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• Use of soft and hard MS ionization techniques for unknown compounds elucidation by GC-TOF-MS

  Portolés, T., Pitarch, E., Lopez, F. J., Hernandez, F. & Niessen, W. M. A., 2011, In : RCM. Rapid Communications in Mass Spectrometry. 25, p. 1589-1599

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods.

  Kool, J., Jonker, N., Irth, H. & Niessen, W. M. A., 2011, In : Analytical and Bioanalytical Chemistry. 401, p. 1109-1125

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Proteins
  • Immobilized Proteins
  • Ligands
  143 Downloads (Pure)

• Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

  de Azevedo Marques, L., Maada, I., De Kanter, F. J. J., Lingeman, H., Irth, H., Niessen, W. M. A. & Giera, M. A., 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 1, p. 85-92

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Galantamine
  • Kinetics
  • Degradation
  • Acetylcholinesterase
  • Dehydration

• Recent developments in protein-ligand affinity mass spectrometry

  Jonker, N., Kool, J., Irth, H. & Niessen, W. M. A., 2011, In : Analytical and Bioanalytical Chemistry. 399, 8, p. 2669-2681

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Libraries
  • Ligands
  • Technology
  145 Downloads (Pure)

• Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In : Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

  Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography A. 1218, 13, p. 1715-1723

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Characterization (materials science)
  • Human Serum Albumin
  • Pharmaceutical Preparations

• Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

  Martha, C. T., Hoogendoorn, J. C., Irth, H. & Niessen, W. M. A., 2011, In : Talanta. 84, 3, p. 623-631

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Mass spectrometry
  • Catalysts
  • 2-imidazoline
  • Reaction products

• On-line Protein Digestion in Combination with Chromatographic Separation and Mass Spectrometric Detection.

  Hoos, S. J. & Niessen, W. M. A., 2011, Protein and peptide analysis by LC-MS: Experimental strategies. Letzel, T. (ed.). RSC Publishing, p. 71-86

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

• Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

  de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In : MedChemComm. 2, p. 590-595

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nicotinic Receptors
  • Screening
  • Proteins
  • Throughput
  • Injections

• Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

  Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In : Journal of Chromatography B. 879, 20, p. 1781-1788

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Screening
  • Acetylcholine
  • Carrier Proteins
  • Ligands
  • Binders

• On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples.

  Lakayan, D., Haselberg, R., Niessen, W. M. A., Somsen, G. W. & Kool, J., 2016, In : Journal of Chromatography A. 1452, p. 81-88

  Research output: Contribution to Journal › Article › Academic › peer-review

• Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

  Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Microfluidics
  • Venoms
  • Snake Venoms
  • Acetylcholine
  • Carrier Proteins

• Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

  Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In : Analytical Chemistry. 83, 1, p. 125-132

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Chemical detection
  • Mass spectrometry
  • Assays
  • Fluorescence

• Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

  Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In : SLAS Discovery. 23, 3, p. 283-293 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP1A2 Inhibitors
  • Metabolites
  • Mass spectrometry
  • ellipticine
  • Bioactivity

• Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

  Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In : Biology. 3, p. 139-156

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bioactivity
  • Mass spectrometry
  • Snails
  • Purification
  • toads

• Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

  Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In : Analyst. 136, p. 2763-2769

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-aminoacridone
  • urine
  • labeling
  • Labeling
  • Malondialdehyde

• LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

  Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In : Microchemical Journal. 141, p. 135-140 6 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Assays
  • Warfarin
  • Plasmas
  • Pharmaceutical Preparations
  • Monitoring

• Identification of new omeprazole metabolites in wastewaters and surface waters.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In : Science of the Total Environment. 468-469, p. 706-714

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Surface waters
  • Metabolites
  • Omeprazole
  • Wastewater
  • metabolite

• High-resolution bioactivity profiling of mixtures towards the acetylcholine binding protein aided by nanofractionation spotter technology.

  Kool, J., Heus, F., de Kloe, G. E., Lingeman, H., Smit, A. B., Leurs, R., de Esch, I. J. P., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Biomolecular Screening. 16, p. 917-924

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bioactivity
  • Fractionation
  • Acetylcholine
  • Carrier Proteins
  • Technology

• Fragmentation pathway of drugs of abuse and their metabolites using accurate mass spectra of QTOF MS.

  Bijlsma, L., Sancho, J. V., Hernandéz, F. & Niessen, W. M. A., 2011, In : Journal of Mass Spectrometry. 46, p. 865-875

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry

  Niessen, W. M. A., 2011, In : Mass Spectrometry Reviews. 30, 4, p. 626-663

  Research output: Contribution to Journal › Article › Academic › peer-review

• Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

  Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Analytical Chemistry. 88, p. 4825-4832

  Research output: Contribution to Journal › Article › Academic › peer-review

• Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

  Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography B. 879, 17-18, p. 1393-1401

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Carboxylic Acids
  • Positive ions
  • Prostaglandins
  • Ions
  • Anti-Inflammatory Agents

• Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

  Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Sterols
  • Gas Chromatography

• Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

  Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biotransformation
  • Metabolites
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

  Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : TrAC. Trends in Analytical Chemistry. 61, p. 17-28

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Carboxylic Acids
  • Liquid chromatography
  • Chain length

• Bioanalytical LC-MS of therapeutic oligonucleotides

  van Dongen, W. D. & Niessen, W. M. A., 2011, In : Bioanalysis. 3, p. 541-564

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Oligonucleotides
  • Metabolites
  • Fluids
  • Therapeutics
  • Biological Products

• At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

  Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In : Toxicon. 110, p. 79-89

  Research output: Contribution to Journal › Article › Academic › peer-review

• At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

  Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Journal of Biomolecular Screening. 21, p. 459-467

  Research output: Contribution to Journal › Article › Academic › peer-review

• Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

  de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In : Biomedical Chromatography. 25, 1-2, p. 278-299

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolism
  • Cholinesterase Inhibitors
  • Degradation
  • Metabolites
  • Pharmaceutical Preparations

• Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

  Kool, J., Giera, M. A., Irth, H. & Niessen, W. M. A., 2011, In : Analytical and Bioanalytical Chemistry. 399, 8, p. 2655-2668

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Screening
  • Mass Spectrometry
  • Complex Mixtures
  • Biological Assay
  164 Downloads (Pure)