A ban on BAM: an update on inhibitors of the β-barrel assembly machinery

Maurice Steenhuis, Peter van Ulsen, Nathaniel I. Martin, Joen Luirink

Research output: Contribution to JournalArticleAcademicpeer-review


Gram-negative pathogens are a rapidly increasing threat to human health worldwide due to high rates of antibiotic resistance and the lack of development of novel antibiotics. The protective cell envelope of gram-negative bacteria is a major permeability barrier that contributes to the problem by restricting the uptake of antibiotics. On the other hand, its unique architecture also makes it a suitable target for antibiotic interference. In particular, essential multiprotein machines that are required for biogenesis of the outer membrane have attracted attention in antibacterial design strategies. Recently, significant progress has been made in the development of inhibitors of the β-barrel assembly machine (BAM) complex. Here, we summarize the current state of drug development efforts targeting the BAM complex in pursuit of new antibiotics.

Original languageEnglish
Article numberfnab059
Pages (from-to)1-8
Number of pages8
JournalFEMS microbiology letters
Issue number11
Early online date28 May 2021
Publication statusPublished - Jun 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine


  • Escherichia coli, potentiators
  • Antibiotics
  • cell envelope stress
  • outer membrane
  • resistance


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