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• Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In : Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples.

  Lakayan, D., Haselberg, R., Niessen, W. M. A., Somsen, G. W. & Kool, J., 2016, In : Journal of Chromatography A. 1452, p. 81-88

  Research output: Contribution to Journal › Article › Academic › peer-review

• Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

  Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Microfluidics
  • Venoms
  • Snake Venoms
  • Acetylcholine
  • Carrier Proteins

• Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

  Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In : SLAS Discovery. 23, 3, p. 283-293 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP1A2 Inhibitors
  • Metabolites
  • Mass spectrometry
  • ellipticine
  • Bioactivity

• Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

  Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In : Biology. 3, p. 139-156

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Bioactivity
  • Mass spectrometry
  • Snails
  • Purification
  • toads

• LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

  Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In : Microchemical Journal. 141, p. 135-140 6 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Assays
  • Warfarin
  • Plasmas
  • Pharmaceutical Preparations
  • Monitoring

• Identification of new omeprazole metabolites in wastewaters and surface waters.

  Boix, C., Ibáñez, M., Zamora, T., Sancho, J. V., Niessen, W. M. A. & Hernández, F., 2014, In : Science of the Total Environment. 468-469, p. 706-714

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Surface waters
  • Metabolites
  • Omeprazole
  • Wastewater
  • metabolite

• Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

  Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Analytical Chemistry. 88, p. 4825-4832

  Research output: Contribution to Journal › Article › Academic › peer-review

• Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

  Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Ionization
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Sterols
  • Gas Chromatography

• Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.

  Falck, D., Pirkolachachi, F. R., Giera, M., Honing, M., Kool, J. & Niessen, W. M. A., 2014, In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 235-244

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Biotransformation
  • Metabolites
  • p38 Mitogen-Activated Protein Kinases
  • Screening
  • Lead compounds

• Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

  Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : TrAC. Trends in Analytical Chemistry. 61, p. 17-28

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Chromatography
  • Mass spectrometry
  • Carboxylic Acids
  • Liquid chromatography
  • Chain length

• At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

  Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In : Toxicon. 110, p. 79-89

  Research output: Contribution to Journal › Article › Academic › peer-review

• At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

  Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In : Journal of Biomolecular Screening. 21, p. 459-467

  Research output: Contribution to Journal › Article › Academic › peer-review