A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults

Francisco J. Osuna-Prieto; Lucas Jurado-Fasoli; Abel Plaza-Florido; Wei Yang; Isabelle Kohler; Xinyu Di; José Rubio-López; Guillermo Sanchez-Delgado; Patrick C.N. Rensen; Jonatan R. Ruiz; Borja Martinez-Tellez

doi:10.1111/sms.14405

A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults

Francisco J. Osuna-Prieto^*, Lucas Jurado-Fasoli, Abel Plaza-Florido, Wei Yang, Isabelle Kohler, Xinyu Di, José Rubio-López, Guillermo Sanchez-Delgado, Patrick C.N. Rensen, Jonatan R. Ruiz^*, Borja Martinez-Tellez

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Circulating bile acids (BA) are signaling molecules that control glucose and lipid metabolism. However, the effects of acute exercise on plasma levels of BA in humans remain poorly understood. Here, we evaluate the effects of a bout of maximal endurance exercise (EE) and resistance exercise (RE) on plasma levels of BA in young, sedentary adults. Concentration of eight plasma BA was measured by liquid chromatography–tandem mass spectrometry before and 3, 30, 60, and 120 min after each exercise bout. Cardiorespiratory fitness (CRF) was assessed in 14 young adults (21.8 ± 2.5 yo, 12 women); muscle strength was assessed in 17 young adults (22.4 ± 2.5 yo, 11 women). EE transiently decreased plasma levels of total, primary, and secondary BA at 3 and 30 min after exercise. RE exerted a prolonged reduction in plasma levels of secondary BA (p < 0.001) that lasted until 120 min. Primary BA levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) were different across individuals with low/high CRF levels after EE (p ≤ 0.044); CA levels were different across individuals with low/high handgrip strength levels. High CRF individuals presented higher levels of CA and CDCA 120 min after exercise vs baseline (+77% and +65%) vs the low CRF group (−5% and −39%). High handgrip strength levels individuals presented higher levels of CA 120 min after exercise versus baseline (+63%) versus the low handgrip strength group (+6%). The study findings indicate that an individual's level of physical fitness can influence how circulating BA respond to both endurance and resistance exercise. Additionally, the study suggests that changes in plasma BA levels after exercising could be related to the control of glucose homeostasis in humans.

Original language	English
Pages (from-to)	1607-1620
Number of pages	14
Journal	Scandinavian Journal of Medicine and Science in Sports
Volume	33
Issue number	9
Early online date	6 Jun 2023
DOIs	https://doi.org/10.1111/sms.14405
Publication status	Published - Sept 2023

Bibliographical note

Funding Information:
The study was supported by the (ref. P18‐RT‐4455, and ref. SOMM17/6107/UGR) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016‐79512‐R to JRR), the Spanish Ministry of Education (FPU 16/02828, FPU19/01609), the University of Granada Plan Propio de Investigación 2016‐Excellence actions: Unit of Excellence on Exercise and Health (UCEES), and the Chinese Scholarship Council (CSC; No. 201707060012 to XD, No. 201607060017 to WY). BMT is supported with a Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea—NextGenerationEU (RR_C_2021_04). Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento

Publisher Copyright:
© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.

Funding

The study was supported by the (ref. P18‐RT‐4455, and ref. SOMM17/6107/UGR) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016‐79512‐R to JRR), the Spanish Ministry of Education (FPU 16/02828, FPU19/01609), the University of Granada Plan Propio de Investigación 2016‐Excellence actions: Unit of Excellence on Exercise and Health (UCEES), and the Chinese Scholarship Council (CSC; No. 201707060012 to XD, No. 201607060017 to WY). BMT is supported with a Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea—NextGenerationEU (RR_C_2021_04). Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento

Funders	Funder number
Ministerio de Universidades y la Unión Europea	RR_C_2021_04
University of Granada Plan Propio de Investigación
Ministerio de Educación, Cultura y Deporte	FPU 16/02828, FPU19/01609
Ministerio de Educación, Cultura y Deporte
Ministerio de Economía y Competitividad
China Scholarship Council	201607060017, 201707060012
China Scholarship Council
European Regional Development Fund

Keywords

Chenodeoxycholic acid
cholic acid
exerkines
lipidomics
physical fitness

Access to Document

10.1111/sms.14405

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Osuna-Prieto, F. J., Jurado-Fasoli, L., Plaza-Florido, A., Yang, W., Kohler, I., Di, X., Rubio-López, J., Sanchez-Delgado, G., Rensen, P. C. N., Ruiz, J. R., & Martinez-Tellez, B. (2023). A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults. Scandinavian Journal of Medicine and Science in Sports, 33(9), 1607-1620. https://doi.org/10.1111/sms.14405

@article{55577ad134274878bb63b6d73a480922,

title = "A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults",

abstract = "Circulating bile acids (BA) are signaling molecules that control glucose and lipid metabolism. However, the effects of acute exercise on plasma levels of BA in humans remain poorly understood. Here, we evaluate the effects of a bout of maximal endurance exercise (EE) and resistance exercise (RE) on plasma levels of BA in young, sedentary adults. Concentration of eight plasma BA was measured by liquid chromatography–tandem mass spectrometry before and 3, 30, 60, and 120 min after each exercise bout. Cardiorespiratory fitness (CRF) was assessed in 14 young adults (21.8 ± 2.5 yo, 12 women); muscle strength was assessed in 17 young adults (22.4 ± 2.5 yo, 11 women). EE transiently decreased plasma levels of total, primary, and secondary BA at 3 and 30 min after exercise. RE exerted a prolonged reduction in plasma levels of secondary BA (p < 0.001) that lasted until 120 min. Primary BA levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) were different across individuals with low/high CRF levels after EE (p ≤ 0.044); CA levels were different across individuals with low/high handgrip strength levels. High CRF individuals presented higher levels of CA and CDCA 120 min after exercise vs baseline (+77% and +65%) vs the low CRF group (−5% and −39%). High handgrip strength levels individuals presented higher levels of CA 120 min after exercise versus baseline (+63%) versus the low handgrip strength group (+6%). The study findings indicate that an individual's level of physical fitness can influence how circulating BA respond to both endurance and resistance exercise. Additionally, the study suggests that changes in plasma BA levels after exercising could be related to the control of glucose homeostasis in humans.",

keywords = "Chenodeoxycholic acid, cholic acid, exerkines, lipidomics, physical fitness",

author = "Osuna-Prieto, {Francisco J.} and Lucas Jurado-Fasoli and Abel Plaza-Florido and Wei Yang and Isabelle Kohler and Xinyu Di and Jos{\'e} Rubio-L{\'o}pez and Guillermo Sanchez-Delgado and Rensen, {Patrick C.N.} and Ruiz, {Jonatan R.} and Borja Martinez-Tellez",

note = "Funding Information: The study was supported by the (ref. P18‐RT‐4455, and ref. SOMM17/6107/UGR) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016‐79512‐R to JRR), the Spanish Ministry of Education (FPU 16/02828, FPU19/01609), the University of Granada Plan Propio de Investigaci{\'o}n 2016‐Excellence actions: Unit of Excellence on Exercise and Health (UCEES), and the Chinese Scholarship Council (CSC; No. 201707060012 to XD, No. 201607060017 to WY). BMT is supported with a Maria Zambrano fellowship by the Ministerio de Universidades y la Uni{\'o}n Europea—NextGenerationEU (RR_C_2021_04). Junta de Andaluc{\'i}a, Consejer{\'i}a de Transformaci{\'o}n Econ{\'o}mica, Industria, Conocimiento y Universidades Direcci{\'o}n General de Investigaci{\'o}n y Transferencia del Conocimiento Publisher Copyright: {\textcopyright} 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.",

year = "2023",

month = sep,

doi = "10.1111/sms.14405",

language = "English",

volume = "33",

pages = "1607--1620",

journal = "Scandinavian Journal of Medicine and Science in Sports",

issn = "0905-7188",

publisher = "Blackwell Munksgaard",

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Osuna-Prieto, FJ, Jurado-Fasoli, L, Plaza-Florido, A, Yang, W, Kohler, I, Di, X, Rubio-López, J, Sanchez-Delgado, G, Rensen, PCN, Ruiz, JR & Martinez-Tellez, B 2023, 'A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults', Scandinavian Journal of Medicine and Science in Sports, vol. 33, no. 9, pp. 1607-1620. https://doi.org/10.1111/sms.14405

A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults. / Osuna-Prieto, Francisco J.; Jurado-Fasoli, Lucas; Plaza-Florido, Abel et al.
In: Scandinavian Journal of Medicine and Science in Sports, Vol. 33, No. 9, 09.2023, p. 1607-1620.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults

AU - Osuna-Prieto, Francisco J.

AU - Jurado-Fasoli, Lucas

AU - Plaza-Florido, Abel

AU - Yang, Wei

AU - Kohler, Isabelle

AU - Di, Xinyu

AU - Rubio-López, José

AU - Sanchez-Delgado, Guillermo

AU - Rensen, Patrick C.N.

AU - Ruiz, Jonatan R.

AU - Martinez-Tellez, Borja

N1 - Funding Information: The study was supported by the (ref. P18‐RT‐4455, and ref. SOMM17/6107/UGR) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016‐79512‐R to JRR), the Spanish Ministry of Education (FPU 16/02828, FPU19/01609), the University of Granada Plan Propio de Investigación 2016‐Excellence actions: Unit of Excellence on Exercise and Health (UCEES), and the Chinese Scholarship Council (CSC; No. 201707060012 to XD, No. 201607060017 to WY). BMT is supported with a Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea—NextGenerationEU (RR_C_2021_04). Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento Publisher Copyright: © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.

PY - 2023/9

Y1 - 2023/9

N2 - Circulating bile acids (BA) are signaling molecules that control glucose and lipid metabolism. However, the effects of acute exercise on plasma levels of BA in humans remain poorly understood. Here, we evaluate the effects of a bout of maximal endurance exercise (EE) and resistance exercise (RE) on plasma levels of BA in young, sedentary adults. Concentration of eight plasma BA was measured by liquid chromatography–tandem mass spectrometry before and 3, 30, 60, and 120 min after each exercise bout. Cardiorespiratory fitness (CRF) was assessed in 14 young adults (21.8 ± 2.5 yo, 12 women); muscle strength was assessed in 17 young adults (22.4 ± 2.5 yo, 11 women). EE transiently decreased plasma levels of total, primary, and secondary BA at 3 and 30 min after exercise. RE exerted a prolonged reduction in plasma levels of secondary BA (p < 0.001) that lasted until 120 min. Primary BA levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) were different across individuals with low/high CRF levels after EE (p ≤ 0.044); CA levels were different across individuals with low/high handgrip strength levels. High CRF individuals presented higher levels of CA and CDCA 120 min after exercise vs baseline (+77% and +65%) vs the low CRF group (−5% and −39%). High handgrip strength levels individuals presented higher levels of CA 120 min after exercise versus baseline (+63%) versus the low handgrip strength group (+6%). The study findings indicate that an individual's level of physical fitness can influence how circulating BA respond to both endurance and resistance exercise. Additionally, the study suggests that changes in plasma BA levels after exercising could be related to the control of glucose homeostasis in humans.

AB - Circulating bile acids (BA) are signaling molecules that control glucose and lipid metabolism. However, the effects of acute exercise on plasma levels of BA in humans remain poorly understood. Here, we evaluate the effects of a bout of maximal endurance exercise (EE) and resistance exercise (RE) on plasma levels of BA in young, sedentary adults. Concentration of eight plasma BA was measured by liquid chromatography–tandem mass spectrometry before and 3, 30, 60, and 120 min after each exercise bout. Cardiorespiratory fitness (CRF) was assessed in 14 young adults (21.8 ± 2.5 yo, 12 women); muscle strength was assessed in 17 young adults (22.4 ± 2.5 yo, 11 women). EE transiently decreased plasma levels of total, primary, and secondary BA at 3 and 30 min after exercise. RE exerted a prolonged reduction in plasma levels of secondary BA (p < 0.001) that lasted until 120 min. Primary BA levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) were different across individuals with low/high CRF levels after EE (p ≤ 0.044); CA levels were different across individuals with low/high handgrip strength levels. High CRF individuals presented higher levels of CA and CDCA 120 min after exercise vs baseline (+77% and +65%) vs the low CRF group (−5% and −39%). High handgrip strength levels individuals presented higher levels of CA 120 min after exercise versus baseline (+63%) versus the low handgrip strength group (+6%). The study findings indicate that an individual's level of physical fitness can influence how circulating BA respond to both endurance and resistance exercise. Additionally, the study suggests that changes in plasma BA levels after exercising could be related to the control of glucose homeostasis in humans.

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KW - cholic acid

KW - exerkines

KW - lipidomics

KW - physical fitness

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DO - 10.1111/sms.14405

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EP - 1620

JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

IS - 9

ER -

A bout of endurance and resistance exercise transiently decreases plasma levels of bile acids in young, sedentary adults

Abstract

Bibliographical note

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Keywords

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