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  • R. Leurs
2016

PDEStrIAn: A phosphodiesterase structure and ligan interaction annotated database as a tool for structure-based drug design.

Jansen, C. J. W., Kooistra, A. J., Kanev, G. K., Leurs, R., de Esch, I. J. P. & de Graaf, C., 2016, In : Journal of Medicinal Chemistry. 59, 15, p. 7029-7065

Research output: Contribution to JournalArticle

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.

Veerman, J., van den Bergh, T., Orrling, K. M., Jansen, C. J. W., Cos, P., Maes, L., Chatelain, E., Ioset, J. R., Edink, E. S. E., Tenor, H., Seebeck, T., de Esch, I. J. P., Leurs, R. & Sterk, G. J., 2016, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1573-1581

Research output: Contribution to JournalArticle

Open Access

The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.

de Munnik, S. M., van der Lee, R., Velders, D. M., van Offenbeek, J., Smits-de Vries, L., Leurs, R., Smit, M. J. & Vischer, H. F., 2016, In : Cellular Signalling. 28, 6, p. 595-605

Research output: Contribution to JournalArticle