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• 2020

  Analytics for bioactivity profiling of complex mixtures with a focus on venoms

  Mladic, M., Niessen, W. M. A., Somsen, G. W. & Kool, J., 1 Jan 2020, Snake and spider toxins: methods and protocols. Humana Press Inc., p. 27-49 23 p. (Methods in Molecular Biology; vol. 2068).

  Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

  • Venoms
  • Complex Mixtures
  • Drug Discovery
  • Biological Assay
  • Biological Products
• 2017

  Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS

  Mladic, M., de Waal, T., Burggraaff, L., Slagboom, J., Somsen, G. W., Niessen, W. M. A., Kini, R. M. & Kool, J., Oct 2017, In: Analytical and Bioanalytical Chemistry. 409, 25, p. 5987-5997 11 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access
• 2015

  Amino acid analysis using chromatography–mass spectrometry: An inter platform comparison study

  Krumpochova, P., Bruyneel, B., Molenaar, D., Koukou, A., Wuhrer, M., Niessen, W. M. A. & Giera, M. A., 2015, In: Journal of Pharmaceutical and Biomedical Analysis. 114, p. 398-407

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Spectrometry
  • Liquid chromatography
  • Spectrum Analysis
  • Mass spectrometry
  • Liquid Chromatography

• At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2

  Mladic, M., Scholten, D. J., Niessen, W. M. A., Somsen, G. W., Smit, M. J. & Kool, J., 2015, In: Journal of Chromatography B. 1002, p. 42-53 12 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  • 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide
  • Metabolites
  • Mass spectrometry
  • Chemokine Receptors
  • Mass Spectrometry

• Identification of novel bioactives on the alpha-7-nAChR using an at-line cellular bioassay after nanofractionation

  Otvos, R. A., Mladic, M., Alpizar, G. A., Niessen, W. M. A., Somsen, G. W., Smit, A. B. & Kool, J., Sep 2015, In: European Neuropsychopharmacology. 25, p. S244-S245

  Research output: Contribution to Journal › Article › Academic › peer-review

• Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

  Mladic, M., Scholten, D. J., Wijtmans, M., Falck, D., Leurs, R., Niessen, W. M. A., Smit, M. J. & Kool, J., Sep 2015, In: Analytical and Bioanalytical Chemistry. 407, 23, p. 7067-81 15 p.

  Research output: Contribution to Journal › Article › Academic › peer-review

  Open Access

  • Liquid chromatography
  • Mass spectrometry
  • Chemokine Receptors
  • Metabolites
  • Liquid Chromatography

• Solution-phase electrochemistry-nuclear magnetic resonance of small organic molecules

  Falck, D. & Niessen, W. M. A., 2015, In: TrAC. Trends in Analytical Chemistry. 70, p. 31-39

  Research output: Contribution to Journal › Article › Academic › peer-review

  • Electrochemistry
  • Nuclear magnetic resonance
  • Molecules
  • Spectrometry
  • Electrodes