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  Amino acid analysis using chromatography–mass spectrometry: An inter platform comparison study

  Krumpochova, P., Bruyneel, B., Molenaar, D., Koukou, A., Wuhrer, M., Niessen, W. M. A. & Giera, M. A., 2015, In: Journal of Pharmaceutical and Biomedical Analysis. 114, p. 398-407

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Spectrometry
  • Liquid chromatography
  • Spectrum Analysis
  • Mass spectrometry
  • Liquid Chromatography

• At-line cellular screening methodology for identification of bioactives in mixtures targeting the alpha7-n AChR.

  Ötvös, R. A., Mladic, M., Arias-Alpizar, G., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In: Journal of Biomolecular Screening. 21, p. 459-467

  Research output: Contribution to Journal › Article › Academic › peer-review

• At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2

  Mladic, M., Scholten, D. J., Niessen, W. M. A., Somsen, G. W., Smit, M. J. & Kool, J., 2015, In: Journal of Chromatography B. 1002, p. 42-53 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide
  • Metabolites
  • Mass spectrometry
  • Chemokine Receptors
  • Mass Spectrometry

• At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake vemoms.

  Mladic, M., Zietek, B. M., Krishnamoorthy Iyer, J., Hermarij, P., Niessen, W. M. A., Somsen, G. W., Kini, R. M. & Kool, J., 2016, In: Toxicon. 110, p. 79-89

  Research output: Contribution to Journal › Article › Academic › peer-review

• Development of an online cell-based bioactivity screening method by couplling liquid chromatography in flow cytometry with parallel mass spectrometry.

  Ötvös, R. A., van Nierop, P., Niessen, W. M. A., Manjunatha Kini, R., Somsen, G. W., Smit, A. B. & Kool, J., 2016, In: Analytical Chemistry. 88, p. 4825-4832

  Research output: Contribution to Journal › Article › Academic › peer-review

• Identification of novel bioactives on the alpha-7-nAChR using an at-line cellular bioassay after nanofractionation

  Otvos, R. A., Mladic, M., Alpizar, G. A., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., Sep 2015, In: European Neuropsychopharmacology. 25, p. S244-S245

  Research output: Contribution to Journal › Article › Academic › peer-review

• LC–MS/MS assay for assessing medical adherence in patients under warfarin maintenance therapy

  Farouk, F., Nabhan, S., Niessen, W. M. A. & Azzazy, H. M. E., 1 Sep 2018, In: Microchemical Journal. 141, p. 135-140 6 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Assays
  • Warfarin
  • Plasmas
  • Pharmaceutical Preparations
  • Monitoring

• Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

  Mladic, M., Scholten, D. J., Wijtmans, M., Falck, D., Leurs, R., Niessen, W. M. A., Smit, M. J. & Kool, J., Sep 2015, In: Analytical and Bioanalytical Chemistry. 407, 23, p. 7067-81 15 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Liquid chromatography
  • Mass spectrometry
  • Chemokine Receptors
  • Metabolites
  • Liquid Chromatography

• Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

  Zietek, B. M., Mladic, M., Bruyneel, B., Niessen, W. M. A., Honing, M., Somsen, G. W. & Kool, J., Mar 2018, In: SLAS Discovery. 23, 3, p. 283-293 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Cytochrome P-450 CYP1A2 Inhibitors
  • Metabolites
  • Mass spectrometry
  • ellipticine
  • Bioactivity

• Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

  Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In: Toxicon. 148, p. 213-222 10 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Microfluidics
  • Venoms
  • Snake Venoms
  • Acetylcholine
  • Carrier Proteins

• On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples.

  Lakayan, D., Haselberg, R., Niessen, W. M. A., Somsen, G. W. & Kool, J., 2016, In: Journal of Chromatography A. 1452, p. 81-88

  Research output: Contribution to Journal › Article › Academic › peer-review

• Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In: Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

• Solution-phase electrochemistry-nuclear magnetic resonance of small organic molecules

  Falck, D. & Niessen, W. M. A., 2015, In: TrAC. Trends in Analytical Chemistry. 70, p. 31-39

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Electrochemistry
  • Nuclear magnetic resonance
  • Molecules
  • Spectrometry
  • Electrodes