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• 2017

  Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In: Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access
• 2014

  Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

  Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: TrAC. Trends in Analytical Chemistry. 61, p. 17-28

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Carboxylic Acids
  • Liquid chromatography
  • Chain length

• Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

  Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biotransformation
  • Metabolites
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

  Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Sterols
  • Gas Chromatography

• Identification of new omeprazole metabolites in wastewaters and surface waters.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In: Science of the Total Environment. 468-469, p. 706-714

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Surface waters
  • Metabolites
  • Omeprazole
  • Wastewater
  • metabolite

• Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

  Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In: Biology. 3, p. 139-156

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bioactivity
  • Mass spectrometry
  • Snails
  • Purification
  • toads
• 2011

  Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

  Kool, J., Giera, M. A., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2655-2668

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Screening
  • Mass Spectrometry
  • Complex Mixtures
  • Biological Assay
  169 Downloads (Pure)

• Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

  de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In: Biomedical Chromatography. 25, 1-2, p. 278-299

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Metabolism
  • Cholinesterase Inhibitors
  • Degradation
  • Metabolites
  • Pharmaceutical Preparations

• Bioanalytical LC-MS of therapeutic oligonucleotides

  van Dongen, W. D. & Niessen, W. M. A., 2011, In: Bioanalysis. 3, p. 541-564

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Oligonucleotides
  • Metabolites
  • Fluids
  • Therapeutics
  • Biological Products

• Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

  Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography B. 879, 17-18, p. 1393-1401

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Carboxylic Acids
  • Positive ions
  • Prostaglandins
  • Ions
  • Anti-Inflammatory Agents

• Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry

  Niessen, W. M. A., 2011, In: Mass Spectrometry Reviews. 30, 4, p. 626-663

  Research output: Contribution to Journal › Article › Academic › peer-review

• Fragmentation pathway of drugs of abuse and their metabolites using accurate mass spectra of QTOF MS.

  Bijlsma, L., Sancho, J. V., Hernandéz, F. & Niessen, W. M. A., 2011, In: Journal of Mass Spectrometry. 46, p. 865-875

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• High-resolution bioactivity profiling of mixtures towards the acetylcholine binding protein aided by nanofractionation spotter technology.

  Kool, J., Heus, F., de Kloe, G. E., Lingeman, H., Smit, A. B., Leurs, R., de Esch, I. J. P., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Biomolecular Screening. 16, p. 917-924

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Bioactivity
  • Fractionation
  • Acetylcholine
  • Carrier Proteins
  • Technology

• Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

  Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In: Analyst. 136, p. 2763-2769

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-aminoacridone
  • urine
  • labeling
  • Labeling
  • Malondialdehyde

• Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

  Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In: Analytical Chemistry. 83, 1, p. 125-132

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Chemical detection
  • Mass spectrometry
  • Assays
  • Fluorescence

• Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

  Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In: Journal of Chromatography B. 879, 20, p. 1781-1788

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Screening
  • Acetylcholine
  • Carrier Proteins
  • Ligands
  • Binders

• Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

  de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In: MedChemComm. 2, p. 590-595

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nicotinic Receptors
  • Screening
  • Proteins
  • Throughput
  • Injections

• On-line Protein Digestion in Combination with Chromatographic Separation and Mass Spectrometric Detection.

  Hoos, S. J. & Niessen, W. M. A., 2011, Protein and peptide analysis by LC-MS: Experimental strategies. Letzel, T. (ed.). RSC Publishing, p. 71-86

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

• Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

  Martha, C. T., Hoogendoorn, J. C., Irth, H. & Niessen, W. M. A., 2011, In: Talanta. 84, 3, p. 623-631

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Mass spectrometry
  • Catalysts
  • 2-imidazoline
  • Reaction products

• Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

  Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In: Journal of Chromatography A. 1218, 13, p. 1715-1723

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Characterization (materials science)
  • Human Serum Albumin
  • Pharmaceutical Preparations

• Recent developments in protein-ligand affinity mass spectrometry

  Jonker, N., Kool, J., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 399, 8, p. 2669-2681

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Libraries
  • Ligands
  • Technology
  151 Downloads (Pure)

• Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

  de Azevedo Marques, L., Maada, I., De Kanter, F. J. J., Lingeman, H., Irth, H., Niessen, W. M. A. & Giera, M. A., 2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 1, p. 85-92

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Galantamine
  • Kinetics
  • Degradation
  • Acetylcholinesterase
  • Dehydration

• Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods.

  Kool, J., Jonker, N., Irth, H. & Niessen, W. M. A., 2011, In: Analytical and Bioanalytical Chemistry. 401, p. 1109-1125

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Proteins
  • Immobilized Proteins
  • Ligands
  150 Downloads (Pure)

• Use of soft and hard MS ionization techniques for unknown compounds elucidation by GC-TOF-MS

  Portolés, T., Pitarch, E., Lopez, F. J., Hernandez, F. & Niessen, W. M. A., 2011, In: RCM. Rapid Communications in Mass Spectrometry. 25, p. 1589-1599

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access