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  • 2020
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  • W.M.A. Niessen
2020

Analytics for bioactivity profiling of complex mixtures with a focus on venoms

Mladic, M., Niessen, W. M. A., Somsen, G. W. & Kool, J., 1 Jan 2020, Snake and spider toxins: methods and protocols. Humana Press Inc., p. 27-49 23 p. (Methods in Molecular Biology; vol. 2068).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

2018

LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In : Microchemical Journal. 141, p. 135-140 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In : SLAS Discovery. 23, 3, p. 283-293 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2016

At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Journal of Biomolecular Screening. 21, p. 459-467

Research output: Contribution to JournalArticleAcademicpeer-review

At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In : Toxicon. 110, p. 79-89

Research output: Contribution to JournalArticleAcademicpeer-review

Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Analytical Chemistry. 88, p. 4825-4832

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Amino acid analysis using chromatography–mass spectrometry: An inter platform comparison study

Krumpochova, P., Bruyneel, B., Molenaar, D., Koukou, A., Wuhrer, M., Niessen, W. M. A. & Giera, M. A., 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 114, p. 398-407

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of novel bioactives on the alpha-7-nAChR using an at-line cellular bioassay after nanofractionation

Otvos, R. A., Mladic, M., Alpizar, G. A., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., Sep 2015, In : European Neuropsychopharmacology. 25, p. S244-S245

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Mladic, M., Scholten, D. J., Wijtmans, M., Falck, D., Leurs, R., Niessen, W. M. A., Smit, M. J. & Kool, J., Sep 2015, In : Analytical and Bioanalytical Chemistry. 407, 23, p. 7067-81 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Solution-phase electrochemistry-nuclear magnetic resonance of small organic molecules

Falck, D. & Niessen, W. M. A., 2015, In : TrAC. Trends in Analytical Chemistry. 70, p. 31-39

Research output: Contribution to JournalArticleAcademicpeer-review

2013

A high-throughput sample preparation method for cellular proteomics using 96-well filter plates.

Switzar, L., van Angeren, J. A., Pinkse, M., Kool, J. & Niessen, W. M. A., 2013, In : Journal of Proteomics. 13, p. 2980-2983

Research output: Contribution to JournalArticleAcademicpeer-review

Analytical workflow for rapid screening and purification of bioactives from venom proteomes

Otvos, R. A., Heus, F. A. M., Vonk, F. J., Halff, J., Bruynzeel, B., Paliukhovich, I., Smit, A. B., Niessen, W. M. A. & Kool, J., 2013, In : Toxicon. 76, p. 270-281

Research output: Contribution to JournalArticleAcademicpeer-review

An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity.

Heus, F. A. H., Vonk, F., Otvos, R. A., Bruyneel, B., Smit, A. B., Lingeman, H., Richardson, M., Niessen, W. M. A. & Kool, J., 2013, In : Toxicon. 61, p. 112-124

Research output: Contribution to JournalArticleAcademicpeer-review

Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

van den Broek, I., van Dongen, W. D. & Niessen, W. M. A., 2013, In : Journal of Chromatography B. 929, p. 161-179

Research output: Contribution to JournalArticleAcademicpeer-review

Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures.

Falck, D., Schebb, N. H., Prinatiningtyas, S., Zhang, J., Heus, F. A. H., Morisseau, C., Kool, J., Hammock, B. D. & Niessen, W. M. A., 2013, In : Chromatographia. 76, p. 13-21

Research output: Contribution to JournalArticleAcademicpeer-review

EC–SPE–stripline-NMR analysis of reactive products: A feasibility study.

Falck, D., Oosthoek-de Vries, A. J., Kolkman, A. J., Lingeman, H., Honing, M., Wijmenga, S. S., Kentgens, A. P. M. & Niessen, W. M. A., 2013, In : Analytical and Bioanalytical Chemistry. 405, p. 6711-6720

Research output: Contribution to JournalArticleAcademicpeer-review

Evaluation of different column chemistries for fast urinary metabolic profiling.

Kloos, D., Lingeman, H., Niessen, W. M. A., Deelder, A. M., Giera, M. & Mayboroda, O. A., 2013, In : Journal of Chromatography B. 927, p. 90-96

Research output: Contribution to JournalArticleAcademicpeer-review

High-resolution fractionation after gas chromatography for Effect Directed Analysis.

Pieke, E., Heus, F. A. H., Kamstra, J., Mladic, M., van Velzen, M., Kamminga, D., Lamoree, M. H., Hamers, T., Leonards, P. E. G., Niessen, W. M. A. & Kool, J., 2013, In : Analytical Chemistry. 85, 17, p. 8204-8211

Research output: Contribution to JournalArticleAcademicpeer-review

Hyphenated Techniques, Applications of in Mass Spectrometry

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H. & Niessen, W. M. A., 2013, In : Journal of Chromatography B. 917-918, p. 53-61

Research output: Contribution to JournalArticleAcademicpeer-review

Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry. (I) Degradation experiments.

Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2013, In : Journal of Mass Spectrometry. 48, p. 1091-1100

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment.

Bijlsma, L., Boix, C., Niessen, W. M. A., Ibañez, M., Sancho, J. V. & Hernandez, F., 2013, In : Science of the Total Environment. 443, p. 200-208

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Liquid chromatography-mass spectrometry

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.). Elsevier

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Mass Spectrometry | Atmospheric-pressure ionization

Bruins, A. P. & Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

MSMS and MSn

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Protein digestion: An overview of the available techniques and recent developments

Switzar, L., Giera, M. & Niessen, W. M. A., 2013, In : Journal of Proteome Research. 12, p. 1067-1077

Research output: Contribution to JournalArticleAcademicpeer-review

Tandem mass spectrometry study of p38a kinase inhibitors and related substances

Falck, D., Kool, J., Honing, M. & Niessen, W. M. A., 2013, In : Journal of Mass Spectrometry. 48, p. 718-731

Research output: Contribution to JournalArticleAcademicpeer-review

Thermospray Ionization in Mass Spectrometry

Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

2012

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization

Kloos, D., Derks, R. J. E., Wijtmans, M., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2012, In : Journal of Chromatography A. 1232, p. 19-26

Research output: Contribution to JournalArticleAcademicpeer-review

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In : Journal of Biomolecular Screening. 17, p. 1329-1338

Research output: Contribution to JournalArticleAcademicpeer-review

Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography – tandem mass spectrometry

Niessen, W. M. A., 2012, In : Mass Spectrometry Reviews. 31, p. 626-665

Research output: Contribution to JournalArticleAcademicpeer-review

High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In : Journal of Chromatography A. 1259, p. 213-220

Research output: Contribution to JournalArticleAcademicpeer-review

LC–MS systems for quantitative bioanalysis

van Dongen, W. D. & Niessen, W. M. A., 2012, In : Bioanalysis. 4, p. 2391-2399

Research output: Contribution to JournalArticleAcademicpeer-review

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

Falck, D., de Vlieger, J. S. B., Giera, M., Honing, M., Irth, H., Niessen, W. M. A. & Kool, J., 2012, In : Analytical and Bioanalytical Chemistry. 403, p. 367-375

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA) – a brief overview.

Giera, M., Lingeman, H. & Niessen, W. M. A., 2012, In : Chromatographia. 75, p. 433-440

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access