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  • 2019
  • 2018
  • 2016
  • 2015
  • 2012

Author

  • W.M.A. Niessen
2018

LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In : Microchemical Journal. 141, p. 135-140 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In : SLAS Discovery. 23, 3, p. 283-293 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2016

At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Journal of Biomolecular Screening. 21, p. 459-467

Research output: Contribution to JournalArticleAcademicpeer-review

At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In : Toxicon. 110, p. 79-89

Research output: Contribution to JournalArticleAcademicpeer-review

Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Analytical Chemistry. 88, p. 4825-4832

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Amino acid analysis using chromatography–mass spectrometry: An inter platform comparison study

Krumpochova, P., Bruyneel, B., Molenaar, D., Koukou, A., Wuhrer, M., Niessen, W. M. A. & Giera, M. A., 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 114, p. 398-407

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of novel bioactives on the alpha-7-nAChR using an at-line cellular bioassay after nanofractionation

Otvos, R. A., Mladic, M., Alpizar, G. A., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., Sep 2015, In : European Neuropsychopharmacology. 25, p. S244-S245

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Mladic, M., Scholten, D. J., Wijtmans, M., Falck, D., Leurs, R., Niessen, W. M. A., Smit, M. J. & Kool, J., Sep 2015, In : Analytical and Bioanalytical Chemistry. 407, 23, p. 7067-81 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Solution-phase electrochemistry-nuclear magnetic resonance of small organic molecules

Falck, D. & Niessen, W. M. A., 2015, In : TrAC. Trends in Analytical Chemistry. 70, p. 31-39

Research output: Contribution to JournalArticleAcademicpeer-review

2012

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization

Kloos, D., Derks, R. J. E., Wijtmans, M., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2012, In : Journal of Chromatography A. 1232, p. 19-26

Research output: Contribution to JournalArticleAcademicpeer-review

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In : Journal of Biomolecular Screening. 17, p. 1329-1338

Research output: Contribution to JournalArticleAcademicpeer-review

Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography – tandem mass spectrometry

Niessen, W. M. A., 2012, In : Mass Spectrometry Reviews. 31, p. 626-665

Research output: Contribution to JournalArticleAcademicpeer-review

High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In : Journal of Chromatography A. 1259, p. 213-220

Research output: Contribution to JournalArticleAcademicpeer-review

LC–MS systems for quantitative bioanalysis

van Dongen, W. D. & Niessen, W. M. A., 2012, In : Bioanalysis. 4, p. 2391-2399

Research output: Contribution to JournalArticleAcademicpeer-review

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

Falck, D., de Vlieger, J. S. B., Giera, M., Honing, M., Irth, H., Niessen, W. M. A. & Kool, J., 2012, In : Analytical and Bioanalytical Chemistry. 403, p. 367-375

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA) – a brief overview.

Giera, M., Lingeman, H. & Niessen, W. M. A., 2012, In : Chromatographia. 75, p. 433-440

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access