. 46, p. 865-875

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• High-resolution bioactivity profiling of mixtures towards the acetylcholine binding protein aided by nanofractionation spotter technology.

  Kool, J., Heus, F., de Kloe, G. E., Lingeman, H., Smit, A. B., Leurs, R., de Esch, I. J. P., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Biomolecular Screening. 16, p. 917-924

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bioactivity
  • Fractionation
  • Acetylcholine
  • Carrier Proteins
  • Technology

• High-resolution fractionation after gas chromatography for Effect Directed Analysis.

  Pieke, E., Heus, F. A. H., Kamstra, J., Mladic, M., van Velzen, M., Kamminga, D., Lamoree, M. H., Hamers, T., Leonards, P. E. G., Niessen, W. M. A. & Kool, J., 2013, In: Analytical Chemistry. 85, 17, p. 8204-8211

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Gas chromatography
  • Aryl Hydrocarbon Receptors
  • Bioactivity
  • pentane

• Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

  Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H. & Niessen, W. M. A., 2013, In: Journal of Chromatography B. 917-918, p. 53-61

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Albumins
  • N-acetyl-4-benzoquinoneimine
  • Cysteine
  • Serum
  • Pharmaceutical Preparations

• Identification of new omeprazole metabolites in wastewaters and surface waters.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In: Science of the Total Environment. 468-469, p. 706-714

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Surface waters
  • Metabolites
  • Omeprazole
  • Wastewater
  • metabolite

• Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry. (I) Degradation experiments.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2013, In: Journal of Mass Spectrometry. 48, p. 1091-1100

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Liquid chromatography
  • Mass spectrometry
  • Omeprazole
  • Surface waters
  • Degradation

• Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment.

  Bijlsma, L., Boix, C., Niessen, W. M. A., Ibañez, M., Sancho, J. V. & Hernandez, F., 2013, In: Science of the Total Environment. 443, p. 200-208

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • benzoylecgonine
  • Metabolites
  • benzoylnorecgonine
  • Chlorination
  • degradation product

• Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

  Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In: Analyst. 136, p. 2763-2769

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-aminoacridone
  • urine
  • labeling
  • Labeling
  • Malondialdehyde

• Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

  Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In: Biology. 3, p. 139-156

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bioactivity
  • Mass spectrometry
  • Snails
  • Purification
  • toads

• Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

  Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In: Analytical Chemistry. 83, 1, p. 125-132

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Chemical detection
  • Mass spectrometry
  • Assays
  • Fluorescence

• Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

  Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In: Journal of Chromatography B. 879, 20, p. 1781-1788

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Screening
  • Acetylcholine
  • Carrier Proteins
  • Ligands
  • Binders

• Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

  de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In: MedChemComm. 2, p. 590-595

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nicotinic Receptors
  • Screening
  • Proteins
  • Throughput
  • Injections

• Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

  Martha, C. T., Hoogendoorn, J. C., Irth, H. & Niessen, W. M. A., 2011, In: Talanta. 84, 3, p. 623-631

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Mass spectrometry
  • Catalysts
  • 2-imidazoline
  • Reaction products

• Protein digestion: An overview of the available techniques and recent developments

  Switzar, L., Giera, M. & Niessen, W. M. A., 2013, In: Journal of Proteome Research. 12, p. 1067-1077

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Proteomics
  • Peptides
  • Proteins

• Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

  Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography A. 1218, 13, p. 1715-1723

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Characterization (materials science)
  • Human Serum Albumin
  • Pharmaceutical Preparations

• Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In: Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Recent developments in protein-ligand affinity mass spectrometry

  Jonker, N., Kool, J., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2669-2681

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Libraries
  • Ligands
  • Technology
  148 Downloads (Pure)

• Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

  de Azevedo Marques, L., Maada, I., De Kanter, F. J. J., Lingeman, H., Irth, H., Niessen, W. M. A. & Giera, M. A., 2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 1, p. 85-92

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Galantamine
  • Kinetics
  • Degradation
  • Acetylcholinesterase
  • Dehydration

• Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods.

  Kool, J., Jonker, N., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 401, p. 1109-1125

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Proteins
  • Immobilized Proteins
  • Ligands
  145 Downloads (Pure)

• Tandem mass spectrometry study of p38a kinase inhibitors and related substances

  Falck, D., Kool, J., Honing, M. & Niessen, W. M. A., 2013, In: Journal of Mass Spectrometry. 48, p. 718-731

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Mass spectrometry
  • N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
  • p38 Mitogen-Activated Protein Kinases
  • BIRB 796
  • Lead compounds

• Use of soft and hard MS ionization techniques for unknown compounds elucidation by GC-TOF-MS

  Portolés, T., Pitarch, E., Lopez, F. J., Hernandez, F. & Niessen, W. M. A., 2011, In: RCM. Rapid Communications in Mass Spectrometry. 25, p. 1589-1599

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access
• Chapter

  Hyphenated Techniques, Applications of in Mass Spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• Liquid chromatography-mass spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.). Elsevier

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• Mass Spectrometry | Atmospheric-pressure ionization

  Bruins, A. P. & Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• MSMS and MSn

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• On-line Protein Digestion in Combination with Chromatographic Separation and Mass Spectrometric Detection.

  Hoos, S. J. & Niessen, W. M. A., 2011, Protein and peptide analysis by LC-MS: Experimental strategies. Letzel, T. (ed.). RSC Publishing, p. 71-86

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

• Thermospray Ionization in Mass Spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.).

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic