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2019

Lipid-Conjugated Rigidochromic Probe Discloses Membrane Alteration in Model Cells of Krabbe Disease

Abbandonato, G., Storti, B., Tonazzini, I., Stöckl, M., Subramaniam, V., Montis, C., Nifosì, R., Cecchini, M., Signore, G. & Bizzarri, R., 5 Feb 2019, In : Biophysical Journal. 116, 3, p. 477-486 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Psychosine
Globoid Cell Leukodystrophy
Lipids
Membranes
Cell Membrane
2018

Hydrophobic-Interaction-Induced Stiffening of α -Synuclein Fibril Networks

Semerdzhiev, S. A., Lindhoud, S., Stefanovic, A., Subramaniam, V., Van Der Schoot, P. & Claessens, M. M. A. E., 17 May 2018, In : Physical Review Letters. 120, 20, p. 1-6 6 p., 208102.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
stiffening
interactions
elastic properties
enthalpy
deposits

Orthogonal supramolecular protein assembly on patterned bifunctional surfaces

Wasserberg, D., Cabanas-Danés, J., Subramaniam, V., Huskens, J. & Jonkheijm, P., 14 Feb 2018, In : Chemical Communications. 54, 13, p. 1615-1618 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
His-His-His-His-His-His
Proteins
Peptides
red fluorescent protein
Open Access
File
Synucleins
Fluorescence
Binding Sites
Amyloid
thioflavin T

Spermine induced reversible collapse of deoxyribonucleic acid-bridged nanoparticle-based assemblies

Göeken, K. L., Schasfoort, R. B. M., Subramaniam, V. & Gill, R., Jan 2018, In : Nano Research. 11, 1, p. 383–396 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Spermine
DNA
Nanoparticles
Surface plasmon resonance
Geometry
2017

Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding

Robotta, M., Cattani, J., Martins, J. C., Subramaniam, V. & Drescher, M., 20 Mar 2017, In : Journal of the American Chemical Society.

Research output: Contribution to JournalArticleAcademicpeer-review

alpha-Synuclein
Parkinson Disease
Mutation
Membranes
Intrinsically Disordered Proteins

Controlling Protein Surface Orientation by Strategic Placement of Oligo-Histidine Tags

Wasserberg, D., Cabanas-Danés, J., Prangsma, J., O'Mahony, S., Cazade, P. A., Tromp, E., Blum, C., Thompson, D., Huskens, J., Subramaniam, V. & Jonkheijm, P., 26 Sep 2017, In : ACS Nano. 11, 9, p. 9068-9083 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
His-His-His-His-His-His
histidine
Histidine
Membrane Proteins
proteins

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

Iyer, A., Roeters, S. J., Kogan, V., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 1 Nov 2017, In : Journal of the American Chemical Society. 139, 43, p. 15392-15400 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Amyloid
Circular Dichroism
Polymorphism
Parkinson Disease

Direct Visualization of Model Membrane Remodeling by α-Synuclein Fibrillization

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 20 Jun 2017, In : ChemPhysChem. 18, 12, p. 1620-1626 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Visualization
membranes
Membranes
lipids

Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation

Sidhu, A., Segers-Nolten, I., Raussens, V., Claessens, M. M. A. E. & Subramaniam, V., 15 Mar 2017, In : ACS Chemical Neuroscience. 8, 3, p. 538-547 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Polymorphism
Amyloid
Growth
Assays

Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy

Roeters, S. J., Iyer, A., Pletikapić, G., Kogan, V., Subramaniam, V. & Woutersen, S., 23 Jan 2017, In : Scientific Reports. 7, p. 41051

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
alpha-Synuclein
Atomic Force Microscopy
Spectrum Analysis
Buffers
Osmolar Concentration

Intracellular Manipulation of Phagosomal Transport and Maturation Using Magnetic Tweezers

Shekhar, S., Subramaniam, V. & Kanger, J. S., 2017, In : Methods in Molecular Biology. 1519, p. 93-112 20 p.

Research output: Contribution to JournalArticleAcademic

Phagosomes
Calibration
Immune System Phenomena
Phagocytes
Microspheres

Membrane Binding of Parkinson's Protein α-Synuclein: Effect of Phosphorylation at Positions 87 and 129 by the S to D Mutation Approach

Kumar, P., Schilderink, N., Subramaniam, V. & Huber, M., 1 Jul 2017, In : Israel Journal of Chemistry. 57, 7, p. 762-770 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Phosphorylation
Membranes
Proteins
Spin Labels

Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates

Semerdzhiev, S. A., Shvadchak, V. V., Subramaniam, V. & Claessens, M. M. A. E., 1 Dec 2017, In : Scientific Reports. 7, 1, 7699.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
self assembly
anisotropy
proteins
biopolymers
polarity

Room-temperature in-cell EPR spectroscopy: Alpha-Synuclein disease variants remain intrinsically disordered in the cell

Cattani, J., Subramaniam, V. & Drescher, M., 2017, In : Physical Chemistry Chemical Physics. 19, 28, p. 18147-18151 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

alpha-Synuclein
Paramagnetic resonance
Spectroscopy
Parkinson disease
Conformations

Solubilization of lipids and lipid phases by the styrene-maleic acid copolymer

Dominguez Pardo, J. J., Dörr, J. M., Iyer, A., Cox, R. C., Scheidelaar, S., Koorengevel, M. C., Subramaniam, V. & Killian, J. A., Jan 2017, In : European Biophysics Journal. 46, 1, p. 91-101 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Styrene
Lipids
Membranes
Membrane Lipids
maleic acid
2016

Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm

Chang, L., Weiss, N., van Leeuwen, T. G., Pollnau, M., de Ridder, R. M., Wörhoff, K., Subramaniam, V. & Kanger, J. S., 13 Jun 2016, In : Optics Express. 24, 12, p. 12635-50 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
optical paths
tomography
chips
retarding
lenses

Conformational Compatibility Is Essential for Heterologous Aggregation of α-Synuclein

Sidhu, A., Segers-Nolten, I. & Subramaniam, V., 15 Jun 2016, In : ACS Chemical Neuroscience. 7, 6, p. 719-27 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Seed
Seeds
Agglomeration
Monomers

Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells

Apetri, M. M., Harkes, R., Subramaniam, V., Canters, G. W., Schmidt, T. & Aartsma, T. J., 2016, In : PLoS ONE. 11, 4, p. e0153020

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Transport Vesicles
protein aggregates
amyloid
Neuroblastoma

Fluorescence Methods for Unraveling Oligomeric Amyloid Intermediates

Zijlstra, N., Schilderink, N. & Subramaniam, V., 2016, In : Methods in Molecular Biology. 1345, p. 151-69 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amyloid
Synucleins
Fluorescence
Photobleaching
Poisons

Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology

Raiss, C. C., Braun, T. S., Konings, I. B. M., Grabmayr, H., Hassink, G. C., Sidhu, A., le Feber, J., Bausch, A. R., Jansen, C., Subramaniam, V. & Claessens, M. M. A. E., 17 Mar 2016, In : Scientific Reports. 6, p. 23116

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Lewy Bodies
Parkinson Disease
Pathology
Proteasome Endopeptidase Complex

Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing

Iyer, A., Schilderink, N., Claessens, M. M. A. E. & Subramaniam, V., 6 Dec 2016, In : Biophysical Journal. 111, 11, p. 2440-2449 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
alpha-Synuclein
Lipids
Membranes
Phospholipids
Synucleins

p53 Specifically Binds Triplex DNA In Vitro and in Cells

Brázdová, M., Tichý, V., Helma, R., Bažantová, P., Polášková, A., Krejčí, A., Petr, M., Navrátilová, L., Tichá, O., Nejedlý, K., Bennink, M. L., Subramaniam, V., Bábková, Z., Martínek, T., Lexa, M. & Adámik, M., 2016, In : PLoS ONE. 11, 12, p. e0167439

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA
cells
consensus sequence
Consensus Sequence
Transcription

Size-selective analyte detection with a Young interferometer sensor using multiple wavelengths

Mulder, H. K. P., Blum, C., Subramaniam, V. & Kanger, J. S., 18 Apr 2016, In : Optics Express. 24, 8, p. 8594-619 26 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
interferometers
sensors
wavelengths
beads
proteins

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Iyer, A., Roeters, S. J., Schilderink, N., Hommersom, B., Heeren, R. M. A., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 30 Sep 2016, In : Journal of Biological Chemistry. 291, 40, p. 21110-21122 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
Acetylation
Phospholipids
Membranes
Agglomeration

α-Synuclein Oligomers Stabilize Pre-Existing Defects in Supported Bilayers and Propagate Membrane Damage in a Fractal-Like Pattern

Chaudhary, H., Iyer, A., Subramaniam, V. & Claessens, M. M. A. E., 15 Nov 2016, In : Langmuir. 32, 45, p. 11827-11836 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synucleins
oligomers
Oligomers
Fractals
fractals