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• Thermospray Ionization in Mass Spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.).

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• Tandem mass spectrometry study of p38a kinase inhibitors and related substances

  Falck, D., Kool, J., Honing, M. & Niessen, W. M. A., 2013, In: Journal of Mass Spectrometry. 48, p. 718-731

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Mass spectrometry
  • N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
  • p38 Mitogen-Activated Protein Kinases
  • BIRB 796
  • Lead compounds

• Protein digestion: An overview of the available techniques and recent developments

  Switzar, L., Giera, M. & Niessen, W. M. A., 2013, In: Journal of Proteome Research. 12, p. 1067-1077

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteolysis
  • Digestion
  • Proteomics
  • Peptides
  • Proteins

• On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples.

  Lakayan, D., Haselberg, R., Niessen, W. M. A., Somsen, G. W. & Kool, J., 2016, In: Journal of Chromatography A. 1452, p. 81-88

  Research output: Contribution to Journal › Article › Academic › peer-review

• Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

  Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In: Toxicon. 148, p. 213-222 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Microfluidics
  • Venoms
  • Snake Venoms
  • Acetylcholine
  • Carrier Proteins

• Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

  Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In: SLAS Discovery. 23, 3, p. 283-293 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP1A2 Inhibitors
  • Metabolites
  • Mass spectrometry
  • ellipticine
  • Bioactivity

• MSMS and MSn

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

  Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In: Biology. 3, p. 139-156

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bioactivity
  • Mass spectrometry
  • Snails
  • Purification
  • toads

• Mass Spectrometry | Atmospheric-pressure ionization

  Bruins, A. P. & Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• Liquid chromatography-mass spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering. Reedijk, J. (ed.). Elsevier

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

  Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In: Microchemical Journal. 141, p. 135-140 6 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Assays
  • Warfarin
  • Plasmas
  • Pharmaceutical Preparations
  • Monitoring

• Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment.

  Bijlsma, L., Boix, C., Niessen, W. M. A., Ibañez, M., Sancho, J. V. & Hernandez, F., 2013, In: Science of the Total Environment. 443, p. 200-208

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • benzoylecgonine
  • Metabolites
  • benzoylnorecgonine
  • Chlorination
  • degradation product

• Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry. (I) Degradation experiments.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2013, In: Journal of Mass Spectrometry. 48, p. 1091-1100

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Liquid chromatography
  • Mass spectrometry
  • Omeprazole
  • Surface waters
  • Degradation

• Identification of new omeprazole metabolites in wastewaters and surface waters.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In: Science of the Total Environment. 468-469, p. 706-714

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Surface waters
  • Metabolites
  • Omeprazole
  • Wastewater
  • metabolite

• Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

  Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H. & Niessen, W. M. A., 2013, In: Journal of Chromatography B. 917-918, p. 53-61

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Albumins
  • N-acetyl-4-benzoquinoneimine
  • Cysteine
  • Serum
  • Pharmaceutical Preparations

• Hyphenated Techniques, Applications of in Mass Spectrometry

  Niessen, W. M. A., 2013, Elsevier Reference Module Chemical, Molecular Sciences and Engineering.

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic

• High-resolution fractionation after gas chromatography for Effect Directed Analysis.

  Pieke, E., Heus, F. A. H., Kamstra, J., Mladic, M., van Velzen, M., Kamminga, D., Lamoree, M. H., Hamers, T., Leonards, P. E. G., Niessen, W. M. A. & Kool, J., 2013, In: Analytical Chemistry. 85, 17, p. 8204-8211

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Fractionation
  • Gas chromatography
  • Aryl Hydrocarbon Receptors
  • Bioactivity
  • pentane

• Evaluation of different column chemistries for fast urinary metabolic profiling.

  Kloos, D., Lingeman, H., Niessen, W. M. A., Deelder, A. M., Giera, M. & Mayboroda, O. A., 2013, In: Journal of Chromatography B. 927, p. 90-96

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Porous materials

• EC–SPE–stripline-NMR analysis of reactive products: A feasibility study.

  Falck, D., Oosthoek-de Vries, A. J., Kolkman, A. J., Lingeman, H., Honing, M., Wijmenga, S. S., Kentgens, A. P. M. & Niessen, W. M. A., 2013, In: Analytical and Bioanalytical Chemistry. 405, p. 6711-6720

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Nuclear magnetic resonance spectroscopy
  • Feasibility Studies
  • Solid Phase Extraction
  • Magnetic Resonance Spectroscopy
  • BIRB 796

• Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures.

  Falck, D., Schebb, N. H., Prinatiningtyas, S., Zhang, J., Heus, F. A. H., Morisseau, C., Kool, J., Hammock, B. D. & Niessen, W. M. A., 2013, In: Chromatographia. 76, p. 13-21

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Liquid chromatography
  • Epoxide Hydrolases
  • Liquid Chromatography
  • Metabolites
  • Assays

• Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

  Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In: Analytical Chemistry. 88, p. 4825-4832

  Research output: Contribution to Journal › Article › Academic › peer-review

• Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

  Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Sterols
  • Gas Chromatography

• Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

  Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biotransformation
  • Metabolites
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitors.

  Rea, V., Falck, D., Kool, J., de Kanter, F. J. J., Commandeur, J. N. M., Vermeulen, N. P. E., Niessen, W. M. A. & Honing, M., 2013, In: MedChemComm. 4, p. 371-377

  Research output: Contribution to Journal › Article › Academic › peer-review

  • N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
  • Biotransformation
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

  Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In: TrAC. Trends in Analytical Chemistry. 61, p. 17-28

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Carboxylic Acids
  • Liquid chromatography
  • Chain length

• Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

  van den Broek, I., van Dongen, W. D. & Niessen, W. M. A., 2013, In: Journal of Chromatography B. 929, p. 161-179

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biological Products
  • Mass spectrometry
  • Purification
  • Proteins
  • Toxicokinetics

• At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

  Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In: Toxicon. 110, p. 79-89

  Research output: Contribution to Journal › Article › Academic › peer-review

• At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

  Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In: Journal of Biomolecular Screening. 21, p. 459-467

  Research output: Contribution to Journal › Article › Academic › peer-review

• An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity.

  Heus, F. A. H., Vonk, F., Otvos, R. A., Bruyneel, B., Smit, A. B., Lingeman, H., Richardson, M., Niessen, W. M. A. & Kool, J., 2013, In: Toxicon. 61, p. 112-124

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Snake Venoms
  • Microfluidics
  • Venoms
  • Nicotinic Receptors
  • Bungarotoxins

• Analytical workflow for rapid screening and purification of bioactives from venom proteomes

  Otvos, R. A., Heus, F. A. M., Vonk, F. J., Halff, J., Bruynzeel, B., Paliukhovich, I., Smit, A. B., Niessen, W. M. A. & Kool, J., 2013, In: Toxicon. 76, p. 270-281

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Venoms
  • Workflow
  • Purification
  • Proteome
  • Screening

• A high-throughput sample preparation method for cellular proteomics using 96-well filter plates.

  Switzar, L., van Angeren, J. A., Pinkse, M., Kool, J. & Niessen, W. M. A., 2013, In: Journal of Proteomics. 13, p. 2980-2983

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Proteomics
  • Molecular weight
  • Denaturation
  • Alkylation
  • Organic solvents